Result of FASTA (omim) for pF1KA0267
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0267, 669 aa
  1>>>pF1KA0267 669 - 669 aa - 669 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.5451+/-0.000405; mu= 17.5937+/- 0.025
 mean_var=64.3562+/-13.177, 0's: 0 Z-trim(110.6): 73  B-trim: 1085 in 1/52
 Lambda= 0.159874
 statistics sampled from 18930 (19010) to 18930 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.579), E-opt: 0.2 (0.223), width:  16
 Scan time:  7.660

The best scores are:                                      opt bits E(85289)
NP_006350 (OMIM: 300231,300243) sodium/hydrogen ex ( 669) 4408 1026.1       0
NP_001317581 (OMIM: 300231,300243) sodium/hydrogen ( 617) 4040 941.2       0
XP_016884714 (OMIM: 300231,300243) PREDICTED: sodi ( 617) 4040 941.2       0
NP_001171122 (OMIM: 300231,300243) sodium/hydrogen ( 649) 3471 810.0       0
XP_006724789 (OMIM: 300231,300243) PREDICTED: sodi ( 649) 3471 810.0       0
XP_016884712 (OMIM: 300231,300243) PREDICTED: sodi ( 649) 3471 810.0       0
XP_016884713 (OMIM: 300231,300243) PREDICTED: sodi ( 649) 3471 810.0       0
NP_001036002 (OMIM: 300231,300243) sodium/hydrogen ( 701) 3471 810.0       0
XP_016861692 (OMIM: 608396,613410) PREDICTED: sodi ( 528) 2153 505.9 1.5e-142
NP_775924 (OMIM: 608396,613410) sodium/hydrogen ex ( 645) 2150 505.3 2.9e-142
XP_016885395 (OMIM: 300368) PREDICTED: sodium/hydr ( 706) 2064 485.5 2.9e-136
XP_006724627 (OMIM: 300368) PREDICTED: sodium/hydr ( 706) 2064 485.5 2.9e-136
XP_005272738 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 2038 479.5 1.9e-134
XP_005272739 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 2038 479.5 1.9e-134
NP_001244220 (OMIM: 300368) sodium/hydrogen exchan ( 726) 2038 479.5 1.9e-134
XP_011542292 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 2038 479.5 1.9e-134
XP_016885394 (OMIM: 300368) PREDICTED: sodium/hydr ( 726) 2038 479.5 1.9e-134
NP_115980 (OMIM: 300368) sodium/hydrogen exchanger ( 725) 2007 472.3 2.7e-132
XP_016861691 (OMIM: 608396,613410) PREDICTED: sodi ( 578) 1906 449.0 2.3e-125
XP_011511005 (OMIM: 608396,613410) PREDICTED: sodi ( 429) 1682 397.3 6.3e-110
XP_011511006 (OMIM: 608396,613410) PREDICTED: sodi ( 369)  973 233.7 9.3e-61
NP_056081 (OMIM: 612730) sodium/hydrogen exchanger ( 581)  889 214.4 9.4e-55
NP_001247420 (OMIM: 612730) sodium/hydrogen exchan ( 597)  758 184.2 1.2e-45
NP_003039 (OMIM: 600530) sodium/hydrogen exchanger ( 812)  682 166.7   3e-40
NP_004165 (OMIM: 182307,616868) sodium/hydrogen ex ( 834)  670 164.0 2.1e-39
NP_001011552 (OMIM: 600531) sodium/hydrogen exchan ( 798)  664 162.6 5.2e-39
NP_001271280 (OMIM: 182307,616868) sodium/hydrogen ( 825)  659 161.4 1.2e-38
XP_016879083 (OMIM: 600477) PREDICTED: sodium/hydr ( 544)  649 159.0 4.1e-38
NP_003038 (OMIM: 107310,616291) sodium/hydrogen ex ( 815)  651 159.6 4.3e-38
NP_001310900 (OMIM: 600477) sodium/hydrogen exchan ( 675)  649 159.1   5e-38
XP_011540323 (OMIM: 107310,616291) PREDICTED: sodi ( 705)  649 159.1 5.2e-38
NP_001310902 (OMIM: 600477) sodium/hydrogen exchan ( 895)  649 159.1 6.4e-38
NP_004585 (OMIM: 600477) sodium/hydrogen exchanger ( 896)  649 159.1 6.4e-38
XP_011527041 (OMIM: 612730) PREDICTED: sodium/hydr ( 589)  613 150.8 1.4e-35
XP_011509460 (OMIM: 600531) PREDICTED: sodium/hydr ( 769)  547 135.6 6.7e-31
XP_011527039 (OMIM: 612730) PREDICTED: sodium/hydr ( 602)  543 134.6   1e-30
XP_011527045 (OMIM: 612730) PREDICTED: sodium/hydr ( 334)  531 131.8 4.2e-30
XP_016883245 (OMIM: 612730) PREDICTED: sodium/hydr ( 334)  531 131.8 4.2e-30
XP_011527044 (OMIM: 612730) PREDICTED: sodium/hydr ( 395)  531 131.8 4.8e-30
XP_016883244 (OMIM: 612730) PREDICTED: sodium/hydr ( 395)  531 131.8 4.8e-30
XP_011527042 (OMIM: 612730) PREDICTED: sodium/hydr ( 564)  531 131.8 6.6e-30
XP_016883243 (OMIM: 612730) PREDICTED: sodium/hydr ( 565)  531 131.8 6.6e-30
XP_006723819 (OMIM: 612730) PREDICTED: sodium/hydr ( 614)  531 131.9 7.1e-30
XP_011527038 (OMIM: 612730) PREDICTED: sodium/hydr ( 630)  531 131.9 7.3e-30
NP_001310901 (OMIM: 600477) sodium/hydrogen exchan ( 795)  502 125.2 9.2e-28
XP_011527046 (OMIM: 612730) PREDICTED: sodium/hydr ( 304)  457 114.7 5.3e-25
XP_011527040 (OMIM: 612730) PREDICTED: sodium/hydr ( 591)  435 109.7 3.2e-23
XP_011527043 (OMIM: 612730) PREDICTED: sodium/hydr ( 558)  244 65.6 5.5e-10
NP_001310903 (OMIM: 600477) sodium/hydrogen exchan ( 600)  233 63.1 3.4e-09
NP_001310904 (OMIM: 600477) sodium/hydrogen exchan ( 601)  233 63.1 3.4e-09


>>NP_006350 (OMIM: 300231,300243) sodium/hydrogen exchan  (669 aa)
 initn: 4408 init1: 4408 opt: 4408  Z-score: 5489.5  bits: 1026.1 E(85289):    0
Smith-Waterman score: 4408; 100.0% identity (100.0% similar) in 669 aa overlap (1-669:1-669)

               10        20        30        40        50        60
pF1KA0 MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 KQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 KQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 HVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSIL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSIL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 AYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFH
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KA0 ELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFS
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KA0 GSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGI
              310       320       330       340       350       360

              370       380       390       400       410       420
pF1KA0 TQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVA
              370       380       390       400       410       420

              430       440       450       460       470       480
pF1KA0 IFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFS
              430       440       450       460       470       480

              490       500       510       520       530       540
pF1KA0 TTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYN
              490       500       510       520       530       540

              550       560       570       580       590       600
pF1KA0 FDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISL
              550       560       570       580       590       600

              610       620       630       640       650       660
pF1KA0 TYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNL
              610       620       630       640       650       660

                
pF1KA0 LDNTRHGPA
       :::::::::
NP_006 LDNTRHGPA
                

>>NP_001317581 (OMIM: 300231,300243) sodium/hydrogen exc  (617 aa)
 initn: 4040 init1: 4040 opt: 4040  Z-score: 5031.4  bits: 941.2 E(85289):    0
Smith-Waterman score: 4040; 100.0% identity (100.0% similar) in 617 aa overlap (53-669:1-617)

             30        40        50        60        70        80  
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
                                     ::::::::::::::::::::::::::::::
NP_001                               MDEEIVSEKQAEESHRQDSANLLIFILLLT
                                             10        20        30

             90       100       110       120       130       140  
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
               40        50        60        70        80        90

            150       160       170       180       190       200  
pF1KA0 LVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCV
              100       110       120       130       140       150

            210       220       230       240       250       260  
pF1KA0 TLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAV
              160       170       180       190       200       210

            270       280       290       300       310       320  
pF1KA0 AIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKL
              220       230       240       250       260       270

            330       340       350       360       370       380  
pF1KA0 REFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLF
              280       290       300       310       320       330

            390       400       410       420       430       440  
pF1KA0 ELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRS
              340       350       360       370       380       390

            450       460       470       480       490       500  
pF1KA0 KIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLS
              400       410       420       430       440       450

            510       520       530       540       550       560  
pF1KA0 CLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLP
              460       470       480       490       500       510

            570       580       590       600       610       620  
pF1KA0 ACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMG
              520       530       540       550       560       570

            630       640       650       660         
pF1KA0 NSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
       :::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
              580       590       600       610       

>>XP_016884714 (OMIM: 300231,300243) PREDICTED: sodium/h  (617 aa)
 initn: 4040 init1: 4040 opt: 4040  Z-score: 5031.4  bits: 941.2 E(85289):    0
Smith-Waterman score: 4040; 100.0% identity (100.0% similar) in 617 aa overlap (53-669:1-617)

             30        40        50        60        70        80  
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
                                     ::::::::::::::::::::::::::::::
XP_016                               MDEEIVSEKQAEESHRQDSANLLIFILLLT
                                             10        20        30

             90       100       110       120       130       140  
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
               40        50        60        70        80        90

            150       160       170       180       190       200  
pF1KA0 LVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCV
              100       110       120       130       140       150

            210       220       230       240       250       260  
pF1KA0 TLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAV
              160       170       180       190       200       210

            270       280       290       300       310       320  
pF1KA0 AIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKL
              220       230       240       250       260       270

            330       340       350       360       370       380  
pF1KA0 REFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLF
              280       290       300       310       320       330

            390       400       410       420       430       440  
pF1KA0 ELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRS
              340       350       360       370       380       390

            450       460       470       480       490       500  
pF1KA0 KIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLS
              400       410       420       430       440       450

            510       520       530       540       550       560  
pF1KA0 CLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLHIRVGVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLP
              460       470       480       490       500       510

            570       580       590       600       610       620  
pF1KA0 ACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMG
              520       530       540       550       560       570

            630       640       650       660         
pF1KA0 NSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
       :::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
              580       590       600       610       

>>NP_001171122 (OMIM: 300231,300243) sodium/hydrogen exc  (649 aa)
 initn: 3470 init1: 3470 opt: 3471  Z-score: 4321.7  bits: 810.0 E(85289):    0
Smith-Waterman score: 3966; 95.1% identity (95.1% similar) in 649 aa overlap (53-669:1-649)

             30        40        50        60        70        80  
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
                                     ::::::::::::::::::::::::::::::
NP_001                               MDEEIVSEKQAEESHRQDSANLLIFILLLT
                                             10        20        30

             90       100       110       120       130       140  
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
               40        50        60        70        80        90

                                            150       160       170
pF1KA0 LV--------------------------------TFDPEVFFNILLPPIIFYAGYSLKRR
       ::                                ::::::::::::::::::::::::::
NP_001 LVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRR
              100       110       120       130       140       150

              180       190       200       210       220       230
pF1KA0 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
              160       170       180       190       200       210

              240       250       260       270       280       290
pF1KA0 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
              220       230       240       250       260       270

              300       310       320       330       340       350
pF1KA0 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
              280       290       300       310       320       330

              360       370       380       390       400       410
pF1KA0 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
              340       350       360       370       380       390

              420       430       440       450       460       470
pF1KA0 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
              400       410       420       430       440       450

              480       490       500       510       520       530
pF1KA0 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
              460       470       480       490       500       510

              540       550       560       570       580       590
pF1KA0 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
              520       530       540       550       560       570

              600       610       620       630       640       650
pF1KA0 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
              580       590       600       610       620       630

              660         
pF1KA0 MDDSEPPLNLLDNTRHGPA
       :::::::::::::::::::
NP_001 MDDSEPPLNLLDNTRHGPA
              640         

>>XP_006724789 (OMIM: 300231,300243) PREDICTED: sodium/h  (649 aa)
 initn: 3470 init1: 3470 opt: 3471  Z-score: 4321.7  bits: 810.0 E(85289):    0
Smith-Waterman score: 3966; 95.1% identity (95.1% similar) in 649 aa overlap (53-669:1-649)

             30        40        50        60        70        80  
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
                                     ::::::::::::::::::::::::::::::
XP_006                               MDEEIVSEKQAEESHRQDSANLLIFILLLT
                                             10        20        30

             90       100       110       120       130       140  
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
               40        50        60        70        80        90

                                            150       160       170
pF1KA0 LV--------------------------------TFDPEVFFNILLPPIIFYAGYSLKRR
       ::                                ::::::::::::::::::::::::::
XP_006 LVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRR
              100       110       120       130       140       150

              180       190       200       210       220       230
pF1KA0 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
              160       170       180       190       200       210

              240       250       260       270       280       290
pF1KA0 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
              220       230       240       250       260       270

              300       310       320       330       340       350
pF1KA0 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
              280       290       300       310       320       330

              360       370       380       390       400       410
pF1KA0 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
              340       350       360       370       380       390

              420       430       440       450       460       470
pF1KA0 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
              400       410       420       430       440       450

              480       490       500       510       520       530
pF1KA0 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
              460       470       480       490       500       510

              540       550       560       570       580       590
pF1KA0 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
              520       530       540       550       560       570

              600       610       620       630       640       650
pF1KA0 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
              580       590       600       610       620       630

              660         
pF1KA0 MDDSEPPLNLLDNTRHGPA
       :::::::::::::::::::
XP_006 MDDSEPPLNLLDNTRHGPA
              640         

>>XP_016884712 (OMIM: 300231,300243) PREDICTED: sodium/h  (649 aa)
 initn: 3470 init1: 3470 opt: 3471  Z-score: 4321.7  bits: 810.0 E(85289):    0
Smith-Waterman score: 3966; 95.1% identity (95.1% similar) in 649 aa overlap (53-669:1-649)

             30        40        50        60        70        80  
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
                                     ::::::::::::::::::::::::::::::
XP_016                               MDEEIVSEKQAEESHRQDSANLLIFILLLT
                                             10        20        30

             90       100       110       120       130       140  
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
               40        50        60        70        80        90

                                            150       160       170
pF1KA0 LV--------------------------------TFDPEVFFNILLPPIIFYAGYSLKRR
       ::                                ::::::::::::::::::::::::::
XP_016 LVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRR
              100       110       120       130       140       150

              180       190       200       210       220       230
pF1KA0 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
              160       170       180       190       200       210

              240       250       260       270       280       290
pF1KA0 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
              220       230       240       250       260       270

              300       310       320       330       340       350
pF1KA0 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
              280       290       300       310       320       330

              360       370       380       390       400       410
pF1KA0 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
              340       350       360       370       380       390

              420       430       440       450       460       470
pF1KA0 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
              400       410       420       430       440       450

              480       490       500       510       520       530
pF1KA0 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
              460       470       480       490       500       510

              540       550       560       570       580       590
pF1KA0 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
              520       530       540       550       560       570

              600       610       620       630       640       650
pF1KA0 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
              580       590       600       610       620       630

              660         
pF1KA0 MDDSEPPLNLLDNTRHGPA
       :::::::::::::::::::
XP_016 MDDSEPPLNLLDNTRHGPA
              640         

>>XP_016884713 (OMIM: 300231,300243) PREDICTED: sodium/h  (649 aa)
 initn: 3470 init1: 3470 opt: 3471  Z-score: 4321.7  bits: 810.0 E(85289):    0
Smith-Waterman score: 3966; 95.1% identity (95.1% similar) in 649 aa overlap (53-669:1-649)

             30        40        50        60        70        80  
pF1KA0 RLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLT
                                     ::::::::::::::::::::::::::::::
XP_016                               MDEEIVSEKQAEESHRQDSANLLIFILLLT
                                             10        20        30

             90       100       110       120       130       140  
pF1KA0 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTL
               40        50        60        70        80        90

                                            150       160       170
pF1KA0 LV--------------------------------TFDPEVFFNILLPPIIFYAGYSLKRR
       ::                                ::::::::::::::::::::::::::
XP_016 LVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRR
              100       110       120       130       140       150

              180       190       200       210       220       230
pF1KA0 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSAT
              160       170       180       190       200       210

              240       250       260       270       280       290
pF1KA0 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFK
              220       230       240       250       260       270

              300       310       320       330       340       350
pF1KA0 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFT
              280       290       300       310       320       330

              360       370       380       390       400       410
pF1KA0 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFN
              340       350       360       370       380       390

              420       430       440       450       460       470
pF1KA0 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDT
              400       410       420       430       440       450

              480       490       500       510       520       530
pF1KA0 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAE
              460       470       480       490       500       510

              540       550       560       570       580       590
pF1KA0 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSD
              520       530       540       550       560       570

              600       610       620       630       640       650
pF1KA0 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLP
              580       590       600       610       620       630

              660         
pF1KA0 MDDSEPPLNLLDNTRHGPA
       :::::::::::::::::::
XP_016 MDDSEPPLNLLDNTRHGPA
              640         

>>NP_001036002 (OMIM: 300231,300243) sodium/hydrogen exc  (701 aa)
 initn: 3470 init1: 3470 opt: 3471  Z-score: 4321.2  bits: 810.0 E(85289):    0
Smith-Waterman score: 4334; 95.4% identity (95.4% similar) in 701 aa overlap (1-669:1-701)

               10        20        30        40        50        60
pF1KA0 MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARRGWRRAPLRRGVGSSPRARRLMRPLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 KQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI
               70        80        90       100       110       120

              130       140                                        
pF1KA0 HVPSDVNNVTLSCEVQSSPTTLLV--------------------------------TFDP
       ::::::::::::::::::::::::                                ::::
NP_001 HVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYMLKGEISSHELNNVQDNEMLRKVTFDP
              130       140       150       160       170       180

      150       160       170       180       190       200        
pF1KA0 EVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVT
              190       200       210       220       230       240

      210       220       230       240       250       260        
pF1KA0 GQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSS
              250       260       270       280       290       300

      270       280       290       300       310       320        
pF1KA0 SIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLL
              310       320       330       340       350       360

      330       340       350       360       370       380        
pF1KA0 ETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFL
              370       380       390       400       410       420

      390       400       410       420       430       440        
pF1KA0 AENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AENFIFSYMGLTLFTFQNHVFNPTFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNF
              430       440       450       460       470       480

      450       460       470       480       490       500        
pF1KA0 QHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRV
              490       500       510       520       530       540

      510       520       530       540       550       560        
pF1KA0 GVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVDSDQEHLGVPENERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPI
              550       560       570       580       590       600

      570       580       590       600       610       620        
pF1KA0 ARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTEPATSSAPRRFMGNSSEDA
              610       620       630       640       650       660

      630       640       650       660         
pF1KA0 LDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
       :::::::::::::::::::::::::::::::::::::::::
NP_001 LDRELAFGDHELVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
              670       680       690       700 

>>XP_016861692 (OMIM: 608396,613410) PREDICTED: sodium/h  (528 aa)
 initn: 2076 init1: 1464 opt: 2153  Z-score: 2680.2  bits: 505.9 E(85289): 1.5e-142
Smith-Waterman score: 2166; 65.1% identity (84.5% similar) in 516 aa overlap (143-645:9-521)

            120       130       140       150       160       170  
pF1KA0 GLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVTFDPEVFFNILLPPIIFYAGYSLKRRHF
                                     ..:::::.:::.:::::::.::::::.:::
XP_016                       MKLEEQWCMMTFDPEIFFNVLLPPIIFHAGYSLKKRHF
                                     10        20        30        

            180       190       200       210        220       230 
pF1KA0 FRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLA-GDFYFTDCLLFGAIVSATD
       :.::::::.::::::::::.::: :::: :  :  .:::  :::.:::::.::...::::
XP_016 FQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKNGDFHFTDCLFFGSLMSATD
       40        50        60        70        80        90        

             240       250       260       270       280       290 
pF1KA0 PVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKS
       :::::::::::.:: .::.::::::::::::::::. ::  :.:  .: ..::..:.:.:
XP_016 PVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK-ENPNAFDAAAFFQS
      100       110       120       130       140        150       

             300       310       320       330       340       350 
pF1KA0 IGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTG
       .: :::::.::::::.: ...:::.:::::: :: .::::::::.:::.:: ::: :.::
XP_016 VGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLETGLFFLLSWSAFLSAEAAGLTG
       160       170       180       190       200       210       

             360       370       380       390       400       410 
pF1KA0 VVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNP
       .:::::::.:::::::::::..:. :::::::..:::::: :: ::::.:::::::.:: 
XP_016 IVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNA
       220       230       240       250       260       270       

             420       430       440       450       460       470 
pF1KA0 TFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTA
        :..:::.:::..:: ::::::.::::::..::  ::::::::.:::::.:::::::.: 
XP_016 LFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTE
       280       290       300       310       320       330       

             480       490       500       510               520   
pF1KA0 TYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQ--------EHLGVPENE
       .  .::::.::::.::::::::::::: ::. :.:::::: :.        .:  . . .
XP_016 SQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSSQHQEANNLD
       340       350       360       370       380       390       

           530       540       550       560       570       580   
pF1KA0 RRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQ
       .  :::::: ::::::.:::.::::.:::::::::::::  ::::.: :::::::   ::
XP_016 KNMTKAESARLFRMWYSFDHKYLKPILTHSGPPLTTTLPEWCGPISRLLTSPQAY--GEQ
       400       410       420       430       440       450       

           590       600         610       620         630         
pF1KA0 LKDDDSDLILNDGDISLTYGD--STVNTEPATSSAPRRFMGNS--SEDALDRELAFGDHE
       ::.:: . :.:. .....: .  :.  . ::  .  ..   ..  .:.  . .:..: .:
XP_016 LKEDDVECIVNQDELAINYQEQASSPCSPPARLGLDQKASPQTPGKENIYEGDLGLGGYE
         460       470       480       490       500       510     

     640       650       660         
pF1KA0 LVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
       : .. :                        
XP_016 LKLEQTLGQSQLN                 
         520                         

>>NP_775924 (OMIM: 608396,613410) sodium/hydrogen exchan  (645 aa)
 initn: 2340 init1: 1464 opt: 2150  Z-score: 2675.1  bits: 505.3 E(85289): 2.9e-142
Smith-Waterman score: 2372; 60.2% identity (80.0% similar) in 636 aa overlap (57-645:7-638)

         30        40        50        60        70        80      
pF1KA0 PLWLLLAVGVFDWAGASDGGGGEARAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTIL
                                     ..:::.  . ..: ...::.: .:: ::::
NP_775                         MERQSRVMSEKDEYQFQHQGAVELLVFNFLLILTIL
                                       10        20        30      

         90       100       110       120       130         140    
pF1KA0 TIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTL-SC-EVQSSPTTLLV
       ::::::..: ::::::: ::.:::..::.:::.  .:.:... :. .: ..  ::.::::
NP_775 TIWLFKNHRFRFLHETGGAMVYGLIMGLILRYAT-APTDIESGTVYDCVKLTFSPSTLLV
         40        50        60        70         80        90     

                                          150       160       170  
pF1KA0 --------------------------------TFDPEVFFNILLPPIIFYAGYSLKRRHF
                                       :::::.:::.:::::::.::::::.:::
NP_775 NITDQVYEYKYKREISQHNINPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHF
         100       110       120       130       140       150     

            180       190       200       210        220       230 
pF1KA0 FRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLA-GDFYFTDCLLFGAIVSATD
       :.::::::.::::::::::.::: :::: :  :  .:::  :::.:::::.::...::::
NP_775 FQNLGSILTYAFLGTAISCIVIGLIMYGFVKAMIHAGQLKNGDFHFTDCLFFGSLMSATD
         160       170       180       190       200       210     

             240       250       260       270       280       290 
pF1KA0 PVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKS
       :::::::::::.:: .::.::::::::::::::::. ::  :.:  .: ..::..:.:.:
NP_775 PVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPK-ENPNAFDAAAFFQS
         220       230       240       250       260        270    

             300       310       320       330       340       350 
pF1KA0 IGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTG
       .: :::::.::::::.: ...:::.:::::: :: .::::::::.:::.:: ::: :.::
NP_775 VGNFLGIFAGSFAMGSAYAIITALLTKFTKLCEFPMLETGLFFLLSWSAFLSAEAAGLTG
          280       290       300       310       320       330    

             360       370       380       390       400       410 
pF1KA0 VVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNP
       .:::::::.:::::::::::..:. :::::::..:::::: :: ::::.:::::::.:: 
NP_775 IVAVLFCGVTQAHYTYNNLSSDSKIRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNA
          340       350       360       370       380       390    

             420       430       440       450       460       470 
pF1KA0 TFVVGAFVAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTA
        :..:::.:::..:: ::::::.::::::..::  ::::::::.:::::.:::::::.: 
NP_775 LFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTE
          400       410       420       430       440       450    

             480       490       500       510               520   
pF1KA0 TYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQ--------EHLGVPENE
       .  .::::.::::.::::::::::::: ::. :.:::::: :.        .:  . . .
NP_775 SQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDENLKEDPSSQHQEANNLD
          460       470       480       490       500       510    

           530       540       550       560       570       580   
pF1KA0 RRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQ
       .  :::::: ::::::.:::.::::.:::::::::::::  ::::.: :::::::   ::
NP_775 KNMTKAESARLFRMWYSFDHKYLKPILTHSGPPLTTTLPEWCGPISRLLTSPQAY--GEQ
          520       530       540       550       560         570  

           590       600         610       620         630         
pF1KA0 LKDDDSDLILNDGDISLTYGD--STVNTEPATSSAPRRFMGNS--SEDALDRELAFGDHE
       ::.:: . :.:. .....: .  :.  . ::  .  ..   ..  .:.  . .:..: .:
NP_775 LKEDDVECIVNQDELAINYQEQASSPCSPPARLGLDQKASPQTPGKENIYEGDLGLGGYE
            580       590       600       610       620       630  

     640       650       660         
pF1KA0 LVIRGTRLVLPMDDSEPPLNLLDNTRHGPA
       : .. :                        
NP_775 LKLEQTLGQSQLN                 
            640                      




669 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 18:27:57 2016 done: Wed Nov  2 18:27:58 2016
 Total Scan time:  7.660 Total Display time:  0.170

Function used was FASTA [36.3.4 Apr, 2011]
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