FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3184, 422 aa 1>>>pF1KE3184 422 - 422 aa - 422 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6343+/-0.000375; mu= 16.2306+/- 0.023 mean_var=84.2628+/-16.792, 0's: 0 Z-trim(114.1): 56 B-trim: 1093 in 1/53 Lambda= 0.139719 statistics sampled from 23716 (23772) to 23716 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.279), width: 16 Scan time: 9.140 The best scores are: opt bits E(85289) NP_060708 (OMIM: 212350,610345,614691) acylglycero ( 422) 2821 578.6 1e-164 XP_011514699 (OMIM: 212350,610345,614691) PREDICTE ( 422) 2821 578.6 1e-164 XP_005250080 (OMIM: 212350,610345,614691) PREDICTE ( 350) 2328 479.2 7.1e-135 XP_005257823 (OMIM: 603730) PREDICTED: sphingosine ( 384) 278 66.0 1.9e-10 NP_001136073 (OMIM: 603730) sphingosine kinase 1 i ( 384) 278 66.0 1.9e-10 NP_001136074 (OMIM: 603730) sphingosine kinase 1 i ( 384) 278 66.0 1.9e-10 NP_068807 (OMIM: 603730) sphingosine kinase 1 isof ( 398) 278 66.0 1.9e-10 NP_892010 (OMIM: 603730) sphingosine kinase 1 isof ( 470) 278 66.1 2.2e-10 NP_001191087 (OMIM: 607092) sphingosine kinase 2 i ( 595) 251 60.7 1.2e-08 XP_006723355 (OMIM: 607092) PREDICTED: sphingosine ( 618) 251 60.7 1.2e-08 NP_001191089 (OMIM: 607092) sphingosine kinase 2 i ( 618) 251 60.7 1.2e-08 XP_011525436 (OMIM: 607092) PREDICTED: sphingosine ( 618) 251 60.7 1.2e-08 NP_001191088 (OMIM: 607092) sphingosine kinase 2 i ( 654) 251 60.7 1.2e-08 XP_011525435 (OMIM: 607092) PREDICTED: sphingosine ( 654) 251 60.7 1.2e-08 NP_064511 (OMIM: 607092) sphingosine kinase 2 isof ( 654) 251 60.7 1.2e-08 XP_016882497 (OMIM: 607092) PREDICTED: sphingosine ( 716) 251 60.7 1.3e-08 XP_016882498 (OMIM: 607092) PREDICTED: sphingosine ( 448) 218 53.9 9.3e-07 NP_001230805 (OMIM: 607092) sphingosine kinase 2 i ( 448) 218 53.9 9.3e-07 NP_963842 (OMIM: 608380,608381) ceramide kinase-li ( 532) 217 53.8 1.2e-06 XP_016882499 (OMIM: 607092) PREDICTED: sphingosine ( 401) 185 47.3 8.6e-05 XP_016884398 (OMIM: 610307) PREDICTED: ceramide ki ( 500) 182 46.7 0.00016 NP_073603 (OMIM: 610307) ceramide kinase [Homo sap ( 537) 182 46.7 0.00016 >>NP_060708 (OMIM: 212350,610345,614691) acylglycerol ki (422 aa) initn: 2821 init1: 2821 opt: 2821 Z-score: 3078.3 bits: 578.6 E(85289): 1e-164 Smith-Waterman score: 2821; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KE3 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSP 370 380 390 400 410 420 pF1KE3 TQ :: NP_060 TQ >>XP_011514699 (OMIM: 212350,610345,614691) PREDICTED: a (422 aa) initn: 2821 init1: 2821 opt: 2821 Z-score: 3078.3 bits: 578.6 E(85289): 1e-164 Smith-Waterman score: 2821; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422) 10 20 30 40 50 60 pF1KE3 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 EGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSP 370 380 390 400 410 420 pF1KE3 TQ :: XP_011 TQ >>XP_005250080 (OMIM: 212350,610345,614691) PREDICTED: a (350 aa) initn: 2328 init1: 2328 opt: 2328 Z-score: 2542.4 bits: 479.2 E(85289): 7.1e-135 Smith-Waterman score: 2328; 100.0% identity (100.0% similar) in 349 aa overlap (1-349:1-349) 10 20 30 40 50 60 pF1KE3 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHV ::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGK 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 EGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSP >>XP_005257823 (OMIM: 603730) PREDICTED: sphingosine kin (384 aa) initn: 184 init1: 70 opt: 278 Z-score: 308.6 bits: 66.0 E(85289): 1.9e-10 Smith-Waterman score: 278; 26.5% identity (62.3% similar) in 215 aa overlap (62-270:16-227) 40 50 60 70 80 90 pF1KE3 KHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLS .. :.::: . :::: ::.... :.: . XP_005 MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEA 10 20 30 40 100 110 120 130 140 pF1KE3 GMDVTIVKTDYEGQAKKLL--ELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPI .. :.. :. ...:..:. : . :...: .::: ..:::.:...: : : . :. XP_005 EISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPL 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE3 GFIPLGETSSLSHTLFAESG-NKVQH---ITDATLAIVKGETVPLDVLQIKGEKEQPVFA .: : ..:. .: .: ..: . .:. :: . . :...:... . .:. XP_005 CSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFS 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE3 MTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEP . .: :: . :. .. :: :: ... . :. .:... ..: :. : .. XP_005 VLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAAL--RTYRGRLAYL-PVGRVGSKT 170 180 190 200 210 220 270 280 290 300 310 320 pF1KE3 EETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPT .:: XP_005 PASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAA 230 240 250 260 270 280 >>NP_001136073 (OMIM: 603730) sphingosine kinase 1 isofo (384 aa) initn: 184 init1: 70 opt: 278 Z-score: 308.6 bits: 66.0 E(85289): 1.9e-10 Smith-Waterman score: 278; 26.5% identity (62.3% similar) in 215 aa overlap (62-270:16-227) 40 50 60 70 80 90 pF1KE3 KHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLS .. :.::: . :::: ::.... :.: . NP_001 MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEA 10 20 30 40 100 110 120 130 140 pF1KE3 GMDVTIVKTDYEGQAKKLL--ELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPI .. :.. :. ...:..:. : . :...: .::: ..:::.:...: : : . :. NP_001 EISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPL 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE3 GFIPLGETSSLSHTLFAESG-NKVQH---ITDATLAIVKGETVPLDVLQIKGEKEQPVFA .: : ..:. .: .: ..: . .:. :: . . :...:... . .:. NP_001 CSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFS 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE3 MTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEP . .: :: . :. .. :: :: ... . :. .:... ..: :. : .. NP_001 VLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAAL--RTYRGRLAYL-PVGRVGSKT 170 180 190 200 210 220 270 280 290 300 310 320 pF1KE3 EETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPT .:: NP_001 PASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAA 230 240 250 260 270 280 >>NP_001136074 (OMIM: 603730) sphingosine kinase 1 isofo (384 aa) initn: 184 init1: 70 opt: 278 Z-score: 308.6 bits: 66.0 E(85289): 1.9e-10 Smith-Waterman score: 278; 26.5% identity (62.3% similar) in 215 aa overlap (62-270:16-227) 40 50 60 70 80 90 pF1KE3 KHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLS .. :.::: . :::: ::.... :.: . NP_001 MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEA 10 20 30 40 100 110 120 130 140 pF1KE3 GMDVTIVKTDYEGQAKKLL--ELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPI .. :.. :. ...:..:. : . :...: .::: ..:::.:...: : : . :. NP_001 EISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPL 50 60 70 80 90 100 150 160 170 180 190 200 pF1KE3 GFIPLGETSSLSHTLFAESG-NKVQH---ITDATLAIVKGETVPLDVLQIKGEKEQPVFA .: : ..:. .: .: ..: . .:. :: . . :...:... . .:. NP_001 CSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFS 110 120 130 140 150 160 210 220 230 240 250 260 pF1KE3 MTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEP . .: :: . :. .. :: :: ... . :. .:... ..: :. : .. NP_001 VLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAAL--RTYRGRLAYL-PVGRVGSKT 170 180 190 200 210 220 270 280 290 300 310 320 pF1KE3 EETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPT .:: NP_001 PASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAA 230 240 250 260 270 280 >>NP_068807 (OMIM: 603730) sphingosine kinase 1 isoform (398 aa) initn: 184 init1: 70 opt: 278 Z-score: 308.4 bits: 66.0 E(85289): 1.9e-10 Smith-Waterman score: 278; 26.5% identity (62.3% similar) in 215 aa overlap (62-270:30-241) 40 50 60 70 80 90 pF1KE3 KHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLS .. :.::: . :::: ::.... :.: . NP_068 MDPVVGCGRGLFGFVFSAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEA 10 20 30 40 50 100 110 120 130 140 pF1KE3 GMDVTIVKTDYEGQAKKLL--ELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPI .. :.. :. ...:..:. : . :...: .::: ..:::.:...: : : . :. NP_068 EISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPL 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE3 GFIPLGETSSLSHTLFAESG-NKVQH---ITDATLAIVKGETVPLDVLQIKGEKEQPVFA .: : ..:. .: .: ..: . .:. :: . . :...:... . .:. NP_068 CSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFS 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE3 MTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEP . .: :: . :. .. :: :: ... . :. .:... ..: :. : .. NP_068 VLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAAL--RTYRGRLAYL-PVGRVGSKT 180 190 200 210 220 230 270 280 290 300 310 320 pF1KE3 EETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPT .:: NP_068 PASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAA 240 250 260 270 280 290 >>NP_892010 (OMIM: 603730) sphingosine kinase 1 isoform (470 aa) initn: 184 init1: 70 opt: 278 Z-score: 307.4 bits: 66.1 E(85289): 2.2e-10 Smith-Waterman score: 278; 26.5% identity (62.3% similar) in 215 aa overlap (62-270:102-313) 40 50 60 70 80 90 pF1KE3 KHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLS .. :.::: . :::: ::.... :.: . NP_892 TAPGTPWQREPRVEVMDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEA 80 90 100 110 120 130 100 110 120 130 140 pF1KE3 GMDVTIVKTDYEGQAKKLL--ELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPI .. :.. :. ...:..:. : . :...: .::: ..:::.:...: : : . :. NP_892 EISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPL 140 150 160 170 180 190 150 160 170 180 190 200 pF1KE3 GFIPLGETSSLSHTLFAESG-NKVQH---ITDATLAIVKGETVPLDVLQIKGEKEQPVFA .: : ..:. .: .: ..: . .:. :: . . :...:... . .:. NP_892 CSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFS 200 210 220 230 240 250 210 220 230 240 250 260 pF1KE3 MTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEP . .: :: . :. .. :: :: ... . :. .:... ..: :. : .. NP_892 VLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAAL--RTYRGRLAYL-PVGRVGSKT 260 270 280 290 300 270 280 290 300 310 320 pF1KE3 EETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPT .:: NP_892 PASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAA 310 320 330 340 350 360 >>NP_001191087 (OMIM: 607092) sphingosine kinase 2 isofo (595 aa) initn: 152 init1: 70 opt: 251 Z-score: 276.5 bits: 60.7 E(85289): 1.2e-08 Smith-Waterman score: 272; 24.3% identity (55.9% similar) in 272 aa overlap (50-301:109-380) 20 30 40 50 60 70 pF1KE3 CLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFL--NPAACKGKAR :. : :. . ..: :: . .: : NP_001 DGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRPPRLLLLVNPFGGRGLAW 80 90 100 110 120 130 80 90 100 110 120 130 pF1KE3 TLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENT--DVIIVAGGDGTLQEVVTGV .... :.. .:.. ....:. ...:..:.. . . : :....::: :.::..:. NP_001 QWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGL 140 150 160 170 180 190 140 150 160 170 180 190 pF1KE3 LRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNK----VQHITDATLAIVKGETVPLD : : : :.:.:..: : ..:. .. ..: . .. . . .: . .: ::: NP_001 LDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGGGHPLD 200 210 220 230 240 250 200 210 220 230 240 pF1KE3 VLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGP--------LKIKAAHFF-STLK .:.. . . :.. .. :: :. .. .. :: : . . : . . :. NP_001 LLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLS 260 270 280 290 300 310 250 260 270 280 290 pF1KE3 EWPQT-HQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQP--QDALSQEVS : : . :: . . : .: :: : . . :.: .: : : ::.. : NP_001 YLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGS 320 330 340 350 360 370 300 310 320 330 340 350 pF1KE3 PEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLH :: NP_001 PEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKAALHSPVSEGAPVIPPSS 380 390 400 410 420 430 >>XP_006723355 (OMIM: 607092) PREDICTED: sphingosine kin (618 aa) initn: 152 init1: 70 opt: 251 Z-score: 276.3 bits: 60.7 E(85289): 1.2e-08 Smith-Waterman score: 272; 24.3% identity (55.9% similar) in 272 aa overlap (50-301:132-403) 20 30 40 50 60 70 pF1KE3 CLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFL--NPAACKGKAR :. : :. . ..: :: . .: : XP_006 DGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRPPRLLLLVNPFGGRGLAW 110 120 130 140 150 160 80 90 100 110 120 130 pF1KE3 TLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENT--DVIIVAGGDGTLQEVVTGV .... :.. .:.. ....:. ...:..:.. . . : :....::: :.::..:. XP_006 QWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGL 170 180 190 200 210 220 140 150 160 170 180 190 pF1KE3 LRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNK----VQHITDATLAIVKGETVPLD : : : :.:.:..: : ..:. .. ..: . .. . . .: . .: ::: XP_006 LDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGGGHPLD 230 240 250 260 270 280 200 210 220 230 240 pF1KE3 VLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGP--------LKIKAAHFF-STLK .:.. . . :.. .. :: :. .. .. :: : . . : . . :. XP_006 LLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLS 290 300 310 320 330 340 250 260 270 280 290 pF1KE3 EWPQT-HQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQP--QDALSQEVS : : . :: . . : .: :: : . . :.: .: : : ::.. : XP_006 YLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGS 350 360 370 380 390 400 300 310 320 330 340 350 pF1KE3 PEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLH :: XP_006 PEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKAALHSPVSEGAPVIPPSS 410 420 430 440 450 460 422 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:37:40 2016 done: Sun Nov 6 01:37:42 2016 Total Scan time: 9.140 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]