Result of FASTA (omim) for pF1KB8017
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB8017, 647 aa
  1>>>pF1KB8017 647 - 647 aa - 647 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.9354+/-0.000555; mu= -10.5529+/- 0.034
 mean_var=831.4968+/-187.550, 0's: 0 Z-trim(120.2): 658  B-trim: 0 in 0/57
 Lambda= 0.044478
 statistics sampled from 34348 (35225) to 34348 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.749), E-opt: 0.2 (0.413), width:  16
 Scan time: 11.730

The best scores are:                                      opt bits E(85289)
NP_002305 (OMIM: 601329) LIM domain kinase 1 isofo ( 647) 4556 308.9 3.8e-83
NP_001191355 (OMIM: 601329) LIM domain kinase 1 is ( 613) 4177 284.5 7.7e-76
NP_057952 (OMIM: 601988) LIM domain kinase 2 isofo ( 617) 1503 112.9 3.5e-24
NP_005560 (OMIM: 601988) LIM domain kinase 2 isofo ( 638) 1503 112.9 3.5e-24
NP_001026971 (OMIM: 601988) LIM domain kinase 2 is ( 686) 1426 108.0 1.1e-22
NP_006276 (OMIM: 601782) dual specificity testis-s ( 626)  661 58.9 6.4e-08
XP_016855537 (OMIM: 604746) PREDICTED: dual specif ( 363)  408 42.3  0.0037
XP_016855538 (OMIM: 604746) PREDICTED: dual specif ( 363)  408 42.3  0.0037
NP_001307729 (OMIM: 604746) dual specificity testi ( 488)  410 42.6   0.004
XP_005270412 (OMIM: 604746) PREDICTED: dual specif ( 522)  410 42.7  0.0041
XP_016855536 (OMIM: 604746) PREDICTED: dual specif ( 522)  410 42.7  0.0041
XP_006710350 (OMIM: 604746) PREDICTED: dual specif ( 571)  410 42.7  0.0043
XP_011538799 (OMIM: 604746) PREDICTED: dual specif ( 571)  410 42.7  0.0043
NP_009101 (OMIM: 604746) dual specificity testis-s ( 571)  410 42.7  0.0043
NP_001305159 (OMIM: 601782) dual specificity testi ( 466)  405 42.3  0.0048
XP_011541578 (OMIM: 176942) PREDICTED: tyrosine-pr ( 468)  398 41.8  0.0066
XP_016864722 (OMIM: 176942) PREDICTED: tyrosine-pr ( 764)  398 42.2  0.0086
XP_011541574 (OMIM: 176942) PREDICTED: tyrosine-pr ( 769)  398 42.2  0.0086
XP_016864721 (OMIM: 176942) PREDICTED: tyrosine-pr ( 773)  398 42.2  0.0087
XP_011541572 (OMIM: 176942) PREDICTED: tyrosine-pr ( 837)  398 42.2   0.009
XP_011541568 (OMIM: 176942) PREDICTED: tyrosine-pr ( 837)  398 42.2   0.009
XP_016864718 (OMIM: 176942) PREDICTED: tyrosine-pr ( 837)  398 42.2   0.009
XP_011541571 (OMIM: 176942) PREDICTED: tyrosine-pr ( 837)  398 42.2   0.009
XP_011541569 (OMIM: 176942) PREDICTED: tyrosine-pr ( 837)  398 42.2   0.009


>>NP_002305 (OMIM: 601329) LIM domain kinase 1 isoform 1  (647 aa)
 initn: 4556 init1: 4556 opt: 4556  Z-score: 1613.8  bits: 308.9 E(85289): 3.8e-83
Smith-Waterman score: 4556; 100.0% identity (100.0% similar) in 647 aa overlap (1-647:1-647)

               10        20        30        40        50        60
pF1KB8 MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB8 HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB8 GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB8 SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB8 LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KB8 RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KB8 TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KB8 LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KB8 LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KB8 EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
              550       560       570       580       590       600

              610       620       630       640       
pF1KB8 EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
       :::::::::::::::::::::::::::::::::::::::::::::::
NP_002 EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
              610       620       630       640       

>>NP_001191355 (OMIM: 601329) LIM domain kinase 1 isofor  (613 aa)
 initn: 4177 init1: 4177 opt: 4177  Z-score: 1482.5  bits: 284.5 E(85289): 7.7e-76
Smith-Waterman score: 4177; 99.8% identity (100.0% similar) in 597 aa overlap (51-647:17-613)

               30        40        50        60        70        80
pF1KB8 ELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLSHQYYEKDGQLFCKKDYWARY
                                     .:::::::::::::::::::::::::::::
NP_001               MLLASAPRRRRFLQRAKCCDCSASLSHQYYEKDGQLFCKKDYWARY
                             10        20        30        40      

               90       100       110       120       130       140
pF1KB8 GESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQ
         50        60        70        80        90       100      

              150       160       170       180       190       200
pF1KB8 TVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVR
        110       120       130       140       150       160      

              210       220       230       240       250       260
pF1KB8 VQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHD
        170       180       190       200       210       220      

              270       280       290       300       310       320
pF1KB8 TLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGR
        230       240       250       260       270       280      

              330       340       350       360       370       380
pF1KB8 SESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRT
        290       300       310       320       330       340      

              390       400       410       420       430       440
pF1KB8 FLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSF
        350       360       370       380       390       400      

              450       460       470       480       490       500
pF1KB8 AKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKK
        410       420       430       440       450       460      

              510       520       530       540       550       560
pF1KB8 PDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFG
        470       480       490       500       510       520      

              570       580       590       600       610       620
pF1KB8 LNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQ
        530       540       550       560       570       580      

              630       640       
pF1KB8 LEQLDRGFWETYRRGESGLPAHPEVPD
       :::::::::::::::::::::::::::
NP_001 LEQLDRGFWETYRRGESGLPAHPEVPD
        590       600       610   

>>NP_057952 (OMIM: 601988) LIM domain kinase 2 isoform 2  (617 aa)
 initn: 2174 init1: 578 opt: 1503  Z-score: 555.2  bits: 112.9 E(85289): 3.5e-24
Smith-Waterman score: 2238; 55.7% identity (78.2% similar) in 610 aa overlap (35-625:2-602)

           10        20        30        40        50        60    
pF1KB8 LLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLSHQYY
                                     :.::..       : ::: .:. ::.. ::
NP_057                              MGSYLSVPAYFTSRDLFRCSECQDSLTNWYY
                                            10        20        30 

           70        80        90       100       110       120    
pF1KB8 EKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTY
       ::::.:.: ::::...:: :::::  .: :  :::::.::::::: :..: ..: :::.:
NP_057 EKDGKLYCPKDYWGKFGEFCHGCSLLMT-GPFMVAGEFKYHPECFACMSCKVIIEDGDAY
              40        50         60        70        80        90

          130       140       150       160       170       180    
pF1KB8 TLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDP
       .::.:. ::::.:. ..:..:..:..  .:   .::..:::.:.::...:.::.:::.. 
NP_057 ALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVES
              100       110       120       130       140       150

          190       200       210       220       230       240    
pF1KB8 PHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQ
            .: .... ::.:. :.   .::. .:.:: :::::::::::.:.. ..:..  :.
NP_057 -----AC-SNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAIS
                    160       170       180       190       200    

          250             260       270       280           290    
pF1KB8 ETSRLLQLTLEHDP------HDTLGHGLGPETSPLSSPAYTPSGEAG----SSARQKPVL
       .::. ::: .::::      .  :   :.:. .  . :    . ..     .. :.. . 
NP_057 QTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLR
          210       220       230       240       250       260    

          300       310       320        330       340       350   
pF1KB8 RSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCR-PHRIFRPSDLIHGEVLGKGCFGQA
       :: ::..::: .:   :    .:..::::::      ..:::: ::::::::::: ::::
NP_057 RSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQA
          270       280       290       300       310       320    

           360       370       380       390       400       410   
pF1KB8 IKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFIT
       :::::. ::.::::::::: :::::.::: :::::: :.:::::::::::::::.::..:
NP_057 IKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLT
          330       340       350       360       370       380    

           420       430       440       450       460       470   
pF1KB8 EYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKN
       :::.::::. ...:::  .::.:.: ::: ::::::::::: ::::::::::::.. .:.
NP_057 EYIEGGTLKDFLRSMDP-FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKT
          390       400        410       420       430       440   

           480        490            500       510       520       
pF1KB8 VVVADFGLARLMVDE-KTQP-----EGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYD
       ::::::::.::.:.: :  :        :.:.: :::::::::::::::::::.::.:::
NP_057 VVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYD
           450       460       470       480       490       500   

       530       540       550       560       570       580       
pF1KB8 EKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCC
       : ::.::::::::::::.: :::: ::::.::::::. : ... : .:::.:::... ::
NP_057 ETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICC
           510       520       530       540       550       560   

       590       600       610         620       630       640     
pF1KB8 DLDPEKRPSFVKLEHWLETLRMHLAGHL--PLGPQLEQLDRGFWETYRRGESGLPAHPEV
        :.::.::.: :::  .:.: ..: :.:  ::  .::.::                    
NP_057 RLEPESRPAFSKLEDSFEALSLYL-GELGIPLPAELEELDHTVSMQYGLTRDSPP     
           570       580        590       600       610            

         
pF1KB8 PD

>>NP_005560 (OMIM: 601988) LIM domain kinase 2 isoform 2  (638 aa)
 initn: 2186 init1: 578 opt: 1503  Z-score: 555.1  bits: 112.9 E(85289): 3.5e-24
Smith-Waterman score: 2308; 55.2% identity (78.5% similar) in 627 aa overlap (19-625:6-623)

               10        20        30         40        50         
pF1KB8 MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQ-YLQALNADWHADCFRCCDCSASL
                         : ..  : .::..:  .: . ...:  ::..:::: .:. ::
NP_005              MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSL
                            10        20        30        40       

      60        70        80        90       100       110         
pF1KB8 SHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIG
       .. ::::::.:.: ::::...:: :::::  .: :  :::::.::::::: :..: ..: 
NP_005 TNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMT-GPFMVAGEFKYHPECFACMSCKVIIE
        50        60        70        80         90       100      

     120       130       140       150       160       170         
pF1KB8 DGDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLS
       :::.:.::.:. ::::.:. ..:..:..:..  .:   .::..:::.:.::...:.::.:
NP_005 DGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFS
        110       120       130       140       150       160      

     180       190       200       210       220       230         
pF1KB8 VSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEI
       ::..      .: .... ::.:. :.   .::. .:.:: :::::::::::.:.. ..:.
NP_005 VSVE-----SAC-SNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEV
        170             180       190       200       210       220

     240       250             260       270       280             
pF1KB8 DLLIQETSRLLQLTLEHDP------HDTLGHGLGPETSPLSSPAYTPSGEAG----SSAR
       .  :..::. ::: .::::      .  :   :.:. .  . :    . ..     .. :
NP_005 EDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLR
              230       240       250       260       270       280

     290       300       310       320        330       340        
pF1KB8 QKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCR-PHRIFRPSDLIHGEVLGKG
       .. . :: ::..::: .:   :    .:..::::::      ..:::: :::::::::::
NP_005 RRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKG
              290       300       310       320       330       340

      350       360       370       380       390       400        
pF1KB8 CFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKR
        :::::::::. ::.::::::::: :::::.::: :::::: :.:::::::::::::::.
NP_005 FFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKK
              350       360       370       380       390       400

      410       420       430       440       450       460        
pF1KB8 LNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLV
       ::..::::.::::. ...:::  .::.:.: ::: ::::::::::: ::::::::::::.
NP_005 LNLLTEYIEGGTLKDFLRSMDP-FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLI
              410       420        430       440       450         

      470       480        490            500       510       520  
pF1KB8 RENKNVVVADFGLARLMVDE-KTQP-----EGLRSLKKPDRKKRYTVVGNPYWMAPEMIN
       . .:.::::::::.::.:.: :  :        :.:.: :::::::::::::::::::.:
NP_005 KLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLN
     460       470       480       490       500       510         

            530       540       550       560       570       580  
pF1KB8 GRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPI
       :.:::: ::.::::::::::::.: :::: ::::.::::::. : ... : .:::.:::.
NP_005 GKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPL
     520       530       540       550       560       570         

            590       600       610         620       630       640
pF1KB8 TVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHL--PLGPQLEQLDRGFWETYRRGESGLP
       .. :: :.::.::.: :::  .:.: ..: :.:  ::  .::.::               
NP_005 AAICCRLEPESRPAFSKLEDSFEALSLYL-GELGIPLPAELEELDHTVSMQYGLTRDSPP
     580       590       600        610       620       630        

              
pF1KB8 AHPEVPD

>>NP_001026971 (OMIM: 601988) LIM domain kinase 2 isofor  (686 aa)
 initn: 2091 init1: 523 opt: 1426  Z-score: 528.0  bits: 108.0 E(85289): 1.1e-22
Smith-Waterman score: 2161; 56.2% identity (78.5% similar) in 577 aa overlap (35-594:2-570)

           10        20        30        40        50        60    
pF1KB8 LLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLSHQYY
                                     :.::..       : ::: .:. ::.. ::
NP_001                              MGSYLSVPAYFTSRDLFRCSECQDSLTNWYY
                                            10        20        30 

           70        80        90       100       110       120    
pF1KB8 EKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTY
       ::::.:.: ::::...:: :::::  .: :  :::::.::::::: :..: ..: :::.:
NP_001 EKDGKLYCPKDYWGKFGEFCHGCSLLMT-GPFMVAGEFKYHPECFACMSCKVIIEDGDAY
              40        50         60        70        80        90

          130       140       150       160       170       180    
pF1KB8 TLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDP
       .::.:. ::::.:. ..:..:..:..  .:   .::..:::.:.::...:.::.:::.. 
NP_001 ALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVES
              100       110       120       130       140       150

          190       200       210       220       230       240    
pF1KB8 PHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQ
            .: .... ::.:. :.   .::. .:.:: :::::::::::.:.. ..:..  :.
NP_001 -----AC-SNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAIS
                    160       170       180       190       200    

          250             260       270       280           290    
pF1KB8 ETSRLLQLTLEHDP------HDTLGHGLGPETSPLSSPAYTPSGEAG----SSARQKPVL
       .::. ::: .::::      .  :   :.:. .  . :    . ..     .. :.. . 
NP_001 QTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLR
          210       220       230       240       250       260    

          300       310       320        330       340       350   
pF1KB8 RSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCR-PHRIFRPSDLIHGEVLGKGCFGQA
       :: ::..::: .:   :    .:..::::::      ..:::: ::::::::::: ::::
NP_001 RSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQA
          270       280       290       300       310       320    

           360       370       380       390       400       410   
pF1KB8 IKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFIT
       :::::. ::.::::::::: :::::.::: :::::: :.:::::::::::::::.::..:
NP_001 IKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLT
          330       340       350       360       370       380    

           420       430       440       450       460       470   
pF1KB8 EYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKN
       :::.::::. ...:::  .::.:.: ::: ::::::::::: ::::::::::::.. .:.
NP_001 EYIEGGTLKDFLRSMDP-FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKT
          390       400        410       420       430       440   

           480        490            500       510       520       
pF1KB8 VVVADFGLARLMVDE-KTQP-----EGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYD
       ::::::::.::.:.: :  :        :.:.: :::::::::::::::::::.::.:::
NP_001 VVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYD
           450       460       470       480       490       500   

       530       540       550       560       570       580       
pF1KB8 EKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCC
       : ::.::::::::::::.: :::: ::::.::::::. : ... : .:::.:::... ::
NP_001 ETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICC
           510       520       530       540       550       560   

       590       600       610       620       630       640       
pF1KB8 DLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
        :.::.:                                                     
NP_001 RLEPESRAPPGAAGEGPGCADDEGPVRRQGKVTIKYDPKELRKHLNLEEWILEQLTRLYD
           570       580       590       600       610       620   

>>NP_006276 (OMIM: 601782) dual specificity testis-speci  (626 aa)
 initn: 731 init1: 319 opt: 661  Z-score: 263.1  bits: 58.9 E(85289): 6.4e-08
Smith-Waterman score: 778; 40.2% identity (65.9% similar) in 346 aa overlap (303-644:24-349)

            280       290       300       310       320       330  
pF1KB8 LSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRP-H
                                     :: :. :.  ..    ::  : :..     
NP_006        MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGR----GRPSSYRALRSAVS
                      10        20        30            40         

             340       350       360       370       380       390 
pF1KB8 RIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCL
        . : .:.  .: .: : :... :: ::..:.:::.: . ..  .   : :.::..:  :
NP_006 SLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLK-MNKLPSNRGNT-LREVQLMNRL
      50        60        70        80         90        100       

             400       410       420       430       440       450 
pF1KB8 EHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYL
       .:::.:.:.::  .. .:. .:::..::::. ...: .    :  :. .: ::: :. ::
NP_006 RHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEP-LSWPVRLHLALDIARGLRYL
       110       120       130       140        150       160      

             460        470         480       490       500        
pF1KB8 HSMNIIHRDLNSHNCLVR-ENKN--VVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYT
       :: ...::::.:.::::: :...  .::.:::::          : .   ..  ::.  .
NP_006 HSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLA----------EKIPVYREGARKEPLA
        170       180       190       200                 210      

      510       520       530       540       550       560        
pF1KB8 VVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLD
       :::.:::::::.. :. ::::.:::.:::::::.:.:: ::::::::: ::::.: .:  
NP_006 VVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAF-R
        220       230       240       250       260       270      

      570       580       590       600       610       620        
pF1KB8 RYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGF
            .::  :. ....::.:.:  :  :... . :: .  .:    ::       ..: 
NP_006 TLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRTALTHNQG-
         280       290       300       310       320       330     

      630       640                                                
pF1KB8 WETYRRGESGLPAHPEVPD                                         
         . : : :.   .:.                                            
NP_006 -SVARGGPSATLPRPDPRLSRSRSDLFLPPSPESPPNWGDNLTRVNPFSLREDLRGGKIK
           340       350       360       370       380       390   

>>XP_016855537 (OMIM: 604746) PREDICTED: dual specificit  (363 aa)
 initn: 407 init1: 284 opt: 408  Z-score: 177.6  bits: 42.3 E(85289): 0.0037
Smith-Waterman score: 408; 51.5% identity (81.6% similar) in 103 aa overlap (505-607:4-104)

          480       490       500       510       520       530    
pF1KB8 VVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFS
                                     .. .:::.:.:::::..  . :.::.::::
XP_016                            MGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFS
                                          10        20        30   

          540       550       560       570       580       590    
pF1KB8 FGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKR
       .::.:::::.:..::::::::: .:::.  .:  ..   .:::.:. .:  ::..::. :
XP_016 YGIILCEIIARIQADPDYLPRTENFGLDYDAF--QHMVGDCPPDFLQLTFNCCNMDPKLR
            40        50        60          70        80        90 

          600       610       620       630       640              
pF1KB8 PSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD       
       ::::.. . :: .                                               
XP_016 PSFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPR
             100       110       120       130       140       150 

>>XP_016855538 (OMIM: 604746) PREDICTED: dual specificit  (363 aa)
 initn: 407 init1: 284 opt: 408  Z-score: 177.6  bits: 42.3 E(85289): 0.0037
Smith-Waterman score: 408; 51.5% identity (81.6% similar) in 103 aa overlap (505-607:4-104)

          480       490       500       510       520       530    
pF1KB8 VVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFS
                                     .. .:::.:.:::::..  . :.::.::::
XP_016                            MGSEKLAVVGSPFWMAPEVLRDEPYNEKADVFS
                                          10        20        30   

          540       550       560       570       580       590    
pF1KB8 FGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKR
       .::.:::::.:..::::::::: .:::.  .:  ..   .:::.:. .:  ::..::. :
XP_016 YGIILCEIIARIQADPDYLPRTENFGLDYDAF--QHMVGDCPPDFLQLTFNCCNMDPKLR
            40        50        60          70        80        90 

          600       610       620       630       640              
pF1KB8 PSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD       
       ::::.. . :: .                                               
XP_016 PSFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPR
             100       110       120       130       140       150 

>>NP_001307729 (OMIM: 604746) dual specificity testis-sp  (488 aa)
 initn: 684 init1: 284 opt: 410  Z-score: 177.1  bits: 42.6 E(85289): 0.004
Smith-Waterman score: 702; 46.7% identity (75.1% similar) in 229 aa overlap (382-607:16-229)

             360       370       380       390       400       410 
pF1KB8 QAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNF
                                     ::::..:  : :::.:.:.::  .. .:. 
NP_001                MALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQLHA
                              10        20        30        40     

             420       430       440       450       460       470 
pF1KB8 ITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVREN
       .::::..:.:. .. : . . ::. ::..: ::: :..:::  .:.::::.:.:::....
NP_001 LTEYINSGNLEQLLDS-NLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCLIKRD
          50        60         70        80        90       100    

                480       490       500       510       520        
pF1KB8 KN---VVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDE
       .:   .::::::::. . : .   : :            .:::.:.:::::..  . :.:
NP_001 ENGYSAVVADFGLAEKIPDVSMGSEKL------------AVVGSPFWMAPEVLRDEPYNE
          110       120       130                   140       150  

      530       540       550       560       570       580        
pF1KB8 KVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCD
       :.::::.::.:::::.:..::::::::: .:::.  .:  ..   .:::.:. .:  ::.
NP_001 KADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAF--QHMVGDCPPDFLQLTFNCCN
            160       170       180       190         200       210

      590       600       610       620       630       640        
pF1KB8 LDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD 
       .::. :::::.. . :: .                                         
NP_001 MDPKLRPSFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPH
              220       230       240       250       260       270

>>XP_005270412 (OMIM: 604746) PREDICTED: dual specificit  (522 aa)
 initn: 619 init1: 284 opt: 410  Z-score: 176.8  bits: 42.7 E(85289): 0.0041
Smith-Waterman score: 520; 34.2% identity (58.0% similar) in 307 aa overlap (304-607:25-263)

           280       290       300       310       320       330   
pF1KB8 SSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRI
                                     :.:. :. .::   .  :    ..    :.
XP_005       MDRSKRNSIAGFPPRVERLEEFEGGGGGEGN-VSQVGRVWPSSYRALISAFSRL
                     10        20        30         40        50   

           340       350       360       370       380       390   
pF1KB8 FRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEH
        : .:.   : .:.: :....:: :: .:.::..:  .     .. ..::::..:  : :
XP_005 TRLDDFTC-EKIGSGFFSEVFKVRHRASGQVMALK--MNTLSSNRANMLKEVQLMNRLSH
            60         70        80          90       100       110

           400       410       420       430       440       450   
pF1KB8 PNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHS
       ::.:.:.::  .. .:. .::                                       
XP_005 PNILRFMGVCVHQGQLHALTE---------------------------------------
              120       130                                        

           460       470          480       490       500       510
pF1KB8 MNIIHRDLNSHNCLVRENKN---VVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVV
                  :::.....:   .::::::::. . : .   : :            .::
XP_005 -----------NCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKL------------AVV
                        140       150       160                    

              520       530       540       550       560       570
pF1KB8 GNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRY
       :.:.:::::..  . :.::.::::.::.:::::.:..::::::::: .:::.  .:  ..
XP_005 GSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENFGLDYDAF--QH
      170       180       190       200       210       220        

              580       590       600       610       620       630
pF1KB8 CPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWE
          .:::.:. .:  ::..::. :::::.. . :: .                       
XP_005 MVGDCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLL
        230       240       250       260       270       280      

              640                                                  
pF1KB8 TYRRGESGLPAHPEVPD                                           
                                                                   
XP_005 EKAPGVKRLSSLDDKIPHKSPCPRRTIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAAR
        290       300       310       320       330       340      




647 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 23:15:23 2016 done: Wed Nov  2 23:15:25 2016
 Total Scan time: 11.730 Total Display time:  0.080

Function used was FASTA [36.3.4 Apr, 2011]
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