FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2378, 488 aa 1>>>pF1KE2378 488 - 488 aa - 488 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.1933+/-0.000436; mu= 8.7279+/- 0.027 mean_var=129.4962+/-26.440, 0's: 0 Z-trim(114.3): 118 B-trim: 1250 in 1/53 Lambda= 0.112706 statistics sampled from 23896 (24017) to 23896 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.641), E-opt: 0.2 (0.282), width: 16 Scan time: 9.320 The best scores are: opt bits E(85289) NP_001518 (OMIM: 605164) histone deacetylase 2 [Ho ( 488) 3343 555.4 1.3e-157 XP_016866288 (OMIM: 605164) PREDICTED: histone dea ( 458) 3116 518.5 1.6e-146 XP_011534090 (OMIM: 605164) PREDICTED: histone dea ( 458) 3116 518.5 1.6e-146 NP_004955 (OMIM: 601241) histone deacetylase 1 [Ho ( 482) 2880 480.1 5.8e-135 NP_003874 (OMIM: 605166) histone deacetylase 3 [Ho ( 428) 1833 309.9 9.3e-84 XP_011539611 (OMIM: 601241) PREDICTED: histone dea ( 289) 1614 274.2 3.6e-73 NP_060956 (OMIM: 300269) histone deacetylase 8 iso ( 377) 1089 188.9 2.2e-47 XP_011529288 (OMIM: 300269) PREDICTED: histone dea ( 441) 1083 187.9 4.9e-47 XP_011529289 (OMIM: 300269) PREDICTED: histone dea ( 379) 992 173.1 1.2e-42 XP_011535999 (OMIM: 605166) PREDICTED: histone dea ( 241) 933 163.4 6.6e-40 XP_016885135 (OMIM: 300269) PREDICTED: histone dea ( 274) 882 155.1 2.3e-37 NP_001159890 (OMIM: 300269) histone deacetylase 8 ( 286) 821 145.2 2.3e-34 XP_016885131 (OMIM: 300269) PREDICTED: histone dea ( 350) 816 144.5 4.8e-34 NP_001159891 (OMIM: 300269) histone deacetylase 8 ( 256) 721 128.9 1.7e-29 XP_016885130 (OMIM: 300269) PREDICTED: histone dea ( 389) 536 99.0 2.6e-20 XP_016885133 (OMIM: 300269) PREDICTED: histone dea ( 324) 530 97.9 4.5e-20 XP_016885129 (OMIM: 300269) PREDICTED: histone dea ( 415) 530 98.0 5.5e-20 XP_016885136 (OMIM: 300269) PREDICTED: histone dea ( 268) 469 88.0 3.7e-17 NP_001308156 (OMIM: 300272,300863) histone deacety (1215) 384 74.6 1.8e-12 NP_001308157 (OMIM: 300272,300863) histone deacety (1215) 384 74.6 1.8e-12 NP_001308155 (OMIM: 300272,300863) histone deacety (1215) 384 74.6 1.8e-12 NP_001308158 (OMIM: 300272,300863) histone deacety (1215) 384 74.6 1.8e-12 NP_006035 (OMIM: 300272,300863) histone deacetylas (1215) 384 74.6 1.8e-12 NP_001308154 (OMIM: 300272,300863) histone deacety (1229) 384 74.6 1.8e-12 XP_016885134 (OMIM: 300269) PREDICTED: histone dea ( 315) 374 72.6 1.9e-12 XP_016885132 (OMIM: 300269) PREDICTED: histone dea ( 341) 368 71.6 4e-12 NP_001308826 (OMIM: 606543) histone deacetylase 9 (1025) 368 71.9 9.7e-12 NP_001308806 (OMIM: 606543) histone deacetylase 9 (1025) 368 71.9 9.7e-12 XP_016868317 (OMIM: 606543) PREDICTED: histone dea (1025) 368 71.9 9.7e-12 XP_011513948 (OMIM: 606543) PREDICTED: histone dea (1035) 368 71.9 9.7e-12 XP_011513947 (OMIM: 606543) PREDICTED: histone dea (1038) 368 71.9 9.8e-12 XP_011513946 (OMIM: 606543) PREDICTED: histone dea (1038) 368 71.9 9.8e-12 XP_016868316 (OMIM: 606543) PREDICTED: histone dea (1043) 368 71.9 9.8e-12 XP_011513943 (OMIM: 606543) PREDICTED: histone dea (1043) 368 71.9 9.8e-12 XP_011513944 (OMIM: 606543) PREDICTED: histone dea (1043) 368 71.9 9.8e-12 NP_001308797 (OMIM: 606543) histone deacetylase 9 (1044) 368 71.9 9.8e-12 XP_011513936 (OMIM: 606543) PREDICTED: histone dea (1044) 368 71.9 9.8e-12 XP_016868315 (OMIM: 606543) PREDICTED: histone dea (1066) 368 71.9 1e-11 NP_848510 (OMIM: 606543) histone deacetylase 9 iso (1066) 368 71.9 1e-11 XP_011513941 (OMIM: 606543) PREDICTED: histone dea (1069) 368 71.9 1e-11 NP_848512 (OMIM: 606543) histone deacetylase 9 iso (1069) 368 71.9 1e-11 XP_011513940 (OMIM: 606543) PREDICTED: histone dea (1069) 368 71.9 1e-11 XP_011513939 (OMIM: 606543) PREDICTED: histone dea (1071) 368 71.9 1e-11 XP_011513938 (OMIM: 606543) PREDICTED: histone dea (1071) 368 71.9 1e-11 XP_011513950 (OMIM: 606543) PREDICTED: histone dea (1074) 368 71.9 1e-11 XP_011513937 (OMIM: 606543) PREDICTED: histone dea (1074) 368 71.9 1e-11 XP_011513951 (OMIM: 606543) PREDICTED: histone dea (1074) 368 71.9 1e-11 XP_011513931 (OMIM: 606543) PREDICTED: histone dea (1088) 368 71.9 1e-11 XP_011513933 (OMIM: 606543) PREDICTED: histone dea (1096) 368 71.9 1e-11 NP_478056 (OMIM: 606543) histone deacetylase 9 iso (1011) 342 67.7 1.8e-10 >>NP_001518 (OMIM: 605164) histone deacetylase 2 [Homo s (488 aa) initn: 3343 init1: 3343 opt: 3343 Z-score: 2950.8 bits: 555.4 E(85289): 1.3e-157 Smith-Waterman score: 3343; 100.0% identity (100.0% similar) in 488 aa overlap (1-488:1-488) 10 20 30 40 50 60 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT 430 440 450 460 470 480 pF1KE2 KSEQLSNP :::::::: NP_001 KSEQLSNP >>XP_016866288 (OMIM: 605164) PREDICTED: histone deacety (458 aa) initn: 3116 init1: 3116 opt: 3116 Z-score: 2751.7 bits: 518.5 E(85289): 1.6e-146 Smith-Waterman score: 3116; 100.0% identity (100.0% similar) in 458 aa overlap (31-488:1-458) 10 20 30 40 50 60 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA :::::::::::::::::::::::::::::: XP_016 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKA 10 20 30 70 80 90 100 110 120 pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT 400 410 420 430 440 450 pF1KE2 KSEQLSNP :::::::: XP_016 KSEQLSNP >>XP_011534090 (OMIM: 605164) PREDICTED: histone deacety (458 aa) initn: 3116 init1: 3116 opt: 3116 Z-score: 2751.7 bits: 518.5 E(85289): 1.6e-146 Smith-Waterman score: 3116; 100.0% identity (100.0% similar) in 458 aa overlap (31-488:1-458) 10 20 30 40 50 60 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA :::::::::::::::::::::::::::::: XP_011 MKPHRIRMTHNLLLNYGLYRKMEIYRPHKA 10 20 30 70 80 90 100 110 120 pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE 340 350 360 370 380 390 430 440 450 460 470 480 pF1KE2 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT 400 410 420 430 440 450 pF1KE2 KSEQLSNP :::::::: XP_011 KSEQLSNP >>NP_004955 (OMIM: 601241) histone deacetylase 1 [Homo s (482 aa) initn: 2951 init1: 2811 opt: 2880 Z-score: 2544.0 bits: 480.1 E(85289): 5.8e-135 Smith-Waterman score: 2880; 85.9% identity (95.0% similar) in 483 aa overlap (1-483:1-478) 10 20 30 40 50 60 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA :: .:: ..:::::::::.:::::::::::::::::::::::::::::::::::::::: NP_004 MAQTQGT-RRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA .::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH .:::::.::::.:::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ ::::::::::::::::::::::::::::::::::::::::::::::.:.::::::::: NP_004 GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG ::::..::::::.::::::::::.::::::::::::::.:::::::: ::.::::.:::: NP_004 IFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLG 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE2 GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM :::::::::::::::::::::: ::::::::::::::::::::::::::::::::: ::. NP_004 GGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYL 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE2 EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE :::::::::::::::::::::::::::::. :.::::: .:::::::: .:::::::.:: NP_004 EKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEE 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE2 FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT :::::.::::::.: .. :: ::... :..:.. ..: .: ::.:.:. :: ..::. NP_004 FSDSEEEGEGGRKNSSNFKK-AKRVKTEDEKEKDPEEKKEVTEEEKTKE---EKPEAKGV 420 430 440 450 460 470 pF1KE2 KSEQLSNP : : NP_004 KEEVKLA 480 >>NP_003874 (OMIM: 605166) histone deacetylase 3 [Homo s (428 aa) initn: 1131 init1: 978 opt: 1833 Z-score: 1624.7 bits: 309.9 E(85289): 9.3e-84 Smith-Waterman score: 1833; 58.8% identity (84.4% similar) in 422 aa overlap (10-429:3-421) 10 20 30 40 50 60 pF1KE2 MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA : : :.:: :.::..:: ::::::::. .::.:.:.::::.:: ...:..: NP_003 MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQA 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA . ..: ..::..:: ::. . : ::. ..:... ::::.::::: ::::::. ::.:. NP_003 SQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQ 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH ::..:: . :.:.::::::::::: ::::::::::::..:::::::: ::::::::::: NP_003 GATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHH 120 130 140 150 160 170 190 200 210 220 230 pF1KE2 GDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYG ::::.:::: :::::::::::::.:: :::::. ..:: .:.:: .: :.::::::.:: NP_003 GDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE2 QIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLML ..:.:.:..:...:::. .:::::::::. ::::::::...::..::: ::.::.:::.: NP_003 HLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE2 GGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSN-MTNQNTPE ::::::.:::::::::::.. .. : .::::..:::::.::: :: . :. . :::. . NP_003 GGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQ 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE2 YMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACD :...:.: .::::.:: :::.::.. .: : . : :: : ..: . . . .: NP_003 YLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE--ADAEER-GPEENYSRPEAP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE2 EEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTK .:: :.. ... NP_003 NEFYDGDHDNDKESDVEI 420 >>XP_011539611 (OMIM: 601241) PREDICTED: histone deacety (289 aa) initn: 1677 init1: 1565 opt: 1614 Z-score: 1434.7 bits: 274.2 E(85289): 3.6e-73 Smith-Waterman score: 1614; 80.6% identity (92.7% similar) in 289 aa overlap (195-483:1-285) 170 180 190 200 210 220 pF1KE2 LKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYA :::::::::::::::::::::::::::::: XP_011 MTVSFHKYGEYFPGTGDLRDIGAGKGKYYA 10 20 30 230 240 250 260 270 280 pF1KE2 VNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAK ::.:.::::::::: ::::..::::::.::::::::::.::::::::::::::.::::: XP_011 VNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAK 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE2 CVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKL ::: ::.::::.:::::::::::::::::::::::::: ::::::::::::::::::::: XP_011 CVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKL 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE2 HISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDK :::::::::::: ::.:::::::::::::::::::::::::::::. :.::::: .:::: XP_011 HISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDK 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE2 RISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEE :::: .:::::::.:::::::.::::::.: .. :: ::... :..:.. ..: .: :: XP_011 RISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKK-AKRVKTEDEKEKDPEEKKEVTEE 220 230 240 250 260 470 480 pF1KE2 DKSKDNSGEKTDTKGTKSEQLSNP .:.:. :: ..::.: : XP_011 EKTKE---EKPEAKGVKEEVKLA 270 280 >>NP_060956 (OMIM: 300269) histone deacetylase 8 isoform (377 aa) initn: 975 init1: 551 opt: 1089 Z-score: 971.7 bits: 188.9 E(85289): 2.2e-47 Smith-Waterman score: 1089; 43.4% identity (77.1% similar) in 341 aa overlap (33-372:35-374) 10 20 30 40 50 60 pF1KE2 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA :.: :.:.:. :.:...:.: .:. :. NP_060 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA :::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....: NP_060 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD : . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.:::: NP_060 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI :::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: :: NP_060 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG . ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.::: NP_060 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME :::.. :.:::::: :.: : . .:.: ...: .:::. :.:.:: ..: :. .. NP_060 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQ 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 KIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEF .: . . ::. NP_060 QILNYIKGNLKHVV 370 >>XP_011529288 (OMIM: 300269) PREDICTED: histone deacety (441 aa) initn: 525 init1: 525 opt: 1083 Z-score: 965.4 bits: 187.9 E(85289): 4.9e-47 Smith-Waterman score: 1083; 44.0% identity (77.7% similar) in 332 aa overlap (33-363:73-403) 10 20 30 40 50 60 pF1KE2 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA :.: :.:.:. :.:...:.: .:. :. XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE2 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA :::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....: XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 110 120 130 140 150 160 130 140 150 160 170 180 pF1KE2 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD : . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.:::: XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD 170 180 190 200 210 220 190 200 210 220 230 240 pF1KE2 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI :::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: :: XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI 230 240 250 260 270 280 250 260 270 280 290 300 pF1KE2 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG . ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.::: XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG 290 300 310 320 330 340 310 320 330 340 350 360 pF1KE2 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME :::.. :.:::::: :.: : . .:.: ...: .:::. :.:.:: ..: :. .. XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQ 350 360 370 380 390 400 370 380 390 400 410 420 pF1KE2 KIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEF .: XP_011 QILNYIKEKWPVGFGAQCFYLGKCGKAKTTEGQRNLKHVV 410 420 430 440 >>XP_011529289 (OMIM: 300269) PREDICTED: histone deacety (379 aa) initn: 863 init1: 439 opt: 992 Z-score: 886.4 bits: 173.1 E(85289): 1.2e-42 Smith-Waterman score: 992; 45.2% identity (78.3% similar) in 299 aa overlap (33-330:73-370) 10 20 30 40 50 60 pF1KE2 YSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATA :.: :.:.:. :.:...:.: .:. :. XP_011 EEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASM 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE2 EEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGA :::. .:.: :.. :... .. ... ... ...: :::. .:.:.. :.....: XP_011 EEMATFHTDAYLQHLQKVSQEGDDDHPDSIE-YGLGYDCPATEGIFDYAAAIGGATITAA 110 120 130 140 150 160 130 140 150 160 170 180 pF1KE2 VKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGD : . .:.::.:: :::::.:::::::.:: ::.::.: . .:.::.:.:.:::: XP_011 QCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGD 170 180 190 200 210 220 190 200 210 220 230 240 pF1KE2 GVEEAFYTTDRVMTVSFHKYGE-YFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQI :::.:: :..:::::.::.. .::::::. :.: :::.::.:: :..:::.::.: :: XP_011 GVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQI 230 240 250 260 270 280 250 260 270 280 290 300 pF1KE2 FKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG . ....:.. ..:.::::: :::...:: . ::.: : .::.. . ..: :.::: XP_011 CESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG 290 300 310 320 330 340 310 320 330 340 350 360 pF1KE2 GGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYME :::.. :.:::::: :.: : . .:.: XP_011 GGYNLANTARCWTYLTGVILGKTLSSEIPDHENMPVNT 350 360 370 >>XP_011535999 (OMIM: 605166) PREDICTED: histone deacety (241 aa) initn: 869 init1: 716 opt: 933 Z-score: 837.4 bits: 163.4 E(85289): 6.6e-40 Smith-Waterman score: 933; 54.4% identity (82.3% similar) in 237 aa overlap (195-429:1-234) 170 180 190 200 210 220 pF1KE2 LKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYF-PGTGDLRDIGAGKGKYY :::::::::.:: :::::. ..:: .:.:: XP_011 MTVSFHKYGNYFFPGTGDMYEVGAESGRYY 10 20 30 230 240 250 260 270 280 pF1KE2 AVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHA .: :.::::::.:: ..:.:.:..:...:::. .:::::::::. ::::::::...::. XP_011 CLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHG 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE2 KCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFK .::: ::.::.:::.:::::::.:::::::::::.. .. : .::::..:::::.::: XP_011 ECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFT 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE2 LHISPSN-MTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDP :: . :. . :::. .:...:.: .::::.:: :::.::.. .: : . : :: : XP_011 LHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDE--ADA 160 170 180 190 200 410 420 430 440 450 460 pF1KE2 DKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVK ..: . . . .: .:: :.. ... XP_011 EER-GPEENYSRPEAPNEFYDGDHDNDKESDVEI 210 220 230 240 488 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 09:31:01 2016 done: Sun Nov 6 09:31:02 2016 Total Scan time: 9.320 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]