Result of FASTA (omim) for pF1KSDA0362
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KSDA0362, 1096 aa
  1>>>pF1KSDA0362 1096 - 1096 aa - 1096 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.7412+/-0.000393; mu= 11.7990+/- 0.024
 mean_var=166.4420+/-34.364, 0's: 0 Z-trim(117.3): 350  B-trim: 488 in 1/57
 Lambda= 0.099413
 statistics sampled from 28800 (29203) to 28800 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.342), width:  16
 Scan time: 14.610

The best scores are:                                      opt bits E(85289)
XP_016875984 (OMIM: 609499) PREDICTED: guanine nuc (1182) 7330 1064.4       0
NP_079255 (OMIM: 609499) guanine nucleotide exchan (1123) 6881 1000.0       0
NP_001307745 (OMIM: 609499) guanine nucleotide exc (1129) 6870 998.4       0
NP_001106203 (OMIM: 609499) guanine nucleotide exc (1125) 6867 998.0       0
XP_016875986 (OMIM: 609499) PREDICTED: guanine nuc (1096) 6848 995.3       0
XP_016875982 (OMIM: 609499) PREDICTED: guanine nuc (1207) 6796 987.8       0
XP_011535788 (OMIM: 609499) PREDICTED: guanine nuc (1238) 6794 987.6       0
XP_016875988 (OMIM: 609499) PREDICTED: guanine nuc (1043) 6787 986.5       0
XP_016875987 (OMIM: 609499) PREDICTED: guanine nuc (1087) 6409 932.3       0
NP_001307744 (OMIM: 609499) guanine nucleotide exc (1148) 6347 923.4       0
XP_011535789 (OMIM: 609499) PREDICTED: guanine nuc (1179) 6345 923.2       0
NP_001307746 (OMIM: 609499) guanine nucleotide exc ( 984) 6338 922.1       0
XP_016875983 (OMIM: 609499) PREDICTED: guanine nuc (1187) 6336 921.9       0
XP_011535786 (OMIM: 609499) PREDICTED: guanine nuc (1185) 6334 921.6       0
XP_011535785 (OMIM: 609499) PREDICTED: guanine nuc (1211) 6334 921.6       0
XP_011535784 (OMIM: 609499) PREDICTED: guanine nuc (1211) 6334 921.6       0
XP_011535787 (OMIM: 609499) PREDICTED: guanine nuc (1181) 6331 921.1       0
XP_011535790 (OMIM: 609499) PREDICTED: guanine nuc (1163) 6329 920.9       0
XP_011535792 (OMIM: 609499) PREDICTED: guanine nuc (1152) 6312 918.4       0
XP_016875985 (OMIM: 609499) PREDICTED: guanine nuc (1112) 5875 855.7       0
XP_011535793 (OMIM: 609499) PREDICTED: guanine nuc (1143) 5873 855.4       0
NP_001093325 (OMIM: 311030) proto-oncogene DBL iso ( 985) 2855 422.5 5.8e-117
NP_005360 (OMIM: 311030) proto-oncogene DBL isofor ( 925) 2650 393.1 3.9e-108
NP_001165349 (OMIM: 311030) proto-oncogene DBL iso ( 860) 2601 386.1 4.8e-106
NP_001165348 (OMIM: 311030) proto-oncogene DBL iso ( 821) 2244 334.9 1.2e-90
XP_016885021 (OMIM: 311030) PREDICTED: proto-oncog ( 938) 1513 230.1 4.9e-59
NP_001165350 (OMIM: 311030) proto-oncogene DBL iso ( 941) 1513 230.1 4.9e-59
XP_016885020 (OMIM: 311030) PREDICTED: proto-oncog (1001) 1513 230.1 5.1e-59
XP_011529641 (OMIM: 311030) PREDICTED: proto-oncog (1001) 1513 230.1 5.1e-59
NP_001165347 (OMIM: 311030) proto-oncogene DBL iso (1001) 1513 230.1 5.1e-59
XP_016885018 (OMIM: 311030) PREDICTED: proto-oncog (1041) 1513 230.1 5.3e-59
XP_005262470 (OMIM: 311030) PREDICTED: proto-oncog (1044) 1513 230.1 5.3e-59
XP_016885019 (OMIM: 311030) PREDICTED: proto-oncog ( 979) 1464 223.0 6.6e-57
NP_891992 (OMIM: 610215) rho guanine nucleotide ex ( 580)  658 107.3 2.8e-22
NP_001104740 (OMIM: 610215) rho guanine nucleotide ( 619)  658 107.3 2.9e-22
XP_016865292 (OMIM: 601893,617061) PREDICTED: trip (2612)  636 104.6 7.8e-21
XP_011512412 (OMIM: 601893,617061) PREDICTED: trip (3038)  636 104.7 8.8e-21
XP_011512411 (OMIM: 601893,617061) PREDICTED: trip (3048)  636 104.7 8.8e-21
XP_011512410 (OMIM: 601893,617061) PREDICTED: trip (3058)  636 104.7 8.9e-21
XP_011512409 (OMIM: 601893,617061) PREDICTED: trip (3076)  636 104.7 8.9e-21
XP_016865291 (OMIM: 601893,617061) PREDICTED: trip (2880)  628 103.5 1.9e-20
XP_016865290 (OMIM: 601893,617061) PREDICTED: trip (3093)  628 103.5   2e-20
NP_009049 (OMIM: 601893,617061) triple functional  (3097)  628 103.5   2e-20
NP_001309921 (OMIM: 604605,608901) kalirin isoform (1613)  603 99.7 1.4e-19
NP_001309920 (OMIM: 604605,608901) kalirin isoform (1641)  603 99.7 1.5e-19
XP_016862924 (OMIM: 604605,608901) PREDICTED: kali (1643)  603 99.7 1.5e-19
NP_001309919 (OMIM: 604605,608901) kalirin isoform (1650)  603 99.7 1.5e-19
XP_016862923 (OMIM: 604605,608901) PREDICTED: kali (1652)  603 99.7 1.5e-19
NP_001309918 (OMIM: 604605,608901) kalirin isoform (1654)  603 99.7 1.5e-19
XP_016862922 (OMIM: 604605,608901) PREDICTED: kali (1656)  603 99.7 1.5e-19


>>XP_016875984 (OMIM: 609499) PREDICTED: guanine nucleot  (1182 aa)
 initn: 7330 init1: 7330 opt: 7330  Z-score: 5688.4  bits: 1064.4 E(85289):    0
Smith-Waterman score: 7330; 100.0% identity (100.0% similar) in 1096 aa overlap (1-1096:25-1120)

                                       10        20        30      
pF1KSD                         MPLRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMR
                               ::::::::::::::::::::::::::::::::::::
XP_016 MARVESPVPAARASLTGSCVLGQAMPLRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMR
               10        20        30        40        50        60

         40        50        60        70        80        90      
pF1KSD PHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSP
               70        80        90       100       110       120

        100       110       120       130       140       150      
pF1KSD VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA
              130       140       150       160       170       180

        160       170       180       190       200       210      
pF1KSD ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT
              190       200       210       220       230       240

        220       230       240       250       260       270      
pF1KSD EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA
              250       260       270       280       290       300

        280       290       300       310       320       330      
pF1KSD HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE
              310       320       330       340       350       360

        340       350       360       370       380       390      
pF1KSD AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD
              370       380       390       400       410       420

        400       410       420       430       440       450      
pF1KSD LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL
              430       440       450       460       470       480

        460       470       480       490       500       510      
pF1KSD LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE
              490       500       510       520       530       540

        520       530       540       550       560       570      
pF1KSD LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE
              550       560       570       580       590       600

        580       590       600       610       620       630      
pF1KSD ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR
              610       620       630       640       650       660

        640       650       660       670       680       690      
pF1KSD HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN
              670       680       690       700       710       720

        700       710       720       730       740       750      
pF1KSD RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK
              730       740       750       760       770       780

        760       770       780       790       800       810      
pF1KSD LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH
              790       800       810       820       830       840

        820       830       840       850       860       870      
pF1KSD LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK
              850       860       870       880       890       900

        880       890       900       910       920       930      
pF1KSD KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK
              910       920       930       940       950       960

        940       950       960       970       980       990      
pF1KSD AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD
              970       980       990      1000      1010      1020

       1000      1010      1020      1030      1040      1050      
pF1KSD PLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPK
             1030      1040      1050      1060      1070      1080

       1060      1070      1080      1090                          
pF1KSD KLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLW                    
       ::::::::::::::::::::::::::::::::::::::::                    
XP_016 KLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSV
             1090      1100      1110      1120      1130      1140

XP_016 RLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDLQG
             1150      1160      1170      1180  

>>NP_079255 (OMIM: 609499) guanine nucleotide exchange f  (1123 aa)
 initn: 6872 init1: 6872 opt: 6881  Z-score: 5340.7  bits: 1000.0 E(85289):    0
Smith-Waterman score: 6881; 98.6% identity (99.1% similar) in 1057 aa overlap (40-1096:5-1061)

      10        20        30        40        50        60         
pF1KSD SPASHGPTHGPSDPRTCLPGRGAGGMRPHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVP
                                     : .: :  : ...    :..::::::::::
NP_079                           MTVRRLSLLCRDLWALWLLLKAGADEIMHQDIVP
                                         10        20        30    

      70        80        90       100       110       120         
pF1KSD LCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQD
           40        50        60        70        80        90    

     130       140       150       160       170       180         
pF1KSD AGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 AGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRD
          100       110       120       130       140       150    

     190       200       210       220       230       240         
pF1KSD DFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 DFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQ
          160       170       180       190       200       210    

     250       260       270       280       290       300         
pF1KSD MLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEG
          220       230       240       250       260       270    

     310       320       330       340       350       360         
pF1KSD SEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 SEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAI
          280       290       300       310       320       330    

     370       380       390       400       410       420         
pF1KSD LDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAV
          340       350       360       370       380       390    

     430       440       450       460       470       480         
pF1KSD DSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 DSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKC
          400       410       420       430       440       450    

     490       500       510       520       530       540         
pF1KSD QSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 QSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEV
          460       470       480       490       500       510    

     550       560       570       580       590       600         
pF1KSD FHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 FHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRR
          520       530       540       550       560       570    

     610       620       630       640       650       660         
pF1KSD AKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 AKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLM
          580       590       600       610       620       630    

     670       680       690       700       710       720         
pF1KSD AHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 AHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEK
          640       650       660       670       680       690    

     730       740       750       760       770       780         
pF1KSD YCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 YCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSR
          700       710       720       730       740       750    

     790       800       810       820       830       840         
pF1KSD NCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 NCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGH
          760       770       780       790       800       810    

     850       860       870       880       890       900         
pF1KSD TKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 TKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVK
          820       830       840       850       860       870    

     910       920       930       940       950       960         
pF1KSD GDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 GDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSL
          880       890       900       910       920       930    

     970       980       990      1000      1010      1020         
pF1KSD PLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAP
          940       950       960       970       980       990    

    1030      1040      1050      1060      1070      1080         
pF1KSD EDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 EDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQ
         1000      1010      1020      1030      1040      1050    

    1090                                                           
pF1KSD EGDEGLW                                                     
       :::::::                                                     
NP_079 EGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGG
         1060      1070      1080      1090      1100      1110    

>>NP_001307745 (OMIM: 609499) guanine nucleotide exchang  (1129 aa)
 initn: 6867 init1: 6867 opt: 6870  Z-score: 5332.1  bits: 998.4 E(85289):    0
Smith-Waterman score: 6870; 99.5% identity (99.6% similar) in 1045 aa overlap (56-1096:23-1067)

          30        40        50            60        70        80 
pF1KSD CLPGRGAGGMRPHGRGALGCCGLCSFYTCHGAAG----DEIMHQDIVPLCAADIQDQLKK
                                     :.::    ::::::::::::::::::::::
NP_001         MAEKGASRGTLRRLWSLPRRRRGTAGRSRPDEIMHQDIVPLCAADIQDQLKK
                       10        20        30        40        50  

              90       100       110       120       130       140 
pF1KSD RFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRR
             60        70        80        90       100       110  

             150       160       170       180       190       200 
pF1KSD RDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLS
            120       130       140       150       160       170  

             210       220       230       240       250       260 
pF1KSD SVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAET
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAET
            180       190       200       210       220       230  

             270       280       290       300       310       320 
pF1KSD ELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDN
            240       250       260       270       280       290  

             330       340       350       360       370       380 
pF1KSD QATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFT
            300       310       320       330       340       350  

             390       400       410       420       430       440 
pF1KSD DIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRH
            360       370       380       390       400       410  

             450       460       470       480       490       500 
pF1KSD LCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQE
            420       430       440       450       460       470  

             510       520       530       540       550       560 
pF1KSD IEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLA
            480       490       500       510       520       530  

             570       580       590       600       610       620 
pF1KSD ARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGR
            540       550       560       570       580       590  

             630       640       650       660       670       680 
pF1KSD GSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKK
            600       610       620       630       640       650  

             690       700       710       720       730       740 
pF1KSD DVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLW
            660       670       680       690       700       710  

             750       760       770       780       790       800 
pF1KSD RQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEAL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEAL
            720       730       740       750       760       770  

             810       820       830       840       850       860 
pF1KSD SSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPM
            780       790       800       810       820       830  

             870       880       890       900       910       920 
pF1KSD QRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNA
            840       850       860       870       880       890  

             930       940       950       960       970       980 
pF1KSD REEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSR
            900       910       920       930       940       950  

             990      1000      1010      1020      1030      1040 
pF1KSD GNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQ
            960       970       980       990      1000      1010  

            1050      1060      1070      1080      1090           
pF1KSD INSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLW     
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::     
NP_001 INSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDP
           1020      1030      1040      1050      1060      1070  

NP_001 TTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDLQG
           1080      1090      1100      1110      1120         

>>NP_001106203 (OMIM: 609499) guanine nucleotide exchang  (1125 aa)
 initn: 6867 init1: 6867 opt: 6867  Z-score: 5329.8  bits: 998.0 E(85289):    0
Smith-Waterman score: 6867; 100.0% identity (100.0% similar) in 1037 aa overlap (60-1096:27-1063)

      30        40        50        60        70        80         
pF1KSD RGAGGMRPHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGG
                                     ::::::::::::::::::::::::::::::
NP_001     MRFWLRTEEMALEEMVQRLNAVSKHTDEIMHQDIVPLCAADIQDQLKKRFAYLSGG
                   10        20        30        40        50      

      90       100       110       120       130       140         
pF1KSD RGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVK
         60        70        80        90       100       110      

     150       160       170       180       190       200         
pF1KSD ASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGY
        120       130       140       150       160       170      

     210       220       230       240       250       260         
pF1KSD IDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQS
        180       190       200       210       220       230      

     270       280       290       300       310       320         
pF1KSD TSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLL
        240       250       260       270       280       290      

     330       340       350       360       370       380         
pF1KSD AQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAH
        300       310       320       330       340       350      

     390       400       410       420       430       440         
pF1KSD VEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAE
        360       370       380       390       400       410      

     450       460       470       480       490       500         
pF1KSD IARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETG
        420       430       440       450       460       470      

     510       520       530       540       550       560         
pF1KSD AENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQ
        480       490       500       510       520       530      

     570       580       590       600       610       620         
pF1KSD PVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEE
        540       550       560       570       580       590      

     630       640       650       660       670       680         
pF1KSD SLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNME
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNME
        600       610       620       630       640       650      

     690       700       710       720       730       740         
pF1KSD EIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPF
        660       670       680       690       700       710      

     750       760       770       780       790       800         
pF1KSD FQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILK
        720       730       740       750       760       770      

     810       820       830       840       850       860         
pF1KSD AVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHE
        780       790       800       810       820       830      

     870       880       890       900       910       920         
pF1KSD KAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQ
        840       850       860       870       880       890      

     930       940       950       960       970       980         
pF1KSD APTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKK
        900       910       920       930       940       950      

     990      1000      1010      1020      1030      1040         
pF1KSD LEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEE
        960       970       980       990      1000      1010      

    1050      1060      1070      1080      1090                   
pF1KSD DGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLW             
       :::::::::::::::::::::::::::::::::::::::::::::::             
NP_001 DGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWV
       1020      1030      1040      1050      1060      1070      

NP_001 PASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDLQG
       1080      1090      1100      1110      1120     

>>XP_016875986 (OMIM: 609499) PREDICTED: guanine nucleot  (1096 aa)
 initn: 6848 init1: 6848 opt: 6848  Z-score: 5315.2  bits: 995.3 E(85289):    0
Smith-Waterman score: 6848; 100.0% identity (100.0% similar) in 1034 aa overlap (63-1096:1-1034)

             40        50        60        70        80        90  
pF1KSD GGMRPHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQ
                                     ::::::::::::::::::::::::::::::
XP_016                               MHQDIVPLCAADIQDQLKKRFAYLSGGRGQ
                                             10        20        30

            100       110       120       130       140       150  
pF1KSD DGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASV
               40        50        60        70        80        90

            160       170       180       190       200       210  
pF1KSD LRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDK
              100       110       120       130       140       150

            220       230       240       250       260       270  
pF1KSD SQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSS
              160       170       180       190       200       210

            280       290       300       310       320       330  
pF1KSD VLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQL
              220       230       240       250       260       270

            340       350       360       370       380       390  
pF1KSD NETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEH
              280       290       300       310       320       330

            400       410       420       430       440       450  
pF1KSD LLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIAR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIAR
              340       350       360       370       380       390

            460       470       480       490       500       510  
pF1KSD RRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAEN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAEN
              400       410       420       430       440       450

            520       530       540       550       560       570  
pF1KSD KIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVA
              460       470       480       490       500       510

            580       590       600       610       620       630  
pF1KSD PRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLA
              520       530       540       550       560       570

            640       650       660       670       680       690  
pF1KSD ILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIY
              580       590       600       610       620       630

            700       710       720       730       740       750  
pF1KSD HFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQE
              640       650       660       670       680       690

            760       770       780       790       800       810  
pF1KSD CQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVN
              700       710       720       730       740       750

            820       830       840       850       860       870  
pF1KSD DSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAV
              760       770       780       790       800       810

            880       890       900       910       920       930  
pF1KSD LFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPT
              820       830       840       850       860       870

            940       950       960       970       980       990  
pF1KSD PEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEE
              880       890       900       910       920       930

           1000      1010      1020      1030      1040      1050  
pF1KSD RKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGG
              940       950       960       970       980       990

           1060      1070      1080      1090                      
pF1KSD LGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLW                
       ::::::::::::::::::::::::::::::::::::::::::::                
XP_016 LGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPAS
             1000      1010      1020      1030      1040      1050

XP_016 SLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDLQG
             1060      1070      1080      1090      

>>XP_016875982 (OMIM: 609499) PREDICTED: guanine nucleot  (1207 aa)
 initn: 6787 init1: 6787 opt: 6796  Z-score: 5274.3  bits: 987.8 E(85289):    0
Smith-Waterman score: 7270; 97.8% identity (97.8% similar) in 1121 aa overlap (1-1096:25-1145)

                                       10        20        30      
pF1KSD                         MPLRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMR
                               ::::::::::::::::::::::::::::::::::::
XP_016 MARVESPVPAARASLTGSCVLGQAMPLRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMR
               10        20        30        40        50        60

         40        50        60        70        80        90      
pF1KSD PHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSP
               70        80        90       100       110       120

        100       110       120       130       140       150      
pF1KSD VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA
              130       140       150       160       170       180

        160       170       180       190       200       210      
pF1KSD ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT
              190       200       210       220       230       240

        220       230       240       250       260       270      
pF1KSD EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA
              250       260       270       280       290       300

        280       290       300       310       320       330      
pF1KSD HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE
              310       320       330       340       350       360

        340       350       360       370       380       390      
pF1KSD AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD
              370       380       390       400       410       420

        400       410       420       430       440       450      
pF1KSD LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL
              430       440       450       460       470       480

        460       470       480       490       500       510      
pF1KSD LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE
              490       500       510       520       530       540

        520       530       540       550       560       570      
pF1KSD LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE
              550       560       570       580       590       600

        580       590       600       610       620       630      
pF1KSD ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR
              610       620       630       640       650       660

        640       650       660       670       680       690      
pF1KSD HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN
              670       680       690       700       710       720

        700       710       720       730       740       750      
pF1KSD RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK
              730       740       750       760       770       780

        760       770       780       790       800       810      
pF1KSD LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH
              790       800       810       820       830       840

        820       830       840       850       860       870      
pF1KSD LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK
              850       860       870       880       890       900

        880       890       900       910       920       930      
pF1KSD KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK
              910       920       930       940       950       960

        940       950       960       970       980       990      
pF1KSD AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD
              970       980       990      1000      1010      1020

       1000      1010                               1020      1030 
pF1KSD PLSLEGYVSSAPLTKPPEKGK-------------------------GWSKTSHSLEAPED
       :::::::::::::::::::::                         ::::::::::::::
XP_016 PLSLEGYVSSAPLTKPPEKGKASPTSPDKKAKRHEVKSDPTPFGVRGWSKTSHSLEAPED
             1030      1040      1050      1060      1070      1080

            1040      1050      1060      1070      1080      1090 
pF1KSD DGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEG
             1090      1100      1110      1120      1130      1140

                                                                   
pF1KSD DEGLW                                                       
       :::::                                                       
XP_016 DEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQA
             1150      1160      1170      1180      1190      1200

>>XP_011535788 (OMIM: 609499) PREDICTED: guanine nucleot  (1238 aa)
 initn: 6794 init1: 6794 opt: 6794  Z-score: 5272.6  bits: 987.6 E(85289):    0
Smith-Waterman score: 7043; 95.0% identity (95.0% similar) in 1128 aa overlap (1-1072:25-1152)

                                       10        20        30      
pF1KSD                         MPLRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMR
                               ::::::::::::::::::::::::::::::::::::
XP_011 MARVESPVPAARASLTGSCVLGQAMPLRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMR
               10        20        30        40        50        60

         40        50        60        70        80        90      
pF1KSD PHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSP
               70        80        90       100       110       120

        100       110       120       130       140       150      
pF1KSD VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA
              130       140       150       160       170       180

        160       170       180       190       200       210      
pF1KSD ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT
              190       200       210       220       230       240

        220       230       240       250       260       270      
pF1KSD EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA
              250       260       270       280       290       300

        280       290       300       310       320       330      
pF1KSD HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE
              310       320       330       340       350       360

        340       350       360       370       380       390      
pF1KSD AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD
              370       380       390       400       410       420

        400       410       420       430       440       450      
pF1KSD LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL
              430       440       450       460       470       480

        460       470       480       490       500       510      
pF1KSD LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE
              490       500       510       520       530       540

        520       530       540       550       560       570      
pF1KSD LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE
              550       560       570       580       590       600

        580       590       600       610       620       630      
pF1KSD ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR
              610       620       630       640       650       660

        640       650       660       670       680       690      
pF1KSD HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN
              670       680       690       700       710       720

        700       710       720       730       740       750      
pF1KSD RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK
              730       740       750       760       770       780

        760       770       780       790       800       810      
pF1KSD LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH
              790       800       810       820       830       840

        820       830       840       850       860       870      
pF1KSD LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK
              850       860       870       880       890       900

        880       890       900       910       920       930      
pF1KSD KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK
              910       920       930       940       950       960

        940       950       960       970       980       990      
pF1KSD AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD
              970       980       990      1000      1010      1020

       1000      1010                                              
pF1KSD PLSLEGYVSSAPLTKPPEKGK---------------------------------------
       :::::::::::::::::::::                                       
XP_011 PLSLEGYVSSAPLTKPPEKGKDDTVTSSASESSALSRKRFTLQGFANLKGQKASPTSPDK
             1030      1040      1050      1060      1070      1080

                       1020      1030      1040      1050      1060
pF1KSD -----------------GWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVP
                        :::::::::::::::::::::::::::::::::::::::::::
XP_011 KAKRHEVKSDPTPFGVRGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVP
             1090      1100      1110      1120      1130      1140

             1070      1080      1090                              
pF1KSD GKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLW                        
       ::::::::::::                                                
XP_011 GKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGP
             1150      1160      1170      1180      1190      1200

>>XP_016875988 (OMIM: 609499) PREDICTED: guanine nucleot  (1043 aa)
 initn: 6787 init1: 6787 opt: 6787  Z-score: 5268.2  bits: 986.5 E(85289):    0
Smith-Waterman score: 6787; 100.0% identity (100.0% similar) in 1017 aa overlap (1-1017:25-1041)

                                       10        20        30      
pF1KSD                         MPLRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMR
                               ::::::::::::::::::::::::::::::::::::
XP_016 MARVESPVPAARASLTGSCVLGQAMPLRGGAGPSPASHGPTHGPSDPRTCLPGRGAGGMR
               10        20        30        40        50        60

         40        50        60        70        80        90      
pF1KSD PHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVPLCAADIQDQLKKRFAYLSGGRGQDGSP
               70        80        90       100       110       120

        100       110       120       130       140       150      
pF1KSD VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA
              130       140       150       160       170       180

        160       170       180       190       200       210      
pF1KSD ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT
              190       200       210       220       230       240

        220       230       240       250       260       270      
pF1KSD EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA
              250       260       270       280       290       300

        280       290       300       310       320       330      
pF1KSD HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE
              310       320       330       340       350       360

        340       350       360       370       380       390      
pF1KSD AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD
              370       380       390       400       410       420

        400       410       420       430       440       450      
pF1KSD LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL
              430       440       450       460       470       480

        460       470       480       490       500       510      
pF1KSD LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE
              490       500       510       520       530       540

        520       530       540       550       560       570      
pF1KSD LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE
              550       560       570       580       590       600

        580       590       600       610       620       630      
pF1KSD ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR
              610       620       630       640       650       660

        640       650       660       670       680       690      
pF1KSD HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN
              670       680       690       700       710       720

        700       710       720       730       740       750      
pF1KSD RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK
              730       740       750       760       770       780

        760       770       780       790       800       810      
pF1KSD LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH
              790       800       810       820       830       840

        820       830       840       850       860       870      
pF1KSD LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK
              850       860       870       880       890       900

        880       890       900       910       920       930      
pF1KSD KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK
              910       920       930       940       950       960

        940       950       960       970       980       990      
pF1KSD AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD
              970       980       990      1000      1010      1020

       1000      1010      1020      1030      1040      1050      
pF1KSD PLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPK
       :::::::::::::::::::::                                       
XP_016 PLSLEGYVSSAPLTKPPEKGKEP                                     
             1030      1040                                        

>>XP_016875987 (OMIM: 609499) PREDICTED: guanine nucleot  (1087 aa)
 initn: 6409 init1: 6409 opt: 6409  Z-score: 4975.0  bits: 932.3 E(85289):    0
Smith-Waterman score: 6409; 100.0% identity (100.0% similar) in 970 aa overlap (127-1096:56-1025)

        100       110       120       130       140       150      
pF1KSD VITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQDAGIGFILVIDRRRDKWTSVKASVLRIA
                                     ::::::::::::::::::::::::::::::
XP_016 IFSQHRSHATTSESLTWTSTGTSDARTGVILQDAGIGFILVIDRRRDKWTSVKASVLRIA
          30        40        50        60        70        80     

        160       170       180       190       200       210      
pF1KSD ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRDDFKMKVPVIMLSSVPDLHGYIDKSQLT
          90       100       110       120       130       140     

        220       230       240       250       260       270      
pF1KSD EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQMLQSFGTELAETELPNDVQSTSSVLCA
         150       160       170       180       190       200     

        280       290       300       310       320       330      
pF1KSD HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTEKKDKAKEDLRLALKEGHSVLESLRELQAEGSEPSVNQDQLDNQATVQRLLAQLNETE
         210       220       230       240       250       260     

        340       350       360       370       380       390      
pF1KSD AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAILDAASQKIATFTDIGNSLAHVEHLLRD
         270       280       290       300       310       320     

        400       410       420       430       440       450      
pF1KSD LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGL
         330       340       350       360       370       380     

        460       470       480       490       500       510      
pF1KSD LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSKSLELHRRLETSMKWCDEGIYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQE
         390       400       410       420       430       440     

        520       530       540       550       560       570      
pF1KSD LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNAIYKEYESILNQDLMEHVRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPE
         450       460       470       480       490       500     

        580       590       600       610       620       630      
pF1KSD ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALAKSPCPSPGIRRGSENSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRR
         510       520       530       540       550       560     

        640       650       660       670       680       690      
pF1KSD HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHN
         570       580       590       600       610       620     

        700       710       720       730       740       750      
pF1KSD RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RIFLRELENYTDCPELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRK
         630       640       650       660       670       680     

        760       770       780       790       800       810      
pF1KSD LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMH
         690       700       710       720       730       740     

        820       830       840       850       860       870      
pF1KSD LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCK
         750       760       770       780       790       800     

        880       890       900       910       920       930      
pF1KSD KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KREENGEGYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIK
         810       820       830       840       850       860     

        940       950       960       970       980       990      
pF1KSD AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTD
         870       880       890       900       910       920     

       1000      1010      1020      1030      1040      1050      
pF1KSD PLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPK
         930       940       950       960       970       980     

       1060      1070      1080      1090                          
pF1KSD KLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLW                    
       ::::::::::::::::::::::::::::::::::::::::                    
XP_016 KLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSV
         990      1000      1010      1020      1030      1040     

XP_016 RLGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDLQG
        1050      1060      1070      1080       

>>NP_001307744 (OMIM: 609499) guanine nucleotide exchang  (1148 aa)
 initn: 6329 init1: 6329 opt: 6347  Z-score: 4926.6  bits: 923.4 E(85289):    0
Smith-Waterman score: 6821; 96.3% identity (96.9% similar) in 1082 aa overlap (40-1096:5-1086)

      10        20        30        40        50        60         
pF1KSD SPASHGPTHGPSDPRTCLPGRGAGGMRPHGRGALGCCGLCSFYTCHGAAGDEIMHQDIVP
                                     : .: :  : ...    :..::::::::::
NP_001                           MTVRRLSLLCRDLWALWLLLKAGADEIMHQDIVP
                                         10        20        30    

      70        80        90       100       110       120         
pF1KSD LCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCAADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQD
           40        50        60        70        80        90    

     130       140       150       160       170       180         
pF1KSD AGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFNRD
          100       110       120       130       140       150    

     190       200       210       220       230       240         
pF1KSD DFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVKQTAQ
          160       170       180       190       200       210    

     250       260       270       280       290       300         
pF1KSD MLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLRELQAEG
          220       230       240       250       260       270    

     310       320       330       340       350       360         
pF1KSD SEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQGFREVKAI
          280       290       300       310       320       330    

     370       380       390       400       410       420         
pF1KSD LDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAV
          340       350       360       370       380       390    

     430       440       450       460       470       480         
pF1KSD DSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIYLLASQPVDKC
          400       410       420       430       440       450    

     490       500       510       520       530       540         
pF1KSD QSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEHVRKVFQKQASMEEV
          460       470       480       490       500       510    

     550       560       570       580       590       600         
pF1KSD FHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSENSSSEGGALRRGPYRR
          520       530       540       550       560       570    

     610       620       630       640       650       660         
pF1KSD AKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLM
          580       590       600       610       620       630    

     670       680       690       700       710       720         
pF1KSD AHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPELVGRCFLERMEDFQIYEK
          640       650       660       670       680       690    

     730       740       750       760       770       780         
pF1KSD YCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKYSR
          700       710       720       730       740       750    

     790       800       810       820       830       840         
pF1KSD NCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDGNLGDLGKLLMQGSFSVWTDHKRGH
          760       770       780       790       800       810    

     850       860       870       880       890       900         
pF1KSD TKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKVKELARFKPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVK
          820       830       840       850       860       870    

     910       920       930       940       950       960         
pF1KSD GDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GDAKKFEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSL
          880       890       900       910       920       930    

     970       980       990      1000      1010                   
pF1KSD PLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGK------------
       ::::::::::::::::::::::::::::::::::::::::::::::::            
NP_001 PLPAPTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKASPTSPDKKAKR
          940       950       960       970       980       990    

                   1020      1030      1040      1050      1060    
pF1KSD -------------GWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYT
                    :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEVKSDPTPFGVRGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLVPGKYT
         1000      1010      1020      1030      1040      1050    

         1070      1080      1090                                  
pF1KSD VVADHEKGGPDALRVRSGDVVELVQEGDEGLW                            
       ::::::::::::::::::::::::::::::::                            
NP_001 VVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVRLGPSGSA
         1060      1070      1080      1090      1100      1110    

NP_001 QCLSSSESSPGSAVLSNSSSCSEGGQAPFSDLQG
         1120      1130      1140        




1096 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Thu Nov  3 01:25:19 2016 done: Thu Nov  3 01:25:21 2016
 Total Scan time: 14.610 Total Display time:  0.590

Function used was FASTA [36.3.4 Apr, 2011]
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