Result of FASTA (omim) for pF1KB3680
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB3680, 951 aa
  1>>>pF1KB3680 951 - 951 aa - 951 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 12.4281+/-0.000449; mu= -12.9102+/- 0.028
 mean_var=366.5176+/-75.473, 0's: 0 Z-trim(120.7): 69  B-trim: 333 in 1/57
 Lambda= 0.066993
 statistics sampled from 36257 (36332) to 36257 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.731), E-opt: 0.2 (0.426), width:  16
 Scan time: 13.550

The best scores are:                                      opt bits E(85289)
NP_006687 (OMIM: 602848) bromodomain-containing pr ( 951) 6206 614.7 7.1e-175
XP_005271912 (OMIM: 602848) PREDICTED: bromodomain (1308) 6078 602.4 4.9e-171
XP_005271917 (OMIM: 602848) PREDICTED: bromodomain ( 936) 5984 593.2  2e-168
XP_005271913 (OMIM: 602848) PREDICTED: bromodomain (1293) 5975 592.4 4.8e-168
XP_011541412 (OMIM: 602848) PREDICTED: bromodomain (1175) 5200 517.5 1.6e-145
XP_016864460 (OMIM: 602848) PREDICTED: bromodomain ( 882) 5025 500.5 1.5e-140
XP_016864459 (OMIM: 602848) PREDICTED: bromodomain ( 897) 5025 500.5 1.6e-140
XP_011541411 (OMIM: 602848) PREDICTED: bromodomain (1254) 5025 500.6 2.1e-140
NP_001287891 (OMIM: 602848) bromodomain-containing ( 837) 4314 431.8 7.1e-120
NP_001287890 (OMIM: 602848) bromodomain-containing ( 862) 4314 431.8 7.3e-120
XP_005271918 (OMIM: 602848) PREDICTED: bromodomain ( 878) 4314 431.8 7.4e-120
NP_631938 (OMIM: 602848) bromodomain-containing pr (1235) 4186 419.5 5.2e-116
XP_016864462 (OMIM: 602848) PREDICTED: bromodomain ( 863) 4092 410.3 2.1e-113
XP_016864461 (OMIM: 602848) PREDICTED: bromodomain ( 881) 3592 362.0 7.6e-99
NP_001287895 (OMIM: 602848) bromodomain-containing ( 757) 3587 361.5 9.3e-99
XP_016864465 (OMIM: 602848) PREDICTED: bromodomain ( 808) 3578 360.6 1.8e-98
XP_005271914 (OMIM: 602848) PREDICTED: bromodomain (1238) 3464 349.7 5.3e-95
XP_005271916 (OMIM: 602848) PREDICTED: bromodomain (1165) 3450 348.4 1.3e-94
NP_001157798 (OMIM: 602848) bromodomain-containing ( 866) 3370 340.5 2.1e-92
XP_016864464 (OMIM: 602848) PREDICTED: bromodomain ( 824) 3133 317.6 1.6e-85
XP_016864458 (OMIM: 602848) PREDICTED: bromodomain (1181) 3133 317.7 2.2e-85
XP_016864463 (OMIM: 602848) PREDICTED: bromodomain ( 827) 2411 247.9 1.6e-64
XP_005255181 (OMIM: 180849,600140) PREDICTED: CREB (2427)  314 45.4  0.0041


>>NP_006687 (OMIM: 602848) bromodomain-containing protei  (951 aa)
 initn: 6206 init1: 6206 opt: 6206  Z-score: 3260.5  bits: 614.7 E(85289): 7.1e-175
Smith-Waterman score: 6206; 99.9% identity (99.9% similar) in 951 aa overlap (1-951:1-951)

               10        20        30        40        50        60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
       :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
NP_006 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
              850       860       870       880       890       900

              910       920       930       940       950 
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
       :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
              910       920       930       940       950 

>>XP_005271912 (OMIM: 602848) PREDICTED: bromodomain-con  (1308 aa)
 initn: 6078 init1: 6078 opt: 6078  Z-score: 3191.6  bits: 602.4 E(85289): 4.9e-171
Smith-Waterman score: 6078; 99.8% identity (99.8% similar) in 934 aa overlap (1-934:1-934)

               10        20        30        40        50        60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
       :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_005 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
              850       860       870       880       890       900

              910       920       930       940       950          
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK         
       :::::::::::::::::::::::::::::::: :                          
XP_005 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFMGHEWVWLDSEQDHPNDSELSNDCRSLF
              910       920       930       940       950       960

XP_005 SSWDSSLDLDVGNWRETEDPEAEELEESSPEREPSELLVGDGGSEESQEAARKASHQNLL
              970       980       990      1000      1010      1020

>--
 initn: 596 init1: 437 opt: 577  Z-score: 318.2  bits: 70.7 E(85289): 5.5e-11
Smith-Waterman score: 577; 44.7% identity (73.5% similar) in 215 aa overlap (668-882:1078-1278)

       640       650       660       670       680       690       
pF1KB3 KGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIK
                                     ::: ::      .... : : ..   : : 
XP_005 SGTRQEGREIKASEGERELCRETEELSAKGDPLVAEKP----LGENGKPEVASA-PSVIC
      1050      1060      1070      1080          1090       1100  

       700       710       720       730       740       750       
pF1KB3 DAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLA
        . :   : .   :. . .: : ::::: :.:::...:: .: ::.:.:... :     .
XP_005 TVQGLLTESE---EGEAQQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPL-----V
           1110         1120      1130      1140      1150         

       760       770       780       790       800       810       
pF1KB3 DSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGY
       :.. :  .::...  :.: . .: . ..::... ::.  :.::... ::.::..  ::::
XP_005 DTLFSHATSSKLTDLSQD-DPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVSERQAPGY
         1160      1170       1180      1190      1200      1210   

       820       830       840       850       860       870       
pF1KB3 HSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDV
       ...:.:::::...:.:. .: ::. :.: ::.:::::::::::.::: ::::::::...:
XP_005 KDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEV
          1220      1230      1240      1250      1260      1270   

       880       890       900       910       920       930       
pF1KB3 LEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTR
       :::::                                                       
XP_005 LEQIQVLNIWLDKRKGSSSLEGEPANPVDDGKPVF                         
          1280      1290      1300                                 

>>XP_005271917 (OMIM: 602848) PREDICTED: bromodomain-con  (936 aa)
 initn: 5983 init1: 5983 opt: 5984  Z-score: 3144.7  bits: 593.2 E(85289): 2e-168
Smith-Waterman score: 6067; 98.3% identity (98.3% similar) in 951 aa overlap (1-951:1-936)

               10        20        30        40        50        60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
       :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_005 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
              850       860       870       880       890       900

              910       920       930       940       950 
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
       ::::::::::::::::::               ::::::::::::::::::
XP_005 KSLRGRDSTRKQDASEKD---------------GGTRGRRCAIEADMKMKK
              910                      920       930      

>>XP_005271913 (OMIM: 602848) PREDICTED: bromodomain-con  (1293 aa)
 initn: 5975 init1: 5975 opt: 5975  Z-score: 3137.9  bits: 592.4 E(85289): 4.8e-168
Smith-Waterman score: 5975; 99.9% identity (99.9% similar) in 917 aa overlap (1-917:1-917)

               10        20        30        40        50        60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
       :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_005 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
              850       860       870       880       890       900

              910       920       930       940       950          
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK         
       :::::::::::::::::                                           
XP_005 KSLRGRDSTRKQDASEKMGHEWVWLDSEQDHPNDSELSNDCRSLFSSWDSSLDLDVGNWR
              910       920       930       940       950       960

>--
 initn: 596 init1: 437 opt: 577  Z-score: 318.3  bits: 70.7 E(85289): 5.5e-11
Smith-Waterman score: 577; 44.7% identity (73.5% similar) in 215 aa overlap (668-882:1063-1263)

       640       650       660       670       680       690       
pF1KB3 KGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIK
                                     ::: ::      .... : : ..   : : 
XP_005 SGTRQEGREIKASEGERELCRETEELSAKGDPLVAEKP----LGENGKPEVASA-PSVIC
           1040      1050      1060      1070          1080        

       700       710       720       730       740       750       
pF1KB3 DAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLA
        . :   : .   :. . .: : ::::: :.:::...:: .: ::.:.:... :     .
XP_005 TVQGLLTESE---EGEAQQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPL-----V
      1090         1100      1110      1120      1130              

       760       770       780       790       800       810       
pF1KB3 DSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGY
       :.. :  .::...  :.: . .: . ..::... ::.  :.::... ::.::..  ::::
XP_005 DTLFSHATSSKLTDLSQD-DPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVSERQAPGY
    1140      1150       1160      1170      1180      1190        

       820       830       840       850       860       870       
pF1KB3 HSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDV
       ...:.:::::...:.:. .: ::. :.: ::.:::::::::::.::: ::::::::...:
XP_005 KDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEV
     1200      1210      1220      1230      1240      1250        

       880       890       900       910       920       930       
pF1KB3 LEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTR
       :::::                                                       
XP_005 LEQIQVLNIWLDKRKGSSSLEGEPANPVDDGKPVF                         
     1260      1270      1280      1290                            

>>XP_011541412 (OMIM: 602848) PREDICTED: bromodomain-con  (1175 aa)
 initn: 5200 init1: 5200 opt: 5200  Z-score: 2733.7  bits: 517.5 E(85289): 1.6e-145
Smith-Waterman score: 5200; 99.8% identity (99.8% similar) in 801 aa overlap (134-934:1-801)

           110       120       130       140       150       160   
pF1KB3 RVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKAT
                                     ::::::::::::::::::::::::::::::
XP_011                               MDSRLDELCNDIATKKKLEEEEAEVKRKAT
                                             10        20        30

           170       180       190       200       210       220   
pF1KB3 DAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPST
               40        50        60        70        80        90

           230       240       250       260       270       280   
pF1KB3 PVTSFPGIPDTLPPGSAPLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVTSFPGIPDTLPPGSAPLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPT
              100       110       120       130       140       150

           290       300       310       320       330       340   
pF1KB3 SPRLVNESEMAVASGHLNSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPRLVNESEMAVASGHLNSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRL
              160       170       180       190       200       210

           350       360       370       380       390       400   
pF1KB3 LEAGPTQFTTPLASFTTVASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEAGPTQFTTPLASFTTVASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESV
              220       230       240       250       260       270

           410       420       430       440       450       460   
pF1KB3 APVSQPDNCVPMEAVGDPHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APVSQPDNCVPMEAVGDPHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDG
              280       290       300       310       320       330

           470       480       490       500       510       520   
pF1KB3 KEELDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEEND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEELDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEEND
              340       350       360       370       380       390

           530       540       550       560       570       580   
pF1KB3 DPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKV
       ::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_011 DPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKV
              400       410       420       430       440       450

           590       600       610       620       630       640   
pF1KB3 EPAEPEPVISGAEIVAGVVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPAEPEPVISGAEIVAGVVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETP
              460       470       480       490       500       510

           650       660       670       680       690       700   
pF1KB3 LTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGED
              520       530       540       550       560       570

           710       720       730       740       750       760   
pF1KB3 EEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSS
              580       590       600       610       620       630

           770       780       790       800       810       820   
pF1KB3 PASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQR
              640       650       660       670       680       690

           830       840       850       860       870       880   
pF1KB3 PMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQ
              700       710       720       730       740       750

           890       900       910       920       930       940   
pF1KB3 FLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAI
       ::::::::::::::::::::::::::::::::::::::::::::::::: :         
XP_011 FLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFMGHEWVWLDSE
              760       770       780       790       800       810

           950                                                     
pF1KB3 EADMKMKK                                                    
                                                                   
XP_011 QDHPNDSELSNDCRSLFSSWDSSLDLDVGNWRETEDPEAEELEESSPEREPSELLVGDGG
              820       830       840       850       860       870

>--
 initn: 596 init1: 437 opt: 577  Z-score: 318.9  bits: 70.7 E(85289): 5e-11
Smith-Waterman score: 577; 44.7% identity (73.5% similar) in 215 aa overlap (668-882:945-1145)

       640       650       660       670       680       690       
pF1KB3 KGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIK
                                     ::: ::      .... : : ..   : : 
XP_011 SGTRQEGREIKASEGERELCRETEELSAKGDPLVAEKP----LGENGKPEVASA-PSVIC
          920       930       940       950           960          

       700       710       720       730       740       750       
pF1KB3 DAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLA
        . :   : .   :. . .: : ::::: :.:::...:: .: ::.:.:... :     .
XP_011 TVQGLLTESE---EGEAQQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPL-----V
     970          980       990      1000      1010      1020      

       760       770       780       790       800       810       
pF1KB3 DSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGY
       :.. :  .::...  :.: . .: . ..::... ::.  :.::... ::.::..  ::::
XP_011 DTLFSHATSSKLTDLSQD-DPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVSERQAPGY
            1030       1040      1050      1060      1070      1080

       820       830       840       850       860       870       
pF1KB3 HSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDV
       ...:.:::::...:.:. .: ::. :.: ::.:::::::::::.::: ::::::::...:
XP_011 KDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEV
             1090      1100      1110      1120      1130      1140

       880       890       900       910       920       930       
pF1KB3 LEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTR
       :::::                                                       
XP_011 LEQIQVLNIWLDKRKGSSSLEGEPANPVDDGKPVF                         
             1150      1160      1170                              

>>XP_016864460 (OMIM: 602848) PREDICTED: bromodomain-con  (882 aa)
 initn: 5127 init1: 5009 opt: 5025  Z-score: 2644.1  bits: 500.5 E(85289): 1.5e-140
Smith-Waterman score: 5576; 92.5% identity (92.6% similar) in 951 aa overlap (1-951:1-882)

               10        20        30        40        50        60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
       :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_016 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::.           
XP_016 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQL-----------
              730       740       750       760                    

              790       800       810       820       830       840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
                                                  :::::::::::::::::
XP_016 -------------------------------------------PMDLSTIKKNIENGLIR
                                                770       780      

              850       860       870       880       890       900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
        790       800       810       820       830       840      

              910       920       930       940       950 
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
       ::::::::::::::::::               ::::::::::::::::::
XP_016 KSLRGRDSTRKQDASEKD---------------GGTRGRRCAIEADMKMKK
        850       860                      870       880  

>>XP_016864459 (OMIM: 602848) PREDICTED: bromodomain-con  (897 aa)
 initn: 5009 init1: 5009 opt: 5025  Z-score: 2644.0  bits: 500.5 E(85289): 1.6e-140
Smith-Waterman score: 5715; 94.1% identity (94.2% similar) in 951 aa overlap (1-951:1-897)

               10        20        30        40        50        60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
       :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_016 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::.           
XP_016 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQL-----------
              730       740       750       760                    

              790       800       810       820       830       840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
                                                  :::::::::::::::::
XP_016 -------------------------------------------PMDLSTIKKNIENGLIR
                                                770       780      

              850       860       870       880       890       900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
        790       800       810       820       830       840      

              910       920       930       940       950 
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
       :::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
        850       860       870       880       890       

>>XP_011541411 (OMIM: 602848) PREDICTED: bromodomain-con  (1254 aa)
 initn: 5691 init1: 5009 opt: 5025  Z-score: 2641.8  bits: 500.6 E(85289): 2.1e-140
Smith-Waterman score: 5587; 93.9% identity (94.0% similar) in 934 aa overlap (1-934:1-880)

               10        20        30        40        50        60
pF1KB3 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB3 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYR
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB3 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB3 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSA
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB3 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLEAPMTPVTDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHL
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB3 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTT
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB3 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGD
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB3 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYT
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB3 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQER
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB3 DKPVPLPAPEMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
       :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::::
XP_011 DKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAG
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KB3 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPS
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KB3 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKE
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KB3 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQ
       ::::::::::::::::::::::::::::::::::::::::::::::::.           
XP_011 EDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQL-----------
              730       740       750       760                    

              790       800       810       820       830       840
pF1KB3 AQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIR
                                                  :::::::::::::::::
XP_011 -------------------------------------------PMDLSTIKKNIENGLIR
                                                770       780      

              850       860       870       880       890       900
pF1KB3 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISA
        790       800       810       820       830       840      

              910       920       930       940       950          
pF1KB3 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK         
       :::::::::::::::::::::::::::::::: :                          
XP_011 KSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFMGHEWVWLDSEQDHPNDSELSNDCRSLF
        850       860       870       880       890       900      

XP_011 SSWDSSLDLDVGNWRETEDPEAEELEESSPEREPSELLVGDGGSEESQEAARKASHQNLL
        910       920       930       940       950       960      

>--
 initn: 596 init1: 437 opt: 577  Z-score: 318.5  bits: 70.7 E(85289): 5.3e-11
Smith-Waterman score: 577; 44.7% identity (73.5% similar) in 215 aa overlap (668-882:1024-1224)

       640       650       660       670       680       690       
pF1KB3 KGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIK
                                     ::: ::      .... : : ..   : : 
XP_011 SGTRQEGREIKASEGERELCRETEELSAKGDPLVAEKP----LGENGKPEVASA-PSVIC
          1000      1010      1020      1030          1040         

       700       710       720       730       740       750       
pF1KB3 DAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHTLA
        . :   : .   :. . .: : ::::: :.:::...:: .: ::.:.:... :     .
XP_011 TVQGLLTESE---EGEAQQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPL-----V
     1050         1060      1070      1080      1090           1100

       760       770       780       790       800       810       
pF1KB3 DSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDIAPGY
       :.. :  .::...  :.: . .: . ..::... ::.  :.::... ::.::..  ::::
XP_011 DTLFSHATSSKLTDLSQD-DPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVSERQAPGY
             1110       1120      1130      1140      1150         

       820       830       840       850       860       870       
pF1KB3 HSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAVEMQRDV
       ...:.:::::...:.:. .: ::. :.: ::.:::::::::::.::: ::::::::...:
XP_011 KDVVKRPMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEV
    1160      1170      1180      1190      1200      1210         

       880       890       900       910       920       930       
pF1KB3 LEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLLSLFDGGTR
       :::::                                                       
XP_011 LEQIQVLNIWLDKRKGSSSLEGEPANPVDDGKPVF                         
    1220      1230      1240      1250                             

>>NP_001287891 (OMIM: 602848) bromodomain-containing pro  (837 aa)
 initn: 4309 init1: 4309 opt: 4314  Z-score: 2273.1  bits: 431.8 E(85289): 7.1e-120
Smith-Waterman score: 5136; 91.4% identity (91.5% similar) in 894 aa overlap (58-951:17-837)

        30        40        50        60        70        80       
pF1KB3 ASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFSQKHCASQYSELLETTETPKRKRGEKGE
                                     : :. :::::::::::::::::::::::::
NP_001               MVHPREAMFSIFCHEKWRSKLHCASQYSELLETTETPKRKRGEKGE
                             10        20        30        40      

        90       100       110       120       130       140       
pF1KB3 VVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCNDIAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCNDIAT
         50        60        70        80        90       100      

       150       160       170       180       190       200       
pF1KB3 KKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTT
        110       120       130       140       150       160      

       210       220       230       240       250       260       
pF1KB3 MEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSAPLEAPMTPVTDDSPQKKMLGQKATPPP
       ::::::::                                                    
NP_001 MEEATSGV----------------------------------------------------
        170                                                        

       270       280       290       300       310       320       
pF1KB3 SPLLSELLKKGSLLPTSPRLVNESEMAVASGHLNSTGVLLEVGGVLPMIHGGEIQQTPNT
                            :::::::::::::::::::::::::::::::::::::::
NP_001 ---------------------NESEMAVASGHLNSTGVLLEVGGVLPMIHGGEIQQTPNT
                               180       190       200       210   

       330       340       350       360       370       380       
pF1KB3 VAASPAASGAPTLSRLLEAGPTQFTTPLASFTTVASEPPVKLVPPPVESVSQATIVMMPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAASPAASGAPTLSRLLEAGPTQFTTPLASFTTVASEPPVKLVPPPVESVSQATIVMMPA
           220       230       240       250       260       270   

       390       400       410       420       430       440       
pF1KB3 LPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGDPHTVTVSMDSSEISMIINSIKEECFRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGDPHTVTVSMDSSEISMIINSIKEECFRS
           280       290       300       310       320       330   

       450       460       470       480       490       500       
pF1KB3 GVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVL
           340       350       360       370       380       390   

       510       520       530       540       550       560       
pF1KB3 DVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEEMENKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_001 DVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEETENKG
           400       410       420       430       440       450   

       570       580       590       600       610       620       
pF1KB3 IHELVDIREPSAEIKVEPAEPEPVISGAEIVAGVVPATSMEPPELRSQDLDEELGSTAAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHELVDIREPSAEIKVEPAEPEPVISGAEIVAGVVPATSMEPPELRSQDLDEELGSTAAG
           460       470       480       490       500       510   

       630       640       650       660       670       680       
pF1KB3 EIVEADVAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIVEADVAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEE
           520       530       540       550       560       570   

       690       700       710       720       730       740       
pF1KB3 SGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIH
           580       590       600       610       620       630   

       750       760       770       780       790       800       
pF1KB3 NATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQ
           640       650       660       670       680       690   

       810       820       830       840       850       860       
pF1KB3 PVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVY
           700       710       720       730       740       750   

       870       880       890       900       910       920       
pF1KB3 HMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAF
           760       770       780       790       800       810   

       930       940       950 
pF1KB3 LLSLFDGGTRGRRCAIEADMKMKK
       ::::::::::::::::::::::::
NP_001 LLSLFDGGTRGRRCAIEADMKMKK
           820       830       

>>NP_001287890 (OMIM: 602848) bromodomain-containing pro  (862 aa)
 initn: 4309 init1: 4309 opt: 4314  Z-score: 2272.9  bits: 431.8 E(85289): 7.3e-120
Smith-Waterman score: 5286; 91.9% identity (91.9% similar) in 912 aa overlap (40-951:24-862)

      10        20        30        40        50        60         
pF1KB3 LLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSRAIKPFAEPGRPPDWFSQKHCASQYS
                                     ::::::::::::::::::::::::::::::
NP_001        MVHPREAMFSIFCHEKWRSKLVRVSVSRAIKPFAEPGRPPDWFSQKHCASQYS
                      10        20        30        40        50   

      70        80        90       100       110       120         
pF1KB3 ELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELI
            60        70        80        90       100       110   

     130       140       150       160       170       180         
pF1KB3 QAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAGHMDSRLDELCNDIATKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSPI
           120       130       140       150       160       170   

     190       200       210       220       230       240         
pF1KB3 DSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGIPDTLPPGSAPLEAPMTPV
       ::::::::::::::::::::::::::                                  
NP_001 DSASPGGDYPLGDLTPTTMEEATSGV----------------------------------
           180       190                                           

     250       260       270       280       290       300         
pF1KB3 TDDSPQKKMLGQKATPPPSPLLSELLKKGSLLPTSPRLVNESEMAVASGHLNSTGVLLEV
                                              :::::::::::::::::::::
NP_001 ---------------------------------------NESEMAVASGHLNSTGVLLEV
                                            200       210       220

     310       320       330       340       350       360         
pF1KB3 GGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTTVASEPPVKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPTQFTTPLASFTTVASEPPVKL
              230       240       250       260       270       280

     370       380       390       400       410       420         
pF1KB3 VPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGDPHTVTVSMD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVSQPDNCVPMEAVGDPHTVTVSMD
              290       300       310       320       330       340

     430       440       450       460       470       480         
pF1KB3 SSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYTGEELDFETV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKEELDLAEKMDIAVSYTGEELDFETV
              350       360       370       380       390       400

     490       500       510       520       530       540         
pF1KB3 GDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDIIAIIEDKVDDHPEVLDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAP
              410       420       430       440       450       460

     550       560       570       580       590       600         
pF1KB3 EMTVKQERLDFEEMENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAGVVPATSMEP
       ::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMTVKQERLDFEETENKGIHELVDIREPSAEIKVEPAEPEPVISGAEIVAGVVPATSMEP
              470       480       490       500       510       520

     610       620       630       640       650       660         
pF1KB3 PELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPSHGSNPIEDP
              530       540       550       560       570       580

     670       680       690       700       710       720         
pF1KB3 LEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEGYLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEGYLS
              590       600       610       620       630       640

     730       740       750       760       770       780         
pF1KB3 EMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAI
              650       660       670       680       690       700

     790       800       810       820       830       840         
pF1KB3 MLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDI
              710       720       730       740       750       760

     850       860       870       880       890       900         
pF1KB3 MLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLMFQNAVMYNSSDHDVYHMAVEMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDST
              770       780       790       800       810       820

     910       920       930       940       950 
pF1KB3 RKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
       ::::::::::::::::::::::::::::::::::::::::::
NP_001 RKQDASEKDSVPMGSPAFLLSLFDGGTRGRRCAIEADMKMKK
              830       840       850       860  




951 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 13:37:19 2016 done: Thu Nov  3 13:37:21 2016
 Total Scan time: 13.550 Total Display time:  0.450

Function used was FASTA [36.3.4 Apr, 2011]
Inquiries or Suggestions ?
Send a message to flexiclone AT kazusagt.com