FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4226, 801 aa 1>>>pF1KE4226 801 - 801 aa - 801 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.2119+/-0.000383; mu= -7.5149+/- 0.024 mean_var=311.3150+/-65.643, 0's: 0 Z-trim(121.4): 98 B-trim: 715 in 1/57 Lambda= 0.072690 statistics sampled from 37942 (38045) to 37942 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.768), E-opt: 0.2 (0.446), width: 16 Scan time: 15.990 The best scores are: opt bits E(85289) NP_079174 (OMIM: 613634) DENN domain-containing pr ( 801) 5423 582.9 1.8e-165 NP_001277260 (OMIM: 613634) DENN domain-containing ( 757) 5103 549.3 2.2e-155 XP_011526620 (OMIM: 613634) PREDICTED: DENN domain ( 757) 5103 549.3 2.2e-155 XP_006722969 (OMIM: 613634) PREDICTED: DENN domain ( 757) 5103 549.3 2.2e-155 XP_006722968 (OMIM: 613634) PREDICTED: DENN domain ( 715) 3064 335.5 4.9e-91 NP_001182144 (OMIM: 613292) DENN domain-containing ( 775) 1635 185.7 6.8e-46 XP_011507550 (OMIM: 613292) PREDICTED: DENN domain ( 788) 1625 184.6 1.4e-45 XP_011507548 (OMIM: 613292) PREDICTED: DENN domain ( 823) 1623 184.4 1.7e-45 XP_006711255 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1583 180.2 2.9e-44 XP_011507551 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1583 180.2 2.9e-44 XP_006711256 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1583 180.2 2.9e-44 XP_016855959 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1583 180.2 2.9e-44 NP_659414 (OMIM: 613292) DENN domain-containing pr ( 426) 1503 171.7 6.1e-42 XP_011507553 (OMIM: 613292) PREDICTED: DENN domain ( 447) 1373 158.0 8.1e-38 NP_079096 (OMIM: 613633) DENN domain-containing pr ( 559) 1153 135.0 8.6e-31 XP_011517185 (OMIM: 613633) PREDICTED: DENN domain (1066) 1160 135.9 8.7e-31 XP_005252170 (OMIM: 613633) PREDICTED: DENN domain ( 574) 1153 135.0 8.7e-31 NP_065997 (OMIM: 613633) DENN domain-containing pr (1009) 1153 135.2 1.4e-30 XP_016870440 (OMIM: 613633) PREDICTED: DENN domain (1020) 1153 135.2 1.4e-30 XP_005252168 (OMIM: 613633) PREDICTED: DENN domain (1024) 1153 135.2 1.4e-30 XP_016870437 (OMIM: 613633) PREDICTED: DENN domain (1052) 1153 135.2 1.4e-30 XP_006717258 (OMIM: 613633) PREDICTED: DENN domain (1067) 1153 135.2 1.5e-30 XP_011517189 (OMIM: 613633) PREDICTED: DENN domain ( 592) 1146 134.3 1.5e-30 XP_011517188 (OMIM: 613633) PREDICTED: DENN domain (1042) 1146 134.5 2.4e-30 XP_011517187 (OMIM: 613633) PREDICTED: DENN domain (1049) 1146 134.5 2.4e-30 XP_011517186 (OMIM: 613633) PREDICTED: DENN domain (1056) 1146 134.5 2.4e-30 XP_016870436 (OMIM: 613633) PREDICTED: DENN domain (1058) 1146 134.5 2.4e-30 XP_005252166 (OMIM: 613633) PREDICTED: DENN domain (1070) 1146 134.5 2.4e-30 XP_011517184 (OMIM: 613633) PREDICTED: DENN domain (1085) 1146 134.5 2.4e-30 XP_016855960 (OMIM: 613292) PREDICTED: DENN domain ( 745) 1134 133.1 4.3e-30 XP_005244988 (OMIM: 613292) PREDICTED: DENN domain ( 755) 1134 133.1 4.4e-30 XP_011507549 (OMIM: 613292) PREDICTED: DENN domain ( 803) 1134 133.1 4.6e-30 NP_001287787 (OMIM: 613292) DENN domain-containing ( 396) 1002 119.1 3.8e-26 XP_016870439 (OMIM: 613633) PREDICTED: DENN domain (1025) 680 85.6 1.2e-15 XP_016870438 (OMIM: 613633) PREDICTED: DENN domain (1043) 680 85.6 1.2e-15 XP_016870441 (OMIM: 613633) PREDICTED: DENN domain ( 811) 628 80.1 4.3e-14 XP_016855961 (OMIM: 613292) PREDICTED: DENN domain ( 491) 593 76.3 3.7e-13 XP_006711257 (OMIM: 613292) PREDICTED: DENN domain ( 469) 500 66.5 3.1e-10 XP_011518627 (OMIM: 140750) PREDICTED: suppression ( 737) 385 54.6 1.9e-06 XP_011518629 (OMIM: 140750) PREDICTED: suppression ( 737) 385 54.6 1.9e-06 XP_016873676 (OMIM: 140750) PREDICTED: suppression ( 737) 385 54.6 1.9e-06 XP_011518630 (OMIM: 140750) PREDICTED: suppression ( 737) 385 54.6 1.9e-06 XP_011518628 (OMIM: 140750) PREDICTED: suppression ( 737) 385 54.6 1.9e-06 XP_011518625 (OMIM: 140750) PREDICTED: suppression ( 767) 385 54.6 1.9e-06 XP_011518621 (OMIM: 140750) PREDICTED: suppression ( 977) 385 54.6 2.4e-06 XP_016873674 (OMIM: 140750) PREDICTED: suppression ( 977) 385 54.6 2.4e-06 XP_016873673 (OMIM: 140750) PREDICTED: suppression ( 977) 385 54.6 2.4e-06 XP_016873672 (OMIM: 140750) PREDICTED: suppression (1157) 385 54.7 2.7e-06 XP_011518613 (OMIM: 140750) PREDICTED: suppression (1157) 385 54.7 2.7e-06 XP_016873671 (OMIM: 140750) PREDICTED: suppression (1157) 385 54.7 2.7e-06 >>NP_079174 (OMIM: 613634) DENN domain-containing protei (801 aa) initn: 5423 init1: 5423 opt: 5423 Z-score: 3091.6 bits: 582.9 E(85289): 1.8e-165 Smith-Waterman score: 5423; 99.9% identity (100.0% similar) in 801 aa overlap (1-801:1-801) 10 20 30 40 50 60 pF1KE4 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGS 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LRAPALPSRSDRLQQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 LRAPALPSRSDRLQQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCP 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 WAEEALDSSFLGSGEELDLLSEILDSLSVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNI ::::::::::::::::::::::::::::.::::::::::::::::::::::::::::::: NP_079 WAEEALDSSFLGSGEELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNI 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 PRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 PRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTA 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE4 SADPSIWGDPKPSPLTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 SADPSIWGDPKPSPLTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILA 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE4 PTKPNFDIAWTSQPLDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 PTKPNFDIAWTSQPLDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSN 730 740 750 760 770 780 790 800 pF1KE4 CQKSQPSSRPRVADLKKCFEG ::::::::::::::::::::: NP_079 CQKSQPSSRPRVADLKKCFEG 790 800 >>NP_001277260 (OMIM: 613634) DENN domain-containing pro (757 aa) initn: 5103 init1: 5103 opt: 5103 Z-score: 2910.6 bits: 549.3 E(85289): 2.2e-155 Smith-Waterman score: 5103; 99.9% identity (100.0% similar) in 757 aa overlap (45-801:1-757) 20 30 40 50 60 70 pF1KE4 WFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVEREPPSPAVQHFTFALT :::::::::::::::::::::::::::::: NP_001 MQMVPKFCFPFDVEREPPSPAVQHFTFALT 10 20 30 80 90 100 110 120 130 pF1KE4 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE4 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE4 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE4 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE4 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE4 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE4 EELDLLSEILDSLSVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: NP_001 EELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE 520 530 540 550 560 570 620 630 640 650 660 670 pF1KE4 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP 580 590 600 610 620 630 680 690 700 710 720 730 pF1KE4 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP 640 650 660 670 680 690 740 750 760 770 780 790 pF1KE4 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD 700 710 720 730 740 750 800 pF1KE4 LKKCFEG ::::::: NP_001 LKKCFEG >>XP_011526620 (OMIM: 613634) PREDICTED: DENN domain-con (757 aa) initn: 5103 init1: 5103 opt: 5103 Z-score: 2910.6 bits: 549.3 E(85289): 2.2e-155 Smith-Waterman score: 5103; 99.9% identity (100.0% similar) in 757 aa overlap (45-801:1-757) 20 30 40 50 60 70 pF1KE4 WFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVEREPPSPAVQHFTFALT :::::::::::::::::::::::::::::: XP_011 MQMVPKFCFPFDVEREPPSPAVQHFTFALT 10 20 30 80 90 100 110 120 130 pF1KE4 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE4 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE4 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE4 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE4 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE4 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE4 EELDLLSEILDSLSVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_011 EELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE 520 530 540 550 560 570 620 630 640 650 660 670 pF1KE4 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP 580 590 600 610 620 630 680 690 700 710 720 730 pF1KE4 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP 640 650 660 670 680 690 740 750 760 770 780 790 pF1KE4 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD 700 710 720 730 740 750 800 pF1KE4 LKKCFEG ::::::: XP_011 LKKCFEG >>XP_006722969 (OMIM: 613634) PREDICTED: DENN domain-con (757 aa) initn: 5103 init1: 5103 opt: 5103 Z-score: 2910.6 bits: 549.3 E(85289): 2.2e-155 Smith-Waterman score: 5103; 99.9% identity (100.0% similar) in 757 aa overlap (45-801:1-757) 20 30 40 50 60 70 pF1KE4 WFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVEREPPSPAVQHFTFALT :::::::::::::::::::::::::::::: XP_006 MQMVPKFCFPFDVEREPPSPAVQHFTFALT 10 20 30 80 90 100 110 120 130 pF1KE4 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE4 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE4 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE4 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE4 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE4 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE4 EELDLLSEILDSLSVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_006 EELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE 520 530 540 550 560 570 620 630 640 650 660 670 pF1KE4 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP 580 590 600 610 620 630 680 690 700 710 720 730 pF1KE4 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP 640 650 660 670 680 690 740 750 760 770 780 790 pF1KE4 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD 700 710 720 730 740 750 800 pF1KE4 LKKCFEG ::::::: XP_006 LKKCFEG >>XP_006722968 (OMIM: 613634) PREDICTED: DENN domain-con (715 aa) initn: 3056 init1: 3056 opt: 3064 Z-score: 1755.3 bits: 335.5 E(85289): 4.9e-91 Smith-Waterman score: 4742; 94.3% identity (94.5% similar) in 757 aa overlap (45-801:1-715) 20 30 40 50 60 70 pF1KE4 WFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVEREPPSPAVQHFTFALT :::::::::::::::::::::::::::::: XP_006 MQMVPKFCFPFDVEREPPSPAVQHFTFALT 10 20 30 80 90 100 110 120 130 pF1KE4 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE4 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDV----- 220 230 240 250 260 320 330 340 350 360 370 pF1KE4 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF ::::::::::::::::::::::: XP_006 -------------------------------------GQPVTFSEEVFLAQKPGAPLQAF 270 280 380 390 400 410 420 430 pF1KE4 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG 290 300 310 320 330 340 440 450 460 470 480 490 pF1KE4 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ 350 360 370 380 390 400 500 510 520 530 540 550 pF1KE4 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG 410 420 430 440 450 460 560 570 580 590 600 610 pF1KE4 EELDLLSEILDSLSVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE ::::::::::::::.::::::::::::::::::::::::::::::::::::::::::::: XP_006 EELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE 470 480 490 500 510 520 620 630 640 650 660 670 pF1KE4 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP 530 540 550 560 570 580 680 690 700 710 720 730 pF1KE4 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP 590 600 610 620 630 640 740 750 760 770 780 790 pF1KE4 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD 650 660 670 680 690 700 800 pF1KE4 LKKCFEG ::::::: XP_006 LKKCFEG 710 >>NP_001182144 (OMIM: 613292) DENN domain-containing pro (775 aa) initn: 1718 init1: 848 opt: 1635 Z-score: 944.9 bits: 185.7 E(85289): 6.8e-46 Smith-Waterman score: 1692; 46.9% identity (72.3% similar) in 599 aa overlap (1-584:1-592) 10 20 30 40 50 60 pF1KE4 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE :. :.... .:: ... : :: .::: .: .:: :: ::: .: :::::::::::: NP_001 MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ . . :::::.:::. ...::::::: .: ::::::.::::::.::::::..: ::. NP_001 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS . .. .: :..:... . .. :.: ... . .. : . . : : :.::: NP_001 ELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLK--DQPALVPHSYFIAPDV 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP ::.:::.::::: ::: .:.. :.:..: :::... .:::::::.:.:.: ::::: NP_001 TGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYP 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN : :.:. ::.::::::::::::::::::.:.:: :::..:.:::::.::::.::::. :. NP_001 MYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFS 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE :.. :: :::: :. .:.: . : :.::.: ::.::: :::.::::: .::.:.:: :: NP_001 DLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEE 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE4 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR :. .. .. .. : . :..::::::::..:: ::: :.:::: ::.:::. : .: : NP_001 SFVKHRSSV-MKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPR 360 370 380 390 400 410 430 440 450 460 470 pF1KE4 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----GLKGVQSLLMYKDGDSVLQ ::: :. ..:::: ::.... .:. :::.. :. ::. ::: :.: : .:... NP_001 SYQQWVHTVKKGG-ALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYG 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE4 RGGS--LRAPALPSRSDRL--QQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPL .: .:. .... ... ..: : :::. : : . .. . : NP_001 TCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLDGALYDDEDDDDIERASKL 480 490 500 510 520 530 540 550 560 570 580 pF1KE4 SPED--EGCPWAEEALDSSFLG-----SGEELDLLSEILDSLSVGAKSAGSLRPSQSLDC : :: :. . :. :: ::: .:::.::::.::. ... :.: ..::: NP_001 SSEDGEEASAYLYESDDSVETRVKTPYSGE-MDLLGEILDTLSTHSSDQGKLAAAKSLDF 540 550 560 570 580 590 590 600 610 620 630 640 pF1KE4 CHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPS NP_001 FRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSS 600 610 620 630 640 650 >>XP_011507550 (OMIM: 613292) PREDICTED: DENN domain-con (788 aa) initn: 1706 init1: 848 opt: 1625 Z-score: 939.2 bits: 184.6 E(85289): 1.4e-45 Smith-Waterman score: 1682; 47.2% identity (72.0% similar) in 600 aa overlap (4-584:13-605) 10 20 30 40 pF1KE4 MESRAEGGSPA----VFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQM .:: :. : .:: ... : :: .::: .: .:: :: ::: .: XP_011 MSGRLRNKDKGEQAETGQRANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQS 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 VPKFCFPFDVEREPPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVF :::::::::::: . . :::::.:::. ...::::::: .: ::::::.::::::. XP_011 VPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE4 YKLLNTVGDLLAQDQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRG ::::::..: ::.. .. .: :..:... . .. :.: ... . .. : . . XP_011 YKLLNTLADYLAKELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKD--QP 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 NSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTL : : :.::: ::.:::.::::: ::: .:.. :.:..: :::... .:::::: XP_011 ALVPHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 TSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVV :.:.:.: :::::: :.:. ::.::::::::::::::::::.:.:: :::..:.:::::. XP_011 TACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVM 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 LNVDANTLETTFNDVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDAL ::::.::::. :.:.. :: :::: :. .:.: . : :.::.: ::.::: :::.::::: XP_011 LNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDAL 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 VCSPGQPVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQ .::.:.:: :: :. .. .. .. : . :..::::::::..:: ::: :.:::: ::. XP_011 RYKPGEPITFCEESFVKHRSSV-MKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEE 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE4 EITGCGASSGALRSYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----GLKGVQ :::. : .: :::: :. ..:::: ::.... .:. :::.. :. ::. ::: :. XP_011 EITSGGFCGGNPRSYQQWVHTVKKGG-ALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVK 420 430 440 450 460 470 470 480 490 500 510 pF1KE4 SLLMYKDGDSVLQRGGS--LRAPALPSRSDRL--QQRLPITQHFGKNRPLRPSRRRQLEE : : .:... .: .:. .... ... ..: : :::. : : . XP_011 SKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLDGALYD 480 490 500 510 520 530 520 530 540 550 560 570 pF1KE4 GTSEPPGAGTPPLSPED--EGCPWAEEALDSSFLG-----SGEELDLLSEILDSLSVGAK .. . :: :: :. . :. :: ::: .:::.::::.::. .. XP_011 DEDDDDIERASKLSSEDGEEASAYLYESDDSVETRVKTPYSGE-MDLLGEILDTLSTHSS 540 550 560 570 580 590 580 590 600 610 620 630 pF1KE4 SAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQNASSLDAT . :.: ..::: XP_011 DQGKLAAAKSLDFFRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHG 600 610 620 630 640 650 >>XP_011507548 (OMIM: 613292) PREDICTED: DENN domain-con (823 aa) initn: 1706 init1: 848 opt: 1623 Z-score: 937.7 bits: 184.4 E(85289): 1.7e-45 Smith-Waterman score: 1680; 47.5% identity (72.4% similar) in 587 aa overlap (13-584:61-640) 10 20 30 40 pF1KE4 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQ :: ... : :: .::: .: .:: :: :: XP_011 YPIRGYFYVCAKVFINDYFAQEIRANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQ 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE4 EAMQMVPKFCFPFDVEREPPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLP : .: :::::::::::: . . :::::.:::. ...::::::: .: ::::::.:: XP_011 EILQSVPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLP 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE4 WFEVFYKLLNTVGDLLAQDQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIP ::::.::::::..: ::.. .. .: :..:... . .. :.: ... . .. : . XP_011 WFEVYYKLLNTLADYLAKELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLK 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE4 PPTRGNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTAS . : : :.::: ::.:::.::::: ::: .:.. :.:..: :::... .: XP_011 D--QPALVPHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISS 220 230 240 250 260 230 240 250 260 270 280 pF1KE4 KLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKAL ::::::.:.:.: :::::: :.:. ::.::::::::::::::::::.:.:: :::..:.: XP_011 KLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSL 270 280 290 300 310 320 290 300 310 320 330 340 pF1KE4 EDVVVLNVDANTLETTFNDVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGG ::::.::::.::::. :.:.. :: :::: :. .:.: . : :.::.: ::.::: :::. XP_011 EDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGS 330 340 350 360 370 380 350 360 370 380 390 400 pF1KE4 YRDALVCSPGQPVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFS ::::: .::.:.:: :: :. .. .. .. : . :..::::::::..:: ::: :.::: XP_011 YRDALRYKPGEPITFCEESFVKHRSSV-MKQFLETAINLQLFKQFIDGRLAKLNAGRGFS 390 400 410 420 430 440 410 420 430 440 450 pF1KE4 DQFEQEITGCGASSGALRSYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----G : ::.:::. : .: :::: :. ..:::: ::.... .:. :::.. :. ::. : XP_011 DVFEEEITSGGFCGGNPRSYQQWVHTVKKGG-ALFNTAMTKATPAVRTAYKFAKNHAKLG 450 460 470 480 490 500 460 470 480 490 500 510 pF1KE4 LKGVQSLLMYKDGDSVLQRGGS--LRAPALPSRSDRL--QQRLPITQHFGKNRPLRPSRR :: :.: : .:... .: .:. .... ... ..: : :::. : XP_011 LKEVKSKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLD 510 520 530 540 550 560 520 530 540 550 560 pF1KE4 RQLEEGTSEPPGAGTPPLSPED--EGCPWAEEALDSSFLG-----SGEELDLLSEILDSL : . .. . :: :: :. . :. :: ::: .:::.::::.: XP_011 GALYDDEDDDDIERASKLSSEDGEEASAYLYESDDSVETRVKTPYSGE-MDLLGEILDTL 570 580 590 600 610 620 570 580 590 600 610 620 pF1KE4 SVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQNAS :. ... :.: ..::: XP_011 STHSSDQGKLAAAKSLDFFRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDD 630 640 650 660 670 680 >>XP_006711255 (OMIM: 613292) PREDICTED: DENN domain-con (765 aa) initn: 1662 init1: 848 opt: 1583 Z-score: 915.5 bits: 180.2 E(85289): 2.9e-44 Smith-Waterman score: 1640; 47.2% identity (72.1% similar) in 578 aa overlap (22-584:12-582) 10 20 30 40 50 60 pF1KE4 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE : . .: .: .:: :: ::: .: :::::::::::: XP_006 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ . . :::::.:::. ...::::::: .: ::::::.::::::.::::::..: ::. XP_006 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS . .. .: :..:... . .. :.: ... . .. : . . : : :.::: XP_006 ELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKD--QPALVPHSYFIAPDV 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP ::.:::.::::: ::: .:.. :.:..: :::... .:::::::.:.:.: ::::: XP_006 TGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYP 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN : :.:. ::.::::::::::::::::::.:.:: :::..:.:::::.::::.::::. :. XP_006 MYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFS 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE :.. :: :::: :. .:.: . : :.::.: ::.::: :::.::::: .::.:.:: :: XP_006 DLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEE 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR :. .. .. .. : . :..::::::::..:: ::: :.:::: ::.:::. : .: : XP_006 SFVKHRSSV-MKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPR 350 360 370 380 390 400 430 440 450 460 470 pF1KE4 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----GLKGVQSLLMYKDGDSVLQ ::: :. ..:::: ::.... .:. :::.. :. ::. ::: :.: : .:... XP_006 SYQQWVHTVKKGG-ALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYG 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE4 RGGS--LRAPALPSRSDRL--QQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPL .: .:. .... ... ..: : :::. : : . .. . : XP_006 TCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLDGALYDDEDDDDIERASKL 470 480 490 500 510 520 540 550 560 570 580 pF1KE4 SPED--EGCPWAEEALDSSFLG-----SGEELDLLSEILDSLSVGAKSAGSLRPSQSLDC : :: :. . :. :: ::: .:::.::::.::. ... :.: ..::: XP_006 SSEDGEEASAYLYESDDSVETRVKTPYSGE-MDLLGEILDTLSTHSSDQGKLAAAKSLDF 530 540 550 560 570 580 590 600 610 620 630 640 pF1KE4 CHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPS XP_006 FRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSS 590 600 610 620 630 640 >>XP_011507551 (OMIM: 613292) PREDICTED: DENN domain-con (765 aa) initn: 1662 init1: 848 opt: 1583 Z-score: 915.5 bits: 180.2 E(85289): 2.9e-44 Smith-Waterman score: 1640; 47.2% identity (72.1% similar) in 578 aa overlap (22-584:12-582) 10 20 30 40 50 60 pF1KE4 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE : . .: .: .:: :: ::: .: :::::::::::: XP_011 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ . . :::::.:::. ...::::::: .: ::::::.::::::.::::::..: ::. XP_011 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS . .. .: :..:... . .. :.: ... . .. : . . : : :.::: XP_011 ELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKD--QPALVPHSYFIAPDV 120 130 140 150 160 190 200 210 220 230 240 pF1KE4 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP ::.:::.::::: ::: .:.. :.:..: :::... .:::::::.:.:.: ::::: XP_011 TGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYP 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE4 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN : :.:. ::.::::::::::::::::::.:.:: :::..:.:::::.::::.::::. :. XP_011 MYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFS 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE4 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE :.. :: :::: :. .:.: . : :.::.: ::.::: :::.::::: .::.:.:: :: XP_011 DLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEE 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE4 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR :. .. .. .. : . :..::::::::..:: ::: :.:::: ::.:::. : .: : XP_011 SFVKHRSSV-MKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPR 350 360 370 380 390 400 430 440 450 460 470 pF1KE4 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----GLKGVQSLLMYKDGDSVLQ ::: :. ..:::: ::.... .:. :::.. :. ::. ::: :.: : .:... XP_011 SYQQWVHTVKKGG-ALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYG 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE4 RGGS--LRAPALPSRSDRL--QQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPL .: .:. .... ... ..: : :::. : : . .. . : XP_011 TCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLDGALYDDEDDDDIERASKL 470 480 490 500 510 520 540 550 560 570 580 pF1KE4 SPED--EGCPWAEEALDSSFLG-----SGEELDLLSEILDSLSVGAKSAGSLRPSQSLDC : :: :. . :. :: ::: .:::.::::.::. ... :.: ..::: XP_011 SSEDGEEASAYLYESDDSVETRVKTPYSGE-MDLLGEILDTLSTHSSDQGKLAAAKSLDF 530 540 550 560 570 580 590 600 610 620 630 640 pF1KE4 CHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPS XP_011 FRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSS 590 600 610 620 630 640 801 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 03:19:10 2016 done: Sun Nov 6 03:19:12 2016 Total Scan time: 15.990 Total Display time: 0.230 Function used was FASTA [36.3.4 Apr, 2011]