FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1739, 244 aa 1>>>pF1KE1739 244 - 244 aa - 244 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5820+/-0.0003; mu= 14.7050+/- 0.019 mean_var=91.4792+/-18.078, 0's: 0 Z-trim(120.0): 24 B-trim: 573 in 1/50 Lambda= 0.134095 statistics sampled from 34664 (34688) to 34664 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.407), width: 16 Scan time: 6.880 The best scores are: opt bits E(85289) NP_002332 (OMIM: 600978) lymphotoxin-beta isoform ( 244) 1627 324.0 1.5e-88 NP_033666 (OMIM: 600978) lymphotoxin-beta isoform ( 77) 337 74.0 8.6e-14 XP_011512918 (OMIM: 153440,607507,608446,610988) P ( 205) 189 45.7 7.4e-05 NP_001153212 (OMIM: 153440,607507,608446,610988) l ( 205) 189 45.7 7.4e-05 XP_011512917 (OMIM: 153440,607507,608446,610988) P ( 205) 189 45.7 7.4e-05 XP_011512919 (OMIM: 153440,607507,608446,610988) P ( 205) 189 45.7 7.4e-05 XP_011512920 (OMIM: 153440,607507,608446,610988) P ( 205) 189 45.7 7.4e-05 NP_000586 (OMIM: 153440,607507,608446,610988) lymp ( 205) 189 45.7 7.4e-05 NP_001191273 (OMIM: 604052) tumor necrosis factor ( 192) 166 41.2 0.0015 NP_005109 (OMIM: 604052) tumor necrosis factor lig ( 251) 166 41.3 0.0019 >>NP_002332 (OMIM: 600978) lymphotoxin-beta isoform a [H (244 aa) initn: 1627 init1: 1627 opt: 1627 Z-score: 1710.6 bits: 324.0 E(85289): 1.5e-88 Smith-Waterman score: 1627; 100.0% identity (100.0% similar) in 244 aa overlap (1-244:1-244) 10 20 30 40 50 60 pF1KE1 MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DAEGLALPQDGLYYLYCLVGYRGRAPPGGGDPQGRSVTLRSSLYRAGGAYGPGTPELLLE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNISHPDMVDFARGKTFFGA 190 200 210 220 230 240 pF1KE1 VMVG :::: NP_002 VMVG >>NP_033666 (OMIM: 600978) lymphotoxin-beta isoform b [H (77 aa) initn: 337 init1: 337 opt: 337 Z-score: 368.6 bits: 74.0 E(85289): 8.6e-14 Smith-Waterman score: 337; 77.3% identity (86.7% similar) in 75 aa overlap (1-75:1-75) 10 20 30 40 50 60 pF1KE1 MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLVTETAD :::::::::::::::::::::::::::::::::::::::::::::::::::::: .. . NP_033 MGALGLEGRGGRLQGRGSLLLAVAGATSLVTLLLAVPITVLAVLALVPQDQGGLGFRSCQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 PGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFS .: : . ..:: NP_033 RRSQKQISAPGSQLPTS 70 >>XP_011512918 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05 Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202) 40 50 60 70 80 pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG ::::. :.:. . ...:. :. . XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS 10 20 30 40 50 90 100 110 120 130 140 pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR ::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :. XP_011 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK 60 70 80 90 100 110 150 160 170 180 190 pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP : : . ..: .. : : :: : : .: :: . . : : : XP_011 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE 120 130 140 150 160 200 210 220 230 240 pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG : :. :. :: .:... .. . : .: .. . .:::: XP_011 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL 170 180 190 200 >>NP_001153212 (OMIM: 153440,607507,608446,610988) lymph (205 aa) initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05 Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202) 40 50 60 70 80 pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG ::::. :.:. . ...:. :. . NP_001 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS 10 20 30 40 50 90 100 110 120 130 140 pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR ::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :. NP_001 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK 60 70 80 90 100 110 150 160 170 180 190 pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP : : . ..: .. : : :: : : .: :: . . : : : NP_001 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE 120 130 140 150 160 200 210 220 230 240 pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG : :. :. :: .:... .. . : .: .. . .:::: NP_001 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL 170 180 190 200 >>XP_011512917 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05 Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202) 40 50 60 70 80 pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG ::::. :.:. . ...:. :. . XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS 10 20 30 40 50 90 100 110 120 130 140 pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR ::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :. XP_011 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK 60 70 80 90 100 110 150 160 170 180 190 pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP : : . ..: .. : : :: : : .: :: . . : : : XP_011 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE 120 130 140 150 160 200 210 220 230 240 pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG : :. :. :: .:... .. . : .: .. . .:::: XP_011 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL 170 180 190 200 >>XP_011512919 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05 Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202) 40 50 60 70 80 pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG ::::. :.:. . ...:. :. . XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS 10 20 30 40 50 90 100 110 120 130 140 pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR ::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :. XP_011 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK 60 70 80 90 100 110 150 160 170 180 190 pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP : : . ..: .. : : :: : : .: :: . . : : : XP_011 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE 120 130 140 150 160 200 210 220 230 240 pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG : :. :. :: .:... .. . : .: .. . .:::: XP_011 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL 170 180 190 200 >>XP_011512920 (OMIM: 153440,607507,608446,610988) PREDI (205 aa) initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05 Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202) 40 50 60 70 80 pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG ::::. :.:. . ...:. :. . XP_011 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS 10 20 30 40 50 90 100 110 120 130 140 pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR ::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :. XP_011 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK 60 70 80 90 100 110 150 160 170 180 190 pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP : : . ..: .. : : :: : : .: :: . . : : : XP_011 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE 120 130 140 150 160 200 210 220 230 240 pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG : :. :. :: .:... .. . : .: .. . .:::: XP_011 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL 170 180 190 200 >>NP_000586 (OMIM: 153440,607507,608446,610988) lymphoto (205 aa) initn: 220 init1: 106 opt: 189 Z-score: 208.2 bits: 45.7 E(85289): 7.4e-05 Smith-Waterman score: 211; 30.2% identity (57.3% similar) in 192 aa overlap (61-240:30-202) 40 50 60 70 80 pF1KE1 TLLLAVPITVLAVLALVPQDQGGLVTETADPGAQAQQGLGFQ----KLPEEEPETDLSPG ::::. :.:. . ...:. :. . NP_000 MTPPERLFLPRVCGTTLHLLLLGLLLVLLPGAQGLPGVGLTPSAAQTARQHPKMHLAHS 10 20 30 40 50 90 100 110 120 130 140 pF1KE1 L--PAAHLIGAPLKGQGLGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGR ::::::: : : ..: :... ..::: .: ..:. ..: .: .:.:..: : . :. NP_000 TLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSN-NSLLVPTSGIYFVYSQVVFSGK 60 70 80 90 100 110 150 160 170 180 190 pF1KE1 A--PPGGGDPQ--GRSVTLRSSLYRAGGAYGP-GTPELLLEGAETVTPVLDPARRQGYGP : : . ..: .. : : :: : : .: :: . . : : : NP_000 AYSPKATSSPLYLAHEVQLFSSQY-------PFHVP--LLSSQKMVYP--------GLQE 120 130 140 150 160 200 210 220 230 240 pF1KE1 LWYTSVGFGGLVQLRRGERVYVNISH-PDMVDFARGKTFFGAVMVG : :. :. :: .:... .. . : .: .. . .:::: NP_000 PWLHSMYHGAAFQLTQGDQLSTHTDGIPHLV-LSPSTVFFGAFAL 170 180 190 200 >>NP_001191273 (OMIM: 604052) tumor necrosis factor liga (192 aa) initn: 85 init1: 43 opt: 166 Z-score: 184.5 bits: 41.2 E(85289): 0.0015 Smith-Waterman score: 176; 27.1% identity (55.9% similar) in 170 aa overlap (88-243:36-192) 60 70 80 90 100 pF1KE1 TADPGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLI---GAP---LKGQ--GLGWETTKE : ::: .: .:.: .: :: NP_001 GRLHFSHPLSHTKHISPFVTDAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELG 10 20 30 40 50 60 110 120 130 140 150 160 pF1KE1 QAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGRAPP-----GGGDPQGRSVTLRSSLY :: . .... . : .:..: :..: : .:: . .: :. . .. . NP_001 LAFTKNRMNYTN-KFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPN-KPDSITVVIT 70 80 90 100 110 120 170 180 190 200 210 220 pF1KE1 RAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNIS .. .: : : :: :...: : : :. . .:.. .:..:....::.: NP_001 KVTDSY-P-EPTQLLMGTKSVCEV---------GSNWFQPIYLGAMFSLQEGDKLMVNVS 130 140 150 160 170 230 240 pF1KE1 HPDMVDFAR-GKTFFGAVMVG ..::... :::::: .. NP_001 DISLVDYTKEDKTFFGAFLL 180 190 >>NP_005109 (OMIM: 604052) tumor necrosis factor ligand (251 aa) initn: 61 init1: 43 opt: 166 Z-score: 183.0 bits: 41.3 E(85289): 0.0019 Smith-Waterman score: 176; 27.1% identity (55.9% similar) in 170 aa overlap (88-243:95-251) 60 70 80 90 100 pF1KE1 TADPGAQAQQGLGFQKLPEEEPETDLSPGLPAAHLI---GAP---LKGQ--GLGWETTKE : ::: .: .:.: .: :: NP_005 ACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 QAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGRAPP-----GGGDPQGRSVTLRSSLY :: . .... . : .:..: :..: : .:: . .: :. . .. . NP_005 LAFTKNRMNYTN-KFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPN-KPDSITVVIT 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE1 RAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRRGERVYVNIS .. .: : : :: :...: : : :. . .:.. .:..:....::.: NP_005 KVTDSY-P-EPTQLLMGTKSVCEV---------GSNWFQPIYLGAMFSLQEGDKLMVNVS 190 200 210 220 230 230 240 pF1KE1 HPDMVDFAR-GKTFFGAVMVG ..::... :::::: .. NP_005 DISLVDYTKEDKTFFGAFLL 240 250 244 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 09:58:03 2016 done: Sun Nov 6 09:58:04 2016 Total Scan time: 6.880 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]