Result of FASTA (omim) for
pFN21AE2032
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2032, 622 aa
1>>>pF1KE2032 622 - 622 aa - 622 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5046+/-0.00039; mu= 18.5770+/- 0.024
mean_var=84.8591+/-17.245, 0's: 0 Z-trim(113.7): 333 B-trim: 843 in 1/50
Lambda= 0.139227
statistics sampled from 22759 (23115) to 22759 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.636), E-opt: 0.2 (0.271), width: 16
Scan time: 10.630
The best scores are: opt bits E(85289)
NP_000497 (OMIM: 176930,188050,601367,613679,61439 ( 622) 4354 885.0 0
NP_001298186 (OMIM: 176930,188050,601367,613679,61 ( 606) 4174 848.8 0
NP_005568 (OMIM: 152200) apolipoprotein(a) precurs (2040) 524 116.1 1.2e-24
NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 499 110.4 9.6e-24
XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 499 110.4 9.6e-24
NP_114154 (OMIM: 608018) serine protease 27 isofor ( 290) 478 106.2 1.7e-22
NP_958850 (OMIM: 120580,613783) complement C1s sub ( 688) 456 102.1 6.9e-21
XP_005253817 (OMIM: 120580,613783) PREDICTED: comp ( 688) 456 102.1 6.9e-21
NP_001725 (OMIM: 120580,613783) complement C1s sub ( 688) 456 102.1 6.9e-21
NP_006790 (OMIM: 608159) testisin isoform 1 prepro ( 314) 435 97.6 7e-20
XP_011528291 (OMIM: 206200,609862) PREDICTED: tran ( 680) 434 97.6 1.5e-19
NP_001275929 (OMIM: 206200,609862) transmembrane p ( 824) 434 97.7 1.7e-19
XP_016862361 (OMIM: 257920,600521) PREDICTED: mann ( 615) 431 97.0 2.1e-19
XP_016862358 (OMIM: 257920,600521) PREDICTED: mann ( 702) 431 97.0 2.3e-19
NP_624302 (OMIM: 257920,600521) mannan-binding lec ( 728) 431 97.1 2.3e-19
XP_011511291 (OMIM: 257920,600521) PREDICTED: mann ( 735) 431 97.1 2.4e-19
NP_006601 (OMIM: 605102,613791) mannan-binding lec ( 686) 427 96.2 3.9e-19
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 416 93.8 1.1e-18
XP_011520991 (OMIM: 608018) PREDICTED: serine prot ( 188) 402 90.8 4.7e-18
NP_001305324 (OMIM: 608018) serine protease 27 iso ( 188) 402 90.8 4.7e-18
XP_011535778 (OMIM: 227500,608446,613878) PREDICTE ( 364) 395 89.6 2.1e-17
NP_001254483 (OMIM: 227500,608446,613878) coagulat ( 382) 395 89.6 2.1e-17
XP_011535777 (OMIM: 227500,608446,613878) PREDICTE ( 433) 395 89.7 2.4e-17
XP_016862359 (OMIM: 257920,600521) PREDICTED: mann ( 668) 397 90.2 2.5e-17
NP_001870 (OMIM: 257920,600521) mannan-binding lec ( 699) 397 90.2 2.6e-17
XP_011511292 (OMIM: 257920,600521) PREDICTED: mann ( 706) 397 90.2 2.6e-17
NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 394 89.4 2.6e-17
XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 394 89.4 2.6e-17
XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 394 89.4 2.6e-17
XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 394 89.4 2.6e-17
NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 394 89.4 2.6e-17
XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 396 90.0 2.7e-17
XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 396 90.0 2.8e-17
XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 396 90.0 2.8e-17
NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752) 396 90.0 3.1e-17
XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761) 396 90.0 3.2e-17
NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850) 396 90.1 3.4e-17
NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855) 396 90.1 3.5e-17
XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 391 88.8 3.8e-17
NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 386 87.7 5.8e-17
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 380 86.5 1.3e-16
NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 378 86.5 4.2e-16
NP_659205 (OMIM: 608159) testisin isoform 2 prepro ( 312) 369 84.3 6.9e-16
XP_006713229 (OMIM: 142408) PREDICTED: hepatocyte ( 680) 355 81.8 8.7e-15
XP_011524673 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 348 80.1 1.2e-14
NP_001161077 (OMIM: 604434) kallikrein-11 isoform ( 275) 348 80.1 1.2e-14
XP_011524674 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 348 80.1 1.2e-14
XP_011524675 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 348 80.1 1.2e-14
XP_011524672 (OMIM: 604434) PREDICTED: kallikrein- ( 275) 348 80.1 1.2e-14
XP_011524671 (OMIM: 604434) PREDICTED: kallikrein- ( 307) 348 80.1 1.3e-14
>>NP_000497 (OMIM: 176930,188050,601367,613679,614390) p (622 aa)
initn: 4354 init1: 4354 opt: 4354 Z-score: 4728.1 bits: 885.0 E(85289): 0
Smith-Waterman score: 4354; 100.0% identity (100.0% similar) in 622 aa overlap (1-622:1-622)
10 20 30 40 50 60
pF1KE2 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE2 DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE2 VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE2 RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
550 560 570 580 590 600
610 620
pF1KE2 GFYTHVFRLKKWIQKVIDQFGE
::::::::::::::::::::::
NP_000 GFYTHVFRLKKWIQKVIDQFGE
610 620
>>NP_001298186 (OMIM: 176930,188050,601367,613679,614390 (606 aa)
initn: 4174 init1: 4174 opt: 4174 Z-score: 4532.8 bits: 848.8 E(85289): 0
Smith-Waterman score: 4201; 97.4% identity (97.4% similar) in 622 aa overlap (1-622:1-606)
10 20 30 40 50 60
pF1KE2 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
:::::::::: ::::::::::::::::::::::::::::::::::
NP_001 MAHVRGLQLP----------------VFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
10 20 30 40
70 80 90 100 110 120
pF1KE2 VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE2 NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE2 CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE2 QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE2 DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE2 DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE2 DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE2 VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE2 RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
530 540 550 560 570 580
610 620
pF1KE2 GFYTHVFRLKKWIQKVIDQFGE
::::::::::::::::::::::
NP_001 GFYTHVFRLKKWIQKVIDQFGE
590 600
>>NP_005568 (OMIM: 152200) apolipoprotein(a) precursor [ (2040 aa)
initn: 997 init1: 225 opt: 524 Z-score: 563.3 bits: 116.1 E(85289): 1.2e-24
Smith-Waterman score: 865; 32.0% identity (54.2% similar) in 566 aa overlap (60-617:1574-2037)
30 40 50 60 70 80
pF1KE2 APQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDV--FWAKY
: :: :. .::. :.. : . :.
NP_005 AGLTENYCRNPDSGKQPWCYTTDPCVRWEYCNLTQCSETES-GVLETPTVVPVPSMEAHS
1550 1560 1570 1580 1590 1600
90 100 110 120 130 140
pF1KE2 TACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTH
: : .:: . : .:: : .::: . : .: :: : : ::. . . ..
NP_005 EAAPTEQTPVVR--QCYHGN-----GQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENY
1610 1620 1630 1640 1650
150 160 170 180 190 200
pF1KE2 PGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLS
:. : :.:::::..: ::::.: ::..: . :.. :.. . :: ..: . . .:.
NP_005 PNDGLTMNYCRNPDADT-GPWCFTMDPSIRWEYCNLTRCSDTEGTV-VAPPTVIQVPSLG
1660 1670 1680 1690 1700 1710
210 220 230 240 250 260
pF1KE2 PPLEQ-CVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDF----NSAVQLVENFC
:: :: :. :. :.:. :.:. : :: :: :. .:. : :. . : .:.:
NP_005 PPSEQDCMFGNGKGYRGKKATTVTGTPCQEWA---AQEPHRHSTFIPGTNKWAGLEKNYC
1720 1730 1740 1750 1760 1770
270 280 290 300 310 320
pF1KE2 RNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQT
:::::: .: :::. . : :::. : :.: .
NP_005 RNPDGDINGPWCYTMNPRKLFDYCDIPLC------------------------ASSSF--
1780 1790 1800
330 340 350 360 370 380
pF1KE2 FFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLF
::: .: : :. : :: : :. :::: :
NP_005 ------------DCG-KPQVEPKKCP-------------GSIVGGCVAHPHSWPWQVSL-
1810 1820 1830
390 400 410 420 430 440
pF1KE2 RKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIS
: . .::..::: .::::::::: :. .. : .: :... : ....:
NP_005 RTRFGKHFCGGTLISPEWVLTAAHCL-----KKSSRPSSYKVILGAHQEVNLESHVQEIE
1840 1850 1860 1870 1880 1890
450 460 470 480 490 500
pF1KE2 MLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVT
. .....: . ::::.::..:....: . :.:::. . .. : . .:
NP_005 V-SRLFLEPT-------QADIALLKLSRPAVITDKVMPACLPSPDY---MVTARTECYIT
1900 1910 1920 1930 1940
510 520 530 540 550 560
pF1KE2 GWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRG-
:::. . :. : : .:. ..: ..: ::. : :: .. ::
NP_005 GWGETQGTF----GTG---LLKEAQLLVIENEVCNHYKYI-------CA----EHLARGT
1950 1960 1970 1980
570 580 590 600 610 620
pF1KE2 DACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFG
:.:.::::::.: .... .:..::: :: : .: : :..: :. ::. ..
NP_005 DSCQGDSGGPLVCFE--KDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWIEGMMRNN
1990 2000 2010 2020 2030 2040
pF1KE2 E
>--
initn: 321 init1: 170 opt: 449 Z-score: 481.9 bits: 101.0 E(85289): 4.2e-20
Smith-Waterman score: 449; 31.0% identity (53.5% similar) in 245 aa overlap (60-294:784-1020)
30 40 50 60 70 80
pF1KE2 APQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTA
: :: :. :. :.: : . .
NP_005 AGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEG-TAVAPPTVTPVPSLEAPS
760 770 780 790 800 810
90 100 110 120 130 140
pF1KE2 CETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPG
.. : . : .:: : .::: . : .: :: : : ::. . .:.
NP_005 EQAPTEQRPGVQECYHGN-----GQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPN
820 830 840 850 860
150 160 170 180 190
pF1KE2 ADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPR----------S
: : :.::::: ...:.::: ::.:: . :.. :.. . :.. : :
NP_005 AGLIMNYCRNPDP-VAAPYCYTRDPSVRWEYCNLTQCSDAEGTAVAPPTITPIPSLEAPS
870 880 890 900 910 920
200 210 220 230 240 250
pF1KE2 EGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVE
: . .. : ...: ::.::: .:. : : ::.: .. :. . . :..
NP_005 EQAPTEQRPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYPNAGLIK
930 940 950 960 970 980
260 270 280 290 300 310
pF1KE2 NFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSE
:.::::: . :::.. . ::.:. : .:
NP_005 NYCRNPD-PVAAPWCYTTDPSVRWEYCNLTRCSDAEWTAFVPPNVILAPSLEAFFEQALT
990 1000 1010 1020 1030 1040
320 330 340 350 360 370
pF1KE2 YQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQV
NP_005 EETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPENYPNAGLTRNYCRN
1050 1060 1070 1080 1090 1100
>--
initn: 1054 init1: 169 opt: 448 Z-score: 480.8 bits: 100.8 E(85289): 4.8e-20
Smith-Waterman score: 448; 34.2% identity (61.5% similar) in 187 aa overlap (107-291:1167-1351)
80 90 100 110 120 130
pF1KE2 STATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRY
.: .: : .::: . : .: :: : :
NP_005 SVLATLTVVPDPSTEASSEEAPTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMT
1140 1150 1160 1170 1180 1190
140 150 160 170 180 190
pF1KE2 PHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCG--QDQVTVA
:: . .. .:.. : .:.:::::. . ::::: ::.:: . :.. : ...: ..
NP_005 PHWHQRTTEYYPNGGLTRNYCRNPDAEIS-PWCYTMDPNVRWEYCNLTQCPVTESSVLAT
1200 1210 1220 1230 1240 1250
200 210 220 230 240 250
pF1KE2 MTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSA
: :: . .. :: ...: ::.:.: ...:. : : .:.: . .. ..
NP_005 STAVSEQAPTEQSPTVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPN
1260 1270 1280 1290 1300 1310
260 270 280 290 300 310
pF1KE2 VQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGR
:..:.:::::. : :::. . ::.:. :
NP_005 GGLTRNYCRNPDA-EIRPWCYTMDPSVRWEYCNLTQCPVMESTLLTTPTVVPVPSTELPS
1320 1330 1340 1350 1360 1370
320 330 340 350 360 370
pF1KE2 TATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGM
NP_005 EEAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTR
1380 1390 1400 1410 1420 1430
>--
initn: 331 init1: 175 opt: 430 Z-score: 461.3 bits: 97.2 E(85289): 5.9e-19
Smith-Waterman score: 430; 33.2% identity (60.3% similar) in 199 aa overlap (107-294:27-222)
80 90 100 110 120 130
pF1KE2 STATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRY
.: .: : .::: . : .: :: : :
NP_005 MEHKEVVLLLLLFLKSAAPEQSHVVQDCYHGDGQSYRGTYSTTVTGRTCQAWSSMT
10 20 30 40 50
140 150 160 170 180 190
pF1KE2 PHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMT
::. . .. ..:.: : :.:::::. ...:.::: :: :: . :.. :.. . :..
NP_005 PHQHNRTTENYPNAGLIMNYCRNPDA-VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAP
60 70 80 90 100 110
200 210 220 230 240
pF1KE2 PR----------SEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALS
: :: . .. : ...: ::.:.: ..:. : : ::.: .. :
NP_005 PTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHS
120 130 140 150 160 170
250 260 270 280 290 300
pF1KE2 KHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPG-DFGYCDLNYCEEAVEEETGDGLDE
. .. . :. :.:::::. . .::. :: . ::.:. : .:
NP_005 RTPEYYPNAGLIMNYCRNPDA-VAAPYCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPTVT
180 190 200 210 220 230
310 320 330 340 350 360
pF1KE2 DSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIV
NP_005 PVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPE
240 250 260 270 280 290
>--
initn: 165 init1: 165 opt: 398 Z-score: 426.5 bits: 90.8 E(85289): 5.1e-17
Smith-Waterman score: 420; 33.3% identity (58.6% similar) in 198 aa overlap (108-294:484-678)
80 90 100 110 120 130
pF1KE2 TATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYP
: .: : .::: . : .: :: : : :
NP_005 AVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTP
460 470 480 490 500 510
140 150 160 170 180 190
pF1KE2 HKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTP
:. . .:.: : :.:::::. ...:.::: :: :: . :.. :.. . :.. :
NP_005 HSHSRTPEYYPNAGLIMNYCRNPDA-VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPP
520 530 540 550 560 570
200 210 220 230 240
pF1KE2 R----------SEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSK
:: . .. : ...: ::.:.: ..:. : : ::.: .. :.
NP_005 TVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSR
580 590 600 610 620 630
250 260 270 280 290 300
pF1KE2 HQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPG-DFGYCDLNYCEEAVEEETGDGLDED
.. . :. :.:::::. . .::. :: . ::.:. : .:
NP_005 TPEYYPNAGLIMNYCRNPDA-VAAPYCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPTVTP
640 650 660 670 680 690
310 320 330 340 350 360
pF1KE2 SDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVE
NP_005 VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEY
700 710 720 730 740 750
>--
initn: 329 init1: 150 opt: 266 Z-score: 283.2 bits: 64.3 E(85289): 4.9e-09
Smith-Waterman score: 266; 37.5% identity (59.8% similar) in 112 aa overlap (107-212:1053-1161)
80 90 100 110 120 130
pF1KE2 STATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRY
.: : .::: . : .: :: : :
NP_005 TAFVPPNVILAPSLEAFFEQALTEETPGVQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMT
1030 1040 1050 1060 1070 1080
140 150 160 170 180 190
pF1KE2 PHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVC--GQDQVTVA
::. . ..:.: : .:.:::::. ::::: ::.:: . :.. : ...: ..
NP_005 PHQHSRTPENYPNAGLTRNYCRNPDAEIR-PWCYTMDPSVRWEYCNLTQCLVTESSVLAT
1090 1100 1110 1120 1130 1140
200 210 220 230 240 250
pF1KE2 MT----PRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQD
.: : .:.:: . : ::
NP_005 LTVVPDPSTEASSEE--APTEQSPGVQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHW
1150 1160 1170 1180 1190
>--
initn: 918 init1: 180 opt: 253 Z-score: 269.1 bits: 61.7 E(85289): 3e-08
Smith-Waterman score: 394; 34.1% identity (57.0% similar) in 179 aa overlap (107-275:1387-1563)
80 90 100 110 120 130
pF1KE2 STATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRY
.: .: : .::: .. : .: :: : :
NP_005 TLLTTPTVVPVPSTELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTITGRTCQSWSSMT
1360 1370 1380 1390 1400 1410
140 150 160 170 180 190
pF1KE2 PHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMT
:: . .:.: : .:.:::::. ::::: ::.:: . :.. : . .: :
NP_005 PHWHRRIPLYYPNAGLTRNYCRNPDAEIR-PWCYTMDPSVRWEYCNLTRCPVTESSVLTT
1420 1430 1440 1450 1460 1470
200 210 220 230 240
pF1KE2 PR----------SEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALS
: :: . . :: ...: :..:.: ..:. : : .:.: . .
NP_005 PTVAPVPSTEAPSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQ
1480 1490 1500 1510 1520 1530
250 260 270 280 290 300
pF1KE2 KHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDED
. . . :.::.:::::. .. :::
NP_005 RTPENYPNAGLTENYCRNPDSGKQP-WCYTTDPCVRWEYCNLTQCSETESGVLETPTVVP
1540 1550 1560 1570 1580 1590
>--
initn: 425 init1: 165 opt: 202 Z-score: 213.8 bits: 51.4 E(85289): 3.6e-05
Smith-Waterman score: 420; 33.3% identity (58.6% similar) in 198 aa overlap (108-294:256-450)
80 90 100 110 120 130
pF1KE2 TATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYP
: .: : .::: . : .: :: : : :
NP_005 AVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTP
230 240 250 260 270 280
140 150 160 170 180 190
pF1KE2 HKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTP
:. . .:.: : :.:::::. ...:.::: :: :: . :.. :.. . :.. :
NP_005 HSHSRTPEYYPNAGLIMNYCRNPDA-VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPP
290 300 310 320 330 340
200 210 220 230 240
pF1KE2 R----------SEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSK
:: . .. : ...: ::.:.: ..:. : : ::.: .. :.
NP_005 TVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSR
350 360 370 380 390 400
250 260 270 280 290 300
pF1KE2 HQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPG-DFGYCDLNYCEEAVEEETGDGLDED
.. . :. :.:::::. . .::. :: . ::.:. : .:
NP_005 TPEYYPNAGLIMNYCRNPDA-VAAPYCYTRD-PGVRWEYCNLTQCSDAEGTAVAPPTVTP
410 420 430 440 450 460
310 320 330 340 350 360
pF1KE2 SDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVE
NP_005 VPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEY
470 480 490 500 510 520
>>NP_071402 (OMIM: 609343) brain-specific serine proteas (317 aa)
initn: 393 init1: 145 opt: 499 Z-score: 547.3 bits: 110.4 E(85289): 9.6e-24
Smith-Waterman score: 499; 32.6% identity (62.8% similar) in 261 aa overlap (363-617:49-289)
340 350 360 370 380 390
pF1KE2 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG
:.: : :. . :: : . ... .. :.
NP_071 TSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHH--CA
20 30 40 50 60 70
400 410 420 430 440 450
pF1KE2 ASLISDRWVLTAAHCLLYPPWDKNFTENDLL-VRIGKHSRTRYERNIEKISMLEKIYIHP
.::...:::.:::::. :... :. : .: . .:... . ::
NP_071 GSLLTSRWVITAAHCF-----KDNLNKPYLFSVLLGAWQLGNPGSRSQKVGV-AWVEPHP
80 90 100 110 120 130
460 470 480 490 500 510
pF1KE2 RYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETW
:.:.:. ::::..:.. . ::. . :.:::: :. : . . ..:::....
NP_071 VYSWKEGACADIALVRLERSIQFSERVLPICLPD---ASIHLPPNTHCWISGWGSIQD--
140 150 160 170 180
520 530 540 550 560
pF1KE2 TANVGKGQPSVLQVVNLPIVERPVC-----KDSTRIRITDNMFCAGYKPDEGKRGDACEG
.: .:..:: ...::.. :: . . . ::..:.:::: ::.: ::: :
NP_071 --GVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYL--EGER-DACLG
190 200 210 220 230 240
570 580 590 600 610 620
pF1KE2 DSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
:::::.. . .. : ::.:::::: . .. : : . ..:..:..
NP_071 DSGGPLMCQ--VDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRA
250 260 270 280 290
NP_071 QGGGALRAPSQGSGAAARS
300 310
>>XP_005255530 (OMIM: 609343) PREDICTED: brain-specific (317 aa)
initn: 393 init1: 145 opt: 499 Z-score: 547.3 bits: 110.4 E(85289): 9.6e-24
Smith-Waterman score: 499; 32.6% identity (62.8% similar) in 261 aa overlap (363-617:49-289)
340 350 360 370 380 390
pF1KE2 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG
:.: : :. . :: : . ... .. :.
XP_005 TSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHH--CA
20 30 40 50 60 70
400 410 420 430 440 450
pF1KE2 ASLISDRWVLTAAHCLLYPPWDKNFTENDLL-VRIGKHSRTRYERNIEKISMLEKIYIHP
.::...:::.:::::. :... :. : .: . .:... . ::
XP_005 GSLLTSRWVITAAHCF-----KDNLNKPYLFSVLLGAWQLGNPGSRSQKVGV-AWVEPHP
80 90 100 110 120 130
460 470 480 490 500 510
pF1KE2 RYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETW
:.:.:. ::::..:.. . ::. . :.:::: :. : . . ..:::....
XP_005 VYSWKEGACADIALVRLERSIQFSERVLPICLPD---ASIHLPPNTHCWISGWGSIQD--
140 150 160 170 180
520 530 540 550 560
pF1KE2 TANVGKGQPSVLQVVNLPIVERPVC-----KDSTRIRITDNMFCAGYKPDEGKRGDACEG
.: .:..:: ...::.. :: . . . ::..:.:::: ::.: ::: :
XP_005 --GVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYL--EGER-DACLG
190 200 210 220 230 240
570 580 590 600 610 620
pF1KE2 DSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
:::::.. . .. : ::.:::::: . .. : : . ..:..:..
XP_005 DSGGPLMCQ--VDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRA
250 260 270 280 290
XP_005 QGGGALRAPSQGSGAAARS
300 310
>>NP_114154 (OMIM: 608018) serine protease 27 isoform 1 (290 aa)
initn: 422 init1: 116 opt: 478 Z-score: 525.0 bits: 106.2 E(85289): 1.7e-22
Smith-Waterman score: 534; 35.9% identity (62.0% similar) in 276 aa overlap (363-620:34-279)
340 350 360 370 380 390
pF1KE2 EADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCG
:.: :.:.. : :::: . :.. . .::
NP_114 PAAVPLLLLLCFGSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSH--FCG
10 20 30 40 50 60
400 410 420 430 440
pF1KE2 ASLISDRWVLTAAHCLLYPPWDKNFTENDL---------LVRIGKHSRTRYERNIEKISM
.:::...::::::::. .: .:..: ::. : :. :..:.
NP_114 GSLIAEQWVLTAAHCF------RNTSETSLYQVLLGARQLVQPGPHAMYARVRQVES---
70 80 90 100 110
450 460 470 480 490 500
pF1KE2 LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTG
.: :. . . :.::..:. :: :..:: :::::: . ....:.. :::
NP_114 ------NPLYQGTAS-SADVALVELEAPVPFTNYILPVCLPD---PSVIFETGMNCWVTG
120 130 140 150 160
510 520 530 540 550
pF1KE2 WGNLKETWTANVGKGQPSVLQVVNLPIVERPVC-----KDSTR----IRITDNMFCAGYK
::. .: .: .:: . .::.. : : ::. : ..:.:::.
NP_114 WGSPSEEDLLP----EPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGF-
170 180 190 200 210
560 570 580 590 600 610
pF1KE2 PDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQ
.:::. :::.::::::.: .. : : :..:::::: :... : : .: ..::.
NP_114 -EEGKK-DACKGDSGGPLVCL--VGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHNWIH
220 230 240 250 260 270
620
pF1KE2 KVIDQFGE
..: ..
NP_114 RIIPKLQFQPARLGGQK
280 290
>>NP_958850 (OMIM: 120580,613783) complement C1s subcomp (688 aa)
initn: 377 init1: 114 opt: 456 Z-score: 496.0 bits: 102.1 E(85289): 6.9e-21
Smith-Waterman score: 470; 28.6% identity (51.3% similar) in 472 aa overlap (184-619:249-681)
160 170 180 190 200 210
pF1KE2 ENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQD-QVTVAMTPRSEGSSVNLSPPLEQ
: ::. . . .:.. .. .. :
NP_958 RREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTG
220 230 240 250 260 270
220 230 240 250 260
pF1KE2 CVPDRGQQYQGR-LAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDE--
.:.: . . : .: :.:: . : ..::.. : :: :
NP_958 QKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYV-----FRDVVQIT---CL--DGFEVV
280 290 300 310 320
270 280 290 300 310
pF1KE2 EG--------VWCYVAGKPGDFGY-CDLNYCEEAVEEETGDGLDEDSDRAIEGRTAT-SE
:: : :: .. :. : .. : .: :: . .. : . .
NP_958 EGRVGATSFYSTCQSNGKWSNSKLKCQPVDC--GIPESIENGKVEDPESTLFGSVIRYTC
330 340 350 360 370 380
320 330 340 350 360 370
pF1KE2 YQTFFNPRTFGSGEADCG---------LRPLFEKKSLEDKTERELLESYIDGRIVEGSDA
. .. .. :.:: :. : : . : . :: .: ::. ::::
NP_958 EEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEE--KQRIIGGSDA
390 400 410 420 430 440
380 390 400 410 420 430
pF1KE2 EIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHS
.: :::: : .: :..::.. ::::::: . .. : . : . .
NP_958 DIKNFPWQV--FFDNPW---AGGALINEYWVLTAAHVV------EGNREPTMYVGSTSVQ
450 460 470 480 490
440 450 460 470 480
pF1KE2 RTRYERNIEKISMLEKIYIHPRYNW--------RENLDRDIALMKLKKPVAFSDYIHPVC
.: .. :. :...::: .: : :.: ::::..:: :: .. . :.:
NP_958 TSRLAKS--KMLTPEHVFIHP--GWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPIC
500 510 520 530 540
490 500 510 520 530
pF1KE2 LPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQ--PSV-LQVVNLPIVERPVCKDS
:: . .:.. : : ..::: .. : :. : . :. . ::.:. :.
NP_958 LPGTSSDYNLMD-GDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTA-DA
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE2 TRIRITDNMFCAGYKPDEGKRG-DACEGDSGGPFVMKSPFNN-RWYQMGIVSWGEGCDRD
.: ::.::: :..: :.:.::::: :....: .. ..: :.:::: :
NP_958 EAYVFTPNMICAG-----GEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQC---
610 620 630 640 650
600 610 620
pF1KE2 GKYGFYTHVFRLKKWIQKVIDQFGE
: ::.::.: ::.:....
NP_958 GTYGLYTRVKNYVDWIMKTMQENSTPRED
660 670 680
>>XP_005253817 (OMIM: 120580,613783) PREDICTED: compleme (688 aa)
initn: 377 init1: 114 opt: 456 Z-score: 496.0 bits: 102.1 E(85289): 6.9e-21
Smith-Waterman score: 470; 28.6% identity (51.3% similar) in 472 aa overlap (184-619:249-681)
160 170 180 190 200 210
pF1KE2 ENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQD-QVTVAMTPRSEGSSVNLSPPLEQ
: ::. . . .:.. .. .. :
XP_005 RREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTG
220 230 240 250 260 270
220 230 240 250 260
pF1KE2 CVPDRGQQYQGR-LAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDE--
.:.: . . : .: :.:: . : ..::.. : :: :
XP_005 QKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYV-----FRDVVQIT---CL--DGFEVV
280 290 300 310 320
270 280 290 300 310
pF1KE2 EG--------VWCYVAGKPGDFGY-CDLNYCEEAVEEETGDGLDEDSDRAIEGRTAT-SE
:: : :: .. :. : .. : .: :: . .. : . .
XP_005 EGRVGATSFYSTCQSNGKWSNSKLKCQPVDC--GIPESIENGKVEDPESTLFGSVIRYTC
330 340 350 360 370 380
320 330 340 350 360 370
pF1KE2 YQTFFNPRTFGSGEADCG---------LRPLFEKKSLEDKTERELLESYIDGRIVEGSDA
. .. .. :.:: :. : : . : . :: .: ::. ::::
XP_005 EEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEE--KQRIIGGSDA
390 400 410 420 430 440
380 390 400 410 420 430
pF1KE2 EIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHS
.: :::: : .: :..::.. ::::::: . .. : . : . .
XP_005 DIKNFPWQV--FFDNPW---AGGALINEYWVLTAAHVV------EGNREPTMYVGSTSVQ
450 460 470 480 490
440 450 460 470 480
pF1KE2 RTRYERNIEKISMLEKIYIHPRYNW--------RENLDRDIALMKLKKPVAFSDYIHPVC
.: .. :. :...::: .: : :.: ::::..:: :: .. . :.:
XP_005 TSRLAKS--KMLTPEHVFIHP--GWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPIC
500 510 520 530 540
490 500 510 520 530
pF1KE2 LPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQ--PSV-LQVVNLPIVERPVCKDS
:: . .:.. : : ..::: .. : :. : . :. . ::.:. :.
XP_005 LPGTSSDYNLMD-GDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTA-DA
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE2 TRIRITDNMFCAGYKPDEGKRG-DACEGDSGGPFVMKSPFNN-RWYQMGIVSWGEGCDRD
.: ::.::: :..: :.:.::::: :....: .. ..: :.:::: :
XP_005 EAYVFTPNMICAG-----GEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQC---
610 620 630 640 650
600 610 620
pF1KE2 GKYGFYTHVFRLKKWIQKVIDQFGE
: ::.::.: ::.:....
XP_005 GTYGLYTRVKNYVDWIMKTMQENSTPRED
660 670 680
>>NP_001725 (OMIM: 120580,613783) complement C1s subcomp (688 aa)
initn: 377 init1: 114 opt: 456 Z-score: 496.0 bits: 102.1 E(85289): 6.9e-21
Smith-Waterman score: 470; 28.6% identity (51.3% similar) in 472 aa overlap (184-619:249-681)
160 170 180 190 200 210
pF1KE2 ENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQD-QVTVAMTPRSEGSSVNLSPPLEQ
: ::. . . .:.. .. .. :
NP_001 RREDFDVEAADSAGNCLDSLVFVAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTG
220 230 240 250 260 270
220 230 240 250 260
pF1KE2 CVPDRGQQYQGR-LAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDE--
.:.: . . : .: :.:: . : ..::.. : :: :
NP_001 QKKGWKLRYHGDPMPCPKEDTPNSVWEPAKAKYV-----FRDVVQIT---CL--DGFEVV
280 290 300 310 320
270 280 290 300 310
pF1KE2 EG--------VWCYVAGKPGDFGY-CDLNYCEEAVEEETGDGLDEDSDRAIEGRTAT-SE
:: : :: .. :. : .. : .: :: . .. : . .
NP_001 EGRVGATSFYSTCQSNGKWSNSKLKCQPVDC--GIPESIENGKVEDPESTLFGSVIRYTC
330 340 350 360 370 380
320 330 340 350 360 370
pF1KE2 YQTFFNPRTFGSGEADCG---------LRPLFEKKSLEDKTERELLESYIDGRIVEGSDA
. .. .. :.:: :. : : . : . :: .: ::. ::::
NP_001 EEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPREPFEE--KQRIIGGSDA
390 400 410 420 430 440
380 390 400 410 420 430
pF1KE2 EIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHS
.: :::: : .: :..::.. ::::::: . .. : . : . .
NP_001 DIKNFPWQV--FFDNPW---AGGALINEYWVLTAAHVV------EGNREPTMYVGSTSVQ
450 460 470 480 490
440 450 460 470 480
pF1KE2 RTRYERNIEKISMLEKIYIHPRYNW--------RENLDRDIALMKLKKPVAFSDYIHPVC
.: .. :. :...::: .: : :.: ::::..:: :: .. . :.:
NP_001 TSRLAKS--KMLTPEHVFIHP--GWKLLEVPEGRTNFDNDIALVRLKDPVKMGPTVSPIC
500 510 520 530 540
490 500 510 520 530
pF1KE2 LPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQ--PSV-LQVVNLPIVERPVCKDS
:: . .:.. : : ..::: .. : :. : . :. . ::.:. :.
NP_001 LPGTSSDYNLMD-GDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKVEKPTA-DA
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE2 TRIRITDNMFCAGYKPDEGKRG-DACEGDSGGPFVMKSPFNN-RWYQMGIVSWGEGCDRD
.: ::.::: :..: :.:.::::: :....: .. ..: :.:::: :
NP_001 EAYVFTPNMICAG-----GEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQC---
610 620 630 640 650
600 610 620
pF1KE2 GKYGFYTHVFRLKKWIQKVIDQFGE
: ::.::.: ::.:....
NP_001 GTYGLYTRVKNYVDWIMKTMQENSTPRED
660 670 680
>>NP_006790 (OMIM: 608159) testisin isoform 1 preproprot (314 aa)
initn: 518 init1: 162 opt: 435 Z-score: 477.9 bits: 97.6 E(85289): 7e-20
Smith-Waterman score: 516; 37.2% identity (60.9% similar) in 274 aa overlap (360-621:38-289)
330 340 350 360 370 380
pF1KE2 GSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQEL
: .::: : :::.: ::: : . .
NP_006 LLALLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSL--RLWDSH
10 20 30 40 50 60
390 400 410 420 430 440
pF1KE2 LCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKIS---MLEK
.::.::.: ::.:::::: . .. . .:..:. . ... .. .
NP_006 VCGVSLLSHRWALTAAHC--FETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSN
70 80 90 100 110 120
450 460 470 480 490 500
pF1KE2 IYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGR----VT
::. ::: : ::::.::. ::... .:.:.:: :: .. ...: ::
NP_006 IYLSPRY--LGNSPYDIALVKLSAPVTYTKHIQPICLQ-----ASTFE--FENRTDCWVT
130 140 150 160 170
510 520 530 540 550
pF1KE2 GWGNLKETWTANVGKGQPSVLQVVNLPIVERPVC-----KDSTRIRITDNMFCAGYKPDE
::: .:: . . .: .:: :.. :.. .: : : : : .: ::: . .
NP_006 GWGYIKE----DEALPSPHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGDMVCAG-NAQG
180 190 200 210 220
560 570 580 590 600 610
pF1KE2 GKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
:: ::: ::::::.. .. :. :::.:.:::: :: : .. : ::.. . .::::..
NP_006 GK--DACFGDSGGPLACNK--NGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWIQKLM
230 240 250 260 270 280
620
pF1KE2 DQFGE
: :
NP_006 AQSGMSQPDPSWPLLFFPLLWALPLLGPV
290 300 310
622 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 09:42:20 2016 done: Sun Nov 6 09:42:22 2016
Total Scan time: 10.630 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]