Result of FASTA (omim) for pF1KB3827
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3827, 1168 aa
  1>>>pF1KB3827 1168 - 1168 aa - 1168 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.5368+/-0.000397; mu= 17.8950+/- 0.025
 mean_var=123.7604+/-24.974, 0's: 0 Z-trim(116.2): 40  B-trim: 288 in 1/52
 Lambda= 0.115288
 statistics sampled from 27074 (27114) to 27074 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.318), width:  16
 Scan time: 14.720

The best scores are:                                      opt bits E(85289)
NP_443150 (OMIM: 606283) VPS10 domain-containing r (1168) 7858 1319.2       0
NP_001193500 (OMIM: 606283) VPS10 domain-containin (1159) 7586 1273.9       0
NP_001193501 (OMIM: 606283) VPS10 domain-containin (1179) 7568 1271.0       0
NP_001193498 (OMIM: 606283) VPS10 domain-containin (1179) 7568 1271.0       0
XP_011537501 (OMIM: 606283) PREDICTED: VPS10 domai (1187) 7568 1271.0       0
NP_001013049 (OMIM: 606283) VPS10 domain-containin (1198) 7568 1271.0       0
XP_016871103 (OMIM: 606283) PREDICTED: VPS10 domai (1203) 7568 1271.0       0
NP_001193499 (OMIM: 606283) VPS10 domain-containin (1130) 7564 1270.3       0
XP_011537503 (OMIM: 606283) PREDICTED: VPS10 domai (1116) 7337 1232.5       0
XP_016871104 (OMIM: 606283) PREDICTED: VPS10 domai (1159) 6840 1149.9       0
XP_016871105 (OMIM: 606283) PREDICTED: VPS10 domai (1031) 6306 1061.0       0
XP_016871106 (OMIM: 606283) PREDICTED: VPS10 domai (1018) 6304 1060.7       0
NP_055793 (OMIM: 606285) VPS10 domain-containing r (1222) 5064 854.5       0
XP_016871107 (OMIM: 606283) PREDICTED: VPS10 domai ( 726) 4351 735.7 2.4e-211
XP_011537844 (OMIM: 606285) PREDICTED: VPS10 domai ( 866) 3966 671.7 5.2e-192
NP_065828 (OMIM: 606284) VPS10 domain-containing r (1159) 3301 561.2 1.3e-158
XP_011511816 (OMIM: 606284) PREDICTED: VPS10 domai (1173) 3301 561.3 1.3e-158
XP_011511818 (OMIM: 606284) PREDICTED: VPS10 domai (1160) 3297 560.6  2e-158
XP_016863970 (OMIM: 606284) PREDICTED: VPS10 domai (1166) 3297 560.6 2.1e-158
XP_011511817 (OMIM: 606284) PREDICTED: VPS10 domai (1173) 3297 560.6 2.1e-158
XP_005248044 (OMIM: 606284) PREDICTED: VPS10 domai (1174) 3297 560.6 2.1e-158
XP_005271157 (OMIM: 602458,613589) PREDICTED: sort ( 830)  808 146.5 6.6e-34
NP_002950 (OMIM: 602458,613589) sortilin isoform 1 ( 831)  801 145.3 1.5e-33
NP_001192157 (OMIM: 602458,613589) sortilin isofor ( 694)  755 137.6 2.6e-31
XP_006710875 (OMIM: 602458,613589) PREDICTED: sort ( 695)  748 136.4 5.9e-31
XP_005271158 (OMIM: 602458,613589) PREDICTED: sort ( 695)  748 136.4 5.9e-31
XP_005271159 (OMIM: 602458,613589) PREDICTED: sort ( 695)  748 136.4 5.9e-31
XP_016873660 (OMIM: 104300,602005) PREDICTED: sort (1769)  652 120.8 7.6e-26
XP_016873659 (OMIM: 104300,602005) PREDICTED: sort (2039)  652 120.9 8.5e-26
XP_016873658 (OMIM: 104300,602005) PREDICTED: sort (2110)  652 120.9 8.7e-26
XP_011541265 (OMIM: 104300,602005) PREDICTED: sort (2176)  652 120.9 8.9e-26
NP_003096 (OMIM: 104300,602005) sortilin-related r (2214)  652 120.9   9e-26
XP_011541267 (OMIM: 104300,602005) PREDICTED: sort (1701)  380 75.5 3.1e-12


>>NP_443150 (OMIM: 606283) VPS10 domain-containing recep  (1168 aa)
 initn: 7858 init1: 7858 opt: 7858  Z-score: 7064.9  bits: 1319.2 E(85289):    0
Smith-Waterman score: 7858; 100.0% identity (100.0% similar) in 1168 aa overlap (1-1168:1-1168)

               10        20        30        40        50        60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
             1090      1100      1110      1120      1130      1140

             1150      1160        
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI
       ::::::::::::::::::::::::::::
NP_443 SSLRLQRARHATPPSTPKRGSAGAQYAI
             1150      1160        

>>NP_001193500 (OMIM: 606283) VPS10 domain-containing re  (1159 aa)
 initn: 7568 init1: 7568 opt: 7586  Z-score: 6820.4  bits: 1273.9 E(85289):    0
Smith-Waterman score: 7586; 99.5% identity (99.6% similar) in 1135 aa overlap (1-1134:1-1135)

               10        20        30        40        50        60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120       1130         
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVAL-PSPPSPSTQPG
       :::::::::::::::::::::::::::::::::::::::::::: :.: :  :.:     
NP_001 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRCVSLYPRSPTPDLFLL
             1090      1100      1110      1120      1130      1140

    1140      1150      1160        
pF1KB3 DSSLRLQRARHATPPSTPKRGSAGAQYAI
                                    
NP_001 PDRFRSMCYSDVHSSDGFY          
             1150                   

>>NP_001193501 (OMIM: 606283) VPS10 domain-containing re  (1179 aa)
 initn: 7568 init1: 7568 opt: 7568  Z-score: 6804.1  bits: 1271.0 E(85289):    0
Smith-Waterman score: 7568; 99.8% identity (100.0% similar) in 1126 aa overlap (1-1126:1-1126)

               10        20        30        40        50        60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
       ::::::::::::::::::::::::::::::::::::::::::::..              
NP_001 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
             1090      1100      1110      1120      1130      1140

             1150      1160                   
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI           
                                              
NP_001 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGE
             1150      1160      1170         

>>NP_001193498 (OMIM: 606283) VPS10 domain-containing re  (1179 aa)
 initn: 7568 init1: 7568 opt: 7568  Z-score: 6804.1  bits: 1271.0 E(85289):    0
Smith-Waterman score: 7568; 99.8% identity (100.0% similar) in 1126 aa overlap (1-1126:1-1126)

               10        20        30        40        50        60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
       ::::::::::::::::::::::::::::::::::::::::::::..              
NP_001 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
             1090      1100      1110      1120      1130      1140

             1150      1160                   
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI           
                                              
NP_001 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGK
             1150      1160      1170         

>>XP_011537501 (OMIM: 606283) PREDICTED: VPS10 domain-co  (1187 aa)
 initn: 7568 init1: 7568 opt: 7568  Z-score: 6804.1  bits: 1271.0 E(85289):    0
Smith-Waterman score: 7568; 99.8% identity (100.0% similar) in 1126 aa overlap (1-1126:1-1126)

               10        20        30        40        50        60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
       ::::::::::::::::::::::::::::::::::::::::::::..              
XP_011 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
             1090      1100      1110      1120      1130      1140

             1150      1160                           
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI                   
                                                      
XP_011 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGRYRSTLQSL
             1150      1160      1170      1180       

>>NP_001013049 (OMIM: 606283) VPS10 domain-containing re  (1198 aa)
 initn: 7568 init1: 7568 opt: 7568  Z-score: 6804.0  bits: 1271.0 E(85289):    0
Smith-Waterman score: 7568; 99.8% identity (100.0% similar) in 1126 aa overlap (1-1126:1-1126)

               10        20        30        40        50        60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
       ::::::::::::::::::::::::::::::::::::::::::::..              
NP_001 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
             1090      1100      1110      1120      1130      1140

             1150      1160                                      
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI                              
                                                                 
NP_001 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGSISIVAENQSTKEIPTYVNV
             1150      1160      1170      1180      1190        

>>XP_016871103 (OMIM: 606283) PREDICTED: VPS10 domain-co  (1203 aa)
 initn: 7568 init1: 7568 opt: 7568  Z-score: 6804.0  bits: 1271.0 E(85289):    0
Smith-Waterman score: 7568; 99.8% identity (100.0% similar) in 1126 aa overlap (1-1126:1-1126)

               10        20        30        40        50        60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
       ::::::::::::::::::::::::::::::::::::::::::::..              
XP_016 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
             1090      1100      1110      1120      1130      1140

             1150      1160                                        
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI                                
                                                                   
XP_016 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIEVPNSNFESSGVLGSCSVFSRNP
             1150      1160      1170      1180      1190      1200

>>NP_001193499 (OMIM: 606283) VPS10 domain-containing re  (1130 aa)
 initn: 7564 init1: 7564 opt: 7564  Z-score: 6800.8  bits: 1270.3 E(85289):    0
Smith-Waterman score: 7564; 99.9% identity (100.0% similar) in 1125 aa overlap (1-1125:1-1125)

               10        20        30        40        50        60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
       ::::::::::::::::::::::::::::::::::::::::::::.               
NP_001 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKYFHSC          
             1090      1100      1110      1120      1130          

             1150      1160        
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI

>>XP_011537503 (OMIM: 606283) PREDICTED: VPS10 domain-co  (1116 aa)
 initn: 7337 init1: 7337 opt: 7337  Z-score: 6596.8  bits: 1232.5 E(85289):    0
Smith-Waterman score: 7337; 100.0% identity (100.0% similar) in 1088 aa overlap (1-1088:1-1088)

               10        20        30        40        50        60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
             1030      1040      1050      1060      1070      1080

             1090      1100      1110      1120      1130      1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
       ::::::::                                                    
XP_011 VHAAHLTAGVIKRCYHRDIRELIFPGFSCYHWMCYE                        
             1090      1100      1110                              

>>XP_016871104 (OMIM: 606283) PREDICTED: VPS10 domain-co  (1159 aa)
 initn: 7264 init1: 6840 opt: 6840  Z-score: 6149.8  bits: 1149.9 E(85289):    0
Smith-Waterman score: 7179; 95.9% identity (96.1% similar) in 1126 aa overlap (1-1126:1-1082)

               10        20        30        40        50        60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
       :::::::::::::::::::::::::::::::::::::::::::::::::::         
XP_016 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVE---------
              970       980       990      1000      1010          

             1030      1040      1050      1060      1070      1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
                                          :::::::::::::::::::::::::
XP_016 -----------------------------------ISELLIHTLNQNSVHFELKPGVRVL
                                               1020      1030      

             1090      1100      1110      1120      1130      1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
       ::::::::::::::::::::::::::::::::::::::::::::..              
XP_016 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
       1040      1050      1060      1070      1080      1090      

             1150      1160                                        
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI                                
                                                                   
XP_016 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIEVPNSNFESSGVLGSCSVFSRNP
       1100      1110      1120      1130      1140      1150      




1168 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 14:01:49 2016 done: Thu Nov  3 14:01:51 2016
 Total Scan time: 14.720 Total Display time:  0.530

Function used was FASTA [36.3.4 Apr, 2011]
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