Result of FASTA (ccds) for pF1KA0687
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0687, 1037 aa
  1>>>pF1KA0687 1037 - 1037 aa - 1037 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 10.3908+/-0.00118; mu= -0.7641+/- 0.070
 mean_var=356.8045+/-75.277, 0's: 0 Z-trim(111.1): 649  B-trim: 0 in 0/53
 Lambda= 0.067898
 statistics sampled from 11338 (12082) to 11338 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.694), E-opt: 0.2 (0.371), width:  16
 Scan time:  4.640

The best scores are:                                      opt bits E(32554)
CCDS82487.1 MAP4K4 gene_id:9448|Hs108|chr2         (1165) 4360 442.4 2.5e-123
CCDS56130.1 MAP4K4 gene_id:9448|Hs108|chr2         (1239) 2597 269.8 2.6e-71
CCDS74546.1 MAP4K4 gene_id:9448|Hs108|chr2         (1273) 2597 269.8 2.6e-71
CCDS54673.1 TNIK gene_id:23043|Hs108|chr3          (1268) 2311 241.8 7.1e-63
CCDS54674.1 TNIK gene_id:23043|Hs108|chr3          (1276) 2311 241.8 7.1e-63
CCDS54677.1 TNIK gene_id:23043|Hs108|chr3          (1297) 2311 241.8 7.2e-63
CCDS54678.1 TNIK gene_id:23043|Hs108|chr3          (1305) 2311 241.8 7.3e-63
CCDS54675.1 TNIK gene_id:23043|Hs108|chr3          (1323) 2311 241.8 7.3e-63
CCDS54676.1 TNIK gene_id:23043|Hs108|chr3          (1331) 2311 241.8 7.4e-63
CCDS54679.1 TNIK gene_id:23043|Hs108|chr3          (1352) 2311 241.8 7.4e-63
CCDS46956.1 TNIK gene_id:23043|Hs108|chr3          (1360) 2311 241.8 7.5e-63
CCDS45589.1 MINK1 gene_id:50488|Hs108|chr17        (1303) 2275 238.3 8.3e-62
CCDS45590.1 MINK1 gene_id:50488|Hs108|chr17        (1312) 2275 238.3 8.4e-62
CCDS45588.1 MINK1 gene_id:50488|Hs108|chr17        (1332) 2275 238.3 8.5e-62
CCDS65305.1 NRK gene_id:203447|Hs108|chrX          (1582) 1217 134.7 1.5e-30
CCDS7148.1 MYO3A gene_id:53904|Hs108|chr10         (1616) 1025 115.9   7e-25
CCDS46446.1 MYO3B gene_id:140469|Hs108|chr2        (1314)  999 113.3 3.6e-24
CCDS42773.1 MYO3B gene_id:140469|Hs108|chr2        (1341)  999 113.3 3.6e-24
CCDS58707.1 MAP4K3 gene_id:8491|Hs108|chr2         ( 873)  910 104.4 1.1e-21
CCDS1803.1 MAP4K3 gene_id:8491|Hs108|chr2          ( 894)  910 104.4 1.1e-21
CCDS42564.1 MAP4K1 gene_id:11184|Hs108|chr19       ( 821)  820 95.5 4.8e-19
CCDS59385.1 MAP4K1 gene_id:11184|Hs108|chr19       ( 833)  820 95.5 4.9e-19
CCDS2549.1 STK25 gene_id:10494|Hs108|chr2          ( 426)  809 94.2 6.4e-19
CCDS81582.1 MAP4K2 gene_id:5871|Hs108|chr11        ( 812)  804 94.0 1.4e-18
CCDS8082.1 MAP4K2 gene_id:5871|Hs108|chr11         ( 820)  804 94.0 1.4e-18
CCDS34290.1 STK10 gene_id:6793|Hs108|chr5          ( 968)  799 93.5 2.3e-18
CCDS14631.1 STK26 gene_id:51765|Hs108|chrX         ( 416)  790 92.3 2.3e-18
CCDS76334.1 SLK gene_id:9748|Hs108|chr10           (1204)  785 92.3 6.8e-18
CCDS7553.1 SLK gene_id:9748|Hs108|chr10            (1235)  785 92.3   7e-18
CCDS32001.1 STK24 gene_id:8428|Hs108|chr13         ( 431)  773 90.7 7.5e-18
CCDS13341.1 STK4 gene_id:6789|Hs108|chr20          ( 487)  772 90.6 8.7e-18
CCDS47900.1 STK3 gene_id:6788|Hs108|chr8           ( 491)  770 90.4   1e-17
CCDS59108.1 STK3 gene_id:6788|Hs108|chr8           ( 519)  770 90.4   1e-17
CCDS9488.1 STK24 gene_id:8428|Hs108|chr13          ( 443)  768 90.2 1.1e-17
CCDS63200.1 STK25 gene_id:10494|Hs108|chr2         ( 349)  713 84.7 3.8e-16
CCDS48168.1 STK26 gene_id:51765|Hs108|chrX         ( 339)  686 82.0 2.3e-15
CCDS63199.1 STK25 gene_id:10494|Hs108|chr2         ( 332)  685 81.9 2.4e-15
CCDS66573.1 STK24 gene_id:8428|Hs108|chr13         ( 412)  607 74.4 5.7e-13
CCDS9188.1 TAOK3 gene_id:51347|Hs108|chr12         ( 898)  608 74.8 9.2e-13
CCDS56024.1 TAOK1 gene_id:57551|Hs108|chr17        ( 853)  607 74.7 9.5e-13
CCDS32601.1 TAOK1 gene_id:57551|Hs108|chr17        (1001)  607 74.8 1.1e-12
CCDS10662.1 TAOK2 gene_id:9344|Hs108|chr16         (1049)  593 73.4 2.8e-12
CCDS58448.1 TAOK2 gene_id:9344|Hs108|chr16         (1122)  593 73.4   3e-12
CCDS10663.1 TAOK2 gene_id:9344|Hs108|chr16         (1235)  593 73.5 3.2e-12
CCDS42770.1 STK39 gene_id:27347|Hs108|chr2         ( 545)  579 71.7 4.6e-12
CCDS14554.1 PAK3 gene_id:5063|Hs108|chrX           ( 544)  561 70.0 1.6e-11
CCDS48153.1 PAK3 gene_id:5063|Hs108|chrX           ( 559)  561 70.0 1.6e-11
CCDS48152.1 PAK3 gene_id:5063|Hs108|chrX           ( 565)  561 70.0 1.6e-11
CCDS48151.1 PAK3 gene_id:5063|Hs108|chrX           ( 580)  561 70.0 1.6e-11
CCDS3321.1 PAK2 gene_id:5062|Hs108|chr3            ( 524)  559 69.8 1.8e-11


>>CCDS82487.1 MAP4K4 gene_id:9448|Hs108|chr2              (1165 aa)
 initn: 6508 init1: 3925 opt: 4360  Z-score: 2327.5  bits: 442.4 E(32554): 2.5e-123
Smith-Waterman score: 5995; 87.9% identity (87.9% similar) in 1070 aa overlap (97-1037:97-1165)

         70        80        90       100       110       120      
pF1KA0 KLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLK
                                     ::::::::::::::::::::::::::::::
CCDS82 KLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLK
         70        80        90       100       110       120      

        130       140       150       160       170       180      
pF1KA0 EDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 EDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRN
        130       140       150       160       170       180      

        190       200       210       220       230       240      
pF1KA0 TFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 TFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIP
        190       200       210       220       230       240      

        250       260       270       280       290       300      
pF1KA0 RNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 RNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI
        250       260       270       280       290       300      

        310       320       330       340       350       360      
pF1KA0 DRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 DRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKER
        310       320       330       340       350       360      

        370       380                                              
pF1KA0 SEALRRQQLLQEQQLREQE-----------------------------------------
       :::::::::::::::::::                                         
CCDS82 SEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQERE
        370       380       390       400       410       420      

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
CCDS82 QRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQL
        430       440       450       460       470       480      

                                     390       400       410       
pF1KA0 ----------------------------RSKPSFHAPEPKAHYEPADRAREVPVRTTSRS
                                   ::::::::::::::::::::::::::::::::
CCDS82 LQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRS
        490       500       510       520       530       540      

       420       430       440       450       460       470       
pF1KA0 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP
       ::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::
CCDS82 PVLSRRDSPLQGSGQQNSQAGQRNSTS-IEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP
        550       560       570        580       590       600     

       480       490       500       510       520       530       
pF1KA0 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK
         610       620       630       640       650       660     

       540       550       560       570       580       590       
pF1KA0 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG
         670       680       690       700       710       720     

       600       610       620       630       640       650       
pF1KA0 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI
         730       740       750       760       770       780     

       660       670       680       690       700       710       
pF1KA0 SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS
         790       800       810       820       830       840     

       720       730       740       750       760       770       
pF1KA0 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD
         850       860       870       880       890       900     

       780       790       800       810       820       830       
pF1KA0 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV
         910       920       930       940       950       960     

       840       850       860       870       880       890       
pF1KA0 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI
         970       980       990      1000      1010      1020     

       900       910       920       930       940       950       
pF1KA0 YLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 YLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWG
        1030      1040      1050      1060      1070      1080     

       960       970       980       990      1000      1010       
pF1KA0 EMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 EMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
        1090      1100      1110      1120      1130      1140     

      1020      1030       
pF1KA0 SGGSSQVYFMTLGRTSLLSW
       ::::::::::::::::::::
CCDS82 SGGSSQVYFMTLGRTSLLSW
        1150      1160     

>--
 initn: 619 init1: 619 opt: 619  Z-score: 347.0  bits: 76.0 E(32554): 5.2e-13
Smith-Waterman score: 619; 100.0% identity (100.0% similar) in 96 aa overlap (1-96:1-96)

               10        20        30        40        50        60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
       ::::::::::::::::::::::::::::::::::::                        
CCDS82 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
                                                                   
CCDS82 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
              130       140       150       160       170       180

>>CCDS56130.1 MAP4K4 gene_id:9448|Hs108|chr2              (1239 aa)
 initn: 5563 init1: 2592 opt: 2597  Z-score: 1393.8  bits: 269.8 E(32554): 2.6e-71
Smith-Waterman score: 5200; 79.7% identity (79.7% similar) in 1073 aa overlap (1-859:1-1069)

               10        20        30        40        50        60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
              310       320       330       340       350       360

              370       380                                        
pF1KA0 QENKERSEALRRQQLLQEQQLREQE-----------------------------------
       :::::::::::::::::::::::::                                   
CCDS56 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
              370       380       390       400       410       420

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
CCDS56 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
              430       440       450       460       470       480

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
CCDS56 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP
              490       500       510       520       530       540

              390       400                                        
pF1KA0 -----RSKPSFHAPEPKAHYEPADRAREV-------------------------------
            ::::::::::::::::::::::::                               
CCDS56 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS
              550       560       570       580       590       600

                            410       420       430       440      
pF1KA0 -----------------------PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSI
                              ::::::::::::::::::::::::::::::::::: :
CCDS56 ESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTS-I
              610       620       630       640       650          

        450       460       470       480       490       500      
pF1KA0 EPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQR
     660       670       680       690       700       710         

        510       520       530       540       550       560      
pF1KA0 LENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDE
       :::::::::::::::::::::   ::::::::::::::::::::::::::::::::::::
CCDS56 LENAVKKPEDKKEVFRPLKPA---DLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDE
     720       730       740          750       760       770      

        570       580       590       600       610       620      
pF1KA0 EDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 EDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLI
        780       790       800       810       820       830      

        630       640       650       660       670       680      
pF1KA0 VRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 VRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPT
        840       850       860       870       880       890      

        690       700       710       720       730       740      
pF1KA0 RKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 RKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQG
        900       910       920       930       940       950      

        750       760       770       780       790       800      
pF1KA0 KVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTT
        960       970       980       990      1000      1010      

        810       820       830       840       850       860      
pF1KA0 VGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDL
       :::::::::::::::::::::::::::::::::::::::::::::::::::::       
CCDS56 VGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDL
       1020      1030      1040      1050      1060      1070      

        870       880       890       900       910       920      
pF1KA0 TVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNT
                                                                   
CCDS56 TVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVC
       1080      1090      1100      1110      1120      1130      

>--
 initn: 856 init1: 856 opt: 1116  Z-score: 609.8  bits: 124.7 E(32554): 1.2e-27
Smith-Waterman score: 1116; 95.5% identity (95.5% similar) in 178 aa overlap (860-1037:1070-1239)

     830       840       850       860       870       880         
pF1KA0 ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV
                                     ::::::::::::::::::::::::::::::
CCDS56 ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV
    1040      1050      1060      1070      1080      1090         

     890       900       910       920       930       940         
pF1KA0 DSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRIT
       :::::::::::::        :::::::::::::::::::::::::::::::::::::::
CCDS56 DSGSVYDIYLPTH--------IQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRIT
    1100      1110              1120      1130      1140      1150 

     950       960       970       980       990      1000         
pF1KA0 KDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS56 KDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND
            1160      1170      1180      1190      1200      1210 

    1010      1020      1030       
pF1KA0 KVFFASVRSGGSSQVYFMTLGRTSLLSW
       ::::::::::::::::::::::::::::
CCDS56 KVFFASVRSGGSSQVYFMTLGRTSLLSW
            1220      1230         

>>CCDS74546.1 MAP4K4 gene_id:9448|Hs108|chr2              (1273 aa)
 initn: 5072 init1: 2597 opt: 2597  Z-score: 1393.7  bits: 269.8 E(32554): 2.6e-71
Smith-Waterman score: 4912; 76.7% identity (76.7% similar) in 1072 aa overlap (1-825:1-1069)

               10        20        30        40        50        60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
              310       320       330       340       350       360

              370       380                                        
pF1KA0 QENKERSEALRRQQLLQEQQLREQE-----------------------------------
       :::::::::::::::::::::::::                                   
CCDS74 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
              370       380       390       400       410       420

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
CCDS74 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
              430       440       450       460       470       480

                                           390       400           
pF1KA0 ----------------------------------RSKPSFHAPEPKAHYEPADRAREV--
                                         ::::::::::::::::::::::::  
CCDS74 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVED
              490       500       510       520       530       540

                                                         410       
pF1KA0 ----------------------------------------------------PVRTTSRS
                                                           ::::::::
CCDS74 RFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRS
              550       560       570       580       590       600

       420       430       440       450       460       470       
pF1KA0 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP
              610       620       630       640       650       660

       480       490       500       510       520       530       
pF1KA0 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK
       ::::::::::::::::::::::::::::::::::::::::::::::::::   :::::::
CCDS74 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPA---DLTALAK
              670       680       690       700       710          

       540       550       560       570       580       590       
pF1KA0 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG
       720       730       740       750       760       770       

       600       610       620                                     
pF1KA0 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQ----------------------------
       ::::::::::::::::::::::::::::::::                            
CCDS74 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQSTVDQKRASHHESNGFAGRIHLLPDLLQ
       780       790       800       810       820       830       

                                         630       640       650   
pF1KA0 ------------------------------------TQSASSTLQKHKSSSSFTPFIDPR
                                           ::::::::::::::::::::::::
CCDS74 QSHSSSTSSTSSSPSSSQPTPTMSPQTPQDKLTANETQSASSTLQKHKSSSSFTPFIDPR
       840       850       860       870       880       890       

           660       670       680       690       700       710   
pF1KA0 LLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 LLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKK
       900       910       920       930       940       950       

           720       730       740       750       760       770   
pF1KA0 RFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTIS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 RFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTIS
       960       970       980       990      1000      1010       

           780       790       800       810       820       830   
pF1KA0 GKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::        
CCDS74 GKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKS
      1020      1030      1040      1050      1060      1070       

           840       850       860       870       880       890   
pF1KA0 SVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGS
                                                                   
CCDS74 SVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGS
      1080      1090      1100      1110      1120      1130       

>--
 initn: 862 init1: 856 opt: 1345  Z-score: 730.9  bits: 147.1 E(32554): 2.2e-34
Smith-Waterman score: 1345; 96.2% identity (96.2% similar) in 212 aa overlap (826-1037:1070-1273)

         800       810       820       830       840       850     
pF1KA0 PEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFG
                                     ::::::::::::::::::::::::::::::
CCDS74 PEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFG
    1040      1050      1060      1070      1080      1090         

         860       870       880       890       900       910     
pF1KA0 ELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSI
       :::::::::::::::::::::::::::::::::::::::::::::::        :::::
CCDS74 ELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTH--------IQCSI
    1100      1110      1120      1130      1140              1150 

         920       930       940       950       960       970     
pF1KA0 KPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 KPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWG
            1160      1170      1180      1190      1200      1210 

         980       990      1000      1010      1020      1030     
pF1KA0 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS74 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLL
            1220      1230      1240      1250      1260      1270 

         
pF1KA0 SW
       ::
CCDS74 SW
         

>>CCDS54673.1 TNIK gene_id:23043|Hs108|chr3               (1268 aa)
 initn: 4564 init1: 2071 opt: 2311  Z-score: 1242.3  bits: 241.8 E(32554): 7.1e-63
Smith-Waterman score: 3359; 57.3% identity (67.2% similar) in 1074 aa overlap (1-830:1-1069)

               10        20        30        40        50        60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
       ::.::::.:: .::::.::::::::::::.::::::::::::::::::::::::::::: 
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
       ::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
       :::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
       :::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
       ::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
       :::::::::.::::::::::::::::::::::  .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
              310       320       330         340       350        

              370                                      380         
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
         :::::::::::::                               :.::: ::      
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
      360       370       380       390       400       410        

                                                                   
pF1KA0 QER---------------------------------------------------------
       :::                                                         
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR
      420       430       440       450       460       470        

               390                                                 
pF1KA0 -------SKPSFHAPE--------------------------------------------
              .:: .:  :                                            
CCDS54 QEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGF
      480       490       500       510       520       530        

                      400                              410         
pF1KA0 -------------PKAHYEPA-------------DRAR----------EVPVRTTSRSPV
                    :. . .:.             ::.           .:: :::: ::.
CCDS54 QEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPA
      540       550       560       570       580       590        

     420       430       440       450       460       470         
pF1KA0 LSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP--
       :.:..:: .::.     ..:   .:. . :     .:. . : .:::::.::. .:::  
CCDS54 LARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSS
      600       610       620       630       640       650        

         480       490       500       510       520       530     
pF1KA0 --GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTAL
         ::.::::.::.:: :::..:::::::    : :  :::..... :: .::   :::::
CCDS54 QGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTAL
      660       670       680       690       700       710        

         540          550       560       570                      
pF1KA0 AKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE------------------
       ::::: .   :  :: .:::::::::::: ...::..: :.:                  
CCDS54 AKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTG
         720       730       740       750       760       770     

                   580       590              600       610        
pF1KA0 --GADES-------TSGPEDTRAAS-SLNLS-NG-----ETESVKTMIVHDDVES-----
         :..:.       : : : ..: : : ..: .:     :: . :    :.: ..     
CCDS54 APGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHI
         780       790       800       810       820       830     

                     620       630       640          650       660
pF1KA0 ----------EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTPFIDPRLLQISPS
                  :: ::..    .  ..:  .:  .   .::   :::::.:::. : ::.
CCDS54 NLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPT
         840       850       860       870       880       890     

                  670       680       690       700       710      
pF1KA0 S----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFN
       .        .... :. . .: :  . . .:: ::::::::: ::.::::::::::::::
CCDS54 DEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFN
         900       910       920       930       940       950     

        720       730       740       750       760       770      
pF1KA0 SEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKK
       ::::::::::::::::::.:::::::::::::: ::::::::::::::::::::::::::
CCDS54 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKK
         960       970       980       990      1000      1010     

        780       790       800       810       820       830      
pF1KA0 DKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVE
       .::::::::::::.:::::::::::::: ::::::::.::::::::::::::::      
CCDS54 NKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVE
        1020      1030      1040      1050      1060      1070     

        840       850       860       870       880       890      
pF1KA0 VYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYD
                                                                   
CCDS54 IYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYD
        1080      1090      1100      1110      1120      1130     

>--
 initn: 1211 init1: 780 opt: 1165  Z-score: 635.6  bits: 129.5 E(32554): 4.4e-29
Smith-Waterman score: 1165; 81.6% identity (93.2% similar) in 207 aa overlap (831-1037:1070-1268)

              810       820       830       840       850       860
pF1KA0 KQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHK
                                     ::..::.:::::::::::::::::..: ::
CCDS54 KQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHK
    1040      1050      1060      1070      1080      1090         

              870       880       890       900       910       920
pF1KA0 PLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAI
       :::::::::::::::::.:: .:::..:::::. ::::.:.:.. :        : ::::
CCDS54 PLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN--------ITPHAI
    1100      1110      1120      1130      1140              1150 

              930       940       950       960       970       980
pF1KA0 IILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIE
       .:::.:::::.:::::::::::::::::::::::::::::::::::.::: :::::::::
CCDS54 VILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIE
            1160      1170      1180      1190      1200      1210 

              990      1000      1010      1020      1030       
pF1KA0 IRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
       ::::::::::::::::::::::::::::::::::::::::::::.::::.:.:...:
CCDS54 IRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
            1220      1230      1240      1250      1260        

>>CCDS54674.1 TNIK gene_id:23043|Hs108|chr3               (1276 aa)
 initn: 4614 init1: 2071 opt: 2311  Z-score: 1242.2  bits: 241.8 E(32554): 7.1e-63
Smith-Waterman score: 3308; 56.7% identity (66.9% similar) in 1071 aa overlap (1-822:1-1069)

               10        20        30        40        50        60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
       ::.::::.:: .::::.::::::::::::.::::::::::::::::::::::::::::: 
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
       ::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
       :::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
       :::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
       ::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
       :::::::::.::::::::::::::::::::::  .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
              310       320       330         340       350        

              370                                      380         
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
         :::::::::::::                               :.::: ::      
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
      360       370       380       390       400       410        

                                                                   
pF1KA0 QER---------------------------------------------------------
       :::                                                         
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR
      420       430       440       450       460       470        

               390                                                 
pF1KA0 -------SKPSFHAPE--------------------------------------------
              .:: .:  :                                            
CCDS54 QEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGF
      480       490       500       510       520       530        

                      400                              410         
pF1KA0 -------------PKAHYEPA-------------DRAR----------EVPVRTTSRSPV
                    :. . .:.             ::.           .:: :::: ::.
CCDS54 QEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPA
      540       550       560       570       580       590        

     420       430       440       450       460       470         
pF1KA0 LSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP--
       :.:..:: .::.     ..:   .:. . :     .:. . : .:::::.::. .:::  
CCDS54 LARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSS
      600       610       620       630       640       650        

         480       490       500       510       520            530
pF1KA0 --GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG-----EV
         ::.::::.::.:: :::..:::::::    : :  :::..... :: .::.     . 
CCDS54 QGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDE
      660       670       680       690       700       710        

              540          550       560       570                 
pF1KA0 DLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE-------------
       :::::::::: .   :  :: .:::::::::::: ...::..: :.:             
CCDS54 DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPR
      720       730       740       750       760       770        

                        580       590              600       610   
pF1KA0 -------GADES-------TSGPEDTRAAS-SLNLS-NG-----ETESVKTMIVHDDVES
              :..:.       : : : ..: : : ..: .:     :: . :    :.: ..
CCDS54 LIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNG
      780       790       800       810       820       830        

                          620       630       640          650     
pF1KA0 ---------------EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTPFIDPRLL
                       :: ::..    .  ..:  .:  .   .::   :::::.:::. 
CCDS54 FAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVY
      840       850       860       870       880       890        

         660           670       680       690       700       710 
pF1KA0 QISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKY
       : ::..        .... :. . .: :  . . .:: ::::::::: ::.:::::::::
CCDS54 QTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKY
      900       910       920       930       940       950        

             720       730       740       750       760       770 
pF1KA0 KKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVT
       :::::::::::::::::::::::.:::::::::::::: :::::::::::::::::::::
CCDS54 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVT
      960       970       980       990      1000      1010        

             780       790       800       810       820       830 
pF1KA0 ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIAL
       :::::.::::::::::::.:::::::::::::: ::::::::.::::::::         
CCDS54 ISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIAL
     1020      1030      1040      1050      1060      1070        

             840       850       860       870       880       890 
pF1KA0 KSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS
                                                                   
CCDS54 KNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDS
     1080      1090      1100      1110      1120      1130        

>--
 initn: 1257 init1: 780 opt: 1211  Z-score: 659.9  bits: 134.0 E(32554): 2e-30
Smith-Waterman score: 1211; 82.3% identity (93.5% similar) in 215 aa overlap (823-1037:1070-1276)

            800       810       820       830       840       850  
pF1KA0 HNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFK
                                     ::::::::::..::.:::::::::::::::
CCDS54 HNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFK
    1040      1050      1060      1070      1080      1090         

            860       870       880       890       900       910  
pF1KA0 SFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQ
       ::..: :::::::::::::::::::.:: .:::..:::::. ::::.:.:.. :      
CCDS54 SFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN------
    1100      1110      1120      1130      1140      1150         

            920       930       940       950       960       970  
pF1KA0 CSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTM
         : ::::.:::.:::::.:::::::::::::::::::::::::::::::::::.::: :
CCDS54 --ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIM
            1160      1170      1180      1190      1200      1210 

            980       990      1000      1010      1020      1030  
pF1KA0 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::.:.
CCDS54 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRN
            1220      1230      1240      1250      1260      1270 

            
pF1KA0 SLLSW
       :...:
CCDS54 SMMNW
            

>>CCDS54677.1 TNIK gene_id:23043|Hs108|chr3               (1297 aa)
 initn: 4564 init1: 2071 opt: 2311  Z-score: 1242.1  bits: 241.8 E(32554): 7.2e-63
Smith-Waterman score: 3110; 54.7% identity (64.6% similar) in 1074 aa overlap (1-801:1-1069)

               10        20        30        40        50        60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
       ::.::::.:: .::::.::::::::::::.::::::::::::::::::::::::::::: 
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
       ::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
       :::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
       :::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
       ::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
       :::::::::.::::::::::::::::::::::  .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
              310       320       330         340       350        

              370                                      380         
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
         :::::::::::::                               :.::: ::      
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
      360       370       380       390       400       410        

                                                                   
pF1KA0 ------------------------------------------------------------
                                                                   
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRK
      420       430       440       450       460       470        

                                            390                    
pF1KA0 ----------------QERS-----------------KPSFHAPE---------------
                       :::.                 :: .:  :               
CCDS54 QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIP
      480       490       500       510       520       530        

                                                   400             
pF1KA0 ------------------------------------------PKAHYEPA----------
                                                 :. . .:.          
CCDS54 HLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRI
      540       550       560       570       580       590        

                        410       420       430       440       450
pF1KA0 ---DRAR----------EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRL
          ::.           .:: :::: ::.:.:..:: .::.     ..:   .:. . : 
CCDS54 EKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRR
      600       610       620       630       640       650        

              460       470           480       490       500      
pF1KA0 LWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQR
           .:. . : .:::::.::. .:::    ::.::::.::.:: :::..:::::::   
CCDS54 TEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLP
      660       670       680       690       700       710        

        510       520       530       540          550       560   
pF1KA0 LENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGT
        : :  :::..... :: .::   :::::::::: .   :  :: .:::::::::::: .
CCDS54 HEPAKVKPEESRDITRPSRPA---DLTALAKELRELRIEETNRPMKKVTDYSSSSEESES
      720       730          740       750       760       770     

           570                                  580       590      
pF1KA0 TDEEDDDVEQE--------------------GADES-------TSGPEDTRAAS-SLNLS
       ..::..: :.:                    :..:.       : : : ..: : : ..:
CCDS54 SEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSIS
         780       790       800       810       820       830     

               600       610                      620       630    
pF1KA0 -NG-----ETESVKTMIVHDDVES---------------EPAMTPSKEGTLIVRQTQSAS
        .:     :: . :    :.: ..                :: ::..    .  ..:  .
CCDS54 REGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMD
         840       850       860       870       880       890     

          640          650       660           670       680       
pF1KA0 STLQKHKSSS---SFTPFIDPRLLQISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTR
       :  .   .::   :::::.:::. : ::..        .... :. . .: :  . . .:
CCDS54 SGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEAR
         900       910       920       930       940       950     

       690       700       710       720       730       740       
pF1KA0 KGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGK
       : ::::::::: ::.::::::::::::::::::::::::::::::::.::::::::::::
CCDS54 KISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK
         960       970       980       990      1000      1010     

       750       760       770       780       790       800       
pF1KA0 VYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTV
       :: ::::::::::::::::::::::::::.::::::::::::.:::::::::::      
CCDS54 VYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITV
        1020      1030      1040      1050      1060      1070     

       810       820       830       840       850       860       
pF1KA0 GDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLT
                                                                   
CCDS54 GDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLT
        1080      1090      1100      1110      1120      1130     

>--
 initn: 1402 init1: 780 opt: 1356  Z-score: 736.6  bits: 148.2 E(32554): 1e-34
Smith-Waterman score: 1356; 83.1% identity (93.6% similar) in 236 aa overlap (802-1037:1070-1297)

             780       790       800       810       820       830 
pF1KA0 ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIAL
                                     ::: ::::::::.:::::::::::::::::
CCDS54 ISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIAL
    1040      1050      1060      1070      1080      1090         

             840       850       860       870       880       890 
pF1KA0 KSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS
       :..::.:::::::::::::::::..: :::::::::::::::::::.:: .:::..::::
CCDS54 KNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDS
    1100      1110      1120      1130      1140      1150         

             900       910       920       930       940       950 
pF1KA0 GSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKD
       :. ::::.:.:.. :        : ::::.:::.:::::.::::::::::::::::::::
CCDS54 GNSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKD
    1160      1170              1180      1190      1200      1210 

             960       970       980       990      1000      1010 
pF1KA0 VVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
       :::::::::::::::.::: ::::::::::::::::::::::::::::::::::::::::
CCDS54 VVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
            1220      1230      1240      1250      1260      1270 

            1020      1030       
pF1KA0 FFASVRSGGSSQVYFMTLGRTSLLSW
       :::::::::::::.::::.:.:...:
CCDS54 FFASVRSGGSSQVFFMTLNRNSMMNW
            1280      1290       

>>CCDS54678.1 TNIK gene_id:23043|Hs108|chr3               (1305 aa)
 initn: 4614 init1: 2071 opt: 2311  Z-score: 1242.1  bits: 241.8 E(32554): 7.3e-63
Smith-Waterman score: 3051; 54.2% identity (64.2% similar) in 1071 aa overlap (1-793:1-1069)

               10        20        30        40        50        60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
       ::.::::.:: .::::.::::::::::::.::::::::::::::::::::::::::::: 
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
       ::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
       :::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
       :::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
       ::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
       :::::::::.::::::::::::::::::::::  .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
              310       320       330         340       350        

              370                                      380         
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
         :::::::::::::                               :.::: ::      
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
      360       370       380       390       400       410        

                                                                   
pF1KA0 QER---------------------------------------------------------
       :::                                                         
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRK
      420       430       440       450       460       470        

                                            390                    
pF1KA0 ------------------------------------SKPSFHAPE---------------
                                           .:: .:  :               
CCDS54 QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIP
      480       490       500       510       520       530        

                                                   400             
pF1KA0 ------------------------------------------PKAHYEPA----------
                                                 :. . .:.          
CCDS54 HLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRI
      540       550       560       570       580       590        

                        410       420       430       440       450
pF1KA0 ---DRAR----------EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRL
          ::.           .:: :::: ::.:.:..:: .::.     ..:   .:. . : 
CCDS54 EKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRR
      600       610       620       630       640       650        

              460       470           480       490       500      
pF1KA0 LWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQR
           .:. . : .:::::.::. .:::    ::.::::.::.:: :::..:::::::   
CCDS54 TEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLP
      660       670       680       690       700       710        

        510       520            530       540          550        
pF1KA0 LENAVKKPEDKKEVFRPLKPAG-----EVDLTALAKELRAV---EDVRPPHKVTDYSSSS
        : :  :::..... :: .::.     . :::::::::: .   :  :: .:::::::::
CCDS54 HEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSS
      720       730       740       750       760       770        

      560       570                                  580       590 
pF1KA0 EESGTTDEEDDDVEQE--------------------GADES-------TSGPEDTRAAS-
       ::: ...::..: :.:                    :..:.       : : : ..: : 
CCDS54 EESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSF
      780       790       800       810       820       830        

                    600       610                      620         
pF1KA0 SLNLS-NG-----ETESVKTMIVHDDVES---------------EPAMTPSKEGTLIVRQ
       : ..: .:     :: . :    :.: ..                :: ::..    .  .
CCDS54 SGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTH
      840       850       860       870       880       890        

     630       640          650       660           670       680  
pF1KA0 TQSASSTLQKHKSSS---SFTPFIDPRLLQISPSS----GTTVTSVVGFSCDGMRPEAIR
       .:  .:  .   .::   :::::.:::. : ::..        .... :. . .: :  .
CCDS54 SQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK
      900       910       920       930       940       950        

            690       700       710       720       730       740  
pF1KA0 QDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDR
        . .:: ::::::::: ::.::::::::::::::::::::::::::::::::.:::::::
CCDS54 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR
      960       970       980       990      1000      1010        

            750       760       770       780       790       800  
pF1KA0 SGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQ
       ::::::: ::::::::::::::::::::::::::.::::::::::::.:::         
CCDS54 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ
     1020      1030      1040      1050      1060      1070        

            810       820       830       840       850       860  
pF1KA0 GWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPL
                                                                   
CCDS54 GWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPL
     1080      1090      1100      1110      1120      1130        

>--
 initn: 1471 init1: 780 opt: 1410  Z-score: 765.1  bits: 153.5 E(32554): 2.7e-36
Smith-Waterman score: 1410; 83.6% identity (93.9% similar) in 244 aa overlap (794-1037:1070-1305)

           770       780       790       800       810       820   
pF1KA0 EGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYER
                                     ::::::::::: ::::::::.:::::::::
CCDS54 EGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYER
    1040      1050      1060      1070      1080      1090         

           830       840       850       860       870       880   
pF1KA0 IKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAG
       :::::::::..::.:::::::::::::::::..: :::::::::::::::::::.:: .:
CCDS54 IKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTG
    1100      1110      1120      1130      1140      1150         

           890       900       910       920       930       940   
pF1KA0 FHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVN
       ::..:::::. ::::.:.:.. :        : ::::.:::.:::::.::::::::::::
CCDS54 FHVIDVDSGNSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVN
    1160      1170      1180              1190      1200      1210 

           950       960       970       980       990      1000   
pF1KA0 TYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKF
       :::::::::::::::::::::::.::: ::::::::::::::::::::::::::::::::
CCDS54 TYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKF
            1220      1230      1240      1250      1260      1270 

          1010      1020      1030       
pF1KA0 LCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
       :::::::::::::::::::::.::::.:.:...:
CCDS54 LCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
            1280      1290      1300     

>>CCDS54675.1 TNIK gene_id:23043|Hs108|chr3               (1323 aa)
 initn: 4564 init1: 2071 opt: 2311  Z-score: 1242.0  bits: 241.8 E(32554): 7.3e-63
Smith-Waterman score: 2891; 52.6% identity (62.3% similar) in 1074 aa overlap (1-775:1-1069)

               10        20        30        40        50        60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
       ::.::::.:: .::::.::::::::::::.::::::::::::::::::::::::::::: 
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
       ::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
       :::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
       :::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
       ::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
       :::::::::.::::::::::::::::::::::  .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
              310       320       330         340       350        

              370                                      380         
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
         :::::::::::::                               :.::: ::      
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
      360       370       380       390       400       410        

                                                                   
pF1KA0 -----------------------------------------------QERS---------
                                                      :::.         
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR
      420       430       440       450       460       470        

               390                                                 
pF1KA0 --------KPSFHAPE------------------------------------------PK
               :: .:  :                                          :.
CCDS54 QEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPR
      480       490       500       510       520       530        

                                                  400              
pF1KA0 A-------------------------------------------HYEPA-----------
       .                                           : .:.           
CCDS54 SESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN
      540       550       560       570       580       590        

                                                  410       420    
pF1KA0 -----------------------------DRAR----------EVPVRTTSRSPVLSRRD
                                    ::.           .:: :::: ::.:.:..
CCDS54 VTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKN
      600       610       620       630       640       650        

          430       440       450       460       470           480
pF1KA0 SPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSH
       :: .::.     ..:   .:. . :     .:. . : .:::::.::. .:::    ::.
CCDS54 SPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQ
      660       670       680       690       700       710        

              490       500       510       520       530       540
pF1KA0 PGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELR
       ::::.::.:: :::..:::::::    : :  :::..... :: .::   ::::::::::
CCDS54 PGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAKELR
      720       730       740       750       760          770     

                 550       560       570                           
pF1KA0 AV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE--------------------GAD
        .   :  :: .:::::::::::: ...::..: :.:                    :..
CCDS54 ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN
         780       790       800       810       820       830     

              580       590              600       610             
pF1KA0 ES-------TSGPEDTRAAS-SLNLS-NG-----ETESVKTMIVHDDVES----------
       :.       : : : ..: : : ..: .:     :: . :    :.: ..          
CCDS54 EQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDL
         840       850       860       870       880       890     

                620       630       640          650       660     
pF1KA0 -----EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTPFIDPRLLQISPSS----
             :: ::..    .  ..:  .:  .   .::   :::::.:::. : ::..    
CCDS54 VQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEE
         900       910       920       930       940       950     

             670       680       690       700       710       720 
pF1KA0 GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILC
           .... :. . .: :  . . .:: ::::::::: ::.:::::::::::::::::::
CCDS54 DEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILC
         960       970       980       990      1000      1010     

             730       740       750       760       770       780 
pF1KA0 AALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRV
       :::::::::::::.:::::::::::::: :::::::::::::::::::::::::      
CCDS54 AALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRV
        1020      1030      1040      1050      1060      1070     

             790       800       810       820       830       840 
pF1KA0 YYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWA
                                                                   
CCDS54 YYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWA
        1080      1090      1100      1110      1120      1130     

>--
 initn: 1577 init1: 780 opt: 1524  Z-score: 825.4  bits: 164.7 E(32554): 1.2e-39
Smith-Waterman score: 1524; 84.0% identity (94.3% similar) in 262 aa overlap (776-1037:1070-1323)

         750       760       770       780       790       800     
pF1KA0 GKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWT
                                     :.::::::::::::.:::::::::::::: 
CCDS54 GKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWI
    1040      1050      1060      1070      1080      1090         

         810       820       830       840       850       860     
pF1KA0 TVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVD
       ::::::::.::::::::::::::::::..::.:::::::::::::::::..: :::::::
CCDS54 TVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVD
    1100      1110      1120      1130      1140      1150         

         870       880       890       900       910       920     
pF1KA0 LTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPN
       ::::::::::::.:: .:::..:::::. ::::.:.:.. :        : ::::.:::.
CCDS54 LTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN--------ITPHAIVILPK
    1160      1170      1180      1190      1200              1210 

         930       940       950       960       970       980     
pF1KA0 TDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVE
       :::::.:::::::::::::::::::::::::::::::::::.::: ::::::::::::::
CCDS54 TDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVE
            1220      1230      1240      1250      1260      1270 

         990      1000      1010      1020      1030       
pF1KA0 TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
       :::::::::::::::::::::::::::::::::::::::.::::.:.:...:
CCDS54 TGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
            1280      1290      1300      1310      1320   

>>CCDS54676.1 TNIK gene_id:23043|Hs108|chr3               (1331 aa)
 initn: 4614 init1: 2071 opt: 2311  Z-score: 1242.0  bits: 241.8 E(32554): 7.4e-63
Smith-Waterman score: 2842; 52.0% identity (61.9% similar) in 1071 aa overlap (1-767:1-1069)

               10        20        30        40        50        60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
       ::.::::.:: .::::.::::::::::::.::::::::::::::::::::::::::::: 
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
       ::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
       :::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
       :::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
       ::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
       :::::::::.::::::::::::::::::::::  .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
              310       320       330         340       350        

              370                                      380         
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
         :::::::::::::                               :.::: ::      
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
      360       370       380       390       400       410        

                                                                   
pF1KA0 QER---------------------------------------------------------
       :::                                                         
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR
      420       430       440       450       460       470        

               390                                                 
pF1KA0 -------SKPSFHAPE------------------------------------------PK
              .:: .:  :                                          :.
CCDS54 QEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPR
      480       490       500       510       520       530        

                                                  400              
pF1KA0 A-------------------------------------------HYEPA-----------
       .                                           : .:.           
CCDS54 SESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN
      540       550       560       570       580       590        

                                                  410       420    
pF1KA0 -----------------------------DRAR----------EVPVRTTSRSPVLSRRD
                                    ::.           .:: :::: ::.:.:..
CCDS54 VTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKN
      600       610       620       630       640       650        

          430       440       450       460       470           480
pF1KA0 SPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSH
       :: .::.     ..:   .:. . :     .:. . : .:::::.::. .:::    ::.
CCDS54 SPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQ
      660       670       680       690       700       710        

              490       500       510       520            530     
pF1KA0 PGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG-----EVDLTAL
       ::::.::.:: :::..:::::::    : :  :::..... :: .::.     . :::::
CCDS54 PGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTAL
      720       730       740       750       760       770        

         540          550       560       570                      
pF1KA0 AKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE------------------
       ::::: .   :  :: .:::::::::::: ...::..: :.:                  
CCDS54 AKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTG
      780       790       800       810       820       830        

                   580       590              600       610        
pF1KA0 --GADES-------TSGPEDTRAAS-SLNLS-NG-----ETESVKTMIVHDDVES-----
         :..:.       : : : ..: : : ..: .:     :: . :    :.: ..     
CCDS54 APGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHI
      840       850       860       870       880       890        

                     620       630       640          650       660
pF1KA0 ----------EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTPFIDPRLLQISPS
                  :: ::..    .  ..:  .:  .   .::   :::::.:::. : ::.
CCDS54 NLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPT
      900       910       920       930       940       950        

                  670       680       690       700       710      
pF1KA0 S----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFN
       .        .... :. . .: :  . . .:: ::::::::: ::.::::::::::::::
CCDS54 DEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFN
      960       970       980       990      1000      1010        

        720       730       740       750       760       770      
pF1KA0 SEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKK
       ::::::::::::::::::.:::::::::::::: :::::::::::::::::         
CCDS54 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKK
     1020      1030      1040      1050      1060      1070        

        780       790       800       810       820       830      
pF1KA0 DKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVE
                                                                   
CCDS54 NKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVE
     1080      1090      1100      1110      1120      1130        

>--
 initn: 1635 init1: 824 opt: 1568  Z-score: 848.7  bits: 169.0 E(32554): 6e-41
Smith-Waterman score: 1568; 84.8% identity (94.4% similar) in 270 aa overlap (768-1037:1070-1331)

       740       750       760       770       780       790       
pF1KA0 MLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPE
                                     :::::::::.::::::::::::.:::::::
CCDS54 MLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPE
    1040      1050      1060      1070      1080      1090         

       800       810       820       830       840       850       
pF1KA0 VEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGEL
       ::::::: ::::::::.::::::::::::::::::..::.:::::::::::::::::..:
CCDS54 VEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADL
    1100      1110      1120      1130      1140      1150         

       860       870       880       890       900       910       
pF1KA0 VHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHVRKNPHSMIQCSIKP
        :::::::::::::::::::.:: .:::..:::::. ::::.:.:        :: .: :
CCDS54 QHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSH--------IQGNITP
    1160      1170      1180      1190      1200              1210 

       920       930       940       950       960       970       
pF1KA0 HAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEK
       :::.:::.:::::.:::::::::::::::::::::::::::::::::::.::: ::::::
CCDS54 HAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEK
            1220      1230      1240      1250      1260      1270 

       980       990      1000      1010      1020      1030       
pF1KA0 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
       :::::::::::::::::::::::::::::::::::::::::::::::.::::.:.:...:
CCDS54 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
            1280      1290      1300      1310      1320      1330 

>>CCDS54679.1 TNIK gene_id:23043|Hs108|chr3               (1352 aa)
 initn: 4564 init1: 2071 opt: 2311  Z-score: 1241.9  bits: 241.8 E(32554): 7.4e-63
Smith-Waterman score: 2661; 50.0% identity (59.7% similar) in 1074 aa overlap (1-746:1-1069)

               10        20        30        40        50        60
pF1KA0 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
       ::.::::.:: .::::.::::::::::::.::::::::::::::::::::::::::::: 
CCDS54 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
       ::::::: ::::::::::::::::::::::::.::: :::::::::::::::.:::.:::
CCDS54 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
       :::::::.::::: :::::::.::: :.::::::::::::::::::::::::::::::::
CCDS54 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
       :::::::::::::::::::::::::::::::..::::: :::::::::::::::::::::
CCDS54 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
       ::::::::: :::::::::::: ::::.:::::. :::.::::.::::::::::::::::
CCDS54 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
       :::::::::.::::::::::::::::::::::  .. ::::::.:.::::::::::::::
CCDS54 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ
              310       320       330         340       350        

              370                                      380         
pF1KA0 QENKERSEALRRQQL-------------------------------LQEQQLRE------
         :::::::::::::                               :.::: ::      
CCDS54 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ
      360       370       380       390       400       410        

                                                                   
pF1KA0 QER---------------------------------------------------------
       :::                                                         
CCDS54 QEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRK
      420       430       440       450       460       470        

                                            390                    
pF1KA0 ------------------------------------SKPSFHAPE---------------
                                           .:: .:  :               
CCDS54 QLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVE
      480       490       500       510       520       530        

                                                                   
pF1KA0 ---------------------------PKA------------------------------
                                  :..                              
CCDS54 ERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAV
      540       550       560       570       580       590        

                   400                                             
pF1KA0 -------------HYEPA----------------------------------------DR
                    : .:.                                        ::
CCDS54 KSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDR
      600       610       620       630       640       650        

                   410       420       430       440       450     
pF1KA0 AR----------EVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERV
       .           .:: :::: ::.:.:..:: .::.     ..:   .:. . :     .
CCDS54 SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL
      660       670       680       690       700       710        

         460       470           480       490       500       510 
pF1KA0 EKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAV
       :. . : .:::::.::. .:::    ::.::::.::.:: :::..:::::::    : : 
CCDS54 ESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK
      720       730       740       750       760       770        

             520       530       540          550       560        
pF1KA0 KKPEDKKEVFRPLKPAGEVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEED
        :::..... :: .::   :::::::::: .   :  :: .:::::::::::: ...::.
CCDS54 VKPEESRDITRPSRPA---DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEE
      780       790          800       810       820       830     

      570                                  580       590           
pF1KA0 DDVEQE--------------------GADES-------TSGPEDTRAAS-SLNLS-NG--
       .: :.:                    :..:.       : : : ..: : : ..: .:  
CCDS54 EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTL
         840       850       860       870       880       890     

          600       610                      620       630         
pF1KA0 ---ETESVKTMIVHDDVES---------------EPAMTPSKEGTLIVRQTQSASSTLQK
          :: . :    :.: ..                :: ::..    .  ..:  .:  . 
CCDS54 MIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEY
         900       910       920       930       940       950     

     640          650       660           670       680       690  
pF1KA0 HKSSS---SFTPFIDPRLLQISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVV
         .::   :::::.:::. : ::..        .... :. . .: :  . . .:: :::
CCDS54 GMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVV
         960       970       980       990      1000      1010     

            700       710       720       730       740       750  
pF1KA0 NVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLI
       :::::: ::.::::::::::::::::::::::::::::::::.:::::::::::      
CCDS54 NVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLI
        1020      1030      1040      1050      1060      1070     

            760       770       780       790       800       810  
pF1KA0 NRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEG
                                                                   
CCDS54 NRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEG
        1080      1090      1100      1110      1120      1130     

>--
 initn: 1763 init1: 952 opt: 1696  Z-score: 916.3  bits: 181.6 E(32554): 1e-44
Smith-Waterman score: 1696; 85.2% identity (94.5% similar) in 291 aa overlap (747-1037:1070-1352)

        720       730       740       750       760       770      
pF1KA0 SEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKK
                                     ::: ::::::::::::::::::::::::::
CCDS54 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKK
    1040      1050      1060      1070      1080      1090         

        780       790       800       810       820       830      
pF1KA0 DKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVE
       .::::::::::::.:::::::::::::: ::::::::.::::::::::::::::::..::
CCDS54 NKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVE
    1100      1110      1120      1130      1140      1150         

        840       850       860       870       880       890      
pF1KA0 VYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYD
       .:::::::::::::::::..: :::::::::::::::::::.:: .:::..:::::. ::
CCDS54 IYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYD
    1160      1170      1180      1190      1200      1210         

        900       910       920       930       940       950      
pF1KA0 IYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQW
       ::.:.:.. :        : ::::.:::.:::::.:::::::::::::::::::::::::
CCDS54 IYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQW
    1220              1230      1240      1250      1260      1270 

        960       970       980       990      1000      1010      
pF1KA0 GEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASV
       ::::::::::.::: :::::::::::::::::::::::::::::::::::::::::::::
CCDS54 GEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASV
            1280      1290      1300      1310      1320      1330 

       1020      1030       
pF1KA0 RSGGSSQVYFMTLGRTSLLSW
       ::::::::.::::.:.:...:
CCDS54 RSGGSSQVFFMTLNRNSMMNW
            1340      1350  




1037 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 19:32:52 2016 done: Wed Nov  2 19:32:53 2016
 Total Scan time:  4.640 Total Display time:  0.470

Function used was FASTA [36.3.4 Apr, 2011]
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