FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2517, 441 aa 1>>>pF1KE2517 441 - 441 aa - 441 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2396+/-0.000422; mu= 13.2176+/- 0.026 mean_var=115.6735+/-24.335, 0's: 0 Z-trim(113.7): 170 B-trim: 327 in 1/54 Lambda= 0.119250 statistics sampled from 22903 (23104) to 22903 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.629), E-opt: 0.2 (0.271), width: 16 Scan time: 8.150 The best scores are: opt bits E(85289) NP_003788 (OMIM: 605984) polycomb protein EED isof ( 441) 3073 540.2 4.1e-153 XP_016874001 (OMIM: 605984) PREDICTED: polycomb pr ( 403) 2777 489.2 8.3e-138 XP_011543633 (OMIM: 605984) PREDICTED: polycomb pr ( 415) 2224 394.1 3.7e-109 XP_011543632 (OMIM: 605984) PREDICTED: polycomb pr ( 428) 2224 394.1 3.8e-109 NP_001294936 (OMIM: 605984) polycomb protein EED i ( 466) 2224 394.1 4e-109 XP_016874002 (OMIM: 605984) PREDICTED: polycomb pr ( 323) 1655 296.1 9e-80 NP_001317263 (OMIM: 605984) polycomb protein EED i ( 361) 1655 296.1 9.7e-80 NP_004362 (OMIM: 601924,616414) coatomer subunit a (1224) 188 44.2 0.0023 NP_001091868 (OMIM: 601924,616414) coatomer subuni (1233) 188 44.2 0.0023 NP_001186706 (OMIM: 614784,615973) POC1 centriolar ( 436) 181 42.6 0.0024 NP_758440 (OMIM: 614784,615973) POC1 centriolar pr ( 478) 181 42.6 0.0026 NP_942593 (OMIM: 610767,611081) autophagy-related ( 444) 177 41.9 0.004 XP_005246143 (OMIM: 610767,611081) PREDICTED: auto ( 463) 177 41.9 0.0041 XP_005246141 (OMIM: 610767,611081) PREDICTED: auto ( 480) 177 42.0 0.0042 NP_001177196 (OMIM: 610767,611081) autophagy-relat ( 491) 177 42.0 0.0043 NP_001177195 (OMIM: 610767,611081) autophagy-relat ( 523) 177 42.0 0.0045 XP_006712671 (OMIM: 610767,611081) PREDICTED: auto ( 540) 177 42.0 0.0046 NP_060444 (OMIM: 610767,611081) autophagy-related ( 588) 177 42.0 0.0049 NP_110430 (OMIM: 610767,611081) autophagy-related ( 607) 177 42.0 0.005 XP_005246139 (OMIM: 610767,611081) PREDICTED: auto ( 624) 177 42.1 0.0051 XP_016861593 (OMIM: 614783,614813) PREDICTED: POC1 ( 321) 172 40.9 0.0057 NP_001155052 (OMIM: 614783,614813) POC1 centriolar ( 359) 172 41.0 0.0062 NP_001155053 (OMIM: 614783,614813) POC1 centriolar ( 369) 172 41.0 0.0063 NP_056241 (OMIM: 614783,614813) POC1 centriolar pr ( 407) 172 41.0 0.0068 NP_001269469 (OMIM: 604596) CMT1A duplicated regio ( 714) 174 41.6 0.0081 XP_016879510 (OMIM: 611679) PREDICTED: F-box/WD re ( 724) 174 41.6 0.0082 XP_011521928 (OMIM: 611679) PREDICTED: F-box/WD re ( 745) 174 41.6 0.0084 NP_006373 (OMIM: 604596) CMT1A duplicated region t ( 752) 174 41.6 0.0084 XP_016879509 (OMIM: 611679) PREDICTED: F-box/WD re ( 856) 174 41.7 0.0093 XP_011521927 (OMIM: 611679) PREDICTED: F-box/WD re ( 856) 174 41.7 0.0093 >>NP_003788 (OMIM: 605984) polycomb protein EED isoform (441 aa) initn: 3073 init1: 3073 opt: 3073 Z-score: 2869.8 bits: 540.2 E(85289): 4.1e-153 Smith-Waterman score: 3073; 100.0% identity (100.0% similar) in 441 aa overlap (1-441:1-441) 10 20 30 40 50 60 pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR 370 380 390 400 410 420 430 440 pF1KE2 DSSILIAVCDDASIWRWDRLR ::::::::::::::::::::: NP_003 DSSILIAVCDDASIWRWDRLR 430 440 >>XP_016874001 (OMIM: 605984) PREDICTED: polycomb protei (403 aa) initn: 2777 init1: 2777 opt: 2777 Z-score: 2595.1 bits: 489.2 E(85289): 8.3e-138 Smith-Waterman score: 2777; 100.0% identity (100.0% similar) in 399 aa overlap (1-399:1-399) 10 20 30 40 50 60 pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR ::::::::::::::::::::::::::::::::::::::: XP_016 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKANRDH 370 380 390 400 430 440 pF1KE2 DSSILIAVCDDASIWRWDRLR >>XP_011543633 (OMIM: 605984) PREDICTED: polycomb protei (415 aa) initn: 2223 init1: 2223 opt: 2224 Z-score: 2080.8 bits: 394.1 E(85289): 3.7e-109 Smith-Waterman score: 2552; 93.8% identity (93.8% similar) in 400 aa overlap (1-375:1-400) 10 20 30 40 50 60 pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 250 260 270 280 290 300 310 320 330 pF1KE2 TRDIHRNYVDCVRWLGDLILSKS-------------------------CENAIVCWKPGK ::::::::::::::::::::::: :::::::::::: XP_011 TRDIHRNYVDCVRWLGDLILSKSGRAILHSHQQCMRDPVSPNLRQHLSCENAIVCWKPGK 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE2 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED :::::::::::::::::::::::::::::::::::::::: XP_011 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKEYKTQRNSQEHRGWN 370 380 390 400 410 400 410 420 430 440 pF1KE2 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR >>XP_011543632 (OMIM: 605984) PREDICTED: polycomb protei (428 aa) initn: 2223 init1: 2223 opt: 2224 Z-score: 2080.6 bits: 394.1 E(85289): 3.8e-109 Smith-Waterman score: 2717; 94.1% identity (94.1% similar) in 424 aa overlap (1-399:1-424) 10 20 30 40 50 60 pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 250 260 270 280 290 300 310 320 330 pF1KE2 TRDIHRNYVDCVRWLGDLILSKS-------------------------CENAIVCWKPGK ::::::::::::::::::::::: :::::::::::: XP_011 TRDIHRNYVDCVRWLGDLILSKSGRAILHSHQQCMRDPVSPNLRQHLSCENAIVCWKPGK 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE2 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED 370 380 390 400 410 420 400 410 420 430 440 pF1KE2 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR :::: XP_011 PHKANRDH >>NP_001294936 (OMIM: 605984) polycomb protein EED isofo (466 aa) initn: 2223 init1: 2223 opt: 2224 Z-score: 2080.1 bits: 394.1 E(85289): 4e-109 Smith-Waterman score: 3013; 94.6% identity (94.6% similar) in 466 aa overlap (1-441:1-466) 10 20 30 40 50 60 pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS 250 260 270 280 290 300 310 320 330 pF1KE2 TRDIHRNYVDCVRWLGDLILSKS-------------------------CENAIVCWKPGK ::::::::::::::::::::::: :::::::::::: NP_001 TRDIHRNYVDCVRWLGDLILSKSGRAILHSHQQCMRDPVSPNLRQHLSCENAIVCWKPGK 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE2 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVED 370 380 390 400 410 420 400 410 420 430 440 pF1KE2 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR :::::::::::::::::::::::::::::::::::::::::::::: NP_001 PHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR 430 440 450 460 >>XP_016874002 (OMIM: 605984) PREDICTED: polycomb protei (323 aa) initn: 1677 init1: 1655 opt: 1655 Z-score: 1553.2 bits: 296.1 E(85289): 9e-80 Smith-Waterman score: 2044; 79.9% identity (79.9% similar) in 399 aa overlap (1-399:1-319) 10 20 30 40 50 60 pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :: XP_016 SA---------------------------------------------------------- 310 320 330 340 350 360 pF1KE2 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ :::::::::::::::::::::::::::::::::::::: XP_016 ----------------------SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 250 260 270 280 370 380 390 400 410 420 pF1KE2 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR ::::::::::::::::::::::::::::::::::::::: XP_016 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKANRDH 290 300 310 320 430 440 pF1KE2 DSSILIAVCDDASIWRWDRLR >>NP_001317263 (OMIM: 605984) polycomb protein EED isofo (361 aa) initn: 1655 init1: 1655 opt: 1655 Z-score: 1552.5 bits: 296.1 E(85289): 9.7e-80 Smith-Waterman score: 2340; 81.9% identity (81.9% similar) in 441 aa overlap (1-441:1-361) 10 20 30 40 50 60 pF1KE2 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS :: NP_001 SA---------------------------------------------------------- 310 320 330 340 350 360 pF1KE2 TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ :::::::::::::::::::::::::::::::::::::: NP_001 ----------------------SCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ 250 260 270 280 370 380 390 400 410 420 pF1KE2 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR 290 300 310 320 330 340 430 440 pF1KE2 DSSILIAVCDDASIWRWDRLR ::::::::::::::::::::: NP_001 DSSILIAVCDDASIWRWDRLR 350 360 >>NP_004362 (OMIM: 601924,616414) coatomer subunit alpha (1224 aa) initn: 116 init1: 67 opt: 188 Z-score: 181.4 bits: 44.2 E(85289): 0.0023 Smith-Waterman score: 206; 22.1% identity (50.3% similar) in 308 aa overlap (155-425:58-355) 130 140 150 160 170 180 pF1KE2 ECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK : . ..::.. .:. :.. : .:. NP_004 LHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLF 30 40 50 60 70 80 190 200 210 220 230 240 pF1KE2 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY .:: . : :: . : .::.: :...:.:: :. : : .. :: :. :.. NP_004 TLLGHLDYIRTTFFHHEYP-WILSASDDQTIRVWNWQSRTCVCVL---TGHNHYVMCAQF 90 100 110 120 130 140 250 260 270 280 290 300 pF1KE2 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHF--PDFSTR . ..: ..:.....: :.. : :.. . . ... :. : : .. NP_004 HPTEDLVVSASLDQTVRVWDISGLR-----KKNLSPGAVESDVRGITGVDLFGTTDAVVK 150 160 170 180 190 310 320 330 340 350 pF1KE2 DIHRNYVDCVRWLG-----DLILSKSCENAIVCWKPGKMED-DIDKIKPSESNVT----- . ... : : . ::.: . . . :. .. . ..: . .::. NP_004 HVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFH 200 210 220 230 240 250 360 370 380 pF1KE2 -----ILGRFDYSQCDIWYMR-------FSMD---FW-------QKMLALGNQVGKLYVW ::. . .. .: : : : :: ...: :.. : . :. NP_004 PRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHD-GGMIVF 260 270 280 290 300 310 390 400 410 420 430 440 pF1KE2 DLEVEDPHKAKCTTLTHHKCGAAIRQTSF--SRDSSILIAVCDDASIWRWDRLR :: : : : .. :. .:: .: :.: ... NP_004 KLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAV 320 330 340 350 360 370 NP_004 LLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLI 380 390 400 410 420 430 >>NP_001091868 (OMIM: 601924,616414) coatomer subunit al (1233 aa) initn: 116 init1: 67 opt: 188 Z-score: 181.4 bits: 44.2 E(85289): 0.0023 Smith-Waterman score: 206; 22.1% identity (50.3% similar) in 308 aa overlap (155-425:58-355) 130 140 150 160 170 180 pF1KE2 ECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK : . ..::.. .:. :.. : .:. NP_001 LHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLF 30 40 50 60 70 80 190 200 210 220 230 240 pF1KE2 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY .:: . : :: . : .::.: :...:.:: :. : : .. :: :. :.. NP_001 TLLGHLDYIRTTFFHHEYP-WILSASDDQTIRVWNWQSRTCVCVL---TGHNHYVMCAQF 90 100 110 120 130 140 250 260 270 280 290 300 pF1KE2 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHF--PDFSTR . ..: ..:.....: :.. : :.. . . ... :. : : .. NP_001 HPTEDLVVSASLDQTVRVWDISGLR-----KKNLSPGAVESDVRGITGVDLFGTTDAVVK 150 160 170 180 190 310 320 330 340 350 pF1KE2 DIHRNYVDCVRWLG-----DLILSKSCENAIVCWKPGKMED-DIDKIKPSESNVT----- . ... : : . ::.: . . . :. .. . ..: . .::. NP_001 HVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFH 200 210 220 230 240 250 360 370 380 pF1KE2 -----ILGRFDYSQCDIWYMR-------FSMD---FW-------QKMLALGNQVGKLYVW ::. . .. .: : : : :: ...: :.. : . :. NP_001 PRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHD-GGMIVF 260 270 280 290 300 310 390 400 410 420 430 440 pF1KE2 DLEVEDPHKAKCTTLTHHKCGAAIRQTSF--SRDSSILIAVCDDASIWRWDRLR :: : : : .. :. .:: .: :.: ... NP_001 KLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAV 320 330 340 350 360 370 NP_001 LLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLI 380 390 400 410 420 430 >>NP_001186706 (OMIM: 614784,615973) POC1 centriolar pro (436 aa) initn: 166 init1: 82 opt: 181 Z-score: 180.9 bits: 42.6 E(85289): 0.0024 Smith-Waterman score: 181; 28.6% identity (61.6% similar) in 112 aa overlap (155-266:151-258) 130 140 150 160 170 180 pF1KE2 ECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIK : : : .: ::: ... . . . .. NP_001 SEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 HYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADY :: :....: ..::: . : :...:.: .:.. .. :. ..:: :..... NP_001 HYQVHSGGVNCISFHP-SGNYLITASSDGTLKILDLLEGRLIYT---LQGHTGPVFTVSF 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 DLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDI . :: . : : : .. ::: : NP_001 SKGGELFASGGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEE 240 250 260 270 280 290 441 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 02:47:05 2016 done: Tue Nov 8 02:47:06 2016 Total Scan time: 8.150 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]