Result of FASTA (omim) for pF1KA1376
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA1376, 414 aa
  1>>>pF1KA1376 414 - 414 aa - 414 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.5338+/-0.000334; mu= 16.3396+/- 0.021
 mean_var=71.0128+/-14.151, 0's: 0 Z-trim(115.9): 20  B-trim: 492 in 1/48
 Lambda= 0.152197
 statistics sampled from 26644 (26663) to 26644 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.689), E-opt: 0.2 (0.313), width:  16
 Scan time:  8.170

The best scores are:                                      opt bits E(85289)
NP_065852 (OMIM: 612464) arrestin domain-containin ( 414) 2792 622.0 8.2e-178
NP_001316599 (OMIM: 612464) arrestin domain-contai ( 194) 1309 296.2 4.6e-80
NP_001316601 (OMIM: 612464) arrestin domain-contai ( 194) 1309 296.2 4.6e-80
NP_001316600 (OMIM: 612464) arrestin domain-contai ( 194) 1309 296.2 4.6e-80
NP_006463 (OMIM: 606599) thioredoxin-interacting p ( 391)  946 216.7 8.1e-56
XP_016855574 (OMIM: 606599) PREDICTED: thioredoxin ( 395)  928 212.7 1.3e-54
NP_001300901 (OMIM: 606599) thioredoxin-interactin ( 336)  926 212.3 1.5e-54


>>NP_065852 (OMIM: 612464) arrestin domain-containing pr  (414 aa)
 initn: 2792 init1: 2792 opt: 2792  Z-score: 3313.3  bits: 622.0 E(85289): 8.2e-178
Smith-Waterman score: 2792; 100.0% identity (100.0% similar) in 414 aa overlap (1-414:1-414)

               10        20        30        40        50        60
pF1KA1 MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWT
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA1 ESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 ESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA1 TPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA1 LCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKM
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA1 KEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 KEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMD
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA1 LFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRN
              310       320       330       340       350       360

              370       380       390       400       410    
pF1KA1 NLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
              370       380       390       400       410    

>>NP_001316599 (OMIM: 612464) arrestin domain-containing  (194 aa)
 initn: 1309 init1: 1309 opt: 1309  Z-score: 1558.4  bits: 296.2 E(85289): 4.6e-80
Smith-Waterman score: 1309; 100.0% identity (100.0% similar) in 194 aa overlap (221-414:1-194)

              200       210       220       230       240       250
pF1KA1 ISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANL
                                     ::::::::::::::::::::::::::::::
NP_001                               MVVPKAAIYQTQAFYAKGKMKEVKQLVANL
                                             10        20        30

              260       270       280       290       300       310
pF1KA1 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
               40        50        60        70        80        90

              320       330       340       350       360       370
pF1KA1 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
              100       110       120       130       140       150

              380       390       400       410    
pF1KA1 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
       ::::::::::::::::::::::::::::::::::::::::::::
NP_001 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
              160       170       180       190    

>>NP_001316601 (OMIM: 612464) arrestin domain-containing  (194 aa)
 initn: 1309 init1: 1309 opt: 1309  Z-score: 1558.4  bits: 296.2 E(85289): 4.6e-80
Smith-Waterman score: 1309; 100.0% identity (100.0% similar) in 194 aa overlap (221-414:1-194)

              200       210       220       230       240       250
pF1KA1 ISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANL
                                     ::::::::::::::::::::::::::::::
NP_001                               MVVPKAAIYQTQAFYAKGKMKEVKQLVANL
                                             10        20        30

              260       270       280       290       300       310
pF1KA1 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
               40        50        60        70        80        90

              320       330       340       350       360       370
pF1KA1 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
              100       110       120       130       140       150

              380       390       400       410    
pF1KA1 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
       ::::::::::::::::::::::::::::::::::::::::::::
NP_001 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
              160       170       180       190    

>>NP_001316600 (OMIM: 612464) arrestin domain-containing  (194 aa)
 initn: 1309 init1: 1309 opt: 1309  Z-score: 1558.4  bits: 296.2 E(85289): 4.6e-80
Smith-Waterman score: 1309; 100.0% identity (100.0% similar) in 194 aa overlap (221-414:1-194)

              200       210       220       230       240       250
pF1KA1 ISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANL
                                     ::::::::::::::::::::::::::::::
NP_001                               MVVPKAAIYQTQAFYAKGKMKEVKQLVANL
                                             10        20        30

              260       270       280       290       300       310
pF1KA1 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIG
               40        50        60        70        80        90

              320       330       340       350       360       370
pF1KA1 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDD
              100       110       120       130       140       150

              380       390       400       410    
pF1KA1 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
       ::::::::::::::::::::::::::::::::::::::::::::
NP_001 FERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
              160       170       180       190    

>>NP_006463 (OMIM: 606599) thioredoxin-interacting prote  (391 aa)
 initn: 1038 init1: 672 opt: 946  Z-score: 1123.1  bits: 216.7 E(85289): 8.1e-56
Smith-Waterman score: 1049; 42.1% identity (70.8% similar) in 401 aa overlap (1-399:2-383)

                10        20        30        40        50         
pF1KA1  MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRW
        ... :.::. . :   :: .  ::.::. :.::: .::    :::...: : : ::: :
NP_006 MVMFKKIKSFEVVF---NDPE-KVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLW
               10            20        30        40        50      

      60        70        80        90       100        110        
pF1KA1 TESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSG-RHEYAFSFEL
        .    ::     :.  .  ::. ..: :.   .:. ..:. .  .. : ..:: :.:::
NP_006 MQ----GS-----QQCKQTSEYLRYEDTLL--LEDQPTGENEMVIMRPGNKYEYKFGFEL
             60             70          80        90       100     

      120       130       140       150       160       170        
pF1KA1 PQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKE
       :: ::.:::.:..: : ::::: : ::     . ::.: : . .:.:::.:..: .. ::
NP_006 PQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKE
         110       120       130       140       150       160     

      180       190       200       210       220       230        
pF1KA1 KTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKG
       : . : :  .: .:.::.:.:::.  :. :.: :..::  ::.:::::::   ... :.:
NP_006 KKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANG
         170       180       190       200       210       220     

      240       250       260       270       280       290        
pF1KA1 KMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGA
       . : . : ....::. . ::   .: :: :..  . :::: :.:.::::::..::..::.
NP_006 QTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGS
         230       240       250       260       270       280     

      300       310       320       330       340       350        
pF1KA1 MDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQR
         ..:.::::::.     ..:::::..:. : .:.:..:..:. ::::: : .:. :..:
NP_006 KKVILDLPLVIGS--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHR
         290         300       310       320       330       340   

      360        370       380       390       400       410    
pF1KA1 RNNLAPVSAC-DDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
        ..  :..   ::.. . ..:.: :  ::.:.::: :.:.::               
NP_006 LES--PTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ       
             350       360       370       380       390        

>>XP_016855574 (OMIM: 606599) PREDICTED: thioredoxin-int  (395 aa)
 initn: 1020 init1: 672 opt: 928  Z-score: 1101.6  bits: 212.7 E(85289): 1.3e-54
Smith-Waterman score: 1031; 41.9% identity (70.7% similar) in 399 aa overlap (1-397:2-381)

                10        20        30        40        50         
pF1KA1  MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRW
        ... :.::. . :   :: .  ::.::. :.::: .::    :::...: : : ::: :
XP_016 MVMFKKIKSFEVVF---NDPE-KVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLW
               10            20        30        40        50      

      60        70        80        90       100        110        
pF1KA1 TESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSG-RHEYAFSFEL
        .    ::     :.  .  ::. ..: :.   .:. ..:. .  .. : ..:: :.:::
XP_016 MQ----GS-----QQCKQTSEYLRYEDTLL--LEDQPTGENEMVIMRPGNKYEYKFGFEL
             60             70          80        90       100     

      120       130       140       150       160       170        
pF1KA1 PQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKE
       :: ::.:::.:..: : ::::: : ::     . ::.: : . .:.:::.:..: .. ::
XP_016 PQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKE
         110       120       130       140       150       160     

      180       190       200       210       220       230        
pF1KA1 KTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKG
       : . : :  .: .:.::.:.:::.  :. :.: :..::  ::.:::::::   ... :.:
XP_016 KKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANG
         170       180       190       200       210       220     

      240       250       260       270       280       290        
pF1KA1 KMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGA
       . : . : ....::. . ::   .: :: :..  . :::: :.:.::::::..::..::.
XP_016 QTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGS
         230       240       250       260       270       280     

      300       310       320       330       340       350        
pF1KA1 MDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQR
         ..:.::::::.     ..:::::..:. : .:.:..:..:. ::::: : .:. :..:
XP_016 KKVILDLPLVIGS--RSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHR
         290         300       310       320       330       340   

      360        370       380       390       400       410    
pF1KA1 RNNLAPVSAC-DDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
        .  .:..   ::.. . ..:.: :  ::.:.::: :.:.                 
XP_016 LE--SPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVRIVIFTVKFVLSFL   
             350       360       370       380       390        

>>NP_001300901 (OMIM: 606599) thioredoxin-interacting pr  (336 aa)
 initn: 932 init1: 672 opt: 926  Z-score: 1100.3  bits: 212.3 E(85289): 1.5e-54
Smith-Waterman score: 926; 45.5% identity (75.0% similar) in 292 aa overlap (109-399:41-328)

       80        90       100       110       120       130        
pF1KA1 VEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWV
                                     ..:: :.::::: ::.:::.:..: : :::
NP_001 CILSVTASLMATRFSFPSGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWV
               20        30        40        50        60        70

      140       150       160       170       180       190        
pF1KA1 KAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIE
       :: : ::     . ::.: : . .:.:::.:..: .. ::: . : :  .: .:.::.:.
NP_001 KAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARID
               80        90       100       110       120       130

      200       210       220       230       240       250        
pF1KA1 RKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSG
       :::.  :. :.: :..::  ::.:::::::   ... :.:. : . : ....::. . ::
NP_001 RKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISG
              140       150       160       170       180       190

      260       270       280       290       300       310        
pF1KA1 KTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIGTIPLHPFG
          .: :: :..  . :::: :.:.::::::..::..::.  ..:.::::::.     ..
NP_001 TCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGS--RSGLS
              200       210       220       230       240          

      320       330       340       350       360        370       
pF1KA1 SRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSAC-DDFERALQG
       :::::..:. : .:.:..:..:. ::::: : .:. :..: .  .:..   ::.. . ..
NP_001 SRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLE--SPTTPLLDDMDGSQDS
      250       260       270       280       290         300      

       380       390       400       410    
pF1KA1 PLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR
       :.: :  ::.:.::: :.:.::               
NP_001 PIFMYAPEFKFMPPPTYTEVDPCILNNNVQ       
        310       320       330             




414 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 21:05:35 2016 done: Wed Nov  2 21:05:36 2016
 Total Scan time:  8.170 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]
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