Result of FASTA (omim) for pF1KA0418
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0418, 940 aa
  1>>>pF1KA0418 940 - 940 aa - 940 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 11.3953+/-0.000392; mu= -6.8560+/- 0.025
 mean_var=298.1450+/-61.837, 0's: 0 Z-trim(122.0): 60  B-trim: 346 in 1/57
 Lambda= 0.074278
 statistics sampled from 39306 (39369) to 39306 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.747), E-opt: 0.2 (0.462), width:  16
 Scan time: 13.330

The best scores are:                                      opt bits E(85289)
NP_001295104 (OMIM: 249420,613293) SH3 and PX doma ( 430)  620 80.3 2.2e-14
NP_001017995 (OMIM: 249420,613293) SH3 and PX doma ( 911)  522 70.0 6.2e-11
XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3  ( 939)  522 70.0 6.3e-11
NP_000256 (OMIM: 233700,608512) neutrophil cytosol ( 390)  384 55.0 8.5e-07


>>NP_001295104 (OMIM: 249420,613293) SH3 and PX domain-c  (430 aa)
 initn: 877 init1: 345 opt: 620  Z-score: 379.0  bits: 80.3 E(85289): 2.2e-14
Smith-Waterman score: 817; 48.8% identity (68.4% similar) in 285 aa overlap (1-283:152-396)

                                             10        20        30
pF1KA0                               MILEQYVVVSNYKKQENSELSLQAGEVVDV
                                     :.:::::::.::.:::.::.::..:.:::.
NP_001 FETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDI
             130       140       150       160       170       180 

               40        50        60        70        80        90
pF1KA0 IEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKD
       :::::::::::::.::::::::: ::.:.:..:. ...     :::::... :::....:
NP_001 IEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPE---EEEKYTVIYPYTARDQD
             190       200       210       220          230        

              100       110       120       130       140       150
pF1KA0 EIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGN
       :...:.:..::::.::::::: ::: :::::::::::::          : . :.     
NP_001 EMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKK----------NSGEPL-----
      240       250       260       270                 280        

              160       170       180       190       200       210
pF1KA0 IMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLA
                         ::  : :  .:     ..:  .   .:  :::   . .:   
NP_001 ------------------PPKPGPG--SPSHPGALDLDGVSRQQN--AVGREKELLSSQR
                             290         300         310       320 

              220       230       240         250       260        
pF1KA0 QGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--GFQLPKPPEPPSVEVEYYTIAEFQS
       .:      .    :.  ::..: ::::::. ..  :..::::: ::.:: :::::::::.
NP_001 DGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQT
             330       340       350       360       370       380 

      270       280       290       300       310       320        
pF1KA0 CISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPK
        : :::::..: :.:                                             
NP_001 TIPDGISFQAGLKVEDHKNVHLESPVEVPLRRIKMRTALGKHVAASMEM           
             390       400       410       420       430           

>>NP_001017995 (OMIM: 249420,613293) SH3 and PX domain-c  (911 aa)
 initn: 1222 init1: 370 opt: 522  Z-score: 317.3  bits: 70.0 E(85289): 6.2e-11
Smith-Waterman score: 1244; 32.1% identity (54.2% similar) in 951 aa overlap (1-939:152-910)

                                             10        20        30
pF1KA0                               MILEQYVVVSNYKKQENSELSLQAGEVVDV
                                     :.:::::::.::.:::.::.::..:.:::.
NP_001 FETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDI
             130       140       150       160       170       180 

               40        50        60        70        80        90
pF1KA0 IEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKD
       :::::::::::::.::::::::: ::.:.:..:. ..   .  :::::... :::....:
NP_001 IEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSL---QPEEEEKYTVIYPYTARDQD
             190       200       210          220       230        

              100       110       120       130       140       150
pF1KA0 EIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGN
       :...:.:..::::.::::::: ::: :::::::::::::          : . :.     
NP_001 EMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKK----------NSGEPL-----
      240       250       260       270                 280        

              160       170       180       190       200       210
pF1KA0 IMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLA
                         ::  : :  .:     ..:  .   .:  :::   . .:   
NP_001 ------------------PPKPGPG--SPSHPGALDLDGVSRQQN--AVGREKELLSSQR
                             290         300         310       320 

              220       230       240         250       260        
pF1KA0 QGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--GFQLPKPPEPPSVEVEYYTIAEFQS
       .:      .    :.  ::..: ::::::. ..  :..::::: ::.:: :::::::::.
NP_001 DGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQT
             330       340       350       360       370       380 

      270       280       290       300       310       320        
pF1KA0 CISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPK
        : :::::..: :.:::.:: .::::.:: .:::::::..::: ::      ::. .::.
NP_001 TIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKK------TSNASRPN
             390       400       410       420             430     

      330       340       350       360       370       380        
pF1KA0 VPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEE-----PV
          : :  .  . . : ..: :.. . .     .:  : :   .::    :..      :
NP_001 FLAPLP-HEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDV
         440        450       460       470       480       490    

           390       400       410       420       430       440   
pF1KA0 EDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSAR
         .::..   .  ..     .... . ..   .:..   :  . : :  :  .:.    :
NP_001 LRKASSDMSASAGYEEISDPDMEE-KPSLPPRKESIIKSEGELLERERERQRTEQL---R
          500       510        520       530       540          550

           450       460       470       480       490       500   
pF1KA0 GSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITI
       : .     ::     .  :. : .   ..:   . : .:.   .. ::  .   . ..  
NP_001 GPT--PKPPGVILPMMPAKHIPPA---RDSRRPEPKPDKSRLFQL-KNDMGLECGHKVLA
                560       570          580       590        600    

           510       520       530       540       550       560   
pF1KA0 NTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSV
       . .    .. .   .::.. :: :.   ::    ::.         :  : : :...:  
NP_001 KEV----KKPNLRPISKSKTDL-PEEKPDA----TPQ---------NPFLKSRPQVRP--
              610       620            630                640      

           570       580       590       600       610       620   
pF1KA0 RPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSR
       .: :  .    :.....:: .:: .:::          .::.:. :         .:: .
NP_001 KPAPSPKTEPPQGEDQVDICNLRSKLRP----------AKSQDKSL-------LDGEGPQ
          650       660       670                 680              

           630       640       650       660       670       680   
pF1KA0 RSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESG
         ... ...  .  :       :::.          ..::                    
NP_001 AVGGQDVAFSRSFLPG------EGPG----------RAQD--------------------
       690       700                       710                     

           690       700       710       720       730       740   
pF1KA0 WWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKIERRVQAL
           : :. .: .:..   ..    : :. :  : :        .::  .         :
NP_001 ----RTGKQDGLSPKE---ISCRAPPRPA-KTTDPV--------SKSVPVP--------L
                 720          730                740               

           750       760        770          780       790         
pF1KA0 NTVNQSKKATPPIPSKPPGGFGKTS-GTPAVK---MRNGVRQVAVRPQSVFVSPPPKDNN
       . . :.. ..::    ::   ...:   : :.    ..   ..:  :  ... ::     
NP_001 QEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPF
       750       760       770       780       790       800       

     800       810       820       830       840       850         
pF1KA0 LSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNS
       ::      .:: . :  ::    . ..:..       :.  :.::.             :
NP_001 LS------NSLGGQDDTRGKGSLGPWGTGK------IGENREKAAAA------------S
             810       820       830             840               

     860       870       880        890       900       910        
pF1KA0 IPVSPVRPKPIEKSQFIHNNLKD-VYVSIADYEGDEETAGFQEGVSMEVLERNPNGWWYC
       .: .              ..::: .::..::.:::..:..::::. .:: :.: .:::.:
NP_001 VPNA--------------DGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFC
                         850       860       870       880         

      920       930       940
pF1KA0 QILDGVKPFKGWVPSNYLEKKN
       :.:.:.  ..::.:::::.:: 
NP_001 QVLSGAPSWEGWIPSNYLRKKP
     890       900       910 

>>XP_016864840 (OMIM: 249420,613293) PREDICTED: SH3 and   (939 aa)
 initn: 1229 init1: 370 opt: 522  Z-score: 317.1  bits: 70.0 E(85289): 6.3e-11
Smith-Waterman score: 1198; 31.2% identity (53.0% similar) in 976 aa overlap (1-939:152-938)

                                             10        20        30
pF1KA0                               MILEQYVVVSNYKKQENSELSLQAGEVVDV
                                     :.:::::::.::.:::.::.::..:.:::.
XP_016 FETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDI
             130       140       150       160       170       180 

               40        50        60                              
pF1KA0 IEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDD-------------------------S
       :::::::::::::.::::::::: ::.:.:..:.                         .
XP_016 IEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEVSWRYWSLPRPVGRRRTLG
             190       200       210       220       230       240 

          70        80        90       100       110       120     
pF1KA0 DINTSKTGEEEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPAS
       :. . .  .::::... :::....::...:.:..::::.::::::: ::: :::::::::
XP_016 DLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPAS
             250       260       270       280       290       300 

         130       140       150       160       170       180     
pF1KA0 YLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEI
       ::::          : . :.                       ::  : :  .:     .
XP_016 YLKK----------NSGEPL-----------------------PPKPGPG--SPSHPGAL
                       310                                320      

         190       200       210       220       230       240     
pF1KA0 SLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSL--
       .:  .   .:  :::   . .:   .:      .    :.  ::..: ::::::. ..  
XP_016 DLDGVSRQQN--AVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPR
        330         340       350       360       370       380    

           250       260       270       280       290       300   
pF1KA0 GFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGW
       :..::::: ::.:: :::::::::. : :::::..: :.:::.:: .::::.:: .::::
XP_016 GLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGW
          390       400       410       420       430       440    

           310       320       330       340       350       360   
pF1KA0 APASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEP
       :::..::: ::      ::. .::.   : :  .  . . : ..: :.. . .     .:
XP_016 APATFIDKYKK------TSNASRPNFLAPLP-HEVTQLRLGEAAALENNTGSEATGPSRP
          450             460        470       480       490       

           370       380            390       400       410        
pF1KA0 EYDIPAFGFDSEPELSEE-----PVEDRASGERRPAQPHRPSPASSLQRARFKVGESSED
         : :   .::    :..      :  .::..   .  ..     .... . ..   .:.
XP_016 LPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEE-KPSLPPRKES
       500       510       520       530       540        550      

      420       430       440       450       460       470        
pF1KA0 VALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKL
       .   :  . : :  :  .:.    :: .     ::     .  :. : .   ..:   . 
XP_016 IIKSEGELLERERERQRTEQL---RGPT--PKPPGVILPMMPAKHIPPA---RDSRRPEP
        560       570          580         590       600           

      480       490       500       510       520       530        
pF1KA0 KAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGT
       : .:.   .. ::  .   . ..  . .    .. .   .::.. :: :.   ::    :
XP_016 KPDKSRLFQL-KNDMGLECGHKVLAKEV----KKPNLRPISKSKTDL-PEEKPDA----T
      610        620       630           640       650             

      540       550       560       570       580       590        
pF1KA0 PKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGG
       :.         :  : : :...:  .: :  .    :.....:: .:: .:::       
XP_016 PQ---------NPFLKSRPQVRP--KPAPSPKTEPPQGEDQVDICNLRSKLRP-------
      660                670         680       690       700       

      600       610       620       630       640       650        
pF1KA0 LKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAY
          .::.:. :         .:: .  ... ...  .  :       :::.         
XP_016 ---AKSQDKSL-------LDGEGPQAVGGQDVAFSRSFLPG------EGPG---------
                        710       720       730                    

      660       670       680       690       700       710        
pF1KA0 QKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDT
        ..::                        : :. .: .:..   ..    : :. :  : 
XP_016 -RAQD------------------------RTGKQDGLSPKE---ISCRAPPRPA-KTTDP
                                  740       750          760       

      720       730       740       750       760        770       
pF1KA0 VPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGGFGKTS-GTPAVK---
       :        .::  .         :. . :.. ..::    ::   ...:   : :.   
XP_016 V--------SKSVPVP--------LQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQ
                770               780       790       800       810

          780       790       800       810       820       830    
pF1KA0 MRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAE
        ..   ..:  :  ... ::     ::      .:: . :  ::    . ..:..     
XP_016 CEGHESRAAPTPGRALLVPPKAKPFLS------NSLGGQDDTRGKGSLGPWGTGK-----
              820       830             840       850              

          840       850       860       870       880        890   
pF1KA0 AKGRLAERAASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIHNNLKD-VYVSIADYEGD
         :.  :.::.             :.: .              ..::: .::..::.:::
XP_016 -IGENREKAAAA------------SVPNA--------------DGLKDSLYVAVADFEGD
      860       870                                 880       890  

           900       910       920       930       940
pF1KA0 EETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN
       ..:..::::. .:: :.: .:::.::.:.:.  ..::.:::::.:: 
XP_016 KDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP
            900       910       920       930         

>>NP_000256 (OMIM: 233700,608512) neutrophil cytosol fac  (390 aa)
 initn: 385 init1: 235 opt: 384  Z-score: 243.0  bits: 55.0 E(85289): 8.5e-07
Smith-Waterman score: 384; 38.3% identity (73.0% similar) in 141 aa overlap (1-141:156-294)

                                             10        20        30
pF1KA0                               MILEQYVVVSNYKKQENSELSLQAGEVVDV
                                     .::. : ...::.:  .::..:..:.::.:
NP_000 KLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTGDVVEV
         130       140       150       160       170       180     

               40        50        60        70        80        90
pF1KA0 IEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEEEKYVTVQPYTSQSKD
       .::.:::::: . . ..::.::..::  ..  .  : . . .::   ::... ::.   :
NP_000 VEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGE--PYVAIKAYTAVEGD
         190       200       210       220         230       240   

              100       110       120       130       140       150
pF1KA0 EIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGN
       :... .: .::::.: :.::: ::     :. :. ::.:. .:.   ....         
NP_000 EVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPPRRS
           250       260       270       280       290       300   

              160       170       180       190       200       210
pF1KA0 IMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLA
                                                                   
NP_000 SIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSKPQP
           310       320       330       340       350       360   




940 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 18:52:48 2016 done: Wed Nov  2 18:52:49 2016
 Total Scan time: 13.330 Total Display time:  0.040

Function used was FASTA [36.3.4 Apr, 2011]
Inquiries or Suggestions ?
Send a message to flexiclone AT kazusagt.com