Result of FASTA (omim) for
pF1KSDA0028
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0028, 903 aa
1>>>pF1KSDA0028 903 - 903 aa - 903 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5247+/-0.000455; mu= 20.1522+/- 0.028
mean_var=75.7702+/-15.181, 0's: 0 Z-trim(111.1): 36 B-trim: 159 in 1/48
Lambda= 0.147341
statistics sampled from 19578 (19603) to 19578 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.593), E-opt: 0.2 (0.23), width: 16
Scan time: 10.670
The best scores are: opt bits E(85289)
XP_005265063 (OMIM: 604544,615300,617021) PREDICTE ( 903) 6164 1320.6 0
NP_056155 (OMIM: 604544,615300,617021) probable le ( 903) 6164 1320.6 0
XP_011531856 (OMIM: 604544,615300,617021) PREDICTE ( 830) 5493 1177.9 0
XP_016861531 (OMIM: 604544,615300,617021) PREDICTE ( 804) 5483 1175.8 0
NP_006286 (OMIM: 192150) valine--tRNA ligase [Homo (1264) 206 54.2 4.7e-06
XP_005249419 (OMIM: 192150) PREDICTED: valine--tRN (1265) 206 54.2 4.7e-06
NP_001304893 (OMIM: 151350,615438) leucine--tRNA l (1130) 165 45.4 0.0018
NP_002152 (OMIM: 600709,617093) isoleucine--tRNA l (1262) 164 45.3 0.0023
NP_038203 (OMIM: 600709,617093) isoleucine--tRNA l (1262) 164 45.3 0.0023
NP_064502 (OMIM: 151350,615438) leucine--tRNA liga (1176) 161 44.6 0.0034
>>XP_005265063 (OMIM: 604544,615300,617021) PREDICTED: p (903 aa)
initn: 6164 init1: 6164 opt: 6164 Z-score: 7076.4 bits: 1320.6 E(85289): 0
Smith-Waterman score: 6164; 100.0% identity (100.0% similar) in 903 aa overlap (1-903:1-903)
10 20 30 40 50 60
pF1KSD MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD QVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD MAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFL
850 860 870 880 890 900
pF1KSD VQD
:::
XP_005 VQD
>>NP_056155 (OMIM: 604544,615300,617021) probable leucin (903 aa)
initn: 6164 init1: 6164 opt: 6164 Z-score: 7076.4 bits: 1320.6 E(85289): 0
Smith-Waterman score: 6164; 100.0% identity (100.0% similar) in 903 aa overlap (1-903:1-903)
10 20 30 40 50 60
pF1KSD MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 KWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD QVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 QVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 WFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 SPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 LCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD MAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 MAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFL
850 860 870 880 890 900
pF1KSD VQD
:::
NP_056 VQD
>>XP_011531856 (OMIM: 604544,615300,617021) PREDICTED: p (830 aa)
initn: 5522 init1: 5493 opt: 5493 Z-score: 6306.1 bits: 1177.9 E(85289): 0
Smith-Waterman score: 5493; 99.9% identity (100.0% similar) in 803 aa overlap (1-803:1-803)
10 20 30 40 50 60
pF1KSD MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD QVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQ
::::::::::::::::::::::.
XP_011 LCALMVMAAPLAPHVTSEIWAGILYNCHTEVLEIFPLQLGHRTSHTGPAH
790 800 810 820 830
>>XP_016861531 (OMIM: 604544,615300,617021) PREDICTED: p (804 aa)
initn: 5483 init1: 5483 opt: 5483 Z-score: 6294.8 bits: 1175.8 E(85289): 0
Smith-Waterman score: 5483; 100.0% identity (100.0% similar) in 801 aa overlap (1-801:1-801)
10 20 30 40 50 60
pF1KSD MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD QVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD WFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDA
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQ
:::::::::::::::::::::
XP_016 LCALMVMAAPLAPHVTSEIWADQQ
790 800
>>NP_006286 (OMIM: 192150) valine--tRNA ligase [Homo sap (1264 aa)
initn: 378 init1: 130 opt: 206 Z-score: 229.6 bits: 54.2 E(85289): 4.7e-06
Smith-Waterman score: 346; 20.3% identity (51.5% similar) in 738 aa overlap (23-714:275-972)
10 20 30 40 50
pF1KSD MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYT
: :: .. . :: ... .: :.
NP_006 EKFQQKQKIQQQQPPPGEKKPKPEKREKRDPGVITYDLPTPPGEKKDV---SGPMPDSYS
250 260 270 280 290 300
60 70 80 90 100
pF1KSD LQTRKDV-EKWWHQR--IKEQASKISEADKSKPKFYVLSMFPYP--SGKLHMGHVRVYTI
. . . ::.:. .: . .. ... ..:. . .: : .:.::.::. . .:
NP_006 PRYVEAAWYPWWEQQGFFKPEYGR-PNVSAANPRGVFMMCIPPPNVTGSLHLGHALTNAI
310 320 330 340 350 360
110 120 130 140
pF1KSD SDTIARFQKMRGMQVI-NPMGWDAFGLPAENAAVERNL--------HP----------QS
.:...:...::: .. :: : : :. : ...::..: : .
NP_006 QDSLTRWHRMRGETTLWNP-GCDHAGI-ATQVVVEKKLWREQGLSRHQLGREAFLQEVWK
370 380 390 400 410
150 160 170 180 190 200
pF1KSD WTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWD
: . . .. .:: .:: ..::: : : . :..:.: :. :.. ::::.
NP_006 WKEEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSAAVTEAFVRLHEEGIIYRSTRLVNWS
420 430 440 450 460 470
210 220 230 240 250 260
pF1KSD PVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGM
. ...... .::.. . :. .: . : ...: .: . .: . .
NP_006 CTLNSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTRI
480 490 500 510 520 530
270 280 290 300 310
pF1KSD QAHWIGDC-VGCHLDFTLKVH--GQATGEKLTAYT---ATPEAI---YGTSHVAISPSHR
.. .:: :. : : : :. . . . . . . : . .::. : :.:.:
NP_006 ETM-LGDVAVAVHPKDTRYQHLKGKNVIHPFLSRSLPIVFDEFVDMDFGTGAVKITPAHD
540 550 560 570 580 590
320 330 340 350 360 370
pF1KSD LLHGHSSLKEALR-MALVPGKDCLT----PVMAVNMLTQQEVPVVILAKADL-EGSLDSK
. . ...:. .... .. : : ... . ... .: : . : .: :.
NP_006 QNDYEVGQRHGLEAISIMDSRGALINVPPPFLGLPRFEARKAVLVALKERGLFRGIEDNP
600 610 620 630 640 650
380 390 400 410 420 430
pF1KSD IGIP-STSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARG
. .: . :.:.. : . : ..: ...:: : : . .:.
NP_006 MVVPLCNRSKDVVEPLLRPQWYVRCGEM---------AQAASAAVTRGD--LRILPEAHQ
660 670 680 690 700
440 450 460 470 480 490
pF1KSD KRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGG
. . :....: :::: .:: :: : :. : :: :. ... .
NP_006 RTW--HAWMDNIREWCISRQLWWGHRIPAYFVTVSDPAVPPGED-----PDGRYWVSGRN
710 720 730 740 750
500 510 520 530 540 550
pF1KSD PPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWM
: . . . : . ... :..::. .:. . . :.. . .: ..
NP_006 EAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGW--PNQSEDLSV---FY
760 770 780 790 800 810
560 570 580 590 600
pF1KSD PVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK---GQTFRLPSG
: : : : .. .. ::. :.. : ::... ..... :. . :
NP_006 PGTLLETG--HDILFFWVARMVM---LGLKLTG-RLPFREVYLHAIVRDAHGRKMSKSLG
820 830 840 850 860
610 620 630 640 650 660
pF1KSD QYLQREEVDLTGSVPVHAKTKEKLEVTWE--KMSKSKHNG-VDPEEVVEQYGIDTIRLYI
. . . .:. .. ... .. :. . . .. :.:.. .: . . : :..:. .
NP_006 NVI--DPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGL
870 880 890 900 910 920
670 680 690 700 710 720
pF1KSD LFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEAR
.:: :: . . : .. ..::. : ... ..: :.:
NP_006 CAYMSQGRDINLDV--NRILGYRHFCNKLWNATKFALRGLGKGFVPSPTSQPGGHESLVD
930 940 950 960 970 980
730 740 750 760 770 780
pF1KSD KLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMV
NP_006 RWIRSRLTEAVRLSNQGFQAYDFPAVTTAQYSFWLYELCDVYLECLKPVLNGVDQVAAEC
990 1000 1010 1020 1030 1040
>>XP_005249419 (OMIM: 192150) PREDICTED: valine--tRNA li (1265 aa)
initn: 378 init1: 130 opt: 206 Z-score: 229.6 bits: 54.2 E(85289): 4.7e-06
Smith-Waterman score: 346; 20.3% identity (51.5% similar) in 738 aa overlap (23-714:276-973)
10 20 30 40 50
pF1KSD MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYT
: :: .. . :: ... .: :.
XP_005 KFQQKQKIQQQQPPPGEQKKPKPEKREKRDPGVITYDLPTPPGEKKDV---SGPMPDSYS
250 260 270 280 290 300
60 70 80 90 100
pF1KSD LQTRKDV-EKWWHQR--IKEQASKISEADKSKPKFYVLSMFPYP--SGKLHMGHVRVYTI
. . . ::.:. .: . .. ... ..:. . .: : .:.::.::. . .:
XP_005 PRYVEAAWYPWWEQQGFFKPEYGR-PNVSAANPRGVFMMCIPPPNVTGSLHLGHALTNAI
310 320 330 340 350 360
110 120 130 140
pF1KSD SDTIARFQKMRGMQVI-NPMGWDAFGLPAENAAVERNL--------HP----------QS
.:...:...::: .. :: : : :. : ...::..: : .
XP_005 QDSLTRWHRMRGETTLWNP-GCDHAGI-ATQVVVEKKLWREQGLSRHQLGREAFLQEVWK
370 380 390 400 410
150 160 170 180 190 200
pF1KSD WTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWD
: . . .. .:: .:: ..::: : : . :..:.: :. :.. ::::.
XP_005 WKEEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSAAVTEAFVRLHEEGIIYRSTRLVNWS
420 430 440 450 460 470
210 220 230 240 250 260
pF1KSD PVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGM
. ...... .::.. . :. .: . : ...: .: . .: . .
XP_005 CTLNSAISDIEVDKKELTGRTLLSVPGYKEKVEFGVLVSFAYKVQGSDSDEEVVVATTRI
480 490 500 510 520 530
270 280 290 300 310
pF1KSD QAHWIGDC-VGCHLDFTLKVH--GQATGEKLTAYT---ATPEAI---YGTSHVAISPSHR
.. .:: :. : : : :. . . . . . . : . .::. : :.:.:
XP_005 ETM-LGDVAVAVHPKDTRYQHLKGKNVIHPFLSRSLPIVFDEFVDMDFGTGAVKITPAHD
540 550 560 570 580 590
320 330 340 350 360 370
pF1KSD LLHGHSSLKEALR-MALVPGKDCLT----PVMAVNMLTQQEVPVVILAKADL-EGSLDSK
. . ...:. .... .. : : ... . ... .: : . : .: :.
XP_005 QNDYEVGQRHGLEAISIMDSRGALINVPPPFLGLPRFEARKAVLVALKERGLFRGIEDNP
600 610 620 630 640 650
380 390 400 410 420 430
pF1KSD IGIP-STSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARG
. .: . :.:.. : . : ..: ...:: : : . .:.
XP_005 MVVPLCNRSKDVVEPLLRPQWYVRCGEM---------AQAASAAVTRGD--LRILPEAHQ
660 670 680 690 700
440 450 460 470 480 490
pF1KSD KRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGG
. . :....: :::: .:: :: : :. : :: :. ... .
XP_005 RTW--HAWMDNIREWCISRQLWWGHRIPAYFVTVSDPAVPPGED-----PDGRYWVSGRN
710 720 730 740 750 760
500 510 520 530 540 550
pF1KSD PPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWM
: . . . : . ... :..::. .:. . . :.. . .: ..
XP_005 EAEAREKAAKEFGVSPDKISLQQDEDVLDTWFSSGLFPLSILGW--PNQSEDLSV---FY
770 780 790 800 810
560 570 580 590 600
pF1KSD PVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK---GQTFRLPSG
: : : : .. .. ::. :.. : ::... ..... :. . :
XP_005 PGTLLETG--HDILFFWVARMVM---LGLKLTG-RLPFREVYLHAIVRDAHGRKMSKSLG
820 830 840 850 860
610 620 630 640 650 660
pF1KSD QYLQREEVDLTGSVPVHAKTKEKLEVTWE--KMSKSKHNG-VDPEEVVEQYGIDTIRLYI
. . . .:. .. ... .. :. . . .. :.:.. .: . . : :..:. .
XP_005 NVI--DPLDVIYGISLQGLHNQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGL
870 880 890 900 910 920
670 680 690 700 710 720
pF1KSD LFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEAR
.:: :: . . : .. ..::. : ... ..: :.:
XP_005 CAYMSQGRDINLDV--NRILGYRHFCNKLWNATKFALRGLGKGFVPSPTSQPGGHESLVD
930 940 950 960 970 980
730 740 750 760 770 780
pF1KSD KLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMV
XP_005 RWIRSRLTEAVRLSNQGFQAYDFPAVTTAQYSFWLYELCDVYLECLKPVLNGVDQVAAEC
990 1000 1010 1020 1030 1040
>>NP_001304893 (OMIM: 151350,615438) leucine--tRNA ligas (1130 aa)
initn: 295 init1: 114 opt: 165 Z-score: 183.2 bits: 45.4 E(85289): 0.0018
Smith-Waterman score: 183; 18.8% identity (47.6% similar) in 863 aa overlap (50-830:11-844)
20 30 40 50 60 70
pF1KSD NGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE-KWWHQRIKEQASKISEAD
.. . .:... :: .:. : .. : .
NP_001 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQ
10 20 30 40
80 90 100 110 120 130
pF1KSD KSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAEN-
:: :..: .:: .:.::.::. . . . .:...: . :.: :.: ..
NP_001 TSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKSK
50 60 70 80 90 100
140 150 160 170
pF1KSD AAVERNLHPQSWTQ--------------SNIKHMR--------KQLDRLGLCFSWDRE-I
::.. . .: :. .: ..: :.:: .: : :
NP_001 AAAKAGSSKYQWGIMKSLGLSDEEIVKFSEAEHWLDYFPPLAIQDLKRMGLKVDWRRSFI
110 120 130 140 150 160
180 190 200 210 220 230
pF1KSD TTCLPDYY-KWTQYLFIKLYEAG-LAYQKEALVNWDPVD-QTVLANEQVDEHGCSWRSGA
:: . :: ..... :. : : . . . :. . ..: : : . ... .: . . .
NP_001 TTDVNPYYDSFVRWQFLTLRERNKIKFGKRYTI-YSPKDGQPCMDHDRQTGEGVGPQEYT
170 180 190 200 210
240 250 260 270
pF1KSD KVEQKYLRQWFIKTTAY-AKAMQDALADL-PEWYGIKGMQAHWI-------------GDC
.. : :. . : .. .: . . : : :: . :. :. ::
NP_001 LLKLKVLEPYPSKLSGLKGKNIFLVAATLRPE--TMFGQTNCWVRPDMKYIGFETVNGDI
220 230 240 250 260 270
280 290 300 310 320 330
pF1KSD VGCHL----DFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLH--GHSSLKEA
: ... . . .: .. : : :.: : :..... ..::
NP_001 FICTQKAARNMSYQGFTKDNGVVPVVKELMGEEILGASLSAPLTSYKVIYVLPMLTIKED
280 290 300 310 320 330
340 350 360 370 380
pF1KSD LRMALVPGKDCLTP--VMAV-NMLTQQEVPVVILAKADLEGSLDSK--IGIPSTSSEDTI
..: . .: . :. .. .: . . . :. .. : ::. .. ...
NP_001 KGTGVVTSVPSDSPDDIAALRDLKKKQALRAKYGIRDDMVLPFEPVPVIEIPGFGNLSAV
340 350 360 370 380 390
390 400 410 420 430 440
pF1KSD -LAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDV--TSD
. . : . .. : : .. :.. .. . :. :.: . . : . . ..:
NP_001 TICDELKIQSQNDREKLAEAKEKIYLKGFYEGIMLVDGFKGQKVQDVKKTIQKKMIDAGD
400 410 420 430 440 450
450 460 470 480 490
pF1KSD KLKDWLISRQRYWGTPIPIVHCPVCGPTPVPL------EDLPVTLPNIASFTGKGGPPLA
: .: . . : .: . .. : :. .: . .
NP_001 ALIYMEPEKQVMSRSSDECV-VALCDQWYLDYGEENWKKQTSQCLKNLETFCEETRRNFE
460 470 480 490 500 510
500 510 520 530 540
pF1KSD MASEWVNC-SCPRCKGAAKR----ETDTMDTFVDSAWYYFRYTDPH-----NPH----SP
. :.. .: : : . . : .... ::. :. :: : : : ::
NP_001 ATLGWLQEHACSRTYGLGTHLPWDEQWLIESLSDSTIYMAFYTVAHLLQGGNLHGQAESP
520 530 540 550 560 570
550 560 570 580 590 600
pF1KSD FNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFH-KLLAQGLIKG
.. .. : :. :: . :. .. . .. . : .. .. :. .
NP_001 LGIRPQQMTKEVWDYVFFKEAPFPKTQIAK--EKLDQLKQEFEFWYPVDLRVSGKDLVPN
580 590 600 610 620 630
610 620 630 640 650 660
pF1KSD Q-TFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
. .. : . . :. : . :. .... .: .. :::::: : . ....... :
NP_001 HLSYYLYNHVAMWPEQSD---KWPTAVRANGHLLLNSEKMSKSTGNFLTLTQAIDKFSAD
640 650 660 670 680 690
670 680 690 700 710 720
pF1KSD TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
.:: . :. .: . :.. : :.:: :. .. . : .. : :
NP_001 GMRLALADAGDTVEDANF-VEAMADAGILRLYT--WVEWVKEMVANWDSLRSGPASTFN-
700 710 720 730 740
730 740 750 760 770
pF1KSD EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAI-SQLMGLSNALSQASQSVI--LHSPEF
... : .: :. : .. .. : . .. :. . .. .. : .. . .. .:
NP_001 DRVFASEL----NAGIIKTDQNY-EKMMFKEALKTGFFEFQAAKDKYRELAVEGMHRELV
750 760 770 780 790 800
780 790 800 810 820 830
pF1KSD EDALCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPE
. . .. ::. ::. .::. :. : : :.. .::.. :
NP_001 FRFIEVQTLLLAPFCPHLCEHIWTLLGK-P---------D-SIMNASWPVAGPVNEVLIH
810 820 830 840 850
840 850 860 870 880 890
pF1KSD VVQMAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALI
NP_001 SSQYLMEVTHDLRLRLKNYMMPAKGKKTDKQPLQKPSHCTIYVAKNYPPWQHTTLSVLRK
860 870 880 890 900 910
>>NP_002152 (OMIM: 600709,617093) isoleucine--tRNA ligas (1262 aa)
initn: 380 init1: 155 opt: 164 Z-score: 181.4 bits: 45.3 E(85289): 0.0023
Smith-Waterman score: 281; 20.4% identity (47.7% similar) in 894 aa overlap (79-864:36-856)
50 60 70 80 90 100
pF1KSD KEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTIS
: :::: . :. .: :.::. . ::.
NP_002 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIK
10 20 30 40 50 60
110 120 130 140 150 160
pF1KSD DTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLH---PQSWTQSNIKHMRKQ-----
: ..:. .. :..: .::: :::.: ....: :.. .. .: .. .:
NP_002 DIVTRYAHQSGFHVDRRFGWDCHGLPVEYE-IDKTLGIRGPEDVAKMGITEYNNQCRAIV
70 80 90 100 110 120
170 180 190 200 210
pF1KSD ----------LDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPV
..::: ...: . : :.... . ..: .::. ::.:. .. .. .
NP_002 MRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTA
130 140 150 160 170 180
220 230 240 250 260 270
pF1KSD DQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQA
.: :.: . : .. :.. . :. .: ..: :
NP_002 CNTPLSNFE------SHQNYKDVQDPSV---FVTF----PLEEDETVSLVAWTTTPWTLP
190 200 210 220 230
280 290 300 310
pF1KSD HWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGT-SHVAI----------SPSHR
.. ::. .... .:.. : :. : . : :.: : : . ..:
NP_002 SNLAVCVNPEMQY-VKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYR
240 250 260 270 280 290
320 330 340 350
pF1KSD LLHGH---------------SSLKEALRMALV---P--GKDCLTPVMAVNMLTQQEVPVV
: . . .:: ..: : : . : :.. .. .::
NP_002 PLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVC
300 310 320 330 340 350
360 370 380 390
pF1KSD ILAKA--------DLEGSL--DSKIGIPSTSSED--TILAQTLGLAY-----SE---VIE
. . :. :. :. .: : .:. ..: :. .: :. . .
NP_002 PVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYK
360 370 380 390 400 410
400 410 420 430 440 450
pF1KSD TLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPI
..:. :. . .. . .: . . .: :: : . .: .:: :::.:::::::
NP_002 AVPSWFVRVENMVD-QLLRNNDLCYWVPELVREKRFG-NWLKDA-RDWTISRNRYWGTPI
420 430 440 450 460
460 470 480 490 500 510
pF1KSD PI-----VHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRC-KGAA
:. . :: . . ::.: . .:... .. :.. : :: ::.
NP_002 PLWVSDDFEEVVCIGSVAELEEL--SGAKISDLHRESVDHLTIPS--------RCGKGSL
470 480 490 500 510
520 530 540 550 560 570
pF1KSD KRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARF
.: ....: . .:. . :.. : : : . .:.:. : ... . :
NP_002 HRISEVFDCWFESG--SMPYAQVHYPFE--NKREFEDAFPADFIAEGIDQT-----RGWF
520 530 540 550 560
580 590 600 610 620 630
pF1KSD FSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKL
.. . . . ::......::. .. .::
NP_002 YTLLVLATALFGQ-PPFKNVIVNGLVLAS-----DGQ-----------------------
570 580 590
640 650 660 670 680 690
pF1KSD EVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQ
:::: :.: :: ....:: :..::: :. .: . : ... ::.
NP_002 -----KMSKRKKNYPDPVSIIQKYGADALRLY-LINSPVVRAENLRFKEEGVRDVLKDVL
600 610 620 630 640 650
700 710 720 730 740
pF1KSD RLWTLTTRFI--EARASGKSPQPQLLSN----KEKAEARKLW--EYKNSVISQVTTHFTE
: . ::. .. : . ..: : .:. . : . .:.:. :...
NP_002 LPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAA
660 670 680 690 700 710
750 760 770 780 790
pF1KSD DFSLNSAISQLMGLSNALSQ--------------ASQSVILHSPEFEDALCALMVMAAPL
. : ... .:. . . :.. . .. .. . ..: .: . ::
NP_002 -YRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPY
720 730 740 750 760 770
800 810 820 830 840
pF1KSD APHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFL---------QQPEVVQMA
.: .: .. .: .. . .. :. : : :.. :. :....
NP_002 TPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELG
780 790 800 810 820 830
850 860 870 880 890 900
pF1KSD VLINNKACG--KIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFL
.: .. : :. . :. ::
NP_002 RVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRL
840 850 860 870 880 890
>>NP_038203 (OMIM: 600709,617093) isoleucine--tRNA ligas (1262 aa)
initn: 380 init1: 155 opt: 164 Z-score: 181.4 bits: 45.3 E(85289): 0.0023
Smith-Waterman score: 281; 20.4% identity (47.7% similar) in 894 aa overlap (79-864:36-856)
50 60 70 80 90 100
pF1KSD KEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTIS
: :::: . :. .: :.::. . ::.
NP_038 PENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIK
10 20 30 40 50 60
110 120 130 140 150 160
pF1KSD DTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLH---PQSWTQSNIKHMRKQ-----
: ..:. .. :..: .::: :::.: ....: :.. .. .: .. .:
NP_038 DIVTRYAHQSGFHVDRRFGWDCHGLPVEYE-IDKTLGIRGPEDVAKMGITEYNNQCRAIV
70 80 90 100 110 120
170 180 190 200 210
pF1KSD ----------LDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPV
..::: ...: . : :.... . ..: .::. ::.:. .. .. .
NP_038 MRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTA
130 140 150 160 170 180
220 230 240 250 260 270
pF1KSD DQTVLANEQVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQA
.: :.: . : .. :.. . :. .: ..: :
NP_038 CNTPLSNFE------SHQNYKDVQDPSV---FVTF----PLEEDETVSLVAWTTTPWTLP
190 200 210 220 230
280 290 300 310
pF1KSD HWIGDCVGCHLDFTLKVHGQATGEKLTAYTATPEAIYGT-SHVAI----------SPSHR
.. ::. .... .:.. : :. : . : :.: : : . ..:
NP_038 SNLAVCVNPEMQY-VKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYR
240 250 260 270 280 290
320 330 340 350
pF1KSD LLHGH---------------SSLKEALRMALV---P--GKDCLTPVMAVNMLTQQEVPVV
: . . .:: ..: : : . : :.. .. .::
NP_038 PLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVC
300 310 320 330 340 350
360 370 380 390
pF1KSD ILAKA--------DLEGSL--DSKIGIPSTSSED--TILAQTLGLAY-----SE---VIE
. . :. :. :. .: : .:. ..: :. .: :. . .
NP_038 PVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYK
360 370 380 390 400 410
400 410 420 430 440 450
pF1KSD TLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPI
..:. :. . .. . .: . . .: :: : . .: .:: :::.:::::::
NP_038 AVPSWFVRVENMVD-QLLRNNDLCYWVPELVREKRFG-NWLKDA-RDWTISRNRYWGTPI
420 430 440 450 460
460 470 480 490 500 510
pF1KSD PI-----VHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPRC-KGAA
:. . :: . . ::.: . .:... .. :.. : :: ::.
NP_038 PLWVSDDFEEVVCIGSVAELEEL--SGAKISDLHRESVDHLTIPS--------RCGKGSL
470 480 490 500 510
520 530 540 550 560 570
pF1KSD KRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVMHLFYARF
.: ....: . .:. . :.. : : : . .:.:. : ... . :
NP_038 HRISEVFDCWFESG--SMPYAQVHYPFE--NKREFEDAFPADFIAEGIDQT-----RGWF
520 530 540 550 560
580 590 600 610 620 630
pF1KSD FSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKL
.. . . . ::......::. .. .::
NP_038 YTLLVLATALFGQ-PPFKNVIVNGLVLAS-----DGQ-----------------------
570 580 590
640 650 660 670 680 690
pF1KSD EVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKTDALPGVLRWQQ
:::: :.: :: ....:: :..::: :. .: . : ... ::.
NP_038 -----KMSKRKKNYPDPVSIIQKYGADALRLY-LINSPVVRAENLRFKEEGVRDVLKDVL
600 610 620 630 640 650
700 710 720 730 740
pF1KSD RLWTLTTRFI--EARASGKSPQPQLLSN----KEKAEARKLW--EYKNSVISQVTTHFTE
: . ::. .. : . ..: : .:. . : . .:.:. :...
NP_038 LPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAA
660 670 680 690 700 710
750 760 770 780 790
pF1KSD DFSLNSAISQLMGLSNALSQ--------------ASQSVILHSPEFEDALCALMVMAAPL
. : ... .:. . . :.. . .. .. . ..: .: . ::
NP_038 -YRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPY
720 730 740 750 760 770
800 810 820 830 840
pF1KSD APHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFL---------QQPEVVQMA
.: .: .. .: .. . .. :. : : :.. :. :....
NP_038 TPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELG
780 790 800 810 820 830
850 860 870 880 890 900
pF1KSD VLINNKACG--KIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFL
.: .. : :. . :. ::
NP_038 RVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRL
840 850 860 870 880 890
>>NP_064502 (OMIM: 151350,615438) leucine--tRNA ligase, (1176 aa)
initn: 295 init1: 114 opt: 161 Z-score: 178.4 bits: 44.6 E(85289): 0.0034
Smith-Waterman score: 161; 26.4% identity (59.3% similar) in 91 aa overlap (50-139:11-101)
20 30 40 50 60 70
pF1KSD NGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE-KWWHQRIKEQASKISEAD
.. . .:... :: .:. : .. : .
NP_064 MAERKGTAKVDFLKKIEKEIQQKWDTERVFEVNASNLEKQ
10 20 30 40
80 90 100 110 120 130
pF1KSD KSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENA
:: :..: .:: .:.::.::. . . . .:...: . :.: :.: .
NP_064 TSKGKYFVTFPYPYMNGRLHLGHTFSLSKCEFAVGYQRLKGKCCLFPFGLHCTGMPIKAC
50 60 70 80 90 100
140 150 160 170 180 190
pF1KSD AVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLA
:
NP_064 ADKLKREIELYGCPPDFPDEEEEEEETSVKTEDIIIKDKAKGKKSKAAAKAGSSKYQWGI
110 120 130 140 150 160
903 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 23:28:09 2016 done: Wed Nov 2 23:28:11 2016
Total Scan time: 10.670 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]