Result of FASTA (omim) for pF1KA1299
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA1299, 671 aa
  1>>>pF1KA1299 671 - 671 aa - 671 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 8.6761+/-0.000294; mu= 6.6316+/- 0.019
 mean_var=222.2984+/-46.746, 0's: 0 Z-trim(124.0): 71  B-trim: 0 in 0/61
 Lambda= 0.086021
 statistics sampled from 44698 (44791) to 44698 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.804), E-opt: 0.2 (0.525), width:  16
 Scan time: 10.180

The best scores are:                                      opt bits E(85289)
NP_001139284 (OMIM: 608937) SH2B adapter protein 1 ( 671) 4610 584.8 3.4e-166
NP_056318 (OMIM: 608937) SH2B adapter protein 1 is ( 671) 4610 584.8 3.4e-166
NP_001139268 (OMIM: 608937) SH2B adapter protein 1 ( 671) 4610 584.8 3.4e-166
NP_001139269 (OMIM: 608937) SH2B adapter protein 1 ( 683) 4327 549.7 1.3e-155
NP_001139267 (OMIM: 608937) SH2B adapter protein 1 ( 756) 4316 548.4 3.6e-155
XP_016878604 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 4316 548.4 3.6e-155
XP_016878603 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 4316 548.4 3.6e-155
NP_001295222 (OMIM: 608937) SH2B adapter protein 1 ( 756) 4316 548.4 3.6e-155
XP_016878605 (OMIM: 608937) PREDICTED: SH2B adapte ( 756) 4316 548.4 3.6e-155
XP_016878606 (OMIM: 608937) PREDICTED: SH2B adapte ( 688) 2990 383.8 1.2e-105
NP_001295223 (OMIM: 608937) SH2B adapter protein 1 ( 335) 2320 300.4 7.3e-81
XP_016878607 (OMIM: 608937) PREDICTED: SH2B adapte ( 420) 2026 264.0 8.3e-70
XP_016878608 (OMIM: 608937) PREDICTED: SH2B adapte ( 420) 2026 264.0 8.3e-70
XP_016878609 (OMIM: 608937) PREDICTED: SH2B adapte ( 391) 1740 228.5 3.8e-59
XP_016867169 (OMIM: 605300) PREDICTED: SH2B adapte ( 631)  587 85.5 6.4e-16
XP_016867170 (OMIM: 605300) PREDICTED: SH2B adapte ( 631)  587 85.5 6.4e-16
XP_005277036 (OMIM: 605300) PREDICTED: SH2B adapte ( 632)  587 85.5 6.4e-16
XP_005277034 (OMIM: 605300) PREDICTED: SH2B adapte ( 632)  587 85.5 6.4e-16
XP_011514042 (OMIM: 605300) PREDICTED: SH2B adapte ( 645)  587 85.5 6.5e-16
XP_005277033 (OMIM: 605300) PREDICTED: SH2B adapte ( 673)  587 85.6 6.8e-16
XP_005277032 (OMIM: 605300) PREDICTED: SH2B adapte ( 674)  587 85.6 6.8e-16
NP_066189 (OMIM: 605300) SH2B adapter protein 2 [H ( 675)  587 85.6 6.8e-16
XP_006719243 (OMIM: 133100,187950,254450,605093) P ( 309)  528 78.0   6e-14
NP_001278353 (OMIM: 133100,187950,254450,605093) S ( 373)  528 78.0   7e-14
XP_011536023 (OMIM: 133100,187950,254450,605093) P ( 374)  528 78.0   7e-14
NP_005466 (OMIM: 133100,187950,254450,605093) SH2B ( 575)  528 78.2 9.6e-14
XP_005253876 (OMIM: 133100,187950,254450,605093) P ( 576)  528 78.2 9.6e-14
XP_005253875 (OMIM: 133100,187950,254450,605093) P ( 615)  528 78.2   1e-13
XP_011536022 (OMIM: 133100,187950,254450,605093) P ( 616)  528 78.2   1e-13
XP_011536021 (OMIM: 133100,187950,254450,605093) P ( 616)  528 78.2   1e-13


>>NP_001139284 (OMIM: 608937) SH2B adapter protein 1 iso  (671 aa)
 initn: 4610 init1: 4610 opt: 4610  Z-score: 3104.7  bits: 584.8 E(85289): 3.4e-166
Smith-Waterman score: 4610; 100.0% identity (100.0% similar) in 671 aa overlap (1-671:1-671)

               10        20        30        40        50        60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
              610       620       630       640       650       660

              670 
pF1KA1 GASDCVTDHLP
       :::::::::::
NP_001 GASDCVTDHLP
              670 

>>NP_056318 (OMIM: 608937) SH2B adapter protein 1 isofor  (671 aa)
 initn: 4610 init1: 4610 opt: 4610  Z-score: 3104.7  bits: 584.8 E(85289): 3.4e-166
Smith-Waterman score: 4610; 100.0% identity (100.0% similar) in 671 aa overlap (1-671:1-671)

               10        20        30        40        50        60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
              610       620       630       640       650       660

              670 
pF1KA1 GASDCVTDHLP
       :::::::::::
NP_056 GASDCVTDHLP
              670 

>>NP_001139268 (OMIM: 608937) SH2B adapter protein 1 iso  (671 aa)
 initn: 4610 init1: 4610 opt: 4610  Z-score: 3104.7  bits: 584.8 E(85289): 3.4e-166
Smith-Waterman score: 4610; 100.0% identity (100.0% similar) in 671 aa overlap (1-671:1-671)

               10        20        30        40        50        60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
              610       620       630       640       650       660

              670 
pF1KA1 GASDCVTDHLP
       :::::::::::
NP_001 GASDCVTDHLP
              670 

>>NP_001139269 (OMIM: 608937) SH2B adapter protein 1 iso  (683 aa)
 initn: 4451 init1: 4322 opt: 4327  Z-score: 2914.7  bits: 549.7 E(85289): 1.3e-155
Smith-Waterman score: 4337; 94.3% identity (95.9% similar) in 684 aa overlap (1-670:1-681)

               10        20        30        40        50        60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
              550       560       570       580       590       600

              610       620       630                     640      
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG--------------REQAGSHAGVCEG
       :::::::::::::::::::::::::::::::::              : .:::. :. .:
NP_001 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMRG
              610       620       630       640       650       660

        650       660       670  
pF1KA1 DGCHPDASCTLMPFGASDCVTDHLP 
         :  . . : ::  : .: ....  
NP_001 --CAREMDATPMP-PAPSCPSERVTV
                670        680   

>>NP_001139267 (OMIM: 608937) SH2B adapter protein 1 iso  (756 aa)
 initn: 4312 init1: 4312 opt: 4316  Z-score: 2906.8  bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4316; 99.2% identity (99.4% similar) in 640 aa overlap (1-640:1-638)

               10        20        30        40        50        60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
       ::::::::::::::::::::::::::::::::  : . ::                    
NP_001 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
              610       620       630         640       650        

              670                                                  
pF1KA1 GASDCVTDHLP                                                 
                                                                   
NP_001 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
      660       670       680       690       700       710        

>>XP_016878604 (OMIM: 608937) PREDICTED: SH2B adapter pr  (756 aa)
 initn: 4312 init1: 4312 opt: 4316  Z-score: 2906.8  bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4316; 99.2% identity (99.4% similar) in 640 aa overlap (1-640:1-638)

               10        20        30        40        50        60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
       ::::::::::::::::::::::::::::::::  : . ::                    
XP_016 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
              610       620       630         640       650        

              670                                                  
pF1KA1 GASDCVTDHLP                                                 
                                                                   
XP_016 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
      660       670       680       690       700       710        

>>XP_016878603 (OMIM: 608937) PREDICTED: SH2B adapter pr  (756 aa)
 initn: 4312 init1: 4312 opt: 4316  Z-score: 2906.8  bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4316; 99.2% identity (99.4% similar) in 640 aa overlap (1-640:1-638)

               10        20        30        40        50        60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
       ::::::::::::::::::::::::::::::::  : . ::                    
XP_016 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
              610       620       630         640       650        

              670                                                  
pF1KA1 GASDCVTDHLP                                                 
                                                                   
XP_016 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
      660       670       680       690       700       710        

>>NP_001295222 (OMIM: 608937) SH2B adapter protein 1 iso  (756 aa)
 initn: 4312 init1: 4312 opt: 4316  Z-score: 2906.8  bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4316; 99.2% identity (99.4% similar) in 640 aa overlap (1-640:1-638)

               10        20        30        40        50        60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
       ::::::::::::::::::::::::::::::::  : . ::                    
NP_001 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
              610       620       630         640       650        

              670                                                  
pF1KA1 GASDCVTDHLP                                                 
                                                                   
NP_001 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
      660       670       680       690       700       710        

>>XP_016878605 (OMIM: 608937) PREDICTED: SH2B adapter pr  (756 aa)
 initn: 4312 init1: 4312 opt: 4316  Z-score: 2906.8  bits: 548.4 E(85289): 3.6e-155
Smith-Waterman score: 4316; 99.2% identity (99.4% similar) in 640 aa overlap (1-640:1-638)

               10        20        30        40        50        60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
       ::::::::::::::::::::::::::::::::  : . ::                    
XP_016 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
              610       620       630         640       650        

              670                                                  
pF1KA1 GASDCVTDHLP                                                 
                                                                   
XP_016 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
      660       670       680       690       700       710        

>>XP_016878606 (OMIM: 608937) PREDICTED: SH2B adapter pr  (688 aa)
 initn: 3015 init1: 2982 opt: 2990  Z-score: 2018.0  bits: 383.8 E(85289): 1.2e-105
Smith-Waterman score: 3706; 88.6% identity (88.8% similar) in 640 aa overlap (1-640:1-570)

               10        20        30        40        50        60
pF1KA1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA1 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA1 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
       :::::::::::::::::                                           
XP_016 QDLLLGPSESNDRLSQG-------------------------------------------
              430                                                  

              490       500       510       520       530       540
pF1KA1 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
                                :::::::::::::::::::::::::::::::::::
XP_016 -------------------------SFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
                                440       450       460       470  

              550       560       570       580       590       600
pF1KA1 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
            480       490       500       510       520       530  

              610       620       630       640       650       660
pF1KA1 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGREQAGSHAGVCEGDGCHPDASCTLMPF
       ::::::::::::::::::::::::::::::::  : . ::                    
XP_016 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ--EPTTSHDPPQPPEPPSWTDPPQPGAE
            540       550       560         570       580       590

              670                                                  
pF1KA1 GASDCVTDHLP                                                 
                                                                   
XP_016 EASRAPEVAAAAAAAAKERQEKEKAGGGGVPEELVPVVELVPVVELEEAIAPGSEAQGAG
              600       610       620       630       640       650




671 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 10:53:45 2016 done: Thu Nov  3 10:53:46 2016
 Total Scan time: 10.180 Total Display time:  0.130

Function used was FASTA [36.3.4 Apr, 2011]
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