Result of FASTA (omim) for
pFN21AE0800
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE0800, 1531 aa
1>>>pF1KE0800 1531 - 1531 aa - 1531 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.8231+/-0.000619; mu= 1.7524+/- 0.038
mean_var=251.5570+/-51.499, 0's: 0 Z-trim(112.2): 53 B-trim: 230 in 1/54
Lambda= 0.080864
statistics sampled from 20997 (21033) to 20997 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.582), E-opt: 0.2 (0.247), width: 16
Scan time: 16.110
The best scores are: opt bits E(85289)
NP_001058 (OMIM: 126430) DNA topoisomerase 2-alpha (1531) 10077 1191.0 0
XP_005257689 (OMIM: 126430) PREDICTED: DNA topoiso (1519) 9997 1181.7 0
XP_011523467 (OMIM: 126430) PREDICTED: DNA topoiso (1364) 9006 1066.0 0
XP_011532359 (OMIM: 126431) PREDICTED: DNA topoiso (1589) 6689 795.8 0
NP_001317629 (OMIM: 126431) DNA topoisomerase 2-be (1626) 6650 791.2 0
NP_001059 (OMIM: 126431) DNA topoisomerase 2-beta (1621) 6648 791.0 0
>>NP_001058 (OMIM: 126430) DNA topoisomerase 2-alpha [Ho (1531 aa)
initn: 10077 init1: 10077 opt: 10077 Z-score: 6367.9 bits: 1191.0 E(85289): 0
Smith-Waterman score: 10077; 100.0% identity (100.0% similar) in 1531 aa overlap (1-1531:1-1531)
10 20 30 40 50 60
pF1KE0 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE0 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE0 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE0 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE0 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE0 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE0 TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
1450 1460 1470 1480 1490 1500
1510 1520 1530
pF1KE0 DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
:::::::::::::::::::::::::::::::
NP_001 DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
1510 1520 1530
>>XP_005257689 (OMIM: 126430) PREDICTED: DNA topoisomera (1519 aa)
initn: 9997 init1: 9997 opt: 9997 Z-score: 6317.5 bits: 1181.7 E(85289): 0
Smith-Waterman score: 9997; 100.0% identity (100.0% similar) in 1519 aa overlap (13-1531:1-1519)
10 20 30 40 50 60
pF1KE0 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
10 20 30 40
70 80 90 100 110 120
pF1KE0 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE0 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE0 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE0 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE0 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE0 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE0 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE0 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE0 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE0 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE0 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
650 660 670 680 690 700
730 740 750 760 770 780
pF1KE0 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
710 720 730 740 750 760
790 800 810 820 830 840
pF1KE0 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
770 780 790 800 810 820
850 860 870 880 890 900
pF1KE0 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
830 840 850 860 870 880
910 920 930 940 950 960
pF1KE0 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
890 900 910 920 930 940
970 980 990 1000 1010 1020
pF1KE0 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
950 960 970 980 990 1000
1030 1040 1050 1060 1070 1080
pF1KE0 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
1010 1020 1030 1040 1050 1060
1090 1100 1110 1120 1130 1140
pF1KE0 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
1070 1080 1090 1100 1110 1120
1150 1160 1170 1180 1190 1200
pF1KE0 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
1130 1140 1150 1160 1170 1180
1210 1220 1230 1240 1250 1260
pF1KE0 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
1190 1200 1210 1220 1230 1240
1270 1280 1290 1300 1310 1320
pF1KE0 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
1250 1260 1270 1280 1290 1300
1330 1340 1350 1360 1370 1380
pF1KE0 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
1310 1320 1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KE0 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
1370 1380 1390 1400 1410 1420
1450 1460 1470 1480 1490 1500
pF1KE0 TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
1430 1440 1450 1460 1470 1480
1510 1520 1530
pF1KE0 DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
:::::::::::::::::::::::::::::::
XP_005 DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
1490 1500 1510
>>XP_011523467 (OMIM: 126430) PREDICTED: DNA topoisomera (1364 aa)
initn: 9006 init1: 9006 opt: 9006 Z-score: 5693.3 bits: 1066.0 E(85289): 0
Smith-Waterman score: 9006; 100.0% identity (100.0% similar) in 1363 aa overlap (1-1363:1-1363)
10 20 30 40 50 60
pF1KE0 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE0 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE0 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE0 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE0 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE0 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE0 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE0 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE0 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE0 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE0 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE0 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE0 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE0 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE0 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE0 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE0 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE0 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE0 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE0 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE0 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE0 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE0 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
:::::::::::::::::::::::::::::::::::::::::::
XP_011 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKP
1330 1340 1350 1360
1390 1400 1410 1420 1430 1440
pF1KE0 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
>>XP_011532359 (OMIM: 126431) PREDICTED: DNA topoisomera (1589 aa)
initn: 6509 init1: 6179 opt: 6689 Z-score: 4231.5 bits: 795.8 E(85289): 0
Smith-Waterman score: 6978; 69.2% identity (84.5% similar) in 1570 aa overlap (14-1529:28-1580)
10 20 30
pF1KE0 MEVSPLQPVNENMQVNKIKKNE-------DAKKRLSVERIYQKKTQ
: : ::.: :..:.:::::.::::::
XP_011 MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQ
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 LEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRD
:::::::::::::::: .:: :::::::::.: :::::::::::::::::::::::::::
XP_011 LEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRD
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 PKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT
.:.::.:.::::.:.:::::::::::::::::::.::::::::::::::::::::::::
XP_011 KNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 GGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITF
::::::::::::::::::::::: .:::. ::::::.:: ...: ..: :.:::::::::
XP_011 GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITF
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 QPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKL
:::::::::..:::::::::.:::::.::: . :::..::.::::.:::::::.:.::::
XP_011 QPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKL
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 DETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVD
:::: .:::::: .:.::.::::.::::::::::::::::.:::::::::.::.: ::..
XP_011 DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE0 VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFI
:::::::.::.:: :::::.:.:.: :::::::::::::::::::::::: :::::::.
XP_011 VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFF
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE0 KAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLIL
::: .::::::::::::::::.:::::::.::...:::::::::::::::..: ::::::
XP_011 KAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLIL
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE0 TEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
:::::::.::::::::.:::.:::::::::::::::::::::::::::::::::::::::
XP_011 TEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE0 KNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVK
:.:.: .:::::::::::::::::::::::::::::::::::::::.: :::::::::::
XP_011 KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVK
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE0 VSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFK
.::::::..:::.:::.:::. :.: ::.::::::::::.::::::::::.:::: :.
XP_011 ASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFR
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE0 YSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFI
:.::::::::.::::::.::::::::::::::::::.: ::::..::: .: .:::::::
XP_011 YAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE0 NKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHH
::::::::::::::::::.:::.:::::::::::::::::::::::::::::::::.:::
XP_011 NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHH
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE0 GEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFP
::..:::::.:::::::::::.::::::::::::::::::.:::::::::::.:::::::
XP_011 GEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE0 PKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRL
::. :::::::::::::::::::::::::::::::::::.::.::.:.::::::.::.
XP_011 AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE0 MDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQV
.:: .: ::::.::::::::.::. :::..:::. ... .:.::.:::::::::.:::::
XP_011 LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE0 LEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNS
::::::::.::: ::.::.::::::::::::::::::::.:: .::::::::::.:::::
XP_011 LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNS
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE0 MVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKI
::::::.::::::.:: :::..::.:::.:::::::::.:::::::.:::::::::::::
XP_011 MVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE0 DGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVT
.::: :::. ::.::..:.::::.:::::::::::.:. .:.: ..:... .::: :
XP_011 QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDE---TQNQHDDSSSDSGT
1090 1100 1110 1120 1130
1120 1130 1140 1150 1160 1170
pF1KE0 DSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELE
::: :::.:.: :: ::::: .:: . :. : .:.. :::::::::::::::.:.:::.
XP_011 PSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELD
1140 1150 1160 1170 1180 1190
1180 1190 1200 1210 1220 1230
pF1KE0 AVEAKEKQDEQVGLPGKG-----GKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKK
::..:..: .:. ::. :: : :: :. :..::: :.:.::.:: :::.: ::
XP_011 KVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITA-MKADASKK
1200 1210 1220 1230 1240 1250
1240 1250 1260 1270
pF1KE0 NKKKIK------------NENTEGSPQEDGVELEGLKQRLE-------KKQKREPGTKTK
:: : .:. :.: : :. :.: . :..:.::::...
XP_011 LLKKKKGDLDTAAVKVEFDEEFSGAPVE-GAGEEALTPSVPINKGPKPKREKKEPGTRVR
1260 1270 1280 1290 1300 1310
1280 1290 1300 1310 1320 1330
pF1KE0 KQTTLAFKP-IKKGKKRNPWSDSESDRSSD--ESNFDVPPRETEPRRAAT-KTKFTMDLD
: : . :: :: ::::::::.:: :: :.. : ::.. ::::. . :.:.:..
XP_011 KTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFS
1320 1330 1340 1350 1360 1370
1340 1350 1360 1370 1380 1390
pF1KE0 SDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSD-LEADDVKGSVPL
.:: .: :. ::.. : :.:.:: .. : .. : :: :. :. :
XP_011 EEED-DDADDDDDDNN----DLEELKVKASPITNDGE---DEFVPSDGLDKDEYTFSPGK
1380 1390 1400 1410 1420
1400 1410 1420 1430 1440
pF1KE0 SSSPPATHFPDET--EITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALN
:.. : . :. .. : . . :. .: .:.: : . ::: : :.:
XP_011 SKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDGKPSSDTV---PKPKRAPKQKKVVEAVN
1430 1440 1450 1460 1470 1480
1450 1460 1470 1480 1490
pF1KE0 S------GVSQKPDPAKTKNR--RKRKPSTSDD-SDSNFEKIVSKAVTSKKSKGES----
: :. .: : :.: .::: : :.. .: : . .::. :::: : :
XP_011 SDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKT-TSKKPKKTSFDQD
1490 1500 1510 1520 1530 1540
1500 1510 1520 1530
pF1KE0 ---DDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
: : :: . .. ::.: .::. ::::..
XP_011 SDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMFN
1550 1560 1570 1580
>>NP_001317629 (OMIM: 126431) DNA topoisomerase 2-beta i (1626 aa)
initn: 6509 init1: 6179 opt: 6650 Z-score: 4206.8 bits: 791.2 E(85289): 0
Smith-Waterman score: 6939; 69.3% identity (84.4% similar) in 1568 aa overlap (14-1503:28-1584)
10 20 30
pF1KE0 MEVSPLQPVNENMQVNKIKKNE-------DAKKRLSVERIYQKKTQ
: : ::.: :..:.:::::.::::::
NP_001 MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQ
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE0 LEHILLRPDTYIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRD
:::::::::::::::: .:: :::::::::.: :::::::::::::::::::::::::::
NP_001 LEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRD
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE0 PKMSCIRVTIDPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVT
.:.::.:.::::.:.:::::::::::::::::::.::::::::::::::::::::::::
NP_001 KNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE0 GGRNGYGAKLCNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITF
::::::::::::::::::::::: .:::. ::::::.:: ...: ..: :.:::::::::
NP_001 GGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITF
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE0 QPDLSKFKMQSLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKL
:::::::::..:::::::::.:::::.::: . :::..::.::::.:::::::.:.::::
NP_001 QPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKL
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE0 DETGNSLKVIHEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVD
:::: .:::::: .:.::.::::.::::::::::::::::.:::::::::.::.: ::..
NP_001 DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE0 VVKKKNKGGVAVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFI
:::::::.::.:: :::::.:.:.: :::::::::::::::::::::::: :::::::.
NP_001 VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFF
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE0 KAAIGCGIVESILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLIL
::: .::::::::::::::::.:::::::.::...:::::::::::::::..: ::::::
NP_001 KAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLIL
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE0 TEGDSAKTLAVSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
:::::::.::::::::.:::.:::::::::::::::::::::::::::::::::::::::
NP_001 TEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYK
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE0 KNYEDEDSLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVK
:.:.: .:::::::::::::::::::::::::::::::::::::::.: :::::::::::
NP_001 KSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVK
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE0 VSKNKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFK
.::::::..:::.:::.:::. :.: ::.::::::::::.::::::::::.:::: :.
NP_001 ASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFR
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE0 YSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFI
:.::::::::.::::::.::::::::::::::::::.: ::::..::: .: .:::::::
NP_001 YAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFI
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE0 NKELILFSNSDNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHH
::::::::::::::::::.:::.:::::::::::::::::::::::::::::::::.:::
NP_001 NKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHH
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE0 GEMSLMMTIINLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFP
::..:::::.:::::::::::.::::::::::::::::::.:::::::::::.:::::::
NP_001 GEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFP
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE0 PKDDHTLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRL
::. :::::::::::::::::::::::::::::::::::.::.::.:.::::::.::.
NP_001 AVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM
850 860 870 880 890 900
880 890 900 910 920 930
pF1KE0 MDGEEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQV
.:: .: ::::.::::::::.::. :::..:::. ... .:.::.:::::::::.:::::
NP_001 LDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQV
910 920 930 940 950 960
940 950 960 970 980 990
pF1KE0 LEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNS
::::::::.::: ::.::.::::::::::::::::::::.:: .::::::::::.:::::
NP_001 LEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNS
970 980 990 1000 1010 1020
1000 1010 1020 1030 1040 1050
pF1KE0 MVLFDHVGCLKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKI
::::::.::::::.:: :::..::.:::.:::::::::.:::::::.:::::::::::::
NP_001 MVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100 1110
pF1KE0 DGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVT
.::: :::. ::.::..:.::::.:::::::::::.:. .: .:..:... .::: :
NP_001 QGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEE---DETQNQHDDSSSDSGT
1090 1100 1110 1120 1130
1120 1130 1140 1150 1160 1170
pF1KE0 DSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELE
::: :::.:.: :: ::::: .:: . :. : .:.. :::::::::::::::.:.:::.
NP_001 PSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELD
1140 1150 1160 1170 1180 1190
1180 1190 1200 1210 1220 1230
pF1KE0 AVEAKEKQDEQVGLPGKG-----GKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKK
::..:..: .:. ::. :: : :: :. :..::: :.:.::.:: :::.: ::
NP_001 KVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITA-MKADASKK
1200 1210 1220 1230 1240 1250
1240 1250 1260 1270
pF1KE0 NKKKIK------------NENTEGSPQEDGVELEGLKQRLE-------KKQKREPGTKTK
:: : .:. :.: : :. :.: . :..:.::::...
NP_001 LLKKKKGDLDTAAVKVEFDEEFSGAPVE-GAGEEALTPSVPINKGPKPKREKKEPGTRVR
1260 1270 1280 1290 1300 1310
1280 1290 1300 1310 1320 1330
pF1KE0 KQTTLAFKP-IKKGKKRNPWSDSESDRSSD--ESNFDVPPRETEPRRAAT-KTKFTMDL-
: : . :: :: ::::::::.:: :: :.. : ::.. ::::. . :.:.:.
NP_001 KTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFS
1320 1330 1340 1350 1360 1370
1340 1350 1360
pF1KE0 --------DSDEDFSDFDE--------KTDDED-FVPSDA--------SPPKTKTSPKLS
:.:.: .:..: .: :: :::::. :: :.:..:. :
NP_001 EEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKS
1380 1390 1400 1410 1420 1430
1370 1380 1390 1400 1410
pF1KE0 NKELKPQK--SVVS----DLEADDVKGSVPLSSSPPATHFPDETEI--TNPVPKKNVTVK
.. : : .. : . ...: ... . :. : . :. ::.:.:
NP_001 LHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTV---
1440 1450 1460 1470 1480 1490
1420 1430 1440 1450 1460
pF1KE0 KTAAKSQSSTSTTGAKKRAAPKGTKRDPALNS------GVSQKPDPAKTKNR--RKRKPS
:::. . .: : : . ::: : :.:: :. .: : :.: .::: :
NP_001 --AAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKAS
1500 1510 1520 1530 1540 1550
1470 1480 1490 1500 1510 1520
pF1KE0 TSDD-SDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDED
:.. .: : . .::. :::: : : : : :
NP_001 GSENEGDYNPGRKTSKT-TSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKY
1560 1570 1580 1590 1600
1530
pF1KE0 DLF
NP_001 FAESDEEEDDVDFAMFN
1610 1620
>>NP_001059 (OMIM: 126431) DNA topoisomerase 2-beta isof (1621 aa)
initn: 6509 init1: 6179 opt: 6648 Z-score: 4205.6 bits: 791.0 E(85289): 0
Smith-Waterman score: 6937; 69.6% identity (84.8% similar) in 1555 aa overlap (20-1503:37-1579)
10 20 30 40
pF1KE0 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDT
:: :..:.:::::.::::::::::::::::
NP_001 CGAGAGVGGGNGALTWVNNAAKKEESETANKN-DSSKKLSVERVYQKKTQLEHILLRPDT
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE0 YIGSVELVTQQMWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTI
:::::: .:: :::::::::.: ::::::::::::::::::::::::::: .:.::.:.:
NP_001 YIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSI
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE0 DPENNLISIWNNGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKL
:::.:.:::::::::::::::::::.::::::::::::::::::::::::::::::::::
NP_001 DPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE0 CNIFSTKFTVETASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQ
::::::::::::: .:::. ::::::.:: ...: ..: :.::::::::::::::::::.
NP_001 CNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKME
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE0 SLDKDIVALMVRRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVI
.:::::::::.:::::.::: . :::..::.::::.:::::::.:.:::::::: .::::
NP_001 KLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVI
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE0 HEQVNHRWEVCLTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGV
:: .:.::.::::.::::::::::::::::.:::::::::.::.: ::..:::::::.::
NP_001 HELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGV
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE0 AVKAHQVKNHMWIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVE
.:: :::::.:.:.: :::::::::::::::::::::::: :::::::.::: .:::::
NP_001 SVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVE
370 380 390 400 410 420
410 420 430 440 450 460
pF1KE0 SILNWVKFKAQVQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLA
:::::::::::.:::::::.::...:::::::::::::::..: :::::::::::::.::
NP_001 SILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLA
430 440 450 460 470 480
470 480 490 500 510 520
pF1KE0 VSGLGVVGRDKYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLK
::::::.:::.::::::::::::::::::::::::::::::::::::::::.:.: .:::
NP_001 VSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLK
490 500 510 520 530 540
530 540 550 560 570 580
pF1KE0 TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAF
::::::::::::::::::::::::::::::::::::.: :::::::::::.::::::..:
NP_001 TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSF
550 560 570 580 590 600
590 600 610 620 630 640
pF1KE0 YSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAI
::.:::.:::. :.: ::.::::::::::.::::::::::.:::: :.:.::::::::
NP_001 YSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAI
610 620 630 640 650 660
650 660 670 680 690 700
pF1KE0 SLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNS
.::::::.::::::::::::::::::.: ::::..::: .: .:::::::::::::::::
NP_001 TLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNS
670 680 690 700 710 720
710 720 730 740 750 760
pF1KE0 DNERSIPSMVDGLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTII
::::::::.:::.:::::::::::::::::::::::::::::::::.:::::..:::::.
NP_001 DNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIV
730 740 750 760 770 780
770 780 790 800 810 820
pF1KE0 NLAQNFVGSNNLNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL
:::::::::::.::::::::::::::::::.:::::::::::.::::::: ::. ::::
NP_001 NLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFL
790 800 810 820 830 840
830 840 850 860 870 880
pF1KE0 YDDNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPML
:::::::::::::::::::::::::::::::.::.::.:.::::::.::..:: .: :::
NP_001 YDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPML
850 860 870 880 890 900
890 900 910 920 930 940
pF1KE0 PSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEK
:.::::::::.::. :::..:::. ... .:.::.:::::::::.:::::::::::::.:
NP_001 PNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDK
910 920 930 940 950 960
950 960 970 980 990 1000
pF1KE0 TPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCL
:: ::.::.::::::::::::::::::::.:: .::::::::::.:::::::::::.:::
NP_001 TPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCL
970 980 990 1000 1010 1020
1010 1020 1030 1040 1050 1060
pF1KE0 KKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKP
:::.:: :::..::.:::.:::::::::.:::::::.:::::::::::::.::: :::.
NP_001 KKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRS
1030 1040 1050 1060 1070 1080
1070 1080 1090 1100 1110 1120
pF1KE0 KKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLL
::.::..:.::::.:::::::::::.:. .:.: ..:... .::: : ::: :::.:
NP_001 KKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDE---TQNQHDDSSSDSGTPSGPDFNYIL
1090 1100 1110 1120 1130 1140
1130 1140 1150 1160 1170 1180
pF1KE0 DMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDE
.: :: ::::: .:: . :. : .:.. :::::::::::::::.:.:::. ::..:..:
NP_001 NMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDV
1150 1160 1170 1180 1190 1200
1190 1200 1210 1220 1230 1240
pF1KE0 QVGLPGKG-----GKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIK----
.:. ::. :: : :: :. :..::: :.:.::.:: :::.: :: :: :
NP_001 LAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITA-MKADASKKLLKKKKGDLD
1210 1220 1230 1240 1250 1260
1250 1260 1270 1280
pF1KE0 --------NENTEGSPQEDGVELEGLKQRLE-------KKQKREPGTKTKKQTTLAFKP-
.:. :.: : :. :.: . :..:.::::...: : . ::
NP_001 TAAVKVEFDEEFSGAPVE-GAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPS
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320 1330
pF1KE0 IKKGKKRNPWSDSESDRSSD--ESNFDVPPRETEPRRAAT-KTKFTMDL---------DS
:: ::::::::.:: :: :.. : ::.. ::::. . :.:.:. :.
NP_001 AKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDD
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370
pF1KE0 DEDFSDFDE--------KTDDED-FVPSDA--------SPPKTKTSPKLSNKELKPQK--
:.: .:..: .: :: :::::. :: :.:..:. : .. : :
NP_001 DDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFG
1390 1400 1410 1420 1430 1440
1380 1390 1400 1410 1420
pF1KE0 SVVS----DLEADDVKGSVPLSSSPPATHFPDETEI--TNPVPKKNVTVKKTAAKSQSST
.. : . ...: ... . :. : . :. ::.:.: :::. . .
NP_001 NLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTV-----AAKKGKPS
1450 1460 1470 1480 1490
1430 1440 1450 1460 1470
pF1KE0 STTGAKKRAAPKGTKRDPALNS------GVSQKPDPAKTKNR--RKRKPSTSDD-SDSNF
: : : . ::: : :.:: :. .: : :.: .::: : :.. .: :
NP_001 SDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNP
1500 1510 1520 1530 1540 1550
1480 1490 1500 1510 1520 1530
pF1KE0 EKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
. .::. :::: : : : : :
NP_001 GRKTSKT-TSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDD
1560 1570 1580 1590 1600 1610
1531 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 10:39:27 2016 done: Sun Nov 6 10:39:29 2016
Total Scan time: 16.110 Total Display time: 0.540
Function used was FASTA [36.3.4 Apr, 2011]