Result of FASTA (omim) for pF1KA0597
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0597, 910 aa
  1>>>pF1KA0597 910 - 910 aa - 910 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.2114+/-0.00042; mu= 17.7335+/- 0.026
 mean_var=129.9156+/-25.398, 0's: 0 Z-trim(115.9): 66  B-trim: 29 in 1/49
 Lambda= 0.112524
 statistics sampled from 26537 (26603) to 26537 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.312), width:  16
 Scan time: 14.170

The best scores are:                                      opt bits E(85289)
NP_005876 (OMIM: 613297) E3 ubiquitin-protein liga ( 910) 6182 1016.0       0
XP_011512234 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 842) 5672 933.2       0
NP_001257589 (OMIM: 613297) E3 ubiquitin-protein l ( 862) 5380 885.8       0
NP_001257590 (OMIM: 613297) E3 ubiquitin-protein l ( 805) 5369 884.0       0
XP_011512236 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 791) 5213 858.6       0
XP_011512238 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 637) 4341 717.0 7.3e-206
XP_011512239 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 510) 3398 563.8 7.6e-160
XP_016864433 (OMIM: 613297) PREDICTED: E3 ubiquiti ( 460) 3075 511.3 4.3e-144
XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291)  260 54.1 1.1e-06
NP_001002266 (OMIM: 613335) E3 ubiquitin-protein l ( 291)  260 54.1 1.1e-06
XP_016871383 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 291)  260 54.1 1.1e-06
NP_659458 (OMIM: 613335) E3 ubiquitin-protein liga ( 291)  260 54.1 1.1e-06
NP_060393 (OMIM: 613331) E3 ubiquitin-protein liga ( 272)  258 53.8 1.4e-06
XP_016863824 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285)  258 53.8 1.4e-06
XP_016863825 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 285)  258 53.8 1.4e-06
XP_016863823 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 289)  258 53.8 1.4e-06
NP_001159845 (OMIM: 613331) E3 ubiquitin-protein l ( 289)  258 53.8 1.4e-06
XP_011537795 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573)  257 53.9 2.6e-06
NP_001269795 (OMIM: 613335) E3 ubiquitin-protein l ( 573)  257 53.9 2.6e-06
XP_011537794 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573)  257 53.9 2.6e-06
XP_006717767 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573)  257 53.9 2.6e-06
XP_011537796 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573)  257 53.9 2.6e-06
XP_005271861 (OMIM: 613335) PREDICTED: E3 ubiquiti ( 573)  257 53.9 2.6e-06
XP_011530357 (OMIM: 613331) PREDICTED: E3 ubiquiti ( 545)  249 52.6 6.1e-06
XP_016864504 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 154)  210 45.7  0.0002
NP_848545 (OMIM: 613333) E3 ubiquitin-protein liga ( 253)  210 46.0 0.00029
XP_011541432 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280)  210 46.0 0.00031
XP_011541433 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280)  210 46.0 0.00031
XP_011541431 (OMIM: 613333) PREDICTED: E3 ubiquiti ( 280)  210 46.0 0.00031
XP_005257163 (OMIM: 613337) PREDICTED: probable E3 ( 752)  210 46.4 0.00061
XP_005257160 (OMIM: 613337) PREDICTED: probable E3 ( 799)  210 46.5 0.00064
NP_001275709 (OMIM: 613337) probable E3 ubiquitin- ( 799)  210 46.5 0.00064
XP_011522739 (OMIM: 613337) PREDICTED: probable E3 ( 807)  210 46.5 0.00065
NP_001094345 (OMIM: 613337) probable E3 ubiquitin- ( 808)  210 46.5 0.00065
NP_689811 (OMIM: 613337) probable E3 ubiquitin-pro ( 808)  210 46.5 0.00065
XP_005257159 (OMIM: 613337) PREDICTED: probable E3 ( 824)  210 46.5 0.00066
XP_005257157 (OMIM: 613337) PREDICTED: probable E3 ( 825)  210 46.5 0.00066
XP_011522738 (OMIM: 613337) PREDICTED: probable E3 ( 825)  210 46.5 0.00066
NP_001275708 (OMIM: 613337) probable E3 ubiquitin- ( 846)  210 46.5 0.00067
XP_011522737 (OMIM: 613337) PREDICTED: probable E3 ( 862)  210 46.5 0.00068
XP_005257155 (OMIM: 613337) PREDICTED: probable E3 ( 862)  210 46.5 0.00068
XP_005257153 (OMIM: 613337) PREDICTED: probable E3 ( 863)  210 46.5 0.00068
XP_005257152 (OMIM: 613337) PREDICTED: probable E3 ( 863)  210 46.5 0.00068
XP_005257154 (OMIM: 613337) PREDICTED: probable E3 ( 863)  210 46.5 0.00068
NP_001005416 (OMIM: 613332) E3 ubiquitin-protein l ( 176)  190 42.6  0.0021
XP_006722826 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 176)  190 42.6  0.0021
XP_016882342 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 246)  190 42.7  0.0027
NP_057580 (OMIM: 613332) E3 ubiquitin-protein liga ( 246)  190 42.7  0.0027
NP_001005415 (OMIM: 613332) E3 ubiquitin-protein l ( 246)  190 42.7  0.0027
XP_011526348 (OMIM: 613332) PREDICTED: E3 ubiquiti ( 256)  190 42.7  0.0027


>>NP_005876 (OMIM: 613297) E3 ubiquitin-protein ligase M  (910 aa)
 initn: 6182 init1: 6182 opt: 6182  Z-score: 5430.1  bits: 1016.0 E(85289):    0
Smith-Waterman score: 6182; 100.0% identity (100.0% similar) in 910 aa overlap (1-910:1-910)

               10        20        30        40        50        60
pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMG
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 PQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAE
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KA0 MQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGS
              850       860       870       880       890       900

              910
pF1KA0 SPPPPQSSQE
       ::::::::::
NP_005 SPPPPQSSQE
              910

>>XP_011512234 (OMIM: 613297) PREDICTED: E3 ubiquitin-pr  (842 aa)
 initn: 5672 init1: 5672 opt: 5672  Z-score: 4983.1  bits: 933.2 E(85289):    0
Smith-Waterman score: 5672; 100.0% identity (100.0% similar) in 842 aa overlap (69-910:1-842)

       40        50        60        70        80        90        
pF1KA0 CLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTL
                                     ::::::::::::::::::::::::::::::
XP_011                               MPSRLPIQDIFAGLVTSIGTAIRYWFHYTL
                                             10        20        30

      100       110       120       130       140       150        
pF1KA0 VAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFI
               40        50        60        70        80        90

      160       170       180       190       200       210        
pF1KA0 SLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVV
              100       110       120       130       140       150

      220       230       240       250       260       270        
pF1KA0 GENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERML
              160       170       180       190       200       210

      280       290       300       310       320       330        
pF1KA0 GLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIV
              220       230       240       250       260       270

      340       350       360       370       380       390        
pF1KA0 GYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICS
              280       290       300       310       320       330

      400       410       420       430       440       450        
pF1KA0 LEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLN
              340       350       360       370       380       390

      460       470       480       490       500       510        
pF1KA0 DPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYS
              400       410       420       430       440       450

      520       530       540       550       560       570        
pF1KA0 DAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENE
              460       470       480       490       500       510

      580       590       600       610       620       630        
pF1KA0 NSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIV
              520       530       540       550       560       570

      640       650       660       670       680       690        
pF1KA0 FMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAW
              580       590       600       610       620       630

      700       710       720       730       740       750        
pF1KA0 MPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFY
              640       650       660       670       680       690

      760       770       780       790       800       810        
pF1KA0 PWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLL
              700       710       720       730       740       750

      820       830       840       850       860       870        
pF1KA0 LSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIK
              760       770       780       790       800       810

      880       890       900       910
pF1KA0 NDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE
       ::::::::::::::::::::::::::::::::
XP_011 NDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE
              820       830       840  

>>NP_001257589 (OMIM: 613297) E3 ubiquitin-protein ligas  (862 aa)
 initn: 5373 init1: 5373 opt: 5380  Z-score: 4726.8  bits: 885.8 E(85289):    0
Smith-Waterman score: 5736; 94.6% identity (94.6% similar) in 910 aa overlap (1-910:1-862)

               10        20        30        40        50        60
pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT
       :::                                                 ::::::::
NP_001 FTP------------------------------------------------SRIYKCLFT
                                                               70  

              130       140       150       160       170       180
pF1KA0 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA
             80        90       100       110       120       130  

              190       200       210       220       230       240
pF1KA0 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED
            140       150       160       170       180       190  

              250       260       270       280       290       300
pF1KA0 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF
            200       210       220       230       240       250  

              310       320       330       340       350       360
pF1KA0 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH
            260       270       280       290       300       310  

              370       380       390       400       410       420
pF1KA0 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT
            320       330       340       350       360       370  

              430       440       450       460       470       480
pF1KA0 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF
            380       390       400       410       420       430  

              490       500       510       520       530       540
pF1KA0 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL
            440       450       460       470       480       490  

              550       560       570       580       590       600
pF1KA0 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV
            500       510       520       530       540       550  

              610       620       630       640       650       660
pF1KA0 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR
            560       570       580       590       600       610  

              670       680       690       700       710       720
pF1KA0 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT
            620       630       640       650       660       670  

              730       740       750       760       770       780
pF1KA0 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMG
            680       690       700       710       720       730  

              790       800       810       820       830       840
pF1KA0 PQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAE
            740       750       760       770       780       790  

              850       860       870       880       890       900
pF1KA0 MQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MQNLVHRRIYPFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGS
            800       810       820       830       840       850  

              910
pF1KA0 SPPPPQSSQE
       ::::::::::
NP_001 SPPPPQSSQE
            860  

>>NP_001257590 (OMIM: 613297) E3 ubiquitin-protein ligas  (805 aa)
 initn: 5369 init1: 5369 opt: 5369  Z-score: 4717.5  bits: 884.0 E(85289):    0
Smith-Waterman score: 5369; 100.0% identity (100.0% similar) in 798 aa overlap (113-910:8-805)

             90       100       110       120       130       140  
pF1KA0 VTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLAD
                                     ::::::::::::::::::::::::::::::
NP_001                        MDTAEEGRIYKCLFTGSVSSLLTLPLDMLSTENLLAD
                                      10        20        30       

            150       160       170       180       190       200  
pF1KA0 CLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAAPPFNAAGHHQNEAPAGGNGAEN
        40        50        60        70        80        90       

            210       220       230       240       250       260  
pF1KA0 VAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEEDDAGVEDAADANNGAQDDMNWNA
       100       110       120       130       140       150       

            270       280       290       300       310       320  
pF1KA0 LEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLFILVFAFCPYHIGHFSLVGLGFE
       160       170       180       190       200       210       

            330       340       350       360       370       380  
pF1KA0 EHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFHRSRRLLGVCYIVVKVSLLVVVE
       220       230       240       250       260       270       

            390       400       410       420       430       440  
pF1KA0 IGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMVYVFYFASFILLL
       280       290       300       310       320       330       

            450       460       470       480       490       500  
pF1KA0 REVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRII
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSIVLLMLWLPIRII
       340       350       360       370       380       390       

            510       520       530       540       550       560  
pF1KA0 KSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLKGLVRAWTVTAGY
       400       410       420       430       440       450       

            570       580       590       600       610       620  
pF1KA0 LLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQAILQQGGPVGFQP
       460       470       480       490       500       510       

            630       640       650       660       670       680  
pF1KA0 YRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTAKIHELYTAACGL
       520       530       540       550       560       570       

            690       700       710       720       730       740  
pF1KA0 YVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGVVPLLLGLLFELV
       580       590       600       610       620       630       

            750       760       770       780       790       800  
pF1KA0 IVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIEQVYANGIRNIDL
       640       650       660       670       680       690       

            810       820       830       840       850       860  
pF1KA0 HYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIYPFLLMVVVLMAI
       700       710       720       730       740       750       

            870       880       890       900       910
pF1KA0 LSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE
       ::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE
       760       770       780       790       800     

>>XP_011512236 (OMIM: 613297) PREDICTED: E3 ubiquitin-pr  (791 aa)
 initn: 5213 init1: 5213 opt: 5213  Z-score: 4580.7  bits: 858.6 E(85289):    0
Smith-Waterman score: 5213; 99.3% identity (99.3% similar) in 769 aa overlap (1-769:1-769)

               10        20        30        40        50        60
pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KA0 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KA0 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMG
       :::::::::::::::::::::::::::::::::::::::::   :  ::           
XP_011 LIVAVLLAGVVPLLLGLLFELVIVAPLRVPLDQTPLFYPWQMENLHKLHLPENFYLSAFN
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KA0 PQWWLKTVIEQVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAE
                                                                   
XP_011 GVPTPWIVSPR                                                 
              790                                                  

>>XP_011512238 (OMIM: 613297) PREDICTED: E3 ubiquitin-pr  (637 aa)
 initn: 4341 init1: 4341 opt: 4341  Z-score: 3816.9  bits: 717.0 E(85289): 7.3e-206
Smith-Waterman score: 4341; 100.0% identity (100.0% similar) in 632 aa overlap (1-632:1-632)

               10        20        30        40        50        60
pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILSVIVFGSIVLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALL
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQGHTRQWLKGLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGR
       ::::::::::::::::::::::::::::::::                            
XP_011 GEGLHAAHQAILQQGGPVGFQPYRRPLNFPLRTKKAF                       
              610       620       630                              

              670       680       690       700       710       720
pF1KA0 WLMSFWTGTAKIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKT

>>XP_011512239 (OMIM: 613297) PREDICTED: E3 ubiquitin-pr  (510 aa)
 initn: 3398 init1: 3398 opt: 3398  Z-score: 2990.8  bits: 563.8 E(85289): 7.6e-160
Smith-Waterman score: 3398; 100.0% identity (100.0% similar) in 510 aa overlap (401-910:1-510)

              380       390       400       410       420       430
pF1KA0 IVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTTMFLHWLVGMV
                                     ::::::::::::::::::::::::::::::
XP_011                               MFDATLKDRELSFQSAPGTTMFLHWLVGMV
                                             10        20        30

              440       450       460       470       480       490
pF1KA0 YVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRFILSVIVFGSI
               40        50        60        70        80        90

              500       510       520       530       540       550
pF1KA0 VLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLLMLWLPIRIIKSVLPNFLPYNVMLYSDAPVSELSLELLLLQVVLPALLEQGHTRQWLK
              100       110       120       130       140       150

              560       570       580       590       600       610
pF1KA0 GLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLVRAWTVTAGYLLDLHSYLLGDQEENENSANQQVNNNQHARNNNAIPVVGEGLHAAHQA
              160       170       180       190       200       210

              620       630       640       650       660       670
pF1KA0 ILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILQQGGPVGFQPYRRPLNFPLRIFLLIVFMCITLLIASLICLTLPVFAGRWLMSFWTGTA
              220       230       240       250       260       270

              680       690       700       710       720       730
pF1KA0 KIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIHELYTAACGLYVCWLTIRAVTVMVAWMPQGRRVIFQKVKEWSLMIMKTLIVAVLLAGV
              280       290       300       310       320       330

              740       750       760       770       780       790
pF1KA0 VPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPLLLGLLFELVIVAPLRVPLDQTPLFYPWQDWALGVLHAKIIAAITLMGPQWWLKTVIE
              340       350       360       370       380       390

              800       810       820       830       840       850
pF1KA0 QVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVYANGIRNIDLHYIVRKLAAPVISVLLLSLCVPYVIASGVVPLLGVTAEMQNLVHRRIY
              400       410       420       430       440       450

              860       870       880       890       900       910
pF1KA0 PFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFLLMVVVLMAILSFQVRQFKRLYEHIKNDKYLVGQRLVNYERKSGKQGSSPPPPQSSQE
              460       470       480       490       500       510

>>XP_016864433 (OMIM: 613297) PREDICTED: E3 ubiquitin-pr  (460 aa)
 initn: 3075 init1: 3075 opt: 3075  Z-score: 2707.9  bits: 511.3 E(85289): 4.3e-144
Smith-Waterman score: 3075; 100.0% identity (100.0% similar) in 444 aa overlap (1-444:1-444)

               10        20        30        40        50        60
pF1KA0 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFIHQECLVQWLKHSRKEYCELCKHRFA
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFHYTLVAFAWLGVVPLTACRIYKCLFT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLCAFISLVWLREQIVHGGAPIWLEHAA
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPFNAAGHHQNEAPAGGNGAENVAADQPANPPAENAVVGENPDAQDDQAEEEEEDNEEED
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAGVEDAADANNGAQDDMNWNALEWDRAAEELTWERMLGLDGSLVFLEHVFWVVSLNTLF
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILVFAFCPYHIGHFSLVGLGFEEHVQASHFEGLITTIVGYILLAITLIICHGLATLVKFH
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSRRLLGVCYIVVKVSLLVVVEIGVFPLICGWWLDICSLEMFDATLKDRELSFQSAPGTT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 MFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPVQEMIHLPIYRHLRRF
       ::::::::::::::::::::::::                                    
XP_016 MFLHWLVGMVYVFYFASFILLLREPENEYSIENVGLHGDG                    
              430       440       450       460                    

>>XP_011537797 (OMIM: 613335) PREDICTED: E3 ubiquitin-pr  (291 aa)
 initn: 255 init1: 255 opt: 260  Z-score: 240.7  bits: 54.1 E(85289): 1.1e-06
Smith-Waterman score: 260; 51.6% identity (72.6% similar) in 62 aa overlap (6-67:77-138)

                                        10        20        30     
pF1KA0                          MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFI
                                     .::::.:. ::  :.::  :: ::::..:.
XP_011 SNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFV
         50        60        70        80        90       100      

          40        50        60        70        80        90     
pF1KA0 HQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFH
       :: :: ::.: :  . :::::..: .    .:                            
XP_011 HQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAI
        110       120       130       140       150       160      

         100       110       120       130       140       150     
pF1KA0 YTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLC
                                                                   
XP_011 TCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLW
        170       180       190       200       210       220      

>>NP_001002266 (OMIM: 613335) E3 ubiquitin-protein ligas  (291 aa)
 initn: 255 init1: 255 opt: 260  Z-score: 240.7  bits: 54.1 E(85289): 1.1e-06
Smith-Waterman score: 260; 51.6% identity (72.6% similar) in 62 aa overlap (6-67:77-138)

                                        10        20        30     
pF1KA0                          MDTAEEDICRVCRSEGTPEKPLYHPCVCTGSIKFI
                                     .::::.:. ::  :.::  :: ::::..:.
NP_001 SNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFV
         50        60        70        80        90       100      

          40        50        60        70        80        90     
pF1KA0 HQECLVQWLKHSRKEYCELCKHRFAFTPIYSPDMPSRLPIQDIFAGLVTSIGTAIRYWFH
       :: :: ::.: :  . :::::..: .    .:                            
NP_001 HQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAI
        110       120       130       140       150       160      

         100       110       120       130       140       150     
pF1KA0 YTLVAFAWLGVVPLTACRIYKCLFTGSVSSLLTLPLDMLSTENLLADCLQGCFVVTCTLC
                                                                   
NP_001 TCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLW
        170       180       190       200       210       220      




910 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 09:50:15 2016 done: Thu Nov  3 09:50:17 2016
 Total Scan time: 14.170 Total Display time:  0.220

Function used was FASTA [36.3.4 Apr, 2011]
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