Result of FASTA (omim) for pF1KSDA1785
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA1785, 617 aa
  1>>>pF1KSDA1785 617 - 617 aa - 617 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.2853+/-0.000704; mu= 8.0416+/- 0.043
 mean_var=183.8955+/-41.068, 0's: 0 Z-trim(108.8): 709  B-trim: 805 in 1/52
 Lambda= 0.094578
 statistics sampled from 16040 (16877) to 16040 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.542), E-opt: 0.2 (0.198), width:  16
 Scan time:  8.450

The best scores are:                                      opt bits E(85289)
NP_064562 (OMIM: 608767) protein fem-1 homolog C [ ( 617) 4047 566.4  1e-160
XP_005272092 (OMIM: 608767) PREDICTED: protein fem ( 617) 4047 566.4  1e-160
XP_016865136 (OMIM: 608767) PREDICTED: protein fem ( 464) 2892 408.7 2.3e-113
NP_061178 (OMIM: 613538) protein fem-1 homolog A [ ( 669) 1702 246.5 2.2e-64
NP_056137 (OMIM: 613539) protein fem-1 homolog B [ ( 627) 1387 203.5 1.8e-51
XP_016877348 (OMIM: 613539) PREDICTED: protein fem ( 469)  919 139.5 2.5e-32
XP_016863506 (OMIM: 615929) PREDICTED: ankyrin rep (1116)  325 58.8 1.1e-07
NP_001183959 (OMIM: 610500) ankyrin repeat and KH  ( 581)  320 57.9 1.2e-07
NP_060448 (OMIM: 610500) ankyrin repeat and KH dom ( 616)  320 57.9 1.2e-07
XP_016863505 (OMIM: 615929) PREDICTED: ankyrin rep (1229)  325 58.9 1.2e-07
NP_078944 (OMIM: 610500) ankyrin repeat and KH dom ( 627)  320 57.9 1.2e-07
XP_016863504 (OMIM: 615929) PREDICTED: ankyrin rep (1367)  325 58.9 1.3e-07
XP_016863503 (OMIM: 615929) PREDICTED: ankyrin rep (1479)  325 59.0 1.4e-07
XP_005265730 (OMIM: 615929) PREDICTED: ankyrin rep (1480)  325 59.0 1.4e-07
XP_005265729 (OMIM: 615929) PREDICTED: ankyrin rep (1543)  325 59.0 1.4e-07
XP_016863502 (OMIM: 615929) PREDICTED: ankyrin rep (2238)  325 59.1 1.8e-07
XP_016863501 (OMIM: 615929) PREDICTED: ankyrin rep (2239)  325 59.1 1.8e-07
XP_005265728 (OMIM: 615929) PREDICTED: ankyrin rep (2351)  325 59.2 1.9e-07
NP_942592 (OMIM: 615929) ankyrin repeat domain-con (2352)  325 59.2 1.9e-07
XP_016863500 (OMIM: 615929) PREDICTED: ankyrin rep (2489)  325 59.2   2e-07
NP_001273700 (OMIM: 615929) ankyrin repeat domain- (2490)  325 59.2   2e-07
NP_056389 (OMIM: 615929) ankyrin repeat domain-con (2602)  325 59.2   2e-07
NP_115593 (OMIM: 615929) ankyrin repeat domain-con (2603)  325 59.2   2e-07
XP_016871638 (OMIM: 600465,615493) PREDICTED: anky (1720)  318 58.1   3e-07
XP_016871637 (OMIM: 600465,615493) PREDICTED: anky (1725)  318 58.1   3e-07
XP_016871636 (OMIM: 600465,615493) PREDICTED: anky (1735)  318 58.1   3e-07
XP_016871635 (OMIM: 600465,615493) PREDICTED: anky (1737)  318 58.1   3e-07
XP_016871634 (OMIM: 600465,615493) PREDICTED: anky (1738)  318 58.1   3e-07
XP_016871633 (OMIM: 600465,615493) PREDICTED: anky (1741)  318 58.1   3e-07
XP_016871632 (OMIM: 600465,615493) PREDICTED: anky (1742)  318 58.1   3e-07
XP_016871631 (OMIM: 600465,615493) PREDICTED: anky (1747)  318 58.1   3e-07
XP_016871630 (OMIM: 600465,615493) PREDICTED: anky (1751)  318 58.1   3e-07
XP_016871629 (OMIM: 600465,615493) PREDICTED: anky (1763)  318 58.1   3e-07
XP_016871628 (OMIM: 600465,615493) PREDICTED: anky (1764)  318 58.1   3e-07
XP_016871627 (OMIM: 600465,615493) PREDICTED: anky (1785)  318 58.1 3.1e-07
XP_016871626 (OMIM: 600465,615493) PREDICTED: anky (1786)  318 58.1 3.1e-07
XP_016871625 (OMIM: 600465,615493) PREDICTED: anky (1795)  318 58.1 3.1e-07
XP_016871624 (OMIM: 600465,615493) PREDICTED: anky (1838)  318 58.1 3.1e-07
XP_016871623 (OMIM: 600465,615493) PREDICTED: anky (1845)  318 58.1 3.1e-07
XP_016871622 (OMIM: 600465,615493) PREDICTED: anky (1850)  318 58.1 3.1e-07
XP_016871621 (OMIM: 600465,615493) PREDICTED: anky (1855)  318 58.1 3.1e-07
NP_001191332 (OMIM: 600465,615493) ankyrin-3 isofo (1861)  318 58.1 3.1e-07
XP_016871620 (OMIM: 600465,615493) PREDICTED: anky (1862)  318 58.1 3.2e-07
XP_016871619 (OMIM: 600465,615493) PREDICTED: anky (1866)  318 58.1 3.2e-07
NP_001307803 (OMIM: 600465,615493) ankyrin-3 isofo (1867)  318 58.1 3.2e-07
NP_001191333 (OMIM: 600465,615493) ankyrin-3 isofo (1868)  318 58.1 3.2e-07
XP_005269772 (OMIM: 600465,615493) PREDICTED: anky (1885)  318 58.1 3.2e-07
XP_016871618 (OMIM: 600465,615493) PREDICTED: anky (1888)  318 58.1 3.2e-07
XP_016871617 (OMIM: 600465,615493) PREDICTED: anky (1889)  318 58.1 3.2e-07
XP_006717865 (OMIM: 600465,615493) PREDICTED: anky (1898)  318 58.1 3.2e-07


>>NP_064562 (OMIM: 608767) protein fem-1 homolog C [Homo  (617 aa)
 initn: 4047 init1: 4047 opt: 4047  Z-score: 3006.5  bits: 566.4 E(85289): 1e-160
Smith-Waterman score: 4047; 100.0% identity (100.0% similar) in 617 aa overlap (1-617:1-617)

               10        20        30        40        50        60
pF1KSD MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD KGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 KGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD EIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 EIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD NNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 NNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNH
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD PDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_064 PDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIY
              550       560       570       580       590       600

              610       
pF1KSD YKGHIPEKLETFVSLHR
       :::::::::::::::::
NP_064 YKGHIPEKLETFVSLHR
              610       

>>XP_005272092 (OMIM: 608767) PREDICTED: protein fem-1 h  (617 aa)
 initn: 4047 init1: 4047 opt: 4047  Z-score: 3006.5  bits: 566.4 E(85289): 1e-160
Smith-Waterman score: 4047; 100.0% identity (100.0% similar) in 617 aa overlap (1-617:1-617)

               10        20        30        40        50        60
pF1KSD MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD KGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTS
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAK
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD EIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGK
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD NNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNH
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD PDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIY
              550       560       570       580       590       600

              610       
pF1KSD YKGHIPEKLETFVSLHR
       :::::::::::::::::
XP_005 YKGHIPEKLETFVSLHR
              610       

>>XP_016865136 (OMIM: 608767) PREDICTED: protein fem-1 h  (464 aa)
 initn: 2885 init1: 2885 opt: 2892  Z-score: 2156.3  bits: 408.7 E(85289): 2.3e-113
Smith-Waterman score: 2892; 97.6% identity (98.4% similar) in 451 aa overlap (167-617:15-464)

        140       150       160       170       180       190      
pF1KSD EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLD
                                     .:: :   .  .:. :::::::::::::::
XP_016                 MLIEKVSKASTWLIFLLPKEHHIVFRSA-GNTALHDCAESGSLD
                               10        20         30        40   

        200       210       220       230       240       250      
pF1KSD IMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFV
            50        60        70        80        90       100   

        260       270       280       290       300       310      
pF1KSD DKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPD
           110       120       130       140       150       160   

        320       330       340       350       360       370      
pF1KSD EMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLS
           170       180       190       200       210       220   

        380       390       400       410       420       430      
pF1KSD PMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPL
           230       240       250       260       270       280   

        440       450       460       470       480       490      
pF1KSD QLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTC
           290       300       310       320       330       340   

        500       510       520       530       540       550      
pF1KSD VGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDA
           350       360       370       380       390       400   

        560       570       580       590       600       610      
pF1KSD TNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLH
           410       420       430       440       450       460   

        
pF1KSD R
       :
XP_016 R
        

>>NP_061178 (OMIM: 613538) protein fem-1 homolog A [Homo  (669 aa)
 initn: 2238 init1: 969 opt: 1702  Z-score: 1276.8  bits: 246.5 E(85289): 2.2e-64
Smith-Waterman score: 2682; 64.3% identity (82.4% similar) in 649 aa overlap (22-616:22-669)

               10        20        30        40        50        60
pF1KSD MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFL
                            ::...:.::.. : .: ..:.::::.::::::::.::.:
NP_061 MDLRTAVYNAARDGKLQLLQKLLSGRSREELDELTGEVAGGGTPLLIAARYGHLDVVEYL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD LEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPL
       ...:.::.:.::::.::::::::::::::::::::: ::.::: .::::: :: ::::::
NP_061 VDRCGASVEAGGSVHFDGETIEGAPPLWAASAAGHLDVVRSLLRRGASVNRTTRTNSTPL
               70        80        90       100       110       120

              130        140       150       160       170         
pF1KSD RAACFDGHLEIVKYLV-EHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKS
       ::::::::::.:.::: ::.:::::.::::::::::::::::.:::.::::.::.:::.:
NP_061 RAACFDGHLEVVRYLVGEHQADLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNRRS
              130       140       150       160       170       180

     180       190       200       210       220       230         
pF1KSD VKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHH---
       .:::::::::::::::.:...::   :.::.:::::::::.::::::::::..: ..   
NP_061 AKGNTALHDCAESGSLEILQLLLGCKARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPG
              190       200       210       220       230       240

                                                         240       
pF1KSD --------AQ-----------------------------------------TSKTERINA
               ::                                         ::.   ..:
NP_061 QEQVAGGEAQPGLPQEDPSTSQGCAQPQGAPCCSSSPEEPLNGESYESCCPTSREAAVEA
              250       260       270       280       290       300

       250       260       270       280       290       300       
pF1KSD LELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEE
       :::::::.::::::::::::.:..::..:..   . . :: :  :..::::..:::..::
NP_061 LELLGATYVDKKRDLLGALKHWRRAMELRHQG-GEYLPKPEPPQLVLAYDYSREVNTTEE
              310       320       330        340       350         

       310       320       330       340       350       360       
pF1KSD LEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDM
       ::.::.:::::::::::::::::::::::::::::::::::::::::.::: ::::::::
NP_061 LEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDM
     360       370       380       390       400       410         

       370       380       390        400       410       420      
pF1KSD QQSNLDPLSPMTASSLLSFAELFSFMLQDRA-KGLLGTTVTFDDLMGILCKSVLEIERAI
       :::::.:::::::::.::::::::..::::: :: ::: . : ::::.: :.: :.:::.
NP_061 QQSNLEPLSPMTASSFLSFAELFSYVLQDRAAKGSLGTQIGFADLMGVLTKGVREVERAL
     420       430       440       450       460       470         

        430       440       450       460       470       480      
pF1KSD KQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPL
       .  . :.:  :..:::.:::::. ::::: ::  :.:.:.::.::.::  :::::.:.::
NP_061 QLPREPGDSAQFTKALAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPL
     480       490       500       510       520       530         

        490       500       510       520       530       540      
pF1KSD HLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNL
       :.::::.:: :::::: .::::.:. .:..:::: . :: :.:.:::::: :: : ::: 
NP_061 HMAVDKDTTNVGRYPVGRFPSLHVVKVLLDCGADPDSRDFDNNTPLHIAAQNNCPAIMNA
     540       550       560       570       580       590         

        550       560       570       580       590       600      
pF1KSD LIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIP
       ::..:::.::::  :.:: .::::: .:.. .::.:..::::::::.. ...: ::: ::
NP_061 LIEAGAHMDATNAFKKTAYELLDEKLLARGTMQPFNYVTLQCLAARALDKNKIPYKGFIP
     600       610       620       630       640       650         

        610       
pF1KSD EKLETFVSLHR
       : ::.:. :: 
NP_061 EDLEAFIELH 
     660          

>>NP_056137 (OMIM: 613539) protein fem-1 homolog B [Homo  (627 aa)
 initn: 1212 init1: 725 opt: 1387  Z-score: 1044.9  bits: 203.5 E(85289): 1.8e-51
Smith-Waterman score: 1438; 40.7% identity (70.0% similar) in 634 aa overlap (7-616:8-627)

                10        20        30          40          50     
pF1KSD  MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLIS--EKTNG--ATPLLMAARYGHLD
              :..:: .::.  :. :: ..:. ..  :..   . .:  .:::..::: ::  
NP_056 MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAK
               10        20        30        40        50        60

          60        70        80        90       100       110     
pF1KSD MVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLT
       .:..:::.  .. .  :.: ::: .:.::  :: :..:::..::. :..:::.::.::.:
NP_056 VVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVT
               70        80        90       100       110       120

         120       130       140       150       160       170     
pF1KSD NSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADV
       ::::::::::::.:.:::::::..:.. ..:.. .:::::. :::: ....::::. :: 
NP_056 NSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADP
              130       140       150       160       170       180

         180       190       200       210       220       230     
pF1KSD NRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTH
       : :.  : ::::  ::.: .::.: :. . : .  .:.:::::  :. . ....:..:  
NP_056 NAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLS
              190       200       210       220       230       240

         240       250       260         270       280        290  
pF1KSD HAQTSKTERINALELLGATFVDKKR--DLLGALKYWKKAMNMRYSDRTNIISKPV-PQTL
       ::. ..  ::.:::::::.:.. ..  :.. . .:   ::  :..:  ::. : : :   
NP_056 HADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPP--
              250       260       270       280       290          

            300       310       320       330       340       350  
pF1KSD IMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSG
       : ::    :  . .:::..  : : ..:..:..:::::: .. :.:. : ::::::::. 
NP_056 IHAYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNM
      300       310       320       330       340       350        

            360       370       380       390       400       410  
pF1KSD NFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLM
       .:..::.:: .:: ..:..    .  : ..:: ::..:: :..      :. ::   :. 
NP_056 EFEQCIKLWLHALHLRQKG----NRNTHKDLLRFAQVFSQMIH------LNETVKAPDIE
      360       370           380       390             400        

            420       430       440             450       460      
pF1KSD GILCKSVLEIERAIKQTQCPADPLQLNKA------LSIILHLICLLEKVPCTLEQDHFK-
        .:  ::::::.......  .:    :        :  .:.:.:.  :. :. :.:. : 
NP_056 CVLRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCS-EEDQCKI
      410       420       430       440       450       460        

         470       480       490       500         510       520   
pF1KSD KQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYP--VCKFPSLQVTAILIECGADVNV
       .. :: ...: :: ...:. :::::..::     .   ::.::.  :: .:..:::.::.
NP_056 NKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNA
       470       480       490       500       510       520       

           530       540               550       560       570     
pF1KSD RDSDDNSPLHIAALNNHP--DIMNL------LIKSGAHFDATNLHKQTASDLLDEKEIAK
        :.. :: ::: .  :.:  :...:      :...::: : :: ...:  :  .   ...
NP_056 VDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDK-STTGVSE
       530       540       550       560       570        580      

         580       590       600       610       
pF1KSD NLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLHR
        :..   . .:.:::::..  . : :. .::. :: ::..: 
NP_056 ILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH 
        590       600       610       620        

>>XP_016877348 (OMIM: 613539) PREDICTED: protein fem-1 h  (469 aa)
 initn: 786 init1: 299 opt: 919  Z-score: 701.3  bits: 139.5 E(85289): 2.5e-32
Smith-Waterman score: 970; 38.3% identity (66.9% similar) in 483 aa overlap (154-616:1-469)

           130       140       150       160       170       180   
pF1KSD CFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN
                                     ::. :::: ....::::. :: : :.  : 
XP_016                               MIAAYKGHTDVVRYLLEQRADPNAKAHCGA
                                             10        20        30

           190       200       210       220       230       240   
pF1KSD TALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTE
       ::::  ::.: .::.: :. . : .  .:.:::::  :. . ....:..:  ::. ..  
XP_016 TALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRS
               40        50        60        70        80        90

           250       260         270       280        290       300
pF1KSD RINALELLGATFVDKKR--DLLGALKYWKKAMNMRYSDRTNIISKPV-PQTLIMAYDYAK
       ::.:::::::.:.. ..  :.. . .:   ::  :..:  ::. : : :   : ::    
XP_016 RIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPP--IHAYGNRT
              100       110       120       130       140          

              310       320       330       340       350       360
pF1KSD EVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINL
       :  . .:::..  : : ..:..:..:::::: .. :.:. : ::::::::. .:..::.:
XP_016 ECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKL
      150       160       170       180       190       200        

              370       380       390       400       410       420
pF1KSD WKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVL
       : .:: ..:..    .  : ..:: ::..:: :..      :. ::   :.  .:  :::
XP_016 WLHALHLRQKG----NRNTHKDLLRFAQVFSQMIH------LNETVKAPDIECVLRCSVL
      210           220       230             240       250        

              430       440             450       460        470   
pF1KSD EIERAIKQTQCPADPLQLNKA------LSIILHLICLLEKVPCTLEQDHFK-KQTIYRFL
       :::.......  .:    :        :  .:.:.:.  :. :. :.:. : .. :: ..
XP_016 EIEQSMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCS-EEDQCKINKQIYNLI
      260       270       280       290       300        310       

           480       490       500         510       520       530 
pF1KSD KLHPRGKNNFSPLHLAVDKNTTCVGRYP--VCKFPSLQVTAILIECGADVNVRDSDDNSP
       .: :: ...:. :::::..::     .   ::.::.  :: .:..:::.::. :.. :: 
XP_016 HLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSA
       320       330       340       350       360       370       

             540               550       560       570       580   
pF1KSD LHIAALNNHP--DIMNL------LIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINH
       ::: .  :.:  :...:      :...::: : :: ...:  :  .   ... :..   .
XP_016 LHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDK-STTGVSEILLKTQMK
       380       390       400       410       420        430      

           590       600       610       
pF1KSD TTLQCLAARVIVNHRIYYKGHIPEKLETFVSLHR
        .:.:::::..  . : :. .::. :: ::..: 
XP_016 MSLKCLAARAVRANDINYQDQIPRTLEEFVGFH 
        440       450       460          

>>XP_016863506 (OMIM: 615929) PREDICTED: ankyrin repeat   (1116 aa)
 initn: 420 init1: 261 opt: 325  Z-score: 258.7  bits: 58.8 E(85289): 1.1e-07
Smith-Waterman score: 393; 34.4% identity (66.0% similar) in 253 aa overlap (5-250:190-427)

                                         10        20        30    
pF1KSD                           MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSL
                                     : .. ::  :.....  ::: :.     ..
XP_016 LACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA-----DV
     160       170       180       190       200       210         

           40        50        60        70        80        90    
pF1KSD ISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAG
        .....: : : .:   :..:.:. :::. .::::   . : .:.:     ::  :..::
XP_016 NAQSSTGNTALTYACAGGYVDVVKVLLES-GASIE---DHNENGHT-----PLMEAGSAG
          220       230       240           250            260     

          100       110        120       130       140       150   
pF1KSD HLKVVQSLLNHGASVN-NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCL
       :..:.. ::..::..: ...  . . :  ::. ::::.:..:.:  :: : .. . :: :
XP_016 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL
         270       280       290       300       310       320     

           160       170       180       190       200       210   
pF1KSD MISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEK-DG
       : .:. :: :.:. ::..::.::  . . .. :   : .: ...  .:.   :..:. . 
XP_016 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND
         330       340       350       360       370       380     

            220       230            240       250       260       
pF1KSD YGMTPLLSASVTGHTNIVDFLTHH-----AQTSKTERINALELLGATFVDKKRDLLGALK
        :.:::. :.  :: ..: .:  .     ::: .:.. .:: :                 
XP_016 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE-TALTLACCGGFLEVADFLIKAG
         390       400       410       420        430       440    

       270       280       290       300       310       320       
pF1KSD YWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRE
                                                                   
XP_016 ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL
          450       460       470       480       490       500    

>--
 initn: 358 init1: 244 opt: 312  Z-score: 249.1  bits: 57.1 E(85289): 3.9e-07
Smith-Waterman score: 340; 25.1% identity (48.9% similar) in 605 aa overlap (52-556:432-1017)

              30        40        50        60        70        80 
pF1KSD LLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETI
                                     : :....::. . .:.::.: :.       
XP_016 MVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLI-KAGADIELGCST-------
             410       420       430       440        450          

              90       100       110       120       130       140 
pF1KSD EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKAD
           ::  :.  :::..:. ::  ::.:. :: :..: :  :: .:: ...  :..  ::
XP_016 ----PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGAD
               460       470       480       490       500         

             150       160       170       180        190       200
pF1KSD LEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN-TALHDCAESGSLDIMKM
       ::  .. :.: :: .   ::   .:.:. :::.::: ..... :.:     .: : ....
XP_016 LEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVEL
     510       520       530       540       550       560         

                 210       220       230                           
pF1KSD LLMYCAKME---KDGYGMTPLLSASVTGHTNIVDFL---------------------THH
       :: . :      :::  :  :. :.  :::..: .:                     .: 
XP_016 LLAHGADPTHRLKDGSTM--LIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHD
     570       580         590       600       610       620       

        240       250         260       270       280              
pF1KSD AQTSKTERINALELL-GATFVDKK-RDLLGALKYWKKAMNMRYSDRTNI--------ISK
        . .    ..:: ..      ::   ..  .:   .::.. : :  .:         ::.
XP_016 LNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQ
       630       640       650       660       670       680       

                 290            300       310       320       330  
pF1KSD P---------VPQTLIMAY-----DYAKEVNSAEELEGLIADPDEMRMQALLIRERILGP
       :          :....  :     :   : :    :    :   :  .:.::  ::  . 
XP_016 PQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLL--ERGASI
       690       700       710       720       730         740     

            340       350       360        370       380       390 
pF1KSD SHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQ-QSNLDPLSPMTASSLLSFAELFS
        : : . .      . : .:.      :   . :.. ::.    .:.. .   .  :.  
XP_016 EHRDKKGFTPL--ILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVE
         750         760       770       780       790       800   

                        400       410       420       430          
pF1KSD FML-----------QDRAKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQL--
       ..:           .: .   :...  . ... :: ..  ::.     ..   .::.:  
XP_016 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG-SKLGISPLMLAA
           810       820       830       840       850        860  

       440       450       460                     470       480   
pF1KSD -NKALSIILHLICLLEKVPCTLEQDH--------FKKQT------IYRFLKLHPRGKNNF
        :   . .  :. .   .   .: ..        :. .:      . :  ... :.:...
XP_016 MNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGL
            870       880       890       900       910       920  

           490       500               510                     520 
pF1KSD SPLHLAVDKNTTCVGRYPVCK--------FPSLQVTAILIE--------C------GADV
       .::  :.. . . :::  . :         :: . ::. :         :      :: .
XP_016 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI
            930       940       950       960       970       980  

             530       540       550       560       570       580 
pF1KSD NVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPI
       .::..  :.:: .:: ..: :...::...::  ::                         
XP_016 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV
            990      1000      1010      1020      1030      1040  

             590       600       610                               
pF1KSD NHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLHR                        
                                                                   
XP_016 KEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLE
           1050      1060      1070      1080      1090      1100  

>>NP_001183959 (OMIM: 610500) ankyrin repeat and KH doma  (581 aa)
 initn: 439 init1: 250 opt: 320  Z-score: 258.5  bits: 57.9 E(85289): 1.2e-07
Smith-Waterman score: 373; 33.9% identity (65.3% similar) in 248 aa overlap (10-250:278-511)

                                    10        20        30         
pF1KSD                      MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKT
                                     :: .:    ..:::  ..    ... :...
NP_001 AGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHD----ADVNSQSA
       250       260       270       280       290           300   

      40        50        60        70        80        90         
pF1KSD NGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVV
       .: : : .:   : .:.:. ::.. .:.::   . : .:.:     ::  :..:::..:.
NP_001 TGNTALTYACAGGFVDIVKVLLNE-GANIE---DHNENGHT-----PLMEAASAGHVEVA
           310       320        330          340            350    

     100       110        120       130       140       150        
pF1KSD QSLLNHGASVN-NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCY
       . ::.:::..: ...  . . :  ::. :::..:..:.:  :: : .. . :: :: .:.
NP_001 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM
          360       370       380       390       400       410    

      160       170       180       190       200       210        
pF1KSD KGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEK-DGYGMTP
        :: :.:. ::..::.::  . . .. :   : .: ...  .:.   :..:. .  :.::
NP_001 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP
          420       430       440       450       460       470    

       220       230            240       250       260       270  
pF1KSD LLSASVTGHTNIVDFLTHH-----AQTSKTERINALELLGATFVDKKRDLLGALKYWKKA
       :. :.  :: ..: .:  .     ::: .:.. .:: :                      
NP_001 LMEAAREGHEEMVALLLAQGANINAQTEETQE-TALTLACCGGFSEVADFLIKAGADIEL
          480       490       500        510       520       530   

            280       290       300       310       320       330  
pF1KSD MNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGP
                                                                   
NP_001 GCSTPLMEASQEGHLELVKYLLASGQAGGHEDYFGGHRSGQASGEGGL            
           540       550       560       570       580             

>>NP_060448 (OMIM: 610500) ankyrin repeat and KH domain-  (616 aa)
 initn: 600 init1: 250 opt: 320  Z-score: 258.2  bits: 57.9 E(85289): 1.2e-07
Smith-Waterman score: 373; 33.9% identity (65.3% similar) in 248 aa overlap (10-250:267-500)

                                    10        20        30         
pF1KSD                      MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKT
                                     :: .:    ..:::  ..    ... :...
NP_060 AGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHD----ADVNSQSA
        240       250       260       270       280           290  

      40        50        60        70        80        90         
pF1KSD NGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVV
       .: : : .:   : .:.:. ::.. .:.::   . : .:.:     ::  :..:::..:.
NP_060 TGNTALTYACAGGFVDIVKVLLNE-GANIE---DHNENGHT-----PLMEAASAGHVEVA
            300       310        320               330       340   

     100       110        120       130       140       150        
pF1KSD QSLLNHGASVN-NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCY
       . ::.:::..: ...  . . :  ::. :::..:..:.:  :: : .. . :: :: .:.
NP_060 RVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACM
           350       360       370       380       390       400   

      160       170       180       190       200       210        
pF1KSD KGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEK-DGYGMTP
        :: :.:. ::..::.::  . . .. :   : .: ...  .:.   :..:. .  :.::
NP_060 DGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTP
           410       420       430       440       450       460   

       220       230            240       250       260       270  
pF1KSD LLSASVTGHTNIVDFLTHH-----AQTSKTERINALELLGATFVDKKRDLLGALKYWKKA
       :. :.  :: ..: .:  .     ::: .:.. .:: :                      
NP_060 LMEAAREGHEEMVALLLAQGANINAQTEETQE-TALTLACCGGFSEVADFLIKAGADIEL
           470       480       490        500       510       520  

            280       290       300       310       320       330  
pF1KSD MNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGP
                                                                   
NP_060 GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGAD
            530       540       550       560       570       580  

>>XP_016863505 (OMIM: 615929) PREDICTED: ankyrin repeat   (1229 aa)
 initn: 420 init1: 261 opt: 325  Z-score: 258.1  bits: 58.9 E(85289): 1.2e-07
Smith-Waterman score: 393; 34.4% identity (66.0% similar) in 253 aa overlap (5-250:303-540)

                                         10        20        30    
pF1KSD                           MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSL
                                     : .. ::  :.....  ::: :.     ..
XP_016 LACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA-----DV
            280       290       300       310       320            

           40        50        60        70        80        90    
pF1KSD ISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAG
        .....: : : .:   :..:.:. :::. .::::   . : .:.:     ::  :..::
XP_016 NAQSSTGNTALTYACAGGYVDVVKVLLES-GASIE---DHNENGHT-----PLMEAGSAG
       330       340       350        360               370        

          100       110        120       130       140       150   
pF1KSD HLKVVQSLLNHGASVN-NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCL
       :..:.. ::..::..: ...  . . :  ::. ::::.:..:.:  :: : .. . :: :
XP_016 HVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTAL
      380       390       400       410       420       430        

           160       170       180       190       200       210   
pF1KSD MISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEK-DG
       : .:. :: :.:. ::..::.::  . . .. :   : .: ...  .:.   :..:. . 
XP_016 MEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVND
      440       450       460       470       480       490        

            220       230            240       250       260       
pF1KSD YGMTPLLSASVTGHTNIVDFLTHH-----AQTSKTERINALELLGATFVDKKRDLLGALK
        :.:::. :.  :: ..: .:  .     ::: .:.. .:: :                 
XP_016 EGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQE-TALTLACCGGFLEVADFLIKAG
      500       510       520       530        540       550       

       270       280       290       300       310       320       
pF1KSD YWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRE
                                                                   
XP_016 ADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLL
       560       570       580       590       600       610       

>--
 initn: 358 init1: 244 opt: 312  Z-score: 248.6  bits: 57.1 E(85289): 4.2e-07
Smith-Waterman score: 340; 25.1% identity (48.9% similar) in 605 aa overlap (52-556:545-1130)

              30        40        50        60        70        80 
pF1KSD LLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETI
                                     : :....::. . .:.::.: :.       
XP_016 MVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLI-KAGADIELGCST-------
          520       530       540       550        560             

              90       100       110       120       130       140 
pF1KSD EGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKAD
           ::  :.  :::..:. ::  ::.:. :: :..: :  :: .:: ...  :..  ::
XP_016 ----PLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGAD
            570       580       590       600       610       620  

             150       160       170       180        190       200
pF1KSD LEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGN-TALHDCAESGSLDIMKM
       ::  .. :.: :: .   ::   .:.:. :::.::: ..... :.:     .: : ....
XP_016 LEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVEL
            630       640       650       660       670       680  

                 210       220       230                           
pF1KSD LLMYCAKME---KDGYGMTPLLSASVTGHTNIVDFL---------------------THH
       :: . :      :::  :  :. :.  :::..: .:                     .: 
XP_016 LLAHGADPTHRLKDGSTM--LIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHD
            690       700         710       720       730       740

        240       250         260       270       280              
pF1KSD AQTSKTERINALELL-GATFVDKK-RDLLGALKYWKKAMNMRYSDRTNI--------ISK
        . .    ..:: ..      ::   ..  .:   .::.. : :  .:         ::.
XP_016 LNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQ
              750       760       770       780       790       800

                 290            300       310       320       330  
pF1KSD P---------VPQTLIMAY-----DYAKEVNSAEELEGLIADPDEMRMQALLIRERILGP
       :          :....  :     :   : :    :    :   :  .:.::  ::  . 
XP_016 PQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLL--ERGASI
              810       820       830       840       850          

            340       350       360        370       380       390 
pF1KSD SHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQ-QSNLDPLSPMTASSLLSFAELFS
        : : . .      . : .:.      :   . :.. ::.    .:.. .   .  :.  
XP_016 EHRDKKGFTPL--ILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVE
      860         870       880       890       900       910      

                        400       410       420       430          
pF1KSD FML-----------QDRAKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQL--
       ..:           .: .   :...  . ... :: ..  ::.     ..   .::.:  
XP_016 LLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTG-SKLGISPLMLAA
        920       930       940       950       960        970     

       440       450       460                     470       480   
pF1KSD -NKALSIILHLICLLEKVPCTLEQDH--------FKKQT------IYRFLKLHPRGKNNF
        :   . .  :. .   .   .: ..        :. .:      . :  ... :.:...
XP_016 MNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGL
         980       990      1000      1010      1020      1030     

           490       500               510                     520 
pF1KSD SPLHLAVDKNTTCVGRYPVCK--------FPSLQVTAILIE--------C------GADV
       .::  :.. . . :::  . :         :: . ::. :         :      :: .
XP_016 TPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHI
        1040      1050      1060      1070      1080      1090     

             530       540       550       560       570       580 
pF1KSD NVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPI
       .::..  :.:: .:: ..: :...::...::  ::                         
XP_016 DVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV
        1100      1110      1120      1130      1140      1150     

             590       600       610                               
pF1KSD NHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLHR                        
                                                                   
XP_016 KEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQAAEANKNASILLEELDLE
        1160      1170      1180      1190      1200      1210     




617 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 07:19:02 2016 done: Thu Nov  3 07:19:04 2016
 Total Scan time:  8.450 Total Display time:  0.110

Function used was FASTA [36.3.4 Apr, 2011]
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