Result of FASTA (omim) for pF1KB4388
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4388, 349 aa
  1>>>pF1KB4388 349 - 349 aa - 349 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.8084+/-0.00047; mu= 18.8011+/- 0.029
 mean_var=92.4311+/-23.323, 0's: 0 Z-trim(110.0): 476  B-trim: 2176 in 2/51
 Lambda= 0.133403
 statistics sampled from 17595 (18262) to 17595 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.568), E-opt: 0.2 (0.214), width:  16
 Scan time:  7.430

The best scores are:                                      opt bits E(85289)
NP_005285 (OMIM: 601909) probable G-protein couple ( 349) 2376 468.2 1.2e-131
XP_005251990 (OMIM: 601909) PREDICTED: probable G- ( 349) 2376 468.2 1.2e-131
NP_005675 (OMIM: 604106) probable G-protein couple ( 361) 1595 317.9 2.2e-86
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359)  348 77.9 3.8e-14
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362)  348 77.9 3.8e-14
NP_001124527 (OMIM: 142703) histamine H2 receptor  ( 397)  348 78.0   4e-14
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422)  348 78.0 4.2e-14
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422)  348 78.0 4.2e-14
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422)  348 78.0 4.2e-14
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422)  348 78.0 4.2e-14
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422)  348 78.0 4.2e-14
NP_778227 (OMIM: 608282) trace amine-associated re ( 348)  313 71.2 3.9e-12
NP_000668 (OMIM: 600445) adenosine receptor A3 iso ( 318)  303 69.2 1.4e-11
NP_778237 (OMIM: 608923) trace amine-associated re ( 345)  298 68.3 2.9e-11
NP_055441 (OMIM: 604849) trace amine-associated re ( 306)  290 66.7 7.8e-11
NP_001028252 (OMIM: 604849) trace amine-associated ( 351)  290 66.7 8.5e-11
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic  ( 477)  290 66.9   1e-10
NP_115940 (OMIM: 176400,604161,614837) kiSS-1 rece ( 398)  288 66.4 1.2e-10
NP_444508 (OMIM: 606927) trace amine-associated re ( 342)  287 66.1 1.3e-10
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413)  283 65.5 2.4e-10
NP_612200 (OMIM: 609333) trace amine-associated re ( 339)  278 64.4 4.1e-10
NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349)  275 63.8 6.3e-10
NP_001517 (OMIM: 602393) orexin receptor type 2 [H ( 444)  270 63.0 1.4e-09
XP_016866287 (OMIM: 602393) PREDICTED: orexin rece ( 461)  270 63.0 1.5e-09
XP_011507677 (OMIM: 612250) PREDICTED: G-protein c ( 529)  266 62.3 2.7e-09
XP_011507678 (OMIM: 612250) PREDICTED: G-protein c ( 529)  266 62.3 2.7e-09
XP_005245113 (OMIM: 612250) PREDICTED: G-protein c ( 529)  266 62.3 2.7e-09
XP_016856351 (OMIM: 612250) PREDICTED: G-protein c ( 529)  266 62.3 2.7e-09
XP_011507679 (OMIM: 612250) PREDICTED: G-protein c ( 529)  266 62.3 2.7e-09
XP_005245114 (OMIM: 612250) PREDICTED: G-protein c ( 529)  266 62.3 2.7e-09
NP_722561 (OMIM: 612250) G-protein coupled recepto ( 529)  266 62.3 2.7e-09
XP_011507680 (OMIM: 612250) PREDICTED: G-protein c ( 529)  266 62.3 2.7e-09
NP_001254539 (OMIM: 612250) G-protein coupled rece ( 529)  266 62.3 2.7e-09
XP_016856349 (OMIM: 612250) PREDICTED: G-protein c ( 529)  266 62.3 2.7e-09
XP_016856350 (OMIM: 612250) PREDICTED: G-protein c ( 529)  266 62.3 2.7e-09
NP_001254540 (OMIM: 612250) G-protein coupled rece ( 546)  266 62.3 2.8e-09
XP_005245112 (OMIM: 612250) PREDICTED: G-protein c ( 549)  266 62.3 2.8e-09
NP_001254538 (OMIM: 612250) G-protein coupled rece ( 549)  266 62.3 2.8e-09
XP_016856348 (OMIM: 612250) PREDICTED: G-protein c ( 549)  266 62.3 2.8e-09
XP_006711314 (OMIM: 612250) PREDICTED: G-protein c ( 552)  266 62.3 2.8e-09
XP_011507673 (OMIM: 612250) PREDICTED: G-protein c ( 552)  266 62.3 2.8e-09
XP_011507672 (OMIM: 612250) PREDICTED: G-protein c ( 552)  266 62.3 2.8e-09
XP_016856347 (OMIM: 612250) PREDICTED: G-protein c ( 552)  266 62.3 2.8e-09
XP_011507674 (OMIM: 612250) PREDICTED: G-protein c ( 552)  266 62.3 2.8e-09
XP_011507675 (OMIM: 612250) PREDICTED: G-protein c ( 552)  266 62.3 2.8e-09
NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478)  265 62.1 2.9e-09
XP_006711316 (OMIM: 612250) PREDICTED: G-protein c ( 609)  266 62.4   3e-09
XP_016872445 (OMIM: 606665) PREDICTED: melanopsin  ( 528)  265 62.1 3.1e-09
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328)  259 60.7 5.1e-09
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331)  259 60.7 5.1e-09


>>NP_005285 (OMIM: 601909) probable G-protein coupled re  (349 aa)
 initn: 2376 init1: 2376 opt: 2376  Z-score: 2484.5  bits: 468.2 E(85289): 1.2e-131
Smith-Waterman score: 2376; 100.0% identity (100.0% similar) in 349 aa overlap (1-349:1-349)

               10        20        30        40        50        60
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLLN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 HHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 ACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYHGDVFQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYHGDVFQW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 CAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCN
              250       260       270       280       290       300

              310       320       330       340         
pF1KB4 CVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI
       :::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 CVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI
              310       320       330       340         

>>XP_005251990 (OMIM: 601909) PREDICTED: probable G-prot  (349 aa)
 initn: 2376 init1: 2376 opt: 2376  Z-score: 2484.5  bits: 468.2 E(85289): 1.2e-131
Smith-Waterman score: 2376; 100.0% identity (100.0% similar) in 349 aa overlap (1-349:1-349)

               10        20        30        40        50        60
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNIIVIFVFHCAPLLN
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 HHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFVVSVLKSVSMASL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 ACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYHGDVFQW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHWGKPGYHGDVFQW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 CAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQARFSSQSGETG
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASFLTTWLAISNSFCN
              250       260       270       280       290       300

              310       320       330       340         
pF1KB4 CVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI
       :::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCHI
              310       320       330       340         

>>NP_005675 (OMIM: 604106) probable G-protein coupled re  (361 aa)
 initn: 1591 init1: 1140 opt: 1595  Z-score: 1672.0  bits: 317.9 E(85289): 2.2e-86
Smith-Waterman score: 1595; 67.5% identity (85.8% similar) in 345 aa overlap (8-349:20-361)

                           10        20        30        40        
pF1KB4             MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLIISGNII
                          : : .  : :.::.  .:. :..:...::.:: :::.::. 
NP_005 MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLT
               10        20        30        40        50        60

       50        60        70        80        90       100        
pF1KB4 VIFVFHCAPLLNHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLTCQIFGFV
       :::::::::::.:.::::::::::::::::::::.::.:::::.   :.::::::.::..
NP_005 VIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYI
               70        80        90       100       110       120

      110       120       130       140       150       160        
pF1KB4 VSVLKSVSMASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYSTLVFLPSFFHW
       .::::::::: :::::.:::.::::::.:: :::: :::.::.:::.:: :.:::::: :
NP_005 ISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGW
              130       140       150       160       170       180

      170       180       190       200       210       220        
pF1KB4 GKPGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISER
       ::::::::.:.::: :: :..::: ::: .::::::..::::::.::.::.::::.:..:
NP_005 GKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDR
              190       200       210       220       230       240

      230       240        250       260       270       280       
pF1KB4 QARFSSQSGETG-EVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHSNRFASF
       .::: :.  ... :.   ::.::::::::::::::.::::::::::::::   .:   ::
NP_005 RARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSF
              250       260       270       280       290       300

       290       300       310       320         330       340     
pF1KB4 LTTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSC--ASQTTANDPYTVRSKGPLN
       ::::::::::::::::::::::::. ::.::: .:::::  ...  :..:   . .   :
NP_005 LTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCMCVKDQEAQEP---KPRKRAN
              310       320       330       340       350          

           
pF1KB4 GCHI
       .: :
NP_005 SCSI
       360 

>>NP_071640 (OMIM: 142703) histamine H2 receptor isoform  (359 aa)
 initn: 227 init1: 149 opt: 348  Z-score: 375.0  bits: 77.9 E(85289): 3.8e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)

               10        20        30        40         50         
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
              : ..  ::: . .       : . . ... . .:: ..::..: ..      :
NP_071     MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
                   10               20        30        40         

      60        70        80        90       100          110      
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
        .. :. :: ..: .::..:.  :.: .: ... :  . :.    :.:.  .  .: ..:
NP_071 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
       50        60         70          80        90       100     

        120       130       140       150        160       170     
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
       . .:  ::.::: :.  :: : .:::: :. . . :::. : :: ::   . :..     
NP_071 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
         110       120       130       140       150       160     

              180       190       200       210       220       230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
        : :  . . : .   .. :  .  .. .: :  ::.:.::. ::..    ..: ..:  
NP_071 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
           170        180       190        200           210       

              240       250       260       270       280          
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
       ..:: .. : .     ... ...:  . ..: : :.::.  :. ..  : .  :.    .
NP_071 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
       220            230       240       250       260       270  

      290       300       310       320       330       340        
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
       . ::. .::  : ..:.  :  :. : ..:   .:   :....                 
NP_071 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
            280       290       300          310       320         

                                     
pF1KB4 I                             
                                     
NP_071 REPRQQEEKPLKLQVWSGTEVTAPQGATDR
     330       340       350         

>>XP_006714928 (OMIM: 142703) PREDICTED: histamine H2 re  (362 aa)
 initn: 227 init1: 149 opt: 348  Z-score: 375.0  bits: 77.9 E(85289): 3.8e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)

               10        20        30        40         50         
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
              : ..  ::: . .       : . . ... . .:: ..::..: ..      :
XP_006     MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
                   10               20        30        40         

      60        70        80        90       100          110      
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
        .. :. :: ..: .::..:.  :.: .: ... :  . :.    :.:.  .  .: ..:
XP_006 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
       50        60         70          80        90       100     

        120       130       140       150        160       170     
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
       . .:  ::.::: :.  :: : .:::: :. . . :::. : :: ::   . :..     
XP_006 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
         110       120       130       140       150       160     

              180       190       200       210       220       230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
        : :  . . : .   .. :  .  .. .: :  ::.:.::. ::..    ..: ..:  
XP_006 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
           170        180       190        200           210       

              240       250       260       270       280          
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
       ..:: .. : .     ... ...:  . ..: : :.::.  :. ..  : .  :.    .
XP_006 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
       220            230       240       250       260       270  

      290       300       310       320       330       340        
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
       . ::. .::  : ..:.  :  :. : ..:   .:   :....                 
XP_006 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
            280       290       300          310       320         

                                        
pF1KB4 I                                
                                        
XP_006 REPRQQEEKPLKLQVWSGTEVTAPQGATDRNSS
     330       340       350       360  

>>NP_001124527 (OMIM: 142703) histamine H2 receptor isof  (397 aa)
 initn: 227 init1: 149 opt: 348  Z-score: 374.5  bits: 78.0 E(85289): 4e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)

               10        20        30        40         50         
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
              : ..  ::: . .       : . . ... . .:: ..::..: ..      :
NP_001     MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
                   10               20        30        40         

      60        70        80        90       100          110      
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
        .. :. :: ..: .::..:.  :.: .: ... :  . :.    :.:.  .  .: ..:
NP_001 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
       50        60         70          80        90       100     

        120       130       140       150        160       170     
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
       . .:  ::.::: :.  :: : .:::: :. . . :::. : :: ::   . :..     
NP_001 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
         110       120       130       140       150       160     

              180       190       200       210       220       230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
        : :  . . : .   .. :  .  .. .: :  ::.:.::. ::..    ..: ..:  
NP_001 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
           170        180       190        200           210       

              240       250       260       270       280          
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
       ..:: .. : .     ... ...:  . ..: : :.::.  :. ..  : .  :.    .
NP_001 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
       220            230       240       250       260       270  

      290       300       310       320       330       340        
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
       . ::. .::  : ..:.  :  :. : ..:   .:   :....                 
NP_001 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
            280       290       300          310       320         

                                                                   
pF1KB4 I                                                           
                                                                   
NP_001 REPRQQEEKPLKLQVWSGTEVTAPQGATDRPWLCLPECWSVELTHSFIHLFIHSFANIHP
     330       340       350       360       370       380         

>>XP_016864915 (OMIM: 142703) PREDICTED: histamine H2 re  (422 aa)
 initn: 227 init1: 149 opt: 348  Z-score: 374.2  bits: 78.0 E(85289): 4.2e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)

               10        20        30        40         50         
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
              : ..  ::: . .       : . . ... . .:: ..::..: ..      :
XP_016     MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
                   10               20        30        40         

      60        70        80        90       100          110      
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
        .. :. :: ..: .::..:.  :.: .: ... :  . :.    :.:.  .  .: ..:
XP_016 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
       50        60         70          80        90       100     

        120       130       140       150        160       170     
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
       . .:  ::.::: :.  :: : .:::: :. . . :::. : :: ::   . :..     
XP_016 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
         110       120       130       140       150       160     

              180       190       200       210       220       230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
        : :  . . : .   .. :  .  .. .: :  ::.:.::. ::..    ..: ..:  
XP_016 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
           170        180       190        200           210       

              240       250       260       270       280          
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
       ..:: .. : .     ... ...:  . ..: : :.::.  :. ..  : .  :.    .
XP_016 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
       220            230       240       250       260       270  

      290       300       310       320       330       340        
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
       . ::. .::  : ..:.  :  :. : ..:   .:   :....                 
XP_016 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
            280       290       300          310       320         

                                                                   
pF1KB4 I                                                           
                                                                   
XP_016 REPRQQEEKPLKLQVWSGTEVTAPQGATDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHM
     330       340       350       360       370       380         

>>XP_011532850 (OMIM: 142703) PREDICTED: histamine H2 re  (422 aa)
 initn: 227 init1: 149 opt: 348  Z-score: 374.2  bits: 78.0 E(85289): 4.2e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)

               10        20        30        40         50         
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
              : ..  ::: . .       : . . ... . .:: ..::..: ..      :
XP_011     MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
                   10               20        30        40         

      60        70        80        90       100          110      
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
        .. :. :: ..: .::..:.  :.: .: ... :  . :.    :.:.  .  .: ..:
XP_011 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
       50        60         70          80        90       100     

        120       130       140       150        160       170     
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
       . .:  ::.::: :.  :: : .:::: :. . . :::. : :: ::   . :..     
XP_011 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
         110       120       130       140       150       160     

              180       190       200       210       220       230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
        : :  . . : .   .. :  .  .. .: :  ::.:.::. ::..    ..: ..:  
XP_011 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
           170        180       190        200           210       

              240       250       260       270       280          
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
       ..:: .. : .     ... ...:  . ..: : :.::.  :. ..  : .  :.    .
XP_011 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
       220            230       240       250       260       270  

      290       300       310       320       330       340        
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
       . ::. .::  : ..:.  :  :. : ..:   .:   :....                 
XP_011 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
            280       290       300          310       320         

                                                                   
pF1KB4 I                                                           
                                                                   
XP_011 REPRQQEEKPLKLQVWSGTEVTAPQGATDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHM
     330       340       350       360       370       380         

>>XP_006714927 (OMIM: 142703) PREDICTED: histamine H2 re  (422 aa)
 initn: 227 init1: 149 opt: 348  Z-score: 374.2  bits: 78.0 E(85289): 4.2e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)

               10        20        30        40         50         
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
              : ..  ::: . .       : . . ... . .:: ..::..: ..      :
XP_006     MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
                   10               20        30        40         

      60        70        80        90       100          110      
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
        .. :. :: ..: .::..:.  :.: .: ... :  . :.    :.:.  .  .: ..:
XP_006 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
       50        60         70          80        90       100     

        120       130       140       150        160       170     
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
       . .:  ::.::: :.  :: : .:::: :. . . :::. : :: ::   . :..     
XP_006 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
         110       120       130       140       150       160     

              180       190       200       210       220       230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
        : :  . . : .   .. :  .  .. .: :  ::.:.::. ::..    ..: ..:  
XP_006 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
           170        180       190        200           210       

              240       250       260       270       280          
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
       ..:: .. : .     ... ...:  . ..: : :.::.  :. ..  : .  :.    .
XP_006 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
       220            230       240       250       260       270  

      290       300       310       320       330       340        
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
       . ::. .::  : ..:.  :  :. : ..:   .:   :....                 
XP_006 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
            280       290       300          310       320         

                                                                   
pF1KB4 I                                                           
                                                                   
XP_006 REPRQQEEKPLKLQVWSGTEVTAPQGATDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHM
     330       340       350       360       370       380         

>>XP_011532851 (OMIM: 142703) PREDICTED: histamine H2 re  (422 aa)
 initn: 227 init1: 149 opt: 348  Z-score: 374.2  bits: 78.0 E(85289): 4.2e-14
Smith-Waterman score: 348; 26.8% identity (58.0% similar) in 336 aa overlap (8-331:4-312)

               10        20        30        40         50         
pF1KB4 MNSTLDGNQSSHPFCLLAFGYLETVNFCLLEVLIIVFLTVLI-ISGNIIVIFVFHCAPLL
              : ..  ::: . .       : . . ... . .:: ..::..: ..      :
XP_011     MAPNGTASSFCLDSTA-------CKITITVVLAVLILITVAGNVVVCLAVGLNRRL
                   10               20        30        40         

      60        70        80        90       100          110      
pF1KB4 NHHTTSYFIQTMAYADLFVGVSCVVPSLSLLHHPLPVEESLT---CQIFGFVVSVLKSVS
        .. :. :: ..: .::..:.  :.: .: ... :  . :.    :.:.  .  .: ..:
XP_011 -RNLTNCFIVSLAITDLLLGL-LVLP-FSAIYQ-LSCKWSFGKVFCNIYTSLDVMLCTAS
       50        60         70          80        90       100     

        120       130       140       150        160       170     
pF1KB4 MASLACISIDRYIAITKPLTYNTLVTPWRLRLCIFLIWLYS-TLVFLPSFFHWGK-----
       . .:  ::.::: :.  :: : .:::: :. . . :::. : :: ::   . :..     
XP_011 ILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETS
         110       120       130       140       150       160     

              180       190       200       210       220       230
pF1KB4 PGYHGDVFQWCAESWHTDSYFTLFIVMMLYAPAALIVCFTYFNIFRICQQHTKDISERQA
        : :  . . : .   .. :  .  .. .: :  ::.:.::. ::..    ..: ..:  
XP_011 KGNH--TTSKC-KVQVNEVYGLVDGLVTFYLPL-LIMCITYYRIFKV----ARDQAKRIN
           170        180       190        200           210       

              240       250       260       270       280          
pF1KB4 RFSSQSGETGEVQACPDKRYAMVLFRITSVFYILWLPYIIYFLLESSTGHS--NRFASFL
       ..:: .. : .     ... ...:  . ..: : :.::.  :. ..  : .  :.    .
XP_011 HISSWKAATIR-----EHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAI
       220            230       240       250       260       270  

      290       300       310       320       330       340        
pF1KB4 TTWLAISNSFCNCVIYSLSNSVFQRGLKRLSGAMCTSCASQTTANDPYTVRSKGPLNGCH
       . ::. .::  : ..:.  :  :. : ..:   .:   :....                 
XP_011 VLWLGYANSALNPILYAALNRDFRTGYQQL---FCCRLANRNSHKTSLRSNASQLSRTQS
            280       290       300          310       320         

                                                                   
pF1KB4 I                                                           
                                                                   
XP_011 REPRQQEEKPLKLQVWSGTEVTAPQGATDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHM
     330       340       350       360       370       380         




349 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 14:55:25 2016 done: Thu Nov  3 14:55:27 2016
 Total Scan time:  7.430 Total Display time:  0.030

Function used was FASTA [36.3.4 Apr, 2011]
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