Result of FASTA (omim) for pF1KA0116
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KA0116, 291 aa
  1>>>pF1KA0116 291 - 291 aa - 291 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.3318+/-0.000373; mu= 14.5236+/- 0.023
 mean_var=59.1456+/-11.930, 0's: 0 Z-trim(111.2): 27  B-trim: 151 in 2/55
 Lambda= 0.166768
 statistics sampled from 19766 (19779) to 19766 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.603), E-opt: 0.2 (0.232), width:  16
 Scan time:  6.650

The best scores are:                                      opt bits E(85289)
NP_055819 (OMIM: 606488) exosome complex component ( 291) 1904 466.6 2.4e-131
XP_016861419 (OMIM: 606488) PREDICTED: exosome com ( 210) 1345 332.1 5.6e-91
NP_852480 (OMIM: 606019,616081) exosome complex co ( 276)  374 98.5 1.5e-20
XP_011530337 (OMIM: 606180) PREDICTED: exosome com ( 392)  375 98.8 1.8e-20
NP_005024 (OMIM: 606180) exosome complex component ( 439)  375 98.8 1.9e-20
XP_006719826 (OMIM: 606019,616081) PREDICTED: exos ( 313)  373 98.3   2e-20
NP_001029366 (OMIM: 606180) exosome complex compon ( 456)  375 98.8   2e-20


>>NP_055819 (OMIM: 606488) exosome complex component RRP  (291 aa)
 initn: 1904 init1: 1904 opt: 1904  Z-score: 2478.9  bits: 466.6 E(85289): 2.4e-131
Smith-Waterman score: 1904; 99.7% identity (100.0% similar) in 291 aa overlap (1-291:1-291)

               10        20        30        40        50        60
pF1KA0 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KA0 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KA0 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KA0 ELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMR
              190       200       210       220       230       240

              250       260       270       280       290 
pF1KA0 KVGKGSLDPESIFEMMETGKRVGKVLHASLQSVLHKEESLGPKRQKVGFLG
       :::::::::::::::::::::::::::::::::.:::::::::::::::::
NP_055 KVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG
              250       260       270       280       290 

>>XP_016861419 (OMIM: 606488) PREDICTED: exosome complex  (210 aa)
 initn: 1345 init1: 1345 opt: 1345  Z-score: 1754.3  bits: 332.1 E(85289): 5.6e-91
Smith-Waterman score: 1345; 99.5% identity (100.0% similar) in 206 aa overlap (86-291:5-210)

          60        70        80        90       100       110     
pF1KA0 TDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNN
                                     ::::::::::::::::::::::::::::::
XP_016                           MASSSASATPEFEGRGGDDLGTEIANTLYRIFNN
                                         10        20        30    

         120       130       140       150       160       170     
pF1KA0 KSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEE
           40        50        60        70        80        90    

         180       190       200       210       220       230     
pF1KA0 GSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGV
          100       110       120       130       140       150    

         240       250       260       270       280       290 
pF1KA0 VTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVLHKEESLGPKRQKVGFLG
       ::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_016 VTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG
          160       170       180       190       200       210

>>NP_852480 (OMIM: 606019,616081) exosome complex compon  (276 aa)
 initn: 391 init1: 316 opt: 374  Z-score: 489.9  bits: 98.5 E(85289): 1.5e-20
Smith-Waterman score: 374; 28.9% identity (62.8% similar) in 266 aa overlap (18-276:18-276)

               10        20        30        40        50        60
pF1KA0 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
                        ..:. : :::   ..: . :.   .:...::: ::::.: .. 
NP_852 MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVIC
               10        20        30        40        50        60

               70        80        90        100       110         
pF1KA0 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFE-GRGGDDLGTEIANTLYR-IFNNKSS
       :::::...:. . :..::.   ::     . .:. :  :..  ...:. .   ...:.. 
NP_852 GVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEE--AQVASQFIADVIENSQI
               70        80        90       100         110        

      120       130       140       150       160       170        
pF1KA0 VDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSK
       .. . ::::: .  :::: :.. :.  ::..:: ..:. ::: :...:.: . : : .  
NP_852 IQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINE-ETALA
      120       130       140       150       160       170        

      180       190       200       210        220       230       
pF1KA0 DIELSDDPYDCIRLSVENVPCIVTLCKIGYRH-VVDATLQEEACSLASLLVSVTSKGVVT
       ...:.   :    :.... :  ...  .     .:: : .::  . ..: . .  .: . 
NP_852 EVNLKKKSY----LNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLC
       180           190       200       210       220       230   

       240       250           260       270       280       290 
pF1KA0 CMRKVGKGSLDPESIFEMMETG----KRVGKVLHASLQSVLHKEESLGPKRQKVGFLG
       :..: : ..:   .. . :  .    :.: :..   ..:.  :               
NP_852 CLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK               
           240       250       260       270                     

>>XP_011530337 (OMIM: 606180) PREDICTED: exosome complex  (392 aa)
 initn: 355 init1: 262 opt: 375  Z-score: 488.7  bits: 98.8 E(85289): 1.8e-20
Smith-Waterman score: 375; 28.9% identity (60.2% similar) in 294 aa overlap (1-289:1-284)

               10        20        30        40        50        60
pF1KA0 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
       :  . ::. :. .......:  :.:::   ::: ...     ..  :   :.::.: .: 
XP_011 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRIS---FGTDYGCCIVELGKTRVLG
               10        20        30           40        50       

               70        80        90       100       110       120
pF1KA0 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
        :. :. .:::.. .:: : : .. :  :.: ::    .:: ...   . : . :.. .:
XP_011 QVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCID
        60        70        80        90       100       110       

              130       140       150       160       170       180
pF1KA0 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
        ..::.   :. : . ::. ::.  ::..:: :::. .:: . : : : :  ::     .
XP_011 TESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDE-----V
       120       130       140       150       160       170       

               190        200        210       220       230       
pF1KA0 EL-SDDPYDCIRLSVENVP-CI-VTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVT
        : . .  : . ::....: :.  .. . :   .:: . .::   . .::: . .:    
XP_011 TLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERV-MDGLLVIAMNKHREI
            180       190       200       210        220       230 

        240       250        260       270       280       290     
pF1KA0 C-MRKVGKGSLDPESIFEMME-TGKRVGKVLHASLQSVLHKEESLGPKRQKVGFLG    
       : ... :   :  .....  . .: .:... .  :.. :......  .  : ::      
XP_011 CTIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKA-LENDQKVRKEGGKFGFAESIAN
             240       250       260        270       280       290

XP_011 QRITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDL
              300       310       320       330       340       350

>>NP_005024 (OMIM: 606180) exosome complex component RRP  (439 aa)
 initn: 355 init1: 262 opt: 375  Z-score: 487.9  bits: 98.8 E(85289): 1.9e-20
Smith-Waterman score: 375; 28.9% identity (60.2% similar) in 294 aa overlap (1-289:1-284)

               10        20        30        40        50        60
pF1KA0 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
       :  . ::. :. .......:  :.:::   ::: ...     ..  :   :.::.: .: 
NP_005 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRIS---FGTDYGCCIVELGKTRVLG
               10        20        30           40        50       

               70        80        90       100       110       120
pF1KA0 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
        :. :. .:::.. .:: : : .. :  :.: ::    .:: ...   . : . :.. .:
NP_005 QVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCID
        60        70        80        90       100       110       

              130       140       150       160       170       180
pF1KA0 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
        ..::.   :. : . ::. ::.  ::..:: :::. .:: . : : : :  ::     .
NP_005 TESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDE-----V
       120       130       140       150       160       170       

               190        200        210       220       230       
pF1KA0 EL-SDDPYDCIRLSVENVP-CI-VTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVT
        : . .  : . ::....: :.  .. . :   .:: . .::   . .::: . .:    
NP_005 TLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERV-MDGLLVIAMNKHREI
            180       190       200       210        220       230 

        240       250        260       270       280       290     
pF1KA0 C-MRKVGKGSLDPESIFEMME-TGKRVGKVLHASLQSVLHKEESLGPKRQKVGFLG    
       : ... :   :  .....  . .: .:... .  :.. :......  .  : ::      
NP_005 CTIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKA-LENDQKVRKEGGKFGFAESIAN
             240       250       260        270       280       290

NP_005 QRITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDL
              300       310       320       330       340       350

>>XP_006719826 (OMIM: 606019,616081) PREDICTED: exosome   (313 aa)
 initn: 378 init1: 303 opt: 373  Z-score: 487.7  bits: 98.3 E(85289): 2e-20
Smith-Waterman score: 373; 28.7% identity (63.0% similar) in 265 aa overlap (19-276:56-313)

                           10        20        30        40        
pF1KA0             MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGS
                                     .:. : :::   ..: . :.   .:...::
XP_006 RVESAAAEQARRRGAAQAQTRGREDGGWVQKENCRPDGRELGEFRTTTVNIGSISTADGS
          30        40        50        60        70        80     

       50        60        70        80        90        100       
pF1KA0 ARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFE-GRGGDDLGTEIAN
       : ::::.: .. :::::...:. . :..::.   ::     . .:. :  :..  ...:.
XP_006 ALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEE--AQVAS
          90       100       110       120       130         140   

       110        120       130       140       150       160      
pF1KA0 TLYR-IFNNKSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIP
        .   ...:.. .. . ::::: .  :::: :.. :.  ::..:: ..:. ::: :...:
XP_006 QFIADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLP
           150       160       170       180       190       200   

        170       180       190       200       210        220     
pF1KA0 RVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRH-VVDATLQEEACSLAS
       .: . ..: .  ...:.   :    :.... :  ...  .     .:: : .::  . ..
XP_006 EVTI-NEETALAEVNLKKKSY----LNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGT
            210       220           230       240       250        

         230       240       250           260       270       280 
pF1KA0 LLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETG----KRVGKVLHASLQSVLHKEESLG
       : . .  .: . :..: : ..:   .. . :  .    :.: :..   ..:.  :     
XP_006 LTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK     
      260       270       280       290       300       310        

             290 
pF1KA0 PKRQKVGFLG

>>NP_001029366 (OMIM: 606180) exosome complex component   (456 aa)
 initn: 355 init1: 262 opt: 375  Z-score: 487.7  bits: 98.8 E(85289): 2e-20
Smith-Waterman score: 375; 28.9% identity (60.2% similar) in 294 aa overlap (1-289:1-284)

               10        20        30        40        50        60
pF1KA0 MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILV
       :  . ::. :. .......:  :.:::   ::: ...     ..  :   :.::.: .: 
NP_001 MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRIS---FGTDYGCCIVELGKTRVLG
               10        20        30           40        50       

               70        80        90       100       110       120
pF1KA0 GVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVD
        :. :. .:::.. .:: : : .. :  :.: ::    .:: ...   . : . :.. .:
NP_001 QVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLMERCLRNSKCID
        60        70        80        90       100       110       

              130       140       150       160       170       180
pF1KA0 LKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDI
        ..::.   :. : . ::. ::.  ::..:: :::. .:: . : : : :  ::     .
NP_001 TESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGDE-----V
       120       130       140       150       160       170       

               190        200        210       220       230       
pF1KA0 EL-SDDPYDCIRLSVENVP-CI-VTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVT
        : . .  : . ::....: :.  .. . :   .:: . .::   . .::: . .:    
NP_001 TLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERV-MDGLLVIAMNKHREI
            180       190       200       210        220       230 

        240       250        260       270       280       290     
pF1KA0 C-MRKVGKGSLDPESIFEMME-TGKRVGKVLHASLQSVLHKEESLGPKRQKVGFLG    
       : ... :   :  .....  . .: .:... .  :.. :......  .  : ::      
NP_001 CTIQSSGGIMLLKDQVLRCSKIAGVKVAEITELILKA-LENDQKVRKEGGKFGFAESIAN
             240       250       260        270       280       290

NP_001 QRITAFKMEKAPIDTSDVEEKAEEIIAEAEPPSEVVSTPVLWTPGTAQIGEGVENSWGDL
              300       310       320       330       340       350




291 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Wed Nov  2 18:08:56 2016 done: Wed Nov  2 18:08:57 2016
 Total Scan time:  6.650 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]
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