Result of FASTA (omim) for pF1KB0048
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB0048, 1756 aa
  1>>>pF1KB0048 1756 - 1756 aa - 1756 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 13.7474+/-0.000509; mu= -14.7928+/- 0.032
 mean_var=500.6808+/-104.710, 0's: 0 Z-trim(120.3): 155  B-trim: 578 in 1/60
 Lambda= 0.057318
 statistics sampled from 35246 (35448) to 35246 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.416), width:  16
 Scan time: 18.820

The best scores are:                                      opt bits E(85289)
NP_001317168 (OMIM: 601009) tight junction protein (1768) 11841 995.6       0
NP_001287954 (OMIM: 601009) tight junction protein (1835) 11841 995.6       0
XP_016878018 (OMIM: 601009) PREDICTED: tight junct (1755) 11529 969.8       0
XP_016878017 (OMIM: 601009) PREDICTED: tight junct (1759) 11529 969.8       0
XP_011520274 (OMIM: 601009) PREDICTED: tight junct (1848) 11529 969.8       0
NP_003248 (OMIM: 601009) tight junction protein ZO (1748) 11487 966.3       0
XP_005254674 (OMIM: 601009) PREDICTED: tight junct (1841) 11487 966.3       0
XP_016878011 (OMIM: 601009) PREDICTED: tight junct (1865) 9532 804.6       0
XP_016878012 (OMIM: 601009) PREDICTED: tight junct (1858) 9508 802.6       0
XP_016878016 (OMIM: 601009) PREDICTED: tight junct (1783) 9336 788.4       0
XP_016878015 (OMIM: 601009) PREDICTED: tight junct (1785) 9336 788.4       0
XP_016878014 (OMIM: 601009) PREDICTED: tight junct (1789) 9336 788.4       0
XP_016878010 (OMIM: 601009) PREDICTED: tight junct (1878) 9336 788.4       0
XP_016878020 (OMIM: 601009) PREDICTED: tight junct (1452) 7217 613.1 5.9e-174
XP_016878013 (OMIM: 601009) PREDICTED: tight junct (1798) 6202 529.3 1.3e-148
NP_783297 (OMIM: 601009) tight junction protein ZO (1668) 6174 526.9  6e-148
XP_016878019 (OMIM: 601009) PREDICTED: tight junct (1688) 6174 526.9 6.1e-148
NP_001287955 (OMIM: 601009) tight junction protein (1692) 6174 526.9 6.1e-148
XP_005254677 (OMIM: 601009) PREDICTED: tight junct (1761) 6174 526.9 6.3e-148
XP_005254676 (OMIM: 601009) PREDICTED: tight junct (1781) 6174 526.9 6.3e-148
XP_011517510 (OMIM: 607709,607748,615878) PREDICTE (1167) 2024 183.6 9.2e-45
XP_011517511 (OMIM: 607709,607748,615878) PREDICTE (1167) 2024 183.6 9.2e-45
XP_011517509 (OMIM: 607709,607748,615878) PREDICTE (1167) 2024 183.6 9.2e-45
XP_011517508 (OMIM: 607709,607748,615878) PREDICTE (1167) 2024 183.6 9.2e-45
NP_004808 (OMIM: 607709,607748,615878) tight junct (1190) 2024 183.6 9.3e-45
XP_005252371 (OMIM: 607709,607748,615878) PREDICTE (1194) 2024 183.6 9.4e-45
XP_016870815 (OMIM: 607709,607748,615878) PREDICTE (1213) 2024 183.6 9.5e-45
NP_001163887 (OMIM: 607709,607748,615878) tight ju (1221) 2024 183.6 9.5e-45
XP_011517506 (OMIM: 607709,607748,615878) PREDICTE (1130) 1988 180.6 7.1e-44
XP_016870816 (OMIM: 607709,607748,615878) PREDICTE (1153) 1988 180.7 7.2e-44
NP_001163886 (OMIM: 607709,607748,615878) tight ju (1157) 1988 180.7 7.2e-44
NP_001163885 (OMIM: 607709,607748,615878) tight ju (1020) 1961 178.4 3.1e-43
NP_963923 (OMIM: 607709,607748,615878) tight junct (1043) 1961 178.4 3.1e-43
XP_016870817 (OMIM: 607709,607748,615878) PREDICTE (1047) 1961 178.4 3.1e-43
NP_001254489 (OMIM: 612689) tight junction protein ( 919)  756 78.7 2.8e-13
NP_001254490 (OMIM: 612689) tight junction protein ( 928)  756 78.7 2.8e-13


>>NP_001317168 (OMIM: 601009) tight junction protein ZO-  (1768 aa)
 initn: 11841 init1: 11841 opt: 11841  Z-score: 5309.4  bits: 995.6 E(85289):    0
Smith-Waterman score: 11841; 100.0% identity (100.0% similar) in 1756 aa overlap (1-1756:13-1768)

                           10        20        30        40        
pF1KB0             MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
                   ::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
               10        20        30        40        50        60

       50        60        70        80        90       100        
pF1KB0 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
               70        80        90       100       110       120

      110       120       130       140       150       160        
pF1KB0 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
              130       140       150       160       170       180

      170       180       190       200       210       220        
pF1KB0 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
              190       200       210       220       230       240

      230       240       250       260       270       280        
pF1KB0 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
              250       260       270       280       290       300

      290       300       310       320       330       340        
pF1KB0 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
              310       320       330       340       350       360

      350       360       370       380       390       400        
pF1KB0 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
              370       380       390       400       410       420

      410       420       430       440       450       460        
pF1KB0 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
              430       440       450       460       470       480

      470       480       490       500       510       520        
pF1KB0 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
              490       500       510       520       530       540

      530       540       550       560       570       580        
pF1KB0 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
              550       560       570       580       590       600

      590       600       610       620       630       640        
pF1KB0 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
              610       620       630       640       650       660

      650       660       670       680       690       700        
pF1KB0 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
              670       680       690       700       710       720

      710       720       730       740       750       760        
pF1KB0 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
              730       740       750       760       770       780

      770       780       790       800       810       820        
pF1KB0 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
              790       800       810       820       830       840

      830       840       850       860       870       880        
pF1KB0 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
              850       860       870       880       890       900

      890       900       910       920       930       940        
pF1KB0 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
              910       920       930       940       950       960

      950       960       970       980       990      1000        
pF1KB0 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
              970       980       990      1000      1010      1020

     1010      1020      1030      1040      1050      1060        
pF1KB0 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
             1030      1040      1050      1060      1070      1080

     1070      1080      1090      1100      1110      1120        
pF1KB0 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
             1090      1100      1110      1120      1130      1140

     1130      1140      1150      1160      1170      1180        
pF1KB0 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
             1150      1160      1170      1180      1190      1200

     1190      1200      1210      1220      1230      1240        
pF1KB0 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
             1210      1220      1230      1240      1250      1260

     1250      1260      1270      1280      1290      1300        
pF1KB0 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
             1270      1280      1290      1300      1310      1320

     1310      1320      1330      1340      1350      1360        
pF1KB0 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
             1330      1340      1350      1360      1370      1380

     1370      1380      1390      1400      1410      1420        
pF1KB0 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
             1390      1400      1410      1420      1430      1440

     1430      1440      1450      1460      1470      1480        
pF1KB0 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
             1450      1460      1470      1480      1490      1500

     1490      1500      1510      1520      1530      1540        
pF1KB0 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
             1510      1520      1530      1540      1550      1560

     1550      1560      1570      1580      1590      1600        
pF1KB0 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
             1570      1580      1590      1600      1610      1620

     1610      1620      1630      1640      1650      1660        
pF1KB0 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
             1630      1640      1650      1660      1670      1680

     1670      1680      1690      1700      1710      1720        
pF1KB0 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDP
             1690      1700      1710      1720      1730      1740

     1730      1740      1750      
pF1KB0 KTWQNKCLPGDPNYLVGANCVSVLIDHF
       ::::::::::::::::::::::::::::
NP_001 KTWQNKCLPGDPNYLVGANCVSVLIDHF
             1750      1760        

>>NP_001287954 (OMIM: 601009) tight junction protein ZO-  (1835 aa)
 initn: 11841 init1: 11841 opt: 11841  Z-score: 5309.1  bits: 995.6 E(85289):    0
Smith-Waterman score: 11841; 100.0% identity (100.0% similar) in 1756 aa overlap (1-1756:80-1835)

                                             10        20        30
pF1KB0                               MEETAIWEQHTVTLHRAPGFGFGIAISGGR
                                     ::::::::::::::::::::::::::::::
NP_001 GKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR
      50        60        70        80        90       100         

               40        50        60        70        80        90
pF1KB0 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
     110       120       130       140       150       160         

              100       110       120       130       140       150
pF1KB0 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
     170       180       190       200       210       220         

              160       170       180       190       200       210
pF1KB0 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
     230       240       250       260       270       280         

              220       230       240       250       260       270
pF1KB0 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
     290       300       310       320       330       340         

              280       290       300       310       320       330
pF1KB0 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
     350       360       370       380       390       400         

              340       350       360       370       380       390
pF1KB0 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
     410       420       430       440       450       460         

              400       410       420       430       440       450
pF1KB0 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
     470       480       490       500       510       520         

              460       470       480       490       500       510
pF1KB0 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
     530       540       550       560       570       580         

              520       530       540       550       560       570
pF1KB0 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
     590       600       610       620       630       640         

              580       590       600       610       620       630
pF1KB0 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
     650       660       670       680       690       700         

              640       650       660       670       680       690
pF1KB0 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
     710       720       730       740       750       760         

              700       710       720       730       740       750
pF1KB0 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
     770       780       790       800       810       820         

              760       770       780       790       800       810
pF1KB0 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
     830       840       850       860       870       880         

              820       830       840       850       860       870
pF1KB0 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
     890       900       910       920       930       940         

              880       890       900       910       920       930
pF1KB0 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
     950       960       970       980       990      1000         

              940       950       960       970       980       990
pF1KB0 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
    1010      1020      1030      1040      1050      1060         

             1000      1010      1020      1030      1040      1050
pF1KB0 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
    1070      1080      1090      1100      1110      1120         

             1060      1070      1080      1090      1100      1110
pF1KB0 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
    1130      1140      1150      1160      1170      1180         

             1120      1130      1140      1150      1160      1170
pF1KB0 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
    1190      1200      1210      1220      1230      1240         

             1180      1190      1200      1210      1220      1230
pF1KB0 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
    1250      1260      1270      1280      1290      1300         

             1240      1250      1260      1270      1280      1290
pF1KB0 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
    1310      1320      1330      1340      1350      1360         

             1300      1310      1320      1330      1340      1350
pF1KB0 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
    1370      1380      1390      1400      1410      1420         

             1360      1370      1380      1390      1400      1410
pF1KB0 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
    1430      1440      1450      1460      1470      1480         

             1420      1430      1440      1450      1460      1470
pF1KB0 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
    1490      1500      1510      1520      1530      1540         

             1480      1490      1500      1510      1520      1530
pF1KB0 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
    1550      1560      1570      1580      1590      1600         

             1540      1550      1560      1570      1580      1590
pF1KB0 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
    1610      1620      1630      1640      1650      1660         

             1600      1610      1620      1630      1640      1650
pF1KB0 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
    1670      1680      1690      1700      1710      1720         

             1660      1670      1680      1690      1700      1710
pF1KB0 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMT
    1730      1740      1750      1760      1770      1780         

             1720      1730      1740      1750      
pF1KB0 PDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
       ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
    1790      1800      1810      1820      1830     

>>XP_016878018 (OMIM: 601009) PREDICTED: tight junction   (1755 aa)
 initn: 11529 init1: 11529 opt: 11529  Z-score: 5170.0  bits: 969.8 E(85289):    0
Smith-Waterman score: 11720; 99.3% identity (99.3% similar) in 1756 aa overlap (1-1756:13-1755)

                           10        20        30        40        
pF1KB0             MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
                   ::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
               10        20        30        40        50        60

       50        60        70        80        90       100        
pF1KB0 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
               70        80        90       100       110       120

      110       120       130       140       150       160        
pF1KB0 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
              130       140       150       160       170       180

      170       180       190       200       210       220        
pF1KB0 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
              190       200       210       220       230       240

      230       240       250       260       270       280        
pF1KB0 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
              250       260       270       280       290       300

      290       300       310       320       330       340        
pF1KB0 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
              310       320       330       340       350       360

      350       360       370       380       390       400        
pF1KB0 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
              370       380       390       400       410       420

      410       420       430       440       450       460        
pF1KB0 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
              430       440       450       460       470       480

      470       480       490       500       510       520        
pF1KB0 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
              490       500       510       520       530       540

      530       540       550       560       570       580        
pF1KB0 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
              550       560       570       580       590       600

      590       600       610       620       630       640        
pF1KB0 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
              610       620       630       640       650       660

      650       660       670       680       690       700        
pF1KB0 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
              670       680       690       700       710       720

      710       720       730       740       750       760        
pF1KB0 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
              730       740       750       760       770       780

      770       780       790       800       810       820        
pF1KB0 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
              790       800       810       820       830       840

      830       840       850       860       870       880        
pF1KB0 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
              850       860       870       880       890       900

      890       900       910       920       930       940        
pF1KB0 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
              910       920       930       940       950       960

      950       960       970       980       990      1000        
pF1KB0 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
              970       980       990      1000      1010      1020

     1010      1020      1030      1040      1050      1060        
pF1KB0 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
             1030      1040      1050      1060      1070      1080

     1070      1080      1090      1100      1110      1120        
pF1KB0 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
             1090      1100      1110      1120      1130      1140

     1130      1140      1150      1160      1170      1180        
pF1KB0 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
             1150      1160      1170      1180      1190      1200

     1190      1200      1210      1220      1230      1240        
pF1KB0 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
             1210      1220      1230      1240      1250      1260

     1250      1260      1270      1280      1290      1300        
pF1KB0 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
             1270      1280      1290      1300      1310      1320

     1310      1320      1330      1340      1350      1360        
pF1KB0 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
             1330      1340      1350      1360      1370      1380

     1370      1380      1390      1400      1410      1420        
pF1KB0 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
             1390      1400      1410      1420      1430      1440

     1430      1440      1450      1460      1470      1480        
pF1KB0 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
             1450      1460      1470      1480      1490      1500

     1490      1500      1510      1520      1530      1540        
pF1KB0 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
             1510      1520      1530      1540      1550      1560

     1550      1560      1570      1580      1590      1600        
pF1KB0 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
             1570      1580      1590      1600      1610      1620

     1610      1620      1630      1640      1650      1660        
pF1KB0 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
             1630      1640      1650      1660      1670      1680

     1670      1680      1690      1700      1710      1720        
pF1KB0 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDP
       :::::::::::::::::::::::::::::::::::::::::::::             ::
XP_016 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDG-------------DP
             1690      1700      1710      1720                    

     1730      1740      1750      
pF1KB0 KTWQNKCLPGDPNYLVGANCVSVLIDHF
       ::::::::::::::::::::::::::::
XP_016 KTWQNKCLPGDPNYLVGANCVSVLIDHF
      1730      1740      1750     

>>XP_016878017 (OMIM: 601009) PREDICTED: tight junction   (1759 aa)
 initn: 11529 init1: 11529 opt: 11529  Z-score: 5170.0  bits: 969.8 E(85289):    0
Smith-Waterman score: 11720; 99.3% identity (99.3% similar) in 1756 aa overlap (1-1756:17-1759)

                               10        20        30        40    
pF1KB0                 MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVI
                       ::::::::::::::::::::::::::::::::::::::::::::
XP_016 MERNTFSMDCHSKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVI
               10        20        30        40        50        60

           50        60        70        80        90       100    
pF1KB0 SDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPV
               70        80        90       100       110       120

          110       120       130       140       150       160    
pF1KB0 SRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSV
              130       140       150       160       170       180

          170       180       190       200       210       220    
pF1KB0 ASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTV
              190       200       210       220       230       240

          230       240       250       260       270       280    
pF1KB0 TENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLA
              250       260       270       280       290       300

          290       300       310       320       330       340    
pF1KB0 SDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPV
              310       320       330       340       350       360

          350       360       370       380       390       400    
pF1KB0 KHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDG
              370       380       390       400       410       420

          410       420       430       440       450       460    
pF1KB0 ILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFT
              430       440       450       460       470       480

          470       480       490       500       510       520    
pF1KB0 NIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLS
              490       500       510       520       530       540

          530       540       550       560       570       580    
pF1KB0 FNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGG
              550       560       570       580       590       600

          590       600       610       620       630       640    
pF1KB0 DRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADV
              610       620       630       640       650       660

          650       660       670       680       690       700    
pF1KB0 AREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRL
              670       680       690       700       710       720

          710       720       730       740       750       760    
pF1KB0 NYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLN
              730       740       750       760       770       780

          770       780       790       800       810       820    
pF1KB0 SMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTD
              790       800       810       820       830       840

          830       840       850       860       870       880    
pF1KB0 SRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYP
              850       860       870       880       890       900

          890       900       910       920       930       940    
pF1KB0 PYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRL
              910       920       930       940       950       960

          950       960       970       980       990      1000    
pF1KB0 EEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQN
              970       980       990      1000      1010      1020

         1010      1020      1030      1040      1050      1060    
pF1KB0 HVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEH
             1030      1040      1050      1060      1070      1080

         1070      1080      1090      1100      1110      1120    
pF1KB0 RLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPA
             1090      1100      1110      1120      1130      1140

         1130      1140      1150      1160      1170      1180    
pF1KB0 PLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYS
             1150      1160      1170      1180      1190      1200

         1190      1200      1210      1220      1230      1240    
pF1KB0 RSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEED
             1210      1220      1230      1240      1250      1260

         1250      1260      1270      1280      1290      1300    
pF1KB0 PAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQF
             1270      1280      1290      1300      1310      1320

         1310      1320      1330      1340      1350      1360    
pF1KB0 SEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIA
             1330      1340      1350      1360      1370      1380

         1370      1380      1390      1400      1410      1420    
pF1KB0 ASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYA
             1390      1400      1410      1420      1430      1440

         1430      1440      1450      1460      1470      1480    
pF1KB0 QPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQA
             1450      1460      1470      1480      1490      1500

         1490      1500      1510      1520      1530      1540    
pF1KB0 AFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSE
             1510      1520      1530      1540      1550      1560

         1550      1560      1570      1580      1590      1600    
pF1KB0 TAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPV
             1570      1580      1590      1600      1610      1620

         1610      1620      1630      1640      1650      1660    
pF1KB0 SPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVC
             1630      1640      1650      1660      1670      1680

         1670      1680      1690      1700      1710      1720    
pF1KB0 RDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSS
       :::::::::::::::::::::::::::::::::::::::::::::::::           
XP_016 RDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDG-----------
             1690      1700      1710      1720                    

         1730      1740      1750      
pF1KB0 SGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
         ::::::::::::::::::::::::::::::
XP_016 --DPKTWQNKCLPGDPNYLVGANCVSVLIDHF
      1730      1740      1750         

>>XP_011520274 (OMIM: 601009) PREDICTED: tight junction   (1848 aa)
 initn: 11529 init1: 11529 opt: 11529  Z-score: 5169.7  bits: 969.8 E(85289):    0
Smith-Waterman score: 11720; 99.3% identity (99.3% similar) in 1756 aa overlap (1-1756:106-1848)

                                             10        20        30
pF1KB0                               MEETAIWEQHTVTLHRAPGFGFGIAISGGR
                                     ::::::::::::::::::::::::::::::
XP_011 GKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR
          80        90       100       110       120       130     

               40        50        60        70        80        90
pF1KB0 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
         140       150       160       170       180       190     

              100       110       120       130       140       150
pF1KB0 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
         200       210       220       230       240       250     

              160       170       180       190       200       210
pF1KB0 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
         260       270       280       290       300       310     

              220       230       240       250       260       270
pF1KB0 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
         320       330       340       350       360       370     

              280       290       300       310       320       330
pF1KB0 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
         380       390       400       410       420       430     

              340       350       360       370       380       390
pF1KB0 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
         440       450       460       470       480       490     

              400       410       420       430       440       450
pF1KB0 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
         500       510       520       530       540       550     

              460       470       480       490       500       510
pF1KB0 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
         560       570       580       590       600       610     

              520       530       540       550       560       570
pF1KB0 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
         620       630       640       650       660       670     

              580       590       600       610       620       630
pF1KB0 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
         680       690       700       710       720       730     

              640       650       660       670       680       690
pF1KB0 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
         740       750       760       770       780       790     

              700       710       720       730       740       750
pF1KB0 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
         800       810       820       830       840       850     

              760       770       780       790       800       810
pF1KB0 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
         860       870       880       890       900       910     

              820       830       840       850       860       870
pF1KB0 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
         920       930       940       950       960       970     

              880       890       900       910       920       930
pF1KB0 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
         980       990      1000      1010      1020      1030     

              940       950       960       970       980       990
pF1KB0 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
        1040      1050      1060      1070      1080      1090     

             1000      1010      1020      1030      1040      1050
pF1KB0 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
        1100      1110      1120      1130      1140      1150     

             1060      1070      1080      1090      1100      1110
pF1KB0 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
        1160      1170      1180      1190      1200      1210     

             1120      1130      1140      1150      1160      1170
pF1KB0 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
        1220      1230      1240      1250      1260      1270     

             1180      1190      1200      1210      1220      1230
pF1KB0 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
        1280      1290      1300      1310      1320      1330     

             1240      1250      1260      1270      1280      1290
pF1KB0 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
        1340      1350      1360      1370      1380      1390     

             1300      1310      1320      1330      1340      1350
pF1KB0 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
        1400      1410      1420      1430      1440      1450     

             1360      1370      1380      1390      1400      1410
pF1KB0 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
        1460      1470      1480      1490      1500      1510     

             1420      1430      1440      1450      1460      1470
pF1KB0 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
        1520      1530      1540      1550      1560      1570     

             1480      1490      1500      1510      1520      1530
pF1KB0 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
        1580      1590      1600      1610      1620      1630     

             1540      1550      1560      1570      1580      1590
pF1KB0 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
        1640      1650      1660      1670      1680      1690     

             1600      1610      1620      1630      1640      1650
pF1KB0 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
        1700      1710      1720      1730      1740      1750     

             1660      1670      1680      1690      1700      1710
pF1KB0 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMT
        1760      1770      1780      1790      1800      1810     

             1720      1730      1740      1750      
pF1KB0 PDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
       :::             ::::::::::::::::::::::::::::::
XP_011 PDG-------------DPKTWQNKCLPGDPNYLVGANCVSVLIDHF
                     1820      1830      1840        

>>NP_003248 (OMIM: 601009) tight junction protein ZO-1 i  (1748 aa)
 initn: 11694 init1: 11481 opt: 11487  Z-score: 5151.2  bits: 966.3 E(85289):    0
Smith-Waterman score: 11658; 98.9% identity (98.9% similar) in 1756 aa overlap (1-1756:13-1748)

                           10        20        30        40        
pF1KB0             MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
                   ::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVL
               10        20        30        40        50        60

       50        60        70        80        90       100        
pF1KB0 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPD
               70        80        90       100       110       120

      110       120       130       140       150       160        
pF1KB0 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQ
              130       140       150       160       170       180

      170       180       190       200       210       220        
pF1KB0 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENM
              190       200       210       220       230       240

      230       240       250       260       270       280        
pF1KB0 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHS
              250       260       270       280       290       300

      290       300       310       320       330       340        
pF1KB0 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHAD
              310       320       330       340       350       360

      350       360       370       380       390       400        
pF1KB0 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRP
              370       380       390       400       410       420

      410       420       430       440       450       460        
pF1KB0 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIR
              430       440       450       460       470       480

      470       480       490       500       510       520        
pF1KB0 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKG
              490       500       510       520       530       540

      530       540       550       560       570       580        
pF1KB0 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRAD
              550       560       570       580       590       600

      590       600       610       620       630       640        
pF1KB0 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 FWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREK
              610       620       630       640       650       660

      650       660       670       680       690       700        
pF1KB0 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQ
              670       680       690       700       710       720

      710       720       730       740       750       760        
pF1KB0 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 WYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMND
              730       740       750       760       770       780

      770       780       790       800       810       820        
pF1KB0 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHT
              790       800       810       820       830       840

      830       840       850       860       870       880        
pF1KB0 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSP
              850       860       870       880       890       900

      890       900       910       920       930       940        
pF1KB0 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPT
              910       920       930       940       950       960

      950       960       970       980       990      1000        
pF1KB0 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLK
              970       980       990      1000      1010      1020

     1010      1020      1030      1040      1050      1060        
pF1KB0 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRY
             1030      1040      1050      1060      1070      1080

     1070      1080      1090      1100      1110      1120        
pF1KB0 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSY
             1090      1100      1110      1120      1130      1140

     1130      1140      1150      1160      1170      1180        
pF1KB0 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYE
             1150      1160      1170      1180      1190      1200

     1190      1200      1210      1220      1230      1240        
pF1KB0 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMK
             1210      1220      1230      1240      1250      1260

     1250      1260      1270      1280      1290      1300        
pF1KB0 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHD
             1270      1280      1290      1300      1310      1320

     1310      1320      1330      1340      1350      1360        
pF1KB0 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHL
             1330      1340      1350      1360      1370      1380

     1370      1380      1390      1400      1410      1420        
pF1KB0 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQ
             1390      1400      1410      1420      1430      1440

     1430      1440      1450      1460      1470      1480        
pF1KB0 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
             1450      1460      1470      1480      1490      1500

     1490      1500      1510      1520      1530      1540        
pF1KB0 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHK
             1510      1520      1530      1540      1550      1560

     1550      1560      1570      1580      1590      1600        
pF1KB0 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSA
             1570      1580      1590      1600      1610      1620

     1610      1620      1630      1640      1650      1660        
pF1KB0 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNS
             1630      1640      1650      1660      1670      1680

     1670      1680      1690      1700      1710      1720        
pF1KB0 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDP
       ::::::::::::::::::::::::::::::::::::::                    ::
NP_003 ILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHC--------------------DP
             1690      1700      1710                          1720

     1730      1740      1750      
pF1KB0 KTWQNKCLPGDPNYLVGANCVSVLIDHF
       ::::::::::::::::::::::::::::
NP_003 KTWQNKCLPGDPNYLVGANCVSVLIDHF
             1730      1740        

>>XP_005254674 (OMIM: 601009) PREDICTED: tight junction   (1841 aa)
 initn: 11694 init1: 11481 opt: 11487  Z-score: 5150.9  bits: 966.3 E(85289):    0
Smith-Waterman score: 11658; 98.9% identity (98.9% similar) in 1756 aa overlap (1-1756:106-1841)

                                             10        20        30
pF1KB0                               MEETAIWEQHTVTLHRAPGFGFGIAISGGR
                                     ::::::::::::::::::::::::::::::
XP_005 GKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR
          80        90       100       110       120       130     

               40        50        60        70        80        90
pF1KB0 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
         140       150       160       170       180       190     

              100       110       120       130       140       150
pF1KB0 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
         200       210       220       230       240       250     

              160       170       180       190       200       210
pF1KB0 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
         260       270       280       290       300       310     

              220       230       240       250       260       270
pF1KB0 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
         320       330       340       350       360       370     

              280       290       300       310       320       330
pF1KB0 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
         380       390       400       410       420       430     

              340       350       360       370       380       390
pF1KB0 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
         440       450       460       470       480       490     

              400       410       420       430       440       450
pF1KB0 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
         500       510       520       530       540       550     

              460       470       480       490       500       510
pF1KB0 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
         560       570       580       590       600       610     

              520       530       540       550       560       570
pF1KB0 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
         620       630       640       650       660       670     

              580       590       600       610       620       630
pF1KB0 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
         680       690       700       710       720       730     

              640       650       660       670       680       690
pF1KB0 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
         740       750       760       770       780       790     

              700       710       720       730       740       750
pF1KB0 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
         800       810       820       830       840       850     

              760       770       780       790       800       810
pF1KB0 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
         860       870       880       890       900       910     

              820       830       840       850       860       870
pF1KB0 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
         920       930       940       950       960       970     

              880       890       900       910       920       930
pF1KB0 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
         980       990      1000      1010      1020      1030     

              940       950       960       970       980       990
pF1KB0 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
        1040      1050      1060      1070      1080      1090     

             1000      1010      1020      1030      1040      1050
pF1KB0 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
        1100      1110      1120      1130      1140      1150     

             1060      1070      1080      1090      1100      1110
pF1KB0 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
        1160      1170      1180      1190      1200      1210     

             1120      1130      1140      1150      1160      1170
pF1KB0 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
        1220      1230      1240      1250      1260      1270     

             1180      1190      1200      1210      1220      1230
pF1KB0 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
        1280      1290      1300      1310      1320      1330     

             1240      1250      1260      1270      1280      1290
pF1KB0 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
        1340      1350      1360      1370      1380      1390     

             1300      1310      1320      1330      1340      1350
pF1KB0 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
        1400      1410      1420      1430      1440      1450     

             1360      1370      1380      1390      1400      1410
pF1KB0 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPI
        1460      1470      1480      1490      1500      1510     

             1420      1430      1440      1450      1460      1470
pF1KB0 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKP
        1520      1530      1540      1550      1560      1570     

             1480      1490      1500      1510      1520      1530
pF1KB0 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERK
        1580      1590      1600      1610      1620      1630     

             1540      1550      1560      1570      1580      1590
pF1KB0 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKY
        1640      1650      1660      1670      1680      1690     

             1600      1610      1620      1630      1640      1650
pF1KB0 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGA
        1700      1710      1720      1730      1740      1750     

             1660      1670      1680      1690      1700      1710
pF1KB0 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::    
XP_005 IPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHC----
        1760      1770      1780      1790      1800      1810     

             1720      1730      1740      1750      
pF1KB0 PDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
                       ::::::::::::::::::::::::::::::
XP_005 ----------------DPKTWQNKCLPGDPNYLVGANCVSVLIDHF
                            1820      1830      1840 

>>XP_016878011 (OMIM: 601009) PREDICTED: tight junction   (1865 aa)
 initn: 11515 init1: 9324 opt: 9532  Z-score: 4277.1  bits: 804.6 E(85289):    0
Smith-Waterman score: 11676; 98.3% identity (98.3% similar) in 1773 aa overlap (1-1756:106-1865)

                                             10        20        30
pF1KB0                               MEETAIWEQHTVTLHRAPGFGFGIAISGGR
                                     ::::::::::::::::::::::::::::::
XP_016 GKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR
          80        90       100       110       120       130     

               40        50        60        70        80        90
pF1KB0 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
         140       150       160       170       180       190     

              100       110       120       130       140       150
pF1KB0 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
         200       210       220       230       240       250     

              160       170       180       190       200       210
pF1KB0 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
         260       270       280       290       300       310     

              220       230       240       250       260       270
pF1KB0 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
         320       330       340       350       360       370     

              280       290       300       310       320       330
pF1KB0 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
         380       390       400       410       420       430     

              340       350       360       370       380       390
pF1KB0 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
         440       450       460       470       480       490     

              400       410       420       430       440       450
pF1KB0 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
         500       510       520       530       540       550     

              460       470       480       490       500       510
pF1KB0 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
         560       570       580       590       600       610     

              520       530       540       550       560       570
pF1KB0 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
         620       630       640       650       660       670     

              580       590       600       610       620       630
pF1KB0 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
         680       690       700       710       720       730     

              640       650       660       670       680       690
pF1KB0 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
         740       750       760       770       780       790     

              700       710       720       730       740       750
pF1KB0 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
         800       810       820       830       840       850     

              760       770       780       790       800       810
pF1KB0 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
         860       870       880       890       900       910     

              820       830       840       850       860       870
pF1KB0 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
         920       930       940       950       960       970     

              880       890       900       910       920       930
pF1KB0 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
         980       990      1000      1010      1020      1030     

              940       950       960       970       980       990
pF1KB0 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
        1040      1050      1060      1070      1080      1090     

             1000      1010      1020      1030      1040      1050
pF1KB0 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
        1100      1110      1120      1130      1140      1150     

             1060      1070      1080      1090      1100      1110
pF1KB0 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
        1160      1170      1180      1190      1200      1210     

             1120      1130      1140      1150      1160      1170
pF1KB0 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
        1220      1230      1240      1250      1260      1270     

             1180      1190      1200      1210      1220      1230
pF1KB0 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
        1280      1290      1300      1310      1320      1330     

             1240      1250      1260      1270      1280      1290
pF1KB0 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
        1340      1350      1360      1370      1380      1390     

             1300      1310      1320      1330      1340      1350
pF1KB0 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
        1400      1410      1420      1430      1440      1450     

             1360      1370      1380                       1390   
pF1KB0 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSK-----------------GKPP
       :::::::::::::::::::::::::::::::::::::::                 ::::
XP_016 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKFLGSYTSYDYLKRNVKWGKPP
        1460      1470      1480      1490      1500      1510     

          1400      1410      1420      1430      1440      1450   
pF1KB0 EADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDF
        1520      1530      1540      1550      1560      1570     

          1460      1470      1480      1490      1500      1510   
pF1KB0 QNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYN
        1580      1590      1600      1610      1620      1630     

          1520      1530      1540      1550      1560      1570   
pF1KB0 RFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPE
        1640      1650      1660      1670      1680      1690     

          1580      1590      1600      1610      1620      1630   
pF1KB0 FDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGG
        1700      1710      1720      1730      1740      1750     

          1640      1650      1660      1670      1680      1690   
pF1KB0 VLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGL
        1760      1770      1780      1790      1800      1810     

          1700      1710      1720      1730      1740      1750   
pF1KB0 KFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLI
       ::::::::::::::::::::             :::::::::::::::::::::::::::
XP_016 KFLKPVELRLPHCASMTPDG-------------DPKTWQNKCLPGDPNYLVGANCVSVLI
        1820      1830                   1840      1850      1860  

          
pF1KB0 DHF
       :::
XP_016 DHF
          

>>XP_016878012 (OMIM: 601009) PREDICTED: tight junction   (1858 aa)
 initn: 11680 init1: 9324 opt: 9508  Z-score: 4266.4  bits: 802.6 E(85289):    0
Smith-Waterman score: 11614; 97.9% identity (97.9% similar) in 1773 aa overlap (1-1756:106-1858)

                                             10        20        30
pF1KB0                               MEETAIWEQHTVTLHRAPGFGFGIAISGGR
                                     ::::::::::::::::::::::::::::::
XP_016 GKPSLRRIKGRLHRSKSLDSMDFCELTSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGR
          80        90       100       110       120       130     

               40        50        60        70        80        90
pF1KB0 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNA
         140       150       160       170       180       190     

              100       110       120       130       140       150
pF1KB0 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSAS
         200       210       220       230       240       250     

              160       170       180       190       200       210
pF1KB0 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGN
         260       270       280       290       300       310     

              220       230       240       250       260       270
pF1KB0 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSAN
         320       330       340       350       360       370     

              280       290       300       310       320       330
pF1KB0 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRD
         380       390       400       410       420       430     

              340       350       360       370       380       390
pF1KB0 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVS
         440       450       460       470       480       490     

              400       410       420       430       440       450
pF1KB0 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLE
         500       510       520       530       540       550     

              460       470       480       490       500       510
pF1KB0 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIR
         560       570       580       590       600       610     

              520       530       540       550       560       570
pF1KB0 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ
         620       630       640       650       660       670     

              580       590       600       610       620       630
pF1KB0 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAG
         680       690       700       710       720       730     

              640       650       660       670       680       690
pF1KB0 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDK
         740       750       760       770       780       790     

              700       710       720       730       740       750
pF1KB0 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLR
         800       810       820       830       840       850     

              760       770       780       790       800       810
pF1KB0 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSY
         860       870       880       890       900       910     

              820       830       840       850       860       870
pF1KB0 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVR
         920       930       940       950       960       970     

              880       890       900       910       920       930
pF1KB0 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASST
         980       990      1000      1010      1020      1030     

              940       950       960       970       980       990
pF1KB0 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKV
        1040      1050      1060      1070      1080      1090     

             1000      1010      1020      1030      1040      1050
pF1KB0 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYE
        1100      1110      1120      1130      1140      1150     

             1060      1070      1080      1090      1100      1110
pF1KB0 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEE
        1160      1170      1180      1190      1200      1210     

             1120      1130      1140      1150      1160      1170
pF1KB0 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAG
        1220      1230      1240      1250      1260      1270     

             1180      1190      1200      1210      1220      1230
pF1KB0 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTK
        1280      1290      1300      1310      1320      1330     

             1240      1250      1260      1270      1280      1290
pF1KB0 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSG
        1340      1350      1360      1370      1380      1390     

             1300      1310      1320      1330      1340      1350
pF1KB0 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYF
        1400      1410      1420      1430      1440      1450     

             1360      1370      1380                       1390   
pF1KB0 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSK-----------------GKPP
       :::::::::::::::::::::::::::::::::::::::                 ::::
XP_016 DRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKFLGSYTSYDYLKRNVKWGKPP
        1460      1470      1480      1490      1500      1510     

          1400      1410      1420      1430      1440      1450   
pF1KB0 EADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDF
        1520      1530      1540      1550      1560      1570     

          1460      1470      1480      1490      1500      1510   
pF1KB0 QNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYN
        1580      1590      1600      1610      1620      1630     

          1520      1530      1540      1550      1560      1570   
pF1KB0 RFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPE
        1640      1650      1660      1670      1680      1690     

          1580      1590      1600      1610      1620      1630   
pF1KB0 FDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGG
        1700      1710      1720      1730      1740      1750     

          1640      1650      1660      1670      1680      1690   
pF1KB0 VLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGL
        1760      1770      1780      1790      1800      1810     

          1700      1710      1720      1730      1740      1750   
pF1KB0 KFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLI
       :::::::::::::                    :::::::::::::::::::::::::::
XP_016 KFLKPVELRLPHC--------------------DPKTWQNKCLPGDPNYLVGANCVSVLI
        1820                          1830      1840      1850     

          
pF1KB0 DHF
       :::
XP_016 DHF
          

>>XP_016878016 (OMIM: 601009) PREDICTED: tight junction   (1783 aa)
 initn: 11827 init1: 9324 opt: 9336  Z-score: 4189.8  bits: 788.4 E(85289):    0
Smith-Waterman score: 11797; 99.0% identity (99.0% similar) in 1773 aa overlap (1-1756:11-1783)

                         10        20        30        40        50
pF1KB0           MEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKG
                 ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MLYYLFKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKG
               10        20        30        40        50        60

               60        70        80        90       100       110
pF1KB0 GPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPE
               70        80        90       100       110       120

              120       130       140       150       160       170
pF1KB0 PVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPA
              130       140       150       160       170       180

              180       190       200       210       220       230
pF1KB0 KPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSL
              190       200       210       220       230       240

              240       250       260       270       280       290
pF1KB0 TDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGR
              250       260       270       280       290       300

              300       310       320       330       340       350
pF1KB0 SHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDH
              310       320       330       340       350       360

              360       370       380       390       400       410
pF1KB0 TPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSM
              370       380       390       400       410       420

              420       430       440       450       460       470
pF1KB0 KLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREE
              430       440       450       460       470       480

              480       490       500       510       520       530
pF1KB0 AVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEV
              490       500       510       520       530       540

              540       550       560       570       580       590
pF1KB0 FRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFW
              550       560       570       580       590       600

              600       610       620       630       640       650
pF1KB0 RFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLA
              610       620       630       640       650       660

              660       670       680       690       700       710
pF1KB0 REEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWY
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWY
              670       680       690       700       710       720

              720       730       740       750       760       770
pF1KB0 PIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGW
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGW
              730       740       750       760       770       780

              780       790       800       810       820       830
pF1KB0 YGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSD
              790       800       810       820       830       840

              840       850       860       870       880       890
pF1KB0 YEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQA
              850       860       870       880       890       900

              900       910       920       930       940       950
pF1KB0 QPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPTPA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPTPA
              910       920       930       940       950       960

              960       970       980       990      1000      1010
pF1KB0 PSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLKQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLKQP
              970       980       990      1000      1010      1020

             1020      1030      1040      1050      1060      1070
pF1KB0 AVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYED
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYED
             1030      1040      1050      1060      1070      1080

             1080      1090      1100      1110      1120      1130
pF1KB0 RVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDS
             1090      1100      1110      1120      1130      1140

             1140      1150      1160      1170      1180      1190
pF1KB0 RPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQV
             1150      1160      1170      1180      1190      1200

             1200      1210      1220      1230      1240      1250
pF1KB0 PPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQ
             1210      1220      1230      1240      1250      1260

             1260      1270      1280      1290      1300      1310
pF1KB0 SVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKT
             1270      1280      1290      1300      1310      1320

             1320      1330      1340      1350      1360      1370
pF1KB0 LYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSE
             1330      1340      1350      1360      1370      1380

             1380                       1390      1400      1410   
pF1KB0 PAKPAHSQNQSNFSSYSSK-----------------GKPPEADGVDRSFGEKRYEPIQAT
       :::::::::::::::::::                 ::::::::::::::::::::::::
XP_016 PAKPAHSQNQSNFSSYSSKFLGSYTSYDYLKRNVKWGKPPEADGVDRSFGEKRYEPIQAT
             1390      1400      1410      1420      1430      1440

          1420      1430      1440      1450      1460      1470   
pF1KB0 PPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATF
             1450      1460      1470      1480      1490      1500

          1480      1490      1500      1510      1520      1530   
pF1KB0 RPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFES
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFES
             1510      1520      1530      1540      1550      1560

          1540      1550      1560      1570      1580      1590   
pF1KB0 PKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQIN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQIN
             1570      1580      1590      1600      1610      1620

          1600      1610      1620      1630      1640      1650   
pF1KB0 NISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPE
             1630      1640      1650      1660      1670      1680

          1660      1670      1680      1690      1700      1710   
pF1KB0 GVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDG
             1690      1700      1710      1720      1730      1740

          1720      1730      1740      1750      
pF1KB0 WSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
       :::::::::::::::::::::::::::::::::::::::::::
XP_016 WSFALKSSDSSSGDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
             1750      1760      1770      1780   




1756 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 22:34:27 2016 done: Wed Nov  2 22:34:30 2016
 Total Scan time: 18.820 Total Display time:  1.310

Function used was FASTA [36.3.4 Apr, 2011]
Inquiries or Suggestions ?
Send a message to flexiclone AT kazusagt.com