FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2694, 1249 aa 1>>>pF1KE2694 1249 - 1249 aa - 1249 aa Library: /omim/omim.rfq.tfa 62035967 residues in 87258 sequences Statistics: Expectation_n fit: rho(ln(x))= 14.9958+/-0.000521; mu= -18.1094+/- 0.033 mean_var=856.1176+/-175.687, 0's: 0 Z-trim(123.8): 185 B-trim: 0 in 0/62 Lambda= 0.043834 statistics sampled from 44683 (44901) to 44683 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.776), E-opt: 0.2 (0.515), width: 16 Scan time: 17.050 The best scores are: opt bits E(87258) NP_071934 (OMIM: 610982,613237,614455) inverted fo (1249) 8320 542.9 5.1e-153 XP_005268061 (OMIM: 610982,613237,614455) PREDICTE (1281) 8320 542.9 5.2e-153 XP_016877084 (OMIM: 610982,613237,614455) PREDICTE (1281) 8320 542.9 5.2e-153 NP_001026884 (OMIM: 610982,613237,614455) inverted (1240) 8200 535.3 9.8e-151 XP_005268062 (OMIM: 610982,613237,614455) PREDICTE (1272) 8200 535.3 9.9e-151 NP_116103 (OMIM: 610982,613237,614455) inverted fo ( 234) 1503 111.0 1e-23 XP_011535875 (OMIM: 124900,602121,616632) PREDICTE (1250) 884 72.7 1.8e-11 NP_001300936 (OMIM: 124900,602121,616632) protein (1250) 884 72.7 1.8e-11 XP_011535874 (OMIM: 124900,602121,616632) PREDICTE (1260) 884 72.7 1.8e-11 NP_001073280 (OMIM: 124900,602121,616632) protein (1263) 884 72.7 1.8e-11 NP_005210 (OMIM: 124900,602121,616632) protein dia (1272) 884 72.7 1.9e-11 NP_006720 (OMIM: 300108,300511) protein diaphanous (1101) 841 69.9 1.1e-10 NP_009293 (OMIM: 300108,300511) protein diaphanous (1096) 837 69.6 1.3e-10 NP_112194 (OMIM: 609129,614567) protein diaphanous ( 849) 779 65.8 1.4e-09 XP_011533560 (OMIM: 609129,614567) PREDICTED: prot (1136) 783 66.2 1.4e-09 XP_006719939 (OMIM: 609129,614567) PREDICTED: prot ( 930) 779 65.9 1.5e-09 NP_001245298 (OMIM: 609129,614567) protein diaphan (1112) 779 66.0 1.7e-09 NP_001245297 (OMIM: 609129,614567) protein diaphan (1123) 779 66.0 1.7e-09 NP_001245296 (OMIM: 609129,614567) protein diaphan (1147) 779 66.0 1.7e-09 NP_001245295 (OMIM: 609129,614567) protein diaphan (1182) 779 66.0 1.8e-09 NP_001035982 (OMIM: 609129,614567) protein diaphan (1193) 779 66.0 1.8e-09 NP_055807 (OMIM: 606626) disheveled-associated act (1078) 700 60.9 5.3e-08 XP_005267488 (OMIM: 606626) PREDICTED: disheveled- (1078) 700 60.9 5.3e-08 XP_005267487 (OMIM: 606626) PREDICTED: disheveled- (1078) 700 60.9 5.3e-08 XP_006715109 (OMIM: 606627) PREDICTED: disheveled- (1077) 699 60.9 5.5e-08 XP_006715105 (OMIM: 606627) PREDICTED: disheveled- (1077) 699 60.9 5.5e-08 XP_006715108 (OMIM: 606627) PREDICTED: disheveled- (1077) 699 60.9 5.5e-08 XP_006715106 (OMIM: 606627) PREDICTED: disheveled- (1077) 699 60.9 5.5e-08 XP_016866119 (OMIM: 606627) PREDICTED: disheveled- (1100) 699 60.9 5.6e-08 XP_006715102 (OMIM: 606627) PREDICTED: disheveled- (1176) 699 60.9 5.9e-08 NP_056160 (OMIM: 606627) disheveled-associated act (1067) 673 59.2 1.7e-07 NP_001188356 (OMIM: 606627) disheveled-associated (1068) 665 58.7 2.4e-07 XP_006715103 (OMIM: 606627) PREDICTED: disheveled- (1167) 665 58.8 2.6e-07 NP_001245299 (OMIM: 609129,614567) protein diaphan ( 691) 603 54.6 2.8e-06 XP_011508837 (OMIM: 616285) PREDICTED: formin-like (1048) 511 49.0 0.00021 XP_011508836 (OMIM: 616285) PREDICTED: formin-like (1076) 511 49.0 0.00021 XP_005246322 (OMIM: 616285) PREDICTED: formin-like (1084) 511 49.0 0.00021 XP_005246320 (OMIM: 616285) PREDICTED: formin-like (1087) 511 49.0 0.00021 XP_011508835 (OMIM: 616285) PREDICTED: formin-like (1091) 511 49.0 0.00021 NP_443137 (OMIM: 616285) formin-like protein 2 [Ho (1092) 511 49.0 0.00021 XP_011508834 (OMIM: 616285) PREDICTED: formin-like (1093) 511 49.0 0.00021 XP_011508833 (OMIM: 616285) PREDICTED: formin-like (1094) 511 49.0 0.00021 XP_011508832 (OMIM: 616285) PREDICTED: formin-like (1099) 511 49.0 0.00021 NP_008921 (OMIM: 605875) wiskott-Aldrich syndrome ( 498) 463 45.6 0.001 XP_016857330 (OMIM: 606373,616193) PREDICTED: form (1102) 472 46.5 0.0012 XP_016857329 (OMIM: 606373,616193) PREDICTED: form (1102) 472 46.5 0.0012 XP_016857328 (OMIM: 606373,616193) PREDICTED: form (1159) 472 46.6 0.0012 XP_011542539 (OMIM: 606373,616193) PREDICTED: form (1360) 472 46.6 0.0014 XP_016857327 (OMIM: 606373,616193) PREDICTED: form (1384) 472 46.6 0.0014 XP_016857326 (OMIM: 606373,616193) PREDICTED: form (1417) 472 46.7 0.0014 >>NP_071934 (OMIM: 610982,613237,614455) inverted formin (1249 aa) initn: 8320 init1: 8320 opt: 8320 Z-score: 2868.3 bits: 542.9 E(87258): 5.1e-153 Smith-Waterman score: 8320; 100.0% identity (100.0% similar) in 1249 aa overlap (1-1249:1-1249) 10 20 30 40 50 60 pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KE2 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEEVPPDSDDNKTKKLCVIQ ::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEEVPPDSDDNKTKKLCVIQ 1210 1220 1230 1240 >>XP_005268061 (OMIM: 610982,613237,614455) PREDICTED: i (1281 aa) initn: 8320 init1: 8320 opt: 8320 Z-score: 2868.2 bits: 542.9 E(87258): 5.2e-153 Smith-Waterman score: 8320; 100.0% identity (100.0% similar) in 1249 aa overlap (1-1249:33-1281) 10 20 30 pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANL :::::::::::::::::::::::::::::: XP_005 SQGSVRSSPGQGPEWVGRGGRKVLRIWLGKMSVKEGAQRKWAALKEKLGPQDSDPTEANL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE2 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE2 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE2 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE2 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE2 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE2 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE2 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE2 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE2 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE2 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE2 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE2 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE2 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE2 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE2 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE2 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE2 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KE2 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ 1210 1220 1230 1240 1250 1260 1240 pF1KE2 EEVPPDSDDNKTKKLCVIQ ::::::::::::::::::: XP_005 EEVPPDSDDNKTKKLCVIQ 1270 1280 >>XP_016877084 (OMIM: 610982,613237,614455) PREDICTED: i (1281 aa) initn: 8320 init1: 8320 opt: 8320 Z-score: 2868.2 bits: 542.9 E(87258): 5.2e-153 Smith-Waterman score: 8320; 100.0% identity (100.0% similar) in 1249 aa overlap (1-1249:33-1281) 10 20 30 pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANL :::::::::::::::::::::::::::::: XP_016 SQGSVRSSPGQGPEWVGRGGRKVLRIWLGKMSVKEGAQRKWAALKEKLGPQDSDPTEANL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE2 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE2 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE2 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE2 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE2 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE2 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE2 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE2 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE2 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE2 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE2 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE2 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE2 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE2 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE2 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE2 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE2 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KE2 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ 1210 1220 1230 1240 1250 1260 1240 pF1KE2 EEVPPDSDDNKTKKLCVIQ ::::::::::::::::::: XP_016 EEVPPDSDDNKTKKLCVIQ 1270 1280 >>NP_001026884 (OMIM: 610982,613237,614455) inverted for (1240 aa) initn: 8195 init1: 8195 opt: 8200 Z-score: 2827.4 bits: 535.3 E(87258): 9.8e-151 Smith-Waterman score: 8200; 99.8% identity (99.8% similar) in 1235 aa overlap (1-1235:1-1235) 10 20 30 40 50 60 pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 pF1KE2 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEEVPPDSDDNKTKKLCVIQ ::::::::::::::::::::::::::::::: . : NP_001 SSGSGTLPRARGRASKGTGKRRKKRPSRSQEGLRPRPKAK 1210 1220 1230 1240 >>XP_005268062 (OMIM: 610982,613237,614455) PREDICTED: i (1272 aa) initn: 8195 init1: 8195 opt: 8200 Z-score: 2827.2 bits: 535.3 E(87258): 9.9e-151 Smith-Waterman score: 8200; 99.8% identity (99.8% similar) in 1235 aa overlap (1-1235:33-1267) 10 20 30 pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANL :::::::::::::::::::::::::::::: XP_005 SQGSVRSSPGQGPEWVGRGGRKVLRIWLGKMSVKEGAQRKWAALKEKLGPQDSDPTEANL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ESADPELCIRLLQMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRGVA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RISDALLQLTCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAAL 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE2 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CIYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPED 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE2 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRARTQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE2 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HQEVFASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE2 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ECTLEEVVERLLSVKGRPRPSPLVKAHKSVQANLDQSQRGSSPQNTTTPKPSVEGQQPAA 370 380 390 400 410 420 400 410 420 430 440 450 pF1KE2 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLPGSSAEPPPPPPPPPLPSVG 430 440 450 460 470 480 460 470 480 490 500 510 pF1KE2 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AKALPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGM 490 500 510 520 530 540 520 530 540 550 560 570 pF1KE2 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GWGPPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQ 550 560 570 580 590 600 580 590 600 610 620 630 pF1KE2 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KLPSNVAREHNSMWASLSSPDAEAVEPDFSSIERLFSFPAAKPKEPTMVAPRARKEPKEI 610 620 630 640 650 660 640 650 660 670 680 690 pF1KE2 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TFLDAKKSLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRA 670 680 690 700 710 720 700 710 720 730 740 750 pF1KE2 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FTEERAKLASADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLT 730 740 750 760 770 780 760 770 780 790 800 810 pF1KE2 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRQLPIFCQLILRIGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEK 790 800 810 820 830 840 820 830 840 850 860 870 pF1KE2 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHPDLLQLPRDLEQPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQYTERLQ 850 860 870 880 890 900 880 890 900 910 920 930 pF1KE2 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASISAFRALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDR 910 920 930 940 950 960 940 950 960 970 980 990 pF1KE2 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KEQAAKAERRKQQLAEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLADIRKGFQLRKTA 970 980 990 1000 1010 1020 1000 1010 1020 1030 1040 1050 pF1KE2 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RGRGDTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLV 1030 1040 1050 1060 1070 1080 1060 1070 1080 1090 1100 1110 pF1KE2 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DAVTPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQA 1090 1100 1110 1120 1130 1140 1120 1130 1140 1150 1160 1170 pF1KE2 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKPLKFSSNQPPAAGSSRQDAKDPTSLLGVLQAEADSTSEGLEDAVHSRGARPPAAGPGG 1150 1160 1170 1180 1190 1200 1180 1190 1200 1210 1220 1230 pF1KE2 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEDEDEEDTAPESALDTSLDKSFSEDAVTDSSGSGTLPRARGRASKGTGKRRKKRPSRSQ 1210 1220 1230 1240 1250 1260 1240 pF1KE2 EEVPPDSDDNKTKKLCVIQ : . : XP_005 EGLRPRPKAK 1270 >>NP_116103 (OMIM: 610982,613237,614455) inverted formin (234 aa) initn: 1503 init1: 1503 opt: 1503 Z-score: 547.1 bits: 111.0 E(87258): 1e-23 Smith-Waterman score: 1503; 100.0% identity (100.0% similar) in 234 aa overlap (1-234:1-234) 10 20 30 40 50 60 pF1KE2 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLR 190 200 210 220 230 250 260 270 280 290 300 pF1KE2 LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH >>XP_011535875 (OMIM: 124900,602121,616632) PREDICTED: p (1250 aa) initn: 263 init1: 263 opt: 884 Z-score: 326.9 bits: 72.7 E(87258): 1.8e-11 Smith-Waterman score: 1285; 28.2% identity (56.8% similar) in 1091 aa overlap (73-1034:165-1236) 50 60 70 80 90 100 pF1KE2 QMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARISDALLQLT :: ::. : :: . .: :. . XP_011 RDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHE 140 150 160 170 180 190 110 120 130 140 150 pF1KE2 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTS--NVMVKKQVFELLAALCIY-SPEG . :..: ::.. ::. .: .. . : .:.: . :.:. .. .::.:::: .:: XP_011 IIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMI--DAAKLLSALCILPQPED 200 210 220 230 240 250 160 170 180 190 200 210 pF1KE2 -HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQ . .:.:. . .. .. ::. ... :... .. : :..:::.: :.: :.. XP_011 MNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVH 260 270 280 290 300 310 220 230 240 250 260 270 pF1KE2 LRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELL-RVSG-GVDMSSHQEV .:.:.. : : .:: ::..:. :. .::..:.: :: .: :.. ..:.. .:: XP_011 IRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEV 320 330 340 350 360 370 280 290 300 310 320 330 pF1KE2 FASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---E : :.. :. : . ..::.:: :: .. .. .. .: ... :: . :. . XP_011 FQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFK 380 390 400 410 420 430 340 350 360 pF1KE2 CT---------LEEVVERLLSVKGRPRPSPLVKA--------H------KSVQANLDQSQ : ....... :.. . . : : : :.......:. XP_011 CRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKL 440 450 460 470 480 490 370 380 390 400 410 pF1KE2 RG---------SSPQNTTTPKPSVEGQ----QPAAAAACEPVDHAQSE----SILKVSQP . : :. .: : ..:.. .: . .. :..: : .. : XP_011 QDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVP 500 510 520 530 540 550 420 430 440 pF1KE2 RALEQQASTPPPPP---------PPPLLPGSSAEPPPPPPPPP----------------L .. ..: .:: :: ::: ::.:. ::::::::: : XP_011 PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSL 560 570 580 590 600 610 450 460 470 pF1KE2 PSVGAKALP-------TAPPPPPLP---GL--------GAMAPPAPPLP---------PP :. : . : : ::::::: :. :. :: :::: :: XP_011 PGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPP 620 630 640 650 660 670 480 490 500 510 520 530 pF1KE2 LPGSCEFLPPPPPPLPG-LGCPPPPPPLLPGMGWGPPPPPP-PLLPCTCSPPVAGGMEEV :::: .::::::::: : ::::::: :: : : ::::: : : :: . :: XP_011 LPGSAG-IPPPPPPLPGEAGMPPPPPPL-PG-GPGIPPPPPFPGGPGIPPPPPGMGMPP- 680 690 700 710 720 540 550 560 570 580 pF1KE2 IVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVARE--HNSMWASLSS :.: .: . ... : ..... ::.:: ::.. .. .:.... XP_011 ---PPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKL---VAEDLSQDCFWTKVKE 730 740 750 760 770 780 590 600 610 620 630 640 pF1KE2 PDAEAVEPDFSSIERLFSFP-----AAKPKEPTMVAPRARKEP-KEITFLDAKKSLNLNI : : :... :: : : .: ..:. ::. ::.: . ::.: XP_011 DRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSI 790 800 810 820 830 840 650 660 670 680 690 700 pF1KE2 FLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADH :: .:. .:. .: . . . ....:.: .:: .... : . .: :: ... XP_011 FLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQ 850 860 870 880 890 900 710 720 730 740 750 760 pF1KE2 FYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILR : ... ..: . :.. .:. . .. ..:. : :::: : :... . .. : XP_011 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL 910 920 930 940 950 960 770 780 790 800 810 820 pF1KE2 IGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLE .::..: ::... : ::.:: : :: .::: ....:::: . : :...::.:..: .: XP_011 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 970 980 990 1000 1010 1020 830 840 850 860 870 pF1KE2 QPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQ--YTERLQASIS----AFR . .:. .. : .... .. :.. ..:: :. : ..:. ..:.. . .. . XP_011 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1030 1040 1050 1060 1070 1080 880 890 900 910 920 930 pF1KE2 ALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA : . .: .::..:. : ..::.:. : .. ::..::.:.:::. :.: : XP_011 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKM 1090 1100 1110 1120 1130 1140 940 950 960 970 980 990 pF1KE2 ERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLRKTARGRG :. .::.:.:.. : : . .. .. .:. :.:.:: ...: .: : :: XP_011 --RRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFR---RKRG 1150 1160 1170 1180 1190 1000 1010 1020 1030 1040 1050 pF1KE2 DTDGGSKAA-SMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAV ... ::. .. :.: . . :. :. .. . : XP_011 PRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTILEEAKELVGRAS 1200 1210 1220 1230 1240 1250 1060 1070 1080 1090 1100 1110 pF1KE2 TPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQALKP >>NP_001300936 (OMIM: 124900,602121,616632) protein diap (1250 aa) initn: 263 init1: 263 opt: 884 Z-score: 326.9 bits: 72.7 E(87258): 1.8e-11 Smith-Waterman score: 1280; 28.5% identity (57.0% similar) in 1051 aa overlap (73-995:187-1221) 50 60 70 80 90 100 pF1KE2 QMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARISDALLQLT :: ::. : :: . .: :. . NP_001 RDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHE 160 170 180 190 200 210 110 120 130 140 150 pF1KE2 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTS--NVMVKKQVFELLAALCIY-SPEG . :..: ::.. ::. .: .. . : .:.: . :.:. .. .::.:::: .:: NP_001 IIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMI--DAAKLLSALCILPQPED 220 230 240 250 260 270 160 170 180 190 200 210 pF1KE2 -HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQ . .:.:. . .. .. ::. ... :... .. : :..:::.: :.: :.. NP_001 MNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVH 280 290 300 310 320 330 220 230 240 250 260 270 pF1KE2 LRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELL-RVSG-GVDMSSHQEV .:.:.. : : .:: ::..:. :. .::..:.: :: .: :.. ..:.. .:: NP_001 IRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEV 340 350 360 370 380 390 280 290 300 310 320 330 pF1KE2 FASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---E : :.. :. : . ..::.:: :: .. .. .. .: ... :: . :. . NP_001 FQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFK 400 410 420 430 440 450 340 350 360 pF1KE2 CT---------LEEVVERLLSVKGRPRPSPLVKA--------H------KSVQANLDQSQ : ....... :.. . . : : : :.......:. NP_001 CRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKL 460 470 480 490 500 510 370 380 390 400 410 pF1KE2 RG---------SSPQNTTTPKPSVEGQ----QPAAAAACEPVDHAQSE----SILKVSQP . : :. .: : ..:.. .: . .. :..: : .. : NP_001 QDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVP 520 530 540 550 560 570 420 430 440 pF1KE2 RALEQQASTPPPPP---------PPPLLPGSSAEPPPPPPPPP----------------L .. ..: .:: :: ::: ::.:. ::::::::: : NP_001 PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSL 580 590 600 610 620 630 450 460 470 pF1KE2 PSVGAKALP-------TAPPPPPLP---GL--------GAMAPPAPPLP---------PP :. : . : : ::::::: :. :. :: :::: :: NP_001 PGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPP 640 650 660 670 680 690 480 490 500 510 520 530 pF1KE2 LPGSCEFLPPPPPPLPG-LGCPPPPPPLLPGMGWGPPPPPP-PLLPCTCSPPVAGGMEEV :::: .::::::::: : ::::::: :: : : ::::: : : :: . :: NP_001 LPGSAG-IPPPPPPLPGEAGMPPPPPPL-PG-GPGIPPPPPFPGGPGIPPPPPGMGMPP- 700 710 720 730 740 540 550 560 570 580 pF1KE2 IVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVARE--HNSMWASLSS :.: .: . ... : ..... ::.:: ::.. .. .:.... NP_001 ---PPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKL---VAEDLSQDCFWTKVKE 750 760 770 780 790 800 590 600 610 620 630 640 pF1KE2 PDAEAVEPDFSSIERLFSFP-----AAKPKEPTMVAPRARKEP-KEITFLDAKKSLNLNI : : :... :: : : .: ..:. ::. ::.: . ::.: NP_001 DRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSI 810 820 830 840 850 860 650 660 670 680 690 700 pF1KE2 FLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADH :: .:. .:. .: . . . ....:.: .:: .... : . .: :: ... NP_001 FLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQ 870 880 890 900 910 920 710 720 730 740 750 760 pF1KE2 FYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILR : ... ..: . :.. .:. . .. ..:. : :::: : :... . .. : NP_001 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL 930 940 950 960 970 980 770 780 790 800 810 820 pF1KE2 IGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLE .::..: ::... : ::.:: : :: .::: ....:::: . : :...::.:..: .: NP_001 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 990 1000 1010 1020 1030 1040 830 840 850 860 870 pF1KE2 QPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQ--YTERLQASIS----AFR . .:. .. : .... .. :.. ..:: :. : ..:. ..:.. . .. . NP_001 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1050 1060 1070 1080 1090 1100 880 890 900 910 920 930 pF1KE2 ALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA : . .: .::..:. : ..::.:. : .. ::..::.:.:::. :.: : NP_001 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKM 1110 1120 1130 1140 1150 1160 940 950 960 970 980 990 pF1KE2 ERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLRKTARGRG :. .::.:.:.. : : . .. .. .:. :.:.:: ...: .:. : NP_001 --RRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFRRKRGPRQ 1170 1180 1190 1200 1210 1220 1000 1010 1020 1030 1040 1050 pF1KE2 DTDGGSKAASMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAVT : NP_001 DNLLCPWEVEEEEETFKLPTGRPGVQSHLC 1230 1240 1250 >>XP_011535874 (OMIM: 124900,602121,616632) PREDICTED: p (1260 aa) initn: 263 init1: 263 opt: 884 Z-score: 326.9 bits: 72.7 E(87258): 1.8e-11 Smith-Waterman score: 1285; 28.2% identity (56.8% similar) in 1091 aa overlap (73-1034:175-1246) 50 60 70 80 90 100 pF1KE2 QMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARISDALLQLT :: ::. : :: . .: :. . XP_011 RDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHE 150 160 170 180 190 200 110 120 130 140 150 pF1KE2 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTS--NVMVKKQVFELLAALCIY-SPEG . :..: ::.. ::. .: .. . : .:.: . :.:. .. .::.:::: .:: XP_011 IIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMI--DAAKLLSALCILPQPED 210 220 230 240 250 260 160 170 180 190 200 210 pF1KE2 -HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQ . .:.:. . .. .. ::. ... :... .. : :..:::.: :.: :.. XP_011 MNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVH 270 280 290 300 310 320 220 230 240 250 260 270 pF1KE2 LRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELL-RVSG-GVDMSSHQEV .:.:.. : : .:: ::..:. :. .::..:.: :: .: :.. ..:.. .:: XP_011 IRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEV 330 340 350 360 370 380 280 290 300 310 320 330 pF1KE2 FASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---E : :.. :. : . ..::.:: :: .. .. .. .: ... :: . :. . XP_011 FQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFK 390 400 410 420 430 440 340 350 360 pF1KE2 CT---------LEEVVERLLSVKGRPRPSPLVKA--------H------KSVQANLDQSQ : ....... :.. . . : : : :.......:. XP_011 CRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKL 450 460 470 480 490 500 370 380 390 400 410 pF1KE2 RG---------SSPQNTTTPKPSVEGQ----QPAAAAACEPVDHAQSE----SILKVSQP . : :. .: : ..:.. .: . .. :..: : .. : XP_011 QDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVP 510 520 530 540 550 560 420 430 440 pF1KE2 RALEQQASTPPPPP---------PPPLLPGSSAEPPPPPPPPP----------------L .. ..: .:: :: ::: ::.:. ::::::::: : XP_011 PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSL 570 580 590 600 610 620 450 460 470 pF1KE2 PSVGAKALP-------TAPPPPPLP---GL--------GAMAPPAPPLP---------PP :. : . : : ::::::: :. :. :: :::: :: XP_011 PGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPP 630 640 650 660 670 680 480 490 500 510 520 530 pF1KE2 LPGSCEFLPPPPPPLPG-LGCPPPPPPLLPGMGWGPPPPPP-PLLPCTCSPPVAGGMEEV :::: .::::::::: : ::::::: :: : : ::::: : : :: . :: XP_011 LPGSAG-IPPPPPPLPGEAGMPPPPPPL-PG-GPGIPPPPPFPGGPGIPPPPPGMGMPP- 690 700 710 720 730 540 550 560 570 580 pF1KE2 IVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVARE--HNSMWASLSS :.: .: . ... : ..... ::.:: ::.. .. .:.... XP_011 ---PPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKL---VAEDLSQDCFWTKVKE 740 750 760 770 780 790 590 600 610 620 630 640 pF1KE2 PDAEAVEPDFSSIERLFSFP-----AAKPKEPTMVAPRARKEP-KEITFLDAKKSLNLNI : : :... :: : : .: ..:. ::. ::.: . ::.: XP_011 DRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSI 800 810 820 830 840 850 650 660 670 680 690 700 pF1KE2 FLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADH :: .:. .:. .: . . . ....:.: .:: .... : . .: :: ... XP_011 FLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQ 860 870 880 890 900 910 710 720 730 740 750 760 pF1KE2 FYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILR : ... ..: . :.. .:. . .. ..:. : :::: : :... . .. : XP_011 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL 920 930 940 950 960 970 770 780 790 800 810 820 pF1KE2 IGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLE .::..: ::... : ::.:: : :: .::: ....:::: . : :...::.:..: .: XP_011 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 980 990 1000 1010 1020 1030 830 840 850 860 870 pF1KE2 QPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQ--YTERLQASIS----AFR . .:. .. : .... .. :.. ..:: :. : ..:. ..:.. . .. . XP_011 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1040 1050 1060 1070 1080 1090 880 890 900 910 920 930 pF1KE2 ALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA : . .: .::..:. : ..::.:. : .. ::..::.:.:::. :.: : XP_011 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKM 1100 1110 1120 1130 1140 1150 940 950 960 970 980 990 pF1KE2 ERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLRKTARGRG :. .::.:.:.. : : . .. .. .:. :.:.:: ...: .: : :: XP_011 --RRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFR---RKRG 1160 1170 1180 1190 1200 1000 1010 1020 1030 1040 1050 pF1KE2 DTDGGSKAA-SMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAV ... ::. .. :.: . . :. :. .. . : XP_011 PRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTILEEAKELVGRAS 1210 1220 1230 1240 1250 1260 1060 1070 1080 1090 1100 1110 pF1KE2 TPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQALKP >>NP_001073280 (OMIM: 124900,602121,616632) protein diap (1263 aa) initn: 263 init1: 263 opt: 884 Z-score: 326.9 bits: 72.7 E(87258): 1.8e-11 Smith-Waterman score: 1285; 28.2% identity (56.8% similar) in 1091 aa overlap (73-1034:178-1249) 50 60 70 80 90 100 pF1KE2 QMPSVVNYSGLRKRLEGSDGGWMVQFLEQSGLDLLLEALARLSGRG--VARISDALLQLT :: ::. : :: . .: :. . NP_001 RDMPLLSCLESLRVSLNNNPVSWVQTFGAEGLASLLDILKRLHDEKEETAGSYDSRNKHE 150 160 170 180 190 200 110 120 130 140 150 pF1KE2 CVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTS--NVMVKKQVFELLAALCIY-SPEG . :..: ::.. ::. .: .. . : .:.: . :.:. .. .::.:::: .:: NP_001 IIRCLKAFMNNKFGIKTMLETEEGILLLVRAMDPAVPNMMI--DAAKLLSALCILPQPED 210 220 230 240 250 260 160 170 180 190 200 210 pF1KE2 -HVLTLDALDHYKTVCSQQYRFSIVMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQ . .:.:. . .. .. ::. ... :... .. : :..:::.: :.: :.. NP_001 MNERVLEAMTE-RAEMDEVERFQPLLDGLKSGTTIALKVGCLQLINALITPAEELDFRVH 270 280 290 300 310 320 220 230 240 250 260 270 pF1KE2 LRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELL-RVSG-GVDMSSHQEV .:.:.. : : .:: ::..:. :. .::..:.: :: .: :.. ..:.. .:: NP_001 IRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGEEDSYDLKGRLDDIRMEMDDFNEV 330 340 350 360 370 380 280 290 300 310 320 330 pF1KE2 FASLFHKVSCSPVSAQLLSVLQGLLHLEPTLRSSQLLWEALESLVNRAVLLASDAQ---E : :.. :. : . ..::.:: :: .. .. .. .: ... :: . :. . NP_001 FQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIEECISQIVLHKNGADPDFK 390 400 410 420 430 440 340 350 360 pF1KE2 CT---------LEEVVERLLSVKGRPRPSPLVKA--------H------KSVQANLDQSQ : ....... :.. . . : : : :.......:. NP_001 CRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQVEMKKMESDFEQKL 450 460 470 480 490 500 370 380 390 400 410 pF1KE2 RG---------SSPQNTTTPKPSVEGQ----QPAAAAACEPVDHAQSE----SILKVSQP . : :. .: : ..:.. .: . .. :..: : .. : NP_001 QDLQGEKDALHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVP 510 520 530 540 550 560 420 430 440 pF1KE2 RALEQQASTPPPPP---------PPPLLPGSSAEPPPPPPPPP----------------L .. ..: .:: :: ::: ::.:. ::::::::: : NP_001 PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSL 570 580 590 600 610 620 450 460 470 pF1KE2 PSVGAKALP-------TAPPPPPLP---GL--------GAMAPPAPPLP---------PP :. : . : : ::::::: :. :. :: :::: :: NP_001 PGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPP 630 640 650 660 670 680 480 490 500 510 520 530 pF1KE2 LPGSCEFLPPPPPPLPG-LGCPPPPPPLLPGMGWGPPPPPP-PLLPCTCSPPVAGGMEEV :::: .::::::::: : ::::::: :: : : ::::: : : :: . :: NP_001 LPGSAG-IPPPPPPLPGEAGMPPPPPPL-PG-GPGIPPPPPFPGGPGIPPPPPGMGMPP- 690 700 710 720 730 740 540 550 560 570 580 pF1KE2 IVAQVDHGLGSAWVP------SHRRVNPPTLRMKKLNWQKLPSNVARE--HNSMWASLSS :.: .: . ... : ..... ::.:: ::.. .. .:.... NP_001 ---PPPFGFGVPAAPVLPFGLTPKKLYKPEVQLRRPNWSKL---VAEDLSQDCFWTKVKE 750 760 770 780 790 590 600 610 620 630 640 pF1KE2 PDAEAVEPDFSSIERLFSFP-----AAKPKEPTMVAPRARKEP-KEITFLDAKKSLNLNI : : :... :: : : .: ..:. ::. ::.: . ::.: NP_001 DRFENNEL-FAKLTLTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSI 800 810 820 830 840 850 650 660 670 680 690 700 pF1KE2 FLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADH :: .:. .:. .: . . . ....:.: .:: .... : . .: :: ... NP_001 FLGSFRMPYQEIKNVILEVNEAVLTESMIQNLIKQMPEPEQLKMLSELKDEYDDLAESEQ 860 870 880 890 900 910 710 720 730 740 750 760 pF1KE2 FYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILR : ... ..: . :.. .:. . .. ..:. : :::: : :... . .. : NP_001 FGVVMGTVPRLRPRLNAILFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLL 920 930 940 950 960 970 770 780 790 800 810 820 pF1KE2 IGNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLE .::..: ::... : ::.:: : :: .::: ....:::: . : :...::.:..: .: NP_001 VGNYMNAGSRNAGAFGFNISFLCKLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELA 980 990 1000 1010 1020 1030 830 840 850 860 870 pF1KE2 QPSQAAGINLEIIRSEASSNLKKLLETERKVSASVAEVQEQ--YTERLQASIS----AFR . .:. .. : .... .. :.. ..:: :. : ..:. ..:.. . .. . NP_001 HVEKASRVSAENLQKNLDQMKKQISDVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYN 1040 1050 1060 1070 1080 1090 880 890 900 910 920 930 pF1KE2 ALDELFEAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKA : . .: .::..:. : ..::.:. : .. ::..::.:.:::. :.: : NP_001 KLRMMHSNMETLYKELGEYFLFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKM 1100 1110 1120 1130 1140 1150 940 950 960 970 980 990 pF1KE2 ERRKQQLAEEEARRPRGEDGKPVRK---GPGKQEEVCVIDALLADIRKGFQLRKTARGRG :. .::.:.:.. : : . .. .. .:. :.:.:: ...: .: : :: NP_001 --RRAKLAKEKAEKERLEKQQKREQLIDMNAEGDETGVMDSLLEALQSGAAFR---RKRG 1160 1170 1180 1190 1200 1000 1010 1020 1030 1040 1050 pF1KE2 DTDGGSKAA-SMDPPRATEPVATSNPAGDPVGSTRCPASEPGLDATTASESRGWDLVDAV ... ::. .. :.: . . :. :. .. . : NP_001 PRQANRKAGCAVTSLLASELTKDDAMAAVPAKVSKNSETFPTILEEAKELVGRAS 1210 1220 1230 1240 1250 1260 1060 1070 1080 1090 1100 1110 pF1KE2 TPGPQPTLEQLEEGGPRPLERRSSWYVDASDVLTTEDPQCPQPLEGAWPVTLGDAQALKP 1249 residues in 1 query sequences 62035967 residues in 87258 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Thu Jun 29 17:41:21 2017 done: Thu Jun 29 17:41:23 2017 Total Scan time: 17.050 Total Display time: 0.290 Function used was FASTA [36.3.4 Apr, 2011]