Result of FASTA (omim) for pF1KB4188
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB4188, 357 aa
  1>>>pF1KB4188 357 - 357 aa - 357 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.2606+/-0.000381; mu= 17.0577+/- 0.024
 mean_var=66.4727+/-13.474, 0's: 0 Z-trim(111.9): 28  B-trim: 1175 in 1/48
 Lambda= 0.157309
 statistics sampled from 20630 (20649) to 20630 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.616), E-opt: 0.2 (0.242), width:  16
 Scan time:  7.640

The best scores are:                                      opt bits E(85289)
NP_001229326 (OMIM: 610932) twinfilin-1 isoform 1  ( 357) 2358 544.1 1.8e-154
NP_002813 (OMIM: 610932) twinfilin-1 isoform 2 [Ho ( 350) 2282 526.8 2.7e-149
NP_009215 (OMIM: 607433) twinfilin-2 [Homo sapiens ( 349) 1591 370.0 4.4e-102
NP_005498 (OMIM: 601442) cofilin-1 [Homo sapiens]  ( 166)  152 43.3 0.00048
XP_011534665 (OMIM: 601443,610687) PREDICTED: cofi ( 149)  143 41.2  0.0018
NP_001230574 (OMIM: 601443,610687) cofilin-2 isofo ( 149)  143 41.2  0.0018
NP_619579 (OMIM: 601443,610687) cofilin-2 isoform  ( 166)  143 41.2   0.002
NP_068733 (OMIM: 601443,610687) cofilin-2 isoform  ( 166)  143 41.2   0.002


>>NP_001229326 (OMIM: 610932) twinfilin-1 isoform 1 [Hom  (357 aa)
 initn: 2358 init1: 2358 opt: 2358  Z-score: 2894.4  bits: 544.1 E(85289): 1.8e-154
Smith-Waterman score: 2358; 100.0% identity (100.0% similar) in 357 aa overlap (1-357:1-357)

               10        20        30        40        50        60
pF1KB4 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQ
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB4 TLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB4 ARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIR
              250       260       270       280       290       300

              310       320       330       340       350       
pF1KB4 KIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
              310       320       330       340       350       

>>NP_002813 (OMIM: 610932) twinfilin-1 isoform 2 [Homo s  (350 aa)
 initn: 1237 init1: 1237 opt: 2282  Z-score: 2801.3  bits: 526.8 E(85289): 2.7e-149
Smith-Waterman score: 2282; 98.0% identity (98.0% similar) in 357 aa overlap (1-357:1-350)

               10        20        30        40        50        60
pF1KB4 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQ
       :::::::::::::::::::::::::::::::::::::::::       ::::::::::::
NP_002 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINE-------VQTDVGVDTKHQ
              130       140       150       160              170   

              190       200       210       220       230       240
pF1KB4 TLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDS
           180       190       200       210       220       230   

              250       260       270       280       290       300
pF1KB4 ARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIR
           240       250       260       270       280       290   

              310       320       330       340       350       
pF1KB4 KIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
           300       310       320       330       340       350

>>NP_009215 (OMIM: 607433) twinfilin-2 [Homo sapiens]     (349 aa)
 initn: 1574 init1: 812 opt: 1591  Z-score: 1953.8  bits: 370.0 E(85289): 4.4e-102
Smith-Waterman score: 1591; 64.1% identity (89.2% similar) in 351 aa overlap (1-351:1-344)

               10        20        30        40        50        60
pF1KB4 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPL
       :.:::::.:.:..::.::.:: :. ::.:. ::.::::.:. ..:   ::.:::  ::::
NP_009 MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB4 LEDKQPCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
       :. .::::.:.:::::::::.::.:.:::::.: :: ::::::::::.::::::::::::
NP_009 LDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB4 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQ
       .:::::.:.:. ::.:.: : ..:::::.::.::.::.:::       :.:...:..:::
NP_009 LFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINE-------VKTEISVESKHQ
              130       140       150       160              170   

              190       200       210       220       230       240
pF1KB4 TLQGVAFPISREAFQALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDS
       ::::.:::.. :: .::..:.....::.:...:.. : : :..:  :.. .::.:.:.:.
NP_009 TLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDA
           180       190       200       210       220       230   

              250       260       270       280       290       300
pF1KB4 ARYHFFLYKHSHEGDYLESIVFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIR
       ::::::::::.:::: :::.::::::::: :::.:::::::::::::. ::....... .
NP_009 ARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAK
           240       250       260       270       280       290   

              310       320       330       340       350       
pF1KB4 KIEIDNGDELTADFLYEEVHPKQHAHKQSFAKPKGPAGKRGIRRLIRGPAETEATTD
       :::: .: ::::.:::.:::::::: ::.:::::::.:::: .::::::.:      
NP_009 KIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGDDS 
           300       310       320       330       340          

>>NP_005498 (OMIM: 601442) cofilin-1 [Homo sapiens]       (166 aa)
 initn:  94 init1:  94 opt: 152  Z-score: 193.6  bits: 43.3 E(85289): 0.00048
Smith-Waterman score: 152; 28.3% identity (67.7% similar) in 99 aa overlap (33-129:51-143)

             10        20        30        40        50        60  
pF1KB4 HQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLE
                                     :......:. .:   . :  : .::  .: 
NP_005 RKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQ---TVDDPYATFV-KMLP
               30        40        50        60           70       

             70          80        90       100       110       120
pF1KB4 DKQPCYILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDE
       ::.  : :.    ......  . .:: :.:. . ...::.::... ..::.. :  :: :
NP_005 DKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTG--IKHE
         80        90       100       110       120       130      

              130       140       150       160       170       180
pF1KB4 VFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQ
       . ..  :.:                                                   
NP_005 LQANCYEEVKDRCTLAEKLGGSAVISLEGKPL                            
          140       150       160                                  

>>XP_011534665 (OMIM: 601443,610687) PREDICTED: cofilin-  (149 aa)
 initn: 101 init1: 101 opt: 143  Z-score: 183.2  bits: 41.2 E(85289): 0.0018
Smith-Waterman score: 143; 31.2% identity (64.5% similar) in 93 aa overlap (33-120:34-117)

             10        20        30        40        50          60
pF1KB4 HQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFV--LPL
                                     : .:...:. .   :. .  : :::  :::
XP_011 RKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIG---DTVEDPYTSFVKLLPL
            10        20        30        40           50        60

                70          80        90       100       110       
pF1KB4 LEDKQPC-YILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHI
           . : : :.    ......  . .:: :.:. . ...::.::... ..::.: :  :
XP_011 ----NDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTG--I
                   70        80        90       100       110      

       120       130       140       150       160       170       
pF1KB4 KDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDT
       : :                                                         
XP_011 KHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL                         
          120       130       140                                  

>>NP_001230574 (OMIM: 601443,610687) cofilin-2 isoform 2  (149 aa)
 initn: 101 init1: 101 opt: 143  Z-score: 183.2  bits: 41.2 E(85289): 0.0018
Smith-Waterman score: 143; 31.2% identity (64.5% similar) in 93 aa overlap (33-120:34-117)

             10        20        30        40        50          60
pF1KB4 HQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFV--LPL
                                     : .:...:. .   :. .  : :::  :::
NP_001 RKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIG---DTVEDPYTSFVKLLPL
            10        20        30        40           50        60

                70          80        90       100       110       
pF1KB4 LEDKQPC-YILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHI
           . : : :.    ......  . .:: :.:. . ...::.::... ..::.: :  :
NP_001 ----NDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTG--I
                   70        80        90       100       110      

       120       130       140       150       160       170       
pF1KB4 KDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDT
       : :                                                         
NP_001 KHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL                         
          120       130       140                                  

>>NP_619579 (OMIM: 601443,610687) cofilin-2 isoform 1 [H  (166 aa)
 initn: 101 init1: 101 opt: 143  Z-score: 182.5  bits: 41.2 E(85289): 0.002
Smith-Waterman score: 143; 31.2% identity (64.5% similar) in 93 aa overlap (33-120:51-134)

             10        20        30        40        50          60
pF1KB4 HQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFV--LPL
                                     : .:...:. .   :. .  : :::  :::
NP_619 RKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIG---DTVEDPYTSFVKLLPL
               30        40        50        60           70       

                70          80        90       100       110       
pF1KB4 LEDKQPC-YILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHI
           . : : :.    ......  . .:: :.:. . ...::.::... ..::.: :  :
NP_619 ----NDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTG--I
            80        90       100       110       120       130   

       120       130       140       150       160       170       
pF1KB4 KDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDT
       : :                                                         
NP_619 KHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL                         
             140       150       160                               

>>NP_068733 (OMIM: 601443,610687) cofilin-2 isoform 1 [H  (166 aa)
 initn: 101 init1: 101 opt: 143  Z-score: 182.5  bits: 41.2 E(85289): 0.002
Smith-Waterman score: 143; 31.2% identity (64.5% similar) in 93 aa overlap (33-120:51-134)

             10        20        30        40        50          60
pF1KB4 HQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFV--LPL
                                     : .:...:. .   :. .  : :::  :::
NP_068 RKSSTQEEIKKRKKAVLFCLSDDKRQIIVEEAKQILVGDIG---DTVEDPYTSFVKLLPL
               30        40        50        60           70       

                70          80        90       100       110       
pF1KB4 LEDKQPC-YILF--RLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHI
           . : : :.    ......  . .:: :.:. . ...::.::... ..::.: :  :
NP_068 ----NDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTG--I
            80        90       100       110       120       130   

       120       130       140       150       160       170       
pF1KB4 KDEVFGTVKEDVSLHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDT
       : :                                                         
NP_068 KHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL                         
             140       150       160                               




357 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 14:35:48 2016 done: Thu Nov  3 14:35:50 2016
 Total Scan time:  7.640 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]
Inquiries or Suggestions ?
Send a message to flexiclone AT kazusagt.com