Result of FASTA (omim) for pF1KSDA1688
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA1688, 1083 aa
  1>>>pF1KSDA1688 1083 - 1083 aa - 1083 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.0708+/-0.000472; mu= -4.5575+/- 0.029
 mean_var=364.3445+/-78.467, 0's: 0 Z-trim(120.3): 153  B-trim: 1833 in 2/52
 Lambda= 0.067192
 statistics sampled from 35205 (35435) to 35205 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.415), width:  16
 Scan time: 17.540

The best scores are:                                      opt bits E(85289)
NP_001295137 (OMIM: 615880) rho GTPase-activating  (1083) 7426 735.1 5.3e-211
NP_001295136 (OMIM: 615880) rho GTPase-activating  (1083) 7426 735.1 5.3e-211
XP_016869360 (OMIM: 615880) PREDICTED: rho GTPase- (1114) 5809 578.3 8.3e-164
XP_016869359 (OMIM: 615880) PREDICTED: rho GTPase- (1114) 5809 578.3 8.3e-164
NP_079527 (OMIM: 615880) rho GTPase-activating pro (1114) 5809 578.3 8.3e-164
XP_011515611 (OMIM: 615880) PREDICTED: rho GTPase- (1114) 5809 578.3 8.3e-164
XP_011515610 (OMIM: 615880) PREDICTED: rho GTPase- (1114) 5809 578.3 8.3e-164
XP_011515614 (OMIM: 615880) PREDICTED: rho GTPase- ( 957) 4641 465.0  9e-130
NP_001036134 (OMIM: 610586) rho GTPase-activating  ( 653)  324 46.4 0.00064
XP_011530602 (OMIM: 610586) PREDICTED: rho GTPase- ( 653)  324 46.4 0.00064
NP_001274734 (OMIM: 610586) rho GTPase-activating  ( 663)  324 46.4 0.00065
NP_001020787 (OMIM: 610586) rho GTPase-activating  ( 748)  324 46.5 0.00071
NP_112595 (OMIM: 610586) rho GTPase-activating pro ( 655)  318 45.8 0.00096
XP_016871959 (OMIM: 610585) PREDICTED: rho GTPase- ( 655)  312 45.3  0.0014
XP_011538308 (OMIM: 610585) PREDICTED: rho GTPase- ( 661)  312 45.3  0.0014
NP_001242955 (OMIM: 610585) rho GTPase-activating  ( 608)  309 44.9  0.0017
XP_016871960 (OMIM: 610585) PREDICTED: rho GTPase- ( 552)  307 44.7  0.0018
XP_011538314 (OMIM: 610585) PREDICTED: rho GTPase- ( 552)  307 44.7  0.0018
XP_016871961 (OMIM: 610585) PREDICTED: rho GTPase- ( 552)  307 44.7  0.0018
XP_005264733 (OMIM: 610587) PREDICTED: rho GTPase- ( 607)  308 44.8  0.0018
NP_067049 (OMIM: 610585) rho GTPase-activating pro ( 698)  309 45.0  0.0018
NP_001242954 (OMIM: 610585) rho GTPase-activating  ( 704)  309 45.0  0.0018
XP_011538306 (OMIM: 610585) PREDICTED: rho GTPase- ( 704)  309 45.0  0.0018
XP_011538307 (OMIM: 610585) PREDICTED: rho GTPase- ( 624)  307 44.8  0.0019
XP_005270071 (OMIM: 610585) PREDICTED: rho GTPase- ( 624)  307 44.8  0.0019
XP_011538309 (OMIM: 610585) PREDICTED: rho GTPase- ( 637)  307 44.8   0.002
XP_016860914 (OMIM: 610587) PREDICTED: rho GTPase- ( 611)  306 44.7   0.002
XP_011538317 (OMIM: 610585) PREDICTED: rho GTPase- ( 359)  300 43.9  0.0021
NP_001242953 (OMIM: 610585) rho GTPase-activating  ( 714)  307 44.8  0.0021
XP_011538304 (OMIM: 610585) PREDICTED: rho GTPase- ( 720)  307 44.8  0.0022
XP_011538305 (OMIM: 610585) PREDICTED: rho GTPase- ( 720)  307 44.8  0.0022
NP_055697 (OMIM: 610587) rho GTPase-activating pro ( 638)  300 44.1  0.0031
XP_005264732 (OMIM: 610587) PREDICTED: rho GTPase- ( 645)  300 44.1  0.0032
XP_016860913 (OMIM: 610587) PREDICTED: rho GTPase- ( 649)  300 44.1  0.0032
XP_011531509 (OMIM: 610587) PREDICTED: rho GTPase- ( 620)  299 44.0  0.0033
XP_011531508 (OMIM: 610587) PREDICTED: rho GTPase- ( 620)  299 44.0  0.0033
XP_011531510 (OMIM: 610587) PREDICTED: rho GTPase- ( 620)  299 44.0  0.0033
XP_011531511 (OMIM: 610587) PREDICTED: rho GTPase- ( 528)  297 43.7  0.0033
NP_001159748 (OMIM: 610587) rho GTPase-activating  ( 639)  299 44.0  0.0034
NP_001007232 (OMIM: 610587) rho GTPase-activating  ( 646)  299 44.0  0.0034
XP_016860912 (OMIM: 610587) PREDICTED: rho GTPase- ( 650)  299 44.0  0.0034
XP_011538313 (OMIM: 610585) PREDICTED: rho GTPase- ( 565)  297 43.8  0.0035
XP_016871965 (OMIM: 610585) PREDICTED: rho GTPase- ( 414)  292 43.2  0.0039
XP_016871962 (OMIM: 610585) PREDICTED: rho GTPase- ( 420)  292 43.2  0.0039
NP_001159749 (OMIM: 610587) rho GTPase-activating  ( 606)  295 43.6  0.0042
XP_011538315 (OMIM: 610585) PREDICTED: rho GTPase- ( 436)  290 43.0  0.0046


>>NP_001295137 (OMIM: 615880) rho GTPase-activating prot  (1083 aa)
 initn: 7426 init1: 7426 opt: 7426  Z-score: 3909.2  bits: 735.1 E(85289): 5.3e-211
Smith-Waterman score: 7426; 100.0% identity (100.0% similar) in 1083 aa overlap (1-1083:1-1083)

               10        20        30        40        50        60
pF1KSD MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD GVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMGMQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMGMQR
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD ERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPH
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD VPASLLKLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPASLLKLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQV
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD FVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQHLDTSFME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQHLDTSFME
             1030      1040      1050      1060      1070      1080

          
pF1KSD GVL
       :::
NP_001 GVL
          

>>NP_001295136 (OMIM: 615880) rho GTPase-activating prot  (1083 aa)
 initn: 7426 init1: 7426 opt: 7426  Z-score: 3909.2  bits: 735.1 E(85289): 5.3e-211
Smith-Waterman score: 7426; 100.0% identity (100.0% similar) in 1083 aa overlap (1-1083:1-1083)

               10        20        30        40        50        60
pF1KSD MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
              790       800       810       820       830       840

              850       860       870       880       890       900
pF1KSD GVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMGMQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMGMQR
              850       860       870       880       890       900

              910       920       930       940       950       960
pF1KSD ERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPH
              910       920       930       940       950       960

              970       980       990      1000      1010      1020
pF1KSD VPASLLKLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPASLLKLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQV
              970       980       990      1000      1010      1020

             1030      1040      1050      1060      1070      1080
pF1KSD FVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQHLDTSFME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQHLDTSFME
             1030      1040      1050      1060      1070      1080

          
pF1KSD GVL
       :::
NP_001 GVL
          

>>XP_016869360 (OMIM: 615880) PREDICTED: rho GTPase-acti  (1114 aa)
 initn: 5798 init1: 5798 opt: 5809  Z-score: 3061.8  bits: 578.3 E(85289): 8.3e-164
Smith-Waterman score: 7354; 97.2% identity (97.2% similar) in 1114 aa overlap (1-1083:1-1114)

               10        20        30        40        50        60
pF1KSD MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
              790       800       810       820       830       840

                                             850       860         
pF1KSD -------------------------------GVAISTYAKYCYHKLQKAALTGAKKGLKK
                                      :::::::::::::::::::::::::::::
XP_016 VTQHIKELLERNTKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKK
              850       860       870       880       890       900

     870       880       890       900       910       920         
pF1KSD PNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEG
              910       920       930       940       950       960

     930       940       950       960       970       980         
pF1KSD IFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAH
              970       980       990      1000      1010      1020

     990      1000      1010      1020      1030      1040         
pF1KSD YDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQ
             1030      1040      1050      1060      1070      1080

    1050      1060      1070      1080   
pF1KSD SDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
       ::::::::::::::::::::::::::::::::::
XP_016 SDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
             1090      1100      1110    

>>XP_016869359 (OMIM: 615880) PREDICTED: rho GTPase-acti  (1114 aa)
 initn: 5798 init1: 5798 opt: 5809  Z-score: 3061.8  bits: 578.3 E(85289): 8.3e-164
Smith-Waterman score: 7354; 97.2% identity (97.2% similar) in 1114 aa overlap (1-1083:1-1114)

               10        20        30        40        50        60
pF1KSD MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
              790       800       810       820       830       840

                                             850       860         
pF1KSD -------------------------------GVAISTYAKYCYHKLQKAALTGAKKGLKK
                                      :::::::::::::::::::::::::::::
XP_016 VTQHIKELLERNTKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKK
              850       860       870       880       890       900

     870       880       890       900       910       920         
pF1KSD PNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEG
              910       920       930       940       950       960

     930       940       950       960       970       980         
pF1KSD IFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAH
              970       980       990      1000      1010      1020

     990      1000      1010      1020      1030      1040         
pF1KSD YDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQ
             1030      1040      1050      1060      1070      1080

    1050      1060      1070      1080   
pF1KSD SDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
       ::::::::::::::::::::::::::::::::::
XP_016 SDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
             1090      1100      1110    

>>NP_079527 (OMIM: 615880) rho GTPase-activating protein  (1114 aa)
 initn: 5798 init1: 5798 opt: 5809  Z-score: 3061.8  bits: 578.3 E(85289): 8.3e-164
Smith-Waterman score: 7354; 97.2% identity (97.2% similar) in 1114 aa overlap (1-1083:1-1114)

               10        20        30        40        50        60
pF1KSD MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
              790       800       810       820       830       840

                                             850       860         
pF1KSD -------------------------------GVAISTYAKYCYHKLQKAALTGAKKGLKK
                                      :::::::::::::::::::::::::::::
NP_079 VTQHIKELLERNTKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKK
              850       860       870       880       890       900

     870       880       890       900       910       920         
pF1KSD PNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEG
              910       920       930       940       950       960

     930       940       950       960       970       980         
pF1KSD IFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 IFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAH
              970       980       990      1000      1010      1020

     990      1000      1010      1020      1030      1040         
pF1KSD YDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 YDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQ
             1030      1040      1050      1060      1070      1080

    1050      1060      1070      1080   
pF1KSD SDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
       ::::::::::::::::::::::::::::::::::
NP_079 SDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
             1090      1100      1110    

>>XP_011515611 (OMIM: 615880) PREDICTED: rho GTPase-acti  (1114 aa)
 initn: 5798 init1: 5798 opt: 5809  Z-score: 3061.8  bits: 578.3 E(85289): 8.3e-164
Smith-Waterman score: 7354; 97.2% identity (97.2% similar) in 1114 aa overlap (1-1083:1-1114)

               10        20        30        40        50        60
pF1KSD MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
              790       800       810       820       830       840

                                             850       860         
pF1KSD -------------------------------GVAISTYAKYCYHKLQKAALTGAKKGLKK
                                      :::::::::::::::::::::::::::::
XP_011 VTQHIKELLERNTKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKK
              850       860       870       880       890       900

     870       880       890       900       910       920         
pF1KSD PNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEG
              910       920       930       940       950       960

     930       940       950       960       970       980         
pF1KSD IFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAH
              970       980       990      1000      1010      1020

     990      1000      1010      1020      1030      1040         
pF1KSD YDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQ
             1030      1040      1050      1060      1070      1080

    1050      1060      1070      1080   
pF1KSD SDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
       ::::::::::::::::::::::::::::::::::
XP_011 SDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
             1090      1100      1110    

>>XP_011515610 (OMIM: 615880) PREDICTED: rho GTPase-acti  (1114 aa)
 initn: 5798 init1: 5798 opt: 5809  Z-score: 3061.8  bits: 578.3 E(85289): 8.3e-164
Smith-Waterman score: 7354; 97.2% identity (97.2% similar) in 1114 aa overlap (1-1083:1-1114)

               10        20        30        40        50        60
pF1KSD MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KSD IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KSD ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KSD KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KSD RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KSD PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KSD KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KSD NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KSD TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KSD GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KSD RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
              610       620       630       640       650       660

              670       680       690       700       710       720
pF1KSD AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
              670       680       690       700       710       720

              730       740       750       760       770       780
pF1KSD AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
              730       740       750       760       770       780

              790       800       810       820       830       840
pF1KSD RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
              790       800       810       820       830       840

                                             850       860         
pF1KSD -------------------------------GVAISTYAKYCYHKLQKAALTGAKKGLKK
                                      :::::::::::::::::::::::::::::
XP_011 VTQHIKELLERNTKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKK
              850       860       870       880       890       900

     870       880       890       900       910       920         
pF1KSD PNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEG
              910       920       930       940       950       960

     930       940       950       960       970       980         
pF1KSD IFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAH
              970       980       990      1000      1010      1020

     990      1000      1010      1020      1030      1040         
pF1KSD YDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQ
             1030      1040      1050      1060      1070      1080

    1050      1060      1070      1080   
pF1KSD SDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
       ::::::::::::::::::::::::::::::::::
XP_011 SDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVL
             1090      1100      1110    

>>XP_011515614 (OMIM: 615880) PREDICTED: rho GTPase-acti  (957 aa)
 initn: 4626 init1: 4626 opt: 4641  Z-score: 2450.8  bits: 465.0 E(85289): 9e-130
Smith-Waterman score: 6186; 95.9% identity (96.3% similar) in 954 aa overlap (162-1083:4-957)

             140       150       160        170       180       190
pF1KSD REGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDS-GSSSPPGVFLEKDYEIYRDYS
                                     :: ... : . :::::::::::::::::::
XP_011                            MDGFGPAQNFSENCSSPPGVFLEKDYEIYRDYS
                                          10        20        30   

              200       210       220       230       240       250
pF1KSD ADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGVRSRRPSGSQH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGVRSRRPSGSQH
            40        50        60        70        80        90   

              260       270       280       290       300       310
pF1KSD SPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQPSSPRYGYEP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQPSSPRYGYEP
           100       110       120       130       140       150   

              320       330       340       350       360       370
pF1KSD PLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPNKQGPPSPCQQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPNKQGPPSPCQQ
           160       170       180       190       200       210   

              380       390       400       410       420       430
pF1KSD LVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAPNPGGGSYSLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAPNPGGGSYSLQ
           220       230       240       250       260       270   

              440       450       460       470       480       490
pF1KSD PSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQDTLSSTGYSPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQDTLSSTGYSPG
           280       290       300       310       320       330   

              500       510       520       530       540       550
pF1KSD TRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAEGEAEGARGAA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAEGEAEGARGAA
           340       350       360       370       380       390   

              560       570       580       590       600       610
pF1KSD EPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVVRAFSEDEALA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVVRAFSEDEALA
           400       410       420       430       440       450   

              620       630       640       650       660       670
pF1KSD QQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAACAQFESSRQSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAACAQFESSRQSR
           460       470       480       490       500       510   

              680       690       700       710       720       730
pF1KSD SGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANMLAWSSESIKKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANMLAWSSESIKKP
           520       530       540       550       560       570   

              740       750       760       770       780       790
pF1KSD MIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGLRDELYIQLCR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGLRDELYIQLCR
           580       590       600       610       620       630   

              800       810       820       830       840          
pF1KSD QTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK----------
       ::::::::::::::::::::::::::::::::::::::::::::::::::          
XP_011 QTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTKVTQHIKELLE
           640       650       660       670       680       690   

                                   850       860       870         
pF1KSD ---------------------GVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAK
                            :::::::::::::::::::::::::::::::::::::::
XP_011 RNTKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAK
           700       710       720       730       740       750   

     880       890       900       910       920       930         
pF1KSD NAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDE
           760       770       780       790       800       810   

     940       950       960       970       980       990         
pF1KSD VNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAV
           820       830       840       850       860       870   

    1000      1010      1020      1030      1040      1050         
pF1KSD VHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFEN
           880       890       900       910       920       930   

    1060      1070      1080   
pF1KSD TRKEMSFLRVLIQHLDTSFMEGVL
       ::::::::::::::::::::::::
XP_011 TRKEMSFLRVLIQHLDTSFMEGVL
           940       950       

>>NP_001036134 (OMIM: 610586) rho GTPase-activating prot  (653 aa)
 initn: 219 init1:  95 opt: 324  Z-score: 191.4  bits: 46.4 E(85289): 0.00064
Smith-Waterman score: 324; 34.6% identity (64.5% similar) in 217 aa overlap (872-1078:22-234)

             850       860       870       880       890       900 
pF1KSD VAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMGMQRE
                                     :. ::..  . :. ..::. :.... ... 
NP_001          MTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEK-
                        10        20        30        40        50 

             910       920       930       940       950           
pF1KSD RYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPT--GLEDP
       :: .:  : . ..   . .   : . ::.::.::. . :. :.   :  . :.  .  : 
NP_001 RYGNRLAPML-VEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDV
               60         70        80        90       100         

     960       970       980         990            1000      1010 
pF1KSD HVPASLLKLWYRELEEPLIPHEFYEQCI--AHYDSPEAAVAV------VHALPRINRMVL
       :. ::::::. ::: ::.::.  ::. .  :.  : :  ..:      :..:: .:  .:
NP_001 HTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLL
     110       120       130       140       150       160         

            1020      1030      1040      1050      1060      1070 
pF1KSD CYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLI
        :. :::.  ::  . .:.::.:.::: :..:: :: . .:: .:.:.:   .... :.:
NP_001 KYICRFLDE-VQSYS-GVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMI
     170        180        190       200       210       220       

            1080                                                   
pF1KSD QHLDTSFMEGVL                                                
       .. :  :                                                     
NP_001 SKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNNTKDSPSRQCSWDKSESP
       230       240       250       260       270       280       

>>XP_011530602 (OMIM: 610586) PREDICTED: rho GTPase-acti  (653 aa)
 initn: 219 init1:  95 opt: 324  Z-score: 191.4  bits: 46.4 E(85289): 0.00064
Smith-Waterman score: 324; 34.6% identity (64.5% similar) in 217 aa overlap (872-1078:22-234)

             850       860       870       880       890       900 
pF1KSD VAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMGMQRE
                                     :. ::..  . :. ..::. :.... ... 
XP_011          MTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEK-
                        10        20        30        40        50 

             910       920       930       940       950           
pF1KSD RYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPT--GLEDP
       :: .:  : . ..   . .   : . ::.::.::. . :. :.   :  . :.  .  : 
XP_011 RYGNRLAPML-VEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDV
               60         70        80        90       100         

     960       970       980         990            1000      1010 
pF1KSD HVPASLLKLWYRELEEPLIPHEFYEQCI--AHYDSPEAAVAV------VHALPRINRMVL
       :. ::::::. ::: ::.::.  ::. .  :.  : :  ..:      :..:: .:  .:
XP_011 HTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLL
     110       120       130       140       150       160         

            1020      1030      1040      1050      1060      1070 
pF1KSD CYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLI
        :. :::.  ::  . .:.::.:.::: :..:: :: . .:: .:.:.:   .... :.:
XP_011 KYICRFLDE-VQSYS-GVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMI
     170        180        190       200       210       220       

            1080                                                   
pF1KSD QHLDTSFMEGVL                                                
       .. :  :                                                     
XP_011 SKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNNTKDSPSRQCSWDKSESP
       230       240       250       260       270       280       




1083 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 06:55:36 2016 done: Thu Nov  3 06:55:39 2016
 Total Scan time: 17.540 Total Display time:  0.410

Function used was FASTA [36.3.4 Apr, 2011]
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