FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE4382, 403 aa
  1>>>pF1KE4382 403 - 403 aa - 403 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.8554+/-0.000386; mu= 19.4900+/- 0.024
 mean_var=62.3872+/-12.803, 0's: 0 Z-trim(112.3): 4  B-trim: 1018 in 1/52
 Lambda= 0.162378
 statistics sampled from 21110 (21112) to 21110 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.248), width:  16
 Scan time:  7.100

The best scores are:                                      opt bits E(85289)
NP_002155 (OMIM: 147435) indoleamine 2,3-dioxygena ( 403) 2708 643.1 3.4e-184
NP_919270 (OMIM: 612129) indoleamine 2,3-dioxygena ( 420) 1140 275.8 1.3e-73


>>NP_002155 (OMIM: 147435) indoleamine 2,3-dioxygenase 1  (403 aa)
 initn: 2708 init1: 2708 opt: 2708  Z-score: 3427.8  bits: 643.1 E(85289): 3.4e-184
Smith-Waterman score: 2708; 100.0% identity (100.0% similar) in 403 aa overlap (1-403:1-403)

               10        20        30        40        50        60
pF1KE4 MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
              310       320       330       340       350       360

              370       380       390       400   
pF1KE4 QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
       :::::::::::::::::::::::::::::::::::::::::::
NP_002 QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
              370       380       390       400   

>>NP_919270 (OMIM: 612129) indoleamine 2,3-dioxygenase 2  (420 aa)
 initn: 1145 init1: 815 opt: 1140  Z-score: 1442.4  bits: 275.8 E(85289): 1.3e-73
Smith-Waterman score: 1140; 44.3% identity (75.5% similar) in 388 aa overlap (15-400:32-416)

                               10        20        30        40    
pF1KE4                 MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAK
                                     :::.:: :: ::.  ..::: :  :: ::.
NP_919 LHFHYYDTSNKIMEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIAN
              10        20        30        40        50        60 

           50        60        70        80        90       100    
pF1KE4 HLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLP
       .::.::.. ::. .:.:. .:: . :  :. ::::.:::. .::.::: .:...  .:::
NP_919 KLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLP
              70        80        90       100       110       120 

          110       120       130       140       150       160    
pF1KE4 RNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFF
       ::.:.:. ..:..: ::::::..: ::.:: ::::.  :   :.....::  :.  .::.
NP_919 RNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFI
             130       140       150       160       170       180 

          170       180       190       200       210       220    
pF1KE4 LVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPK
       ::. :::  :. .::..  . .:. . ....::.:: ..   ..   ... :.::.:.: 
NP_919 LVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPD
             190       200       210       220       230       240 

          230       240       250       260       270       280    
pF1KE4 AFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAG
        :.. .::.::::: :: .  ::.:::  ..: ...::::.::.:.. :: .:::...  
NP_919 IFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKE
             250       260       270       280       290       300 

          290       300       310       320       330       340    
pF1KE4 GGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRS
       .:   .::  :: ::::.:. :. ...: ::.:...::.:.  :  ::. ::.::. :::
NP_919 SG---DFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRS
                310       320       330       340       350        

          350       360         370       380       390       400  
pF1KE4 YHLQIVTKYILIPASQ--QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKE
       ::. .::::..  :..  . : :.    :. :. .::::: .:.:::.::. : .:.:  
NP_919 YHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHP
      360       370       380       390       400       410        

         
pF1KE4 G 
         
NP_919 RG
      420




403 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 22:58:39 2016 done: Sat Nov  5 22:58:40 2016
 Total Scan time:  7.100 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]