FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6743, 628 aa 1>>>pF1KE6743 628 - 628 aa - 628 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.8364+/-0.000664; mu= -4.8437+/- 0.041 mean_var=521.0895+/-105.333, 0's: 0 Z-trim(117.8): 230 B-trim: 0 in 0/55 Lambda= 0.056185 statistics sampled from 29834 (30074) to 29834 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.353), width: 16 Scan time: 9.860 The best scores are: opt bits E(85289) NP_476429 (OMIM: 122100,148043) keratin, type II c ( 628) 4128 350.3 1.2e-95 NP_056932 (OMIM: 616671) keratin, type II cytoskel ( 638) 2559 223.1 2.4e-57 NP_000415 (OMIM: 131760,131800,131900,131960,14804 ( 590) 2280 200.4 1.5e-50 NP_000414 (OMIM: 146800,600194) keratin, type II c ( 639) 2257 198.6 5.6e-50 NP_006112 (OMIM: 113800,139350,144200,146590,60096 ( 644) 2257 198.6 5.6e-50 NP_005545 (OMIM: 148041,615726) keratin, type II c ( 564) 2169 191.4 7.2e-48 NP_005546 (OMIM: 148042,615728) keratin, type II c ( 564) 2167 191.3 8.1e-48 NP_775109 (OMIM: 612315,615735) keratin, type II c ( 564) 2157 190.4 1.4e-47 NP_002263 (OMIM: 123940,193900) keratin, type II c ( 520) 2034 180.4 1.4e-44 NP_778253 (OMIM: 611158) keratin, type II cytoskel ( 578) 1975 175.7 4e-43 NP_004684 (OMIM: 609025,612318) keratin, type II c ( 551) 1931 172.1 4.6e-42 NP_787028 (OMIM: 611160) keratin, type II cytoskel ( 535) 1886 168.4 5.6e-41 NP_778238 (OMIM: 608247) keratin, type II cytoskel ( 540) 1820 163.1 2.3e-39 NP_258259 (OMIM: 608245,615896) keratin, type II c ( 523) 1818 162.9 2.5e-39 NP_778223 (OMIM: 194300,608248,613981,614929) kera ( 529) 1745 157.0 1.5e-37 NP_542785 (OMIM: 608246) keratin, type II cytoskel ( 511) 1723 155.2 5.2e-37 NP_001139697 (OMIM: 608246) keratin, type II cytos ( 511) 1723 155.2 5.2e-37 XP_016874238 (OMIM: 608245,615896) PREDICTED: kera ( 441) 1700 153.3 1.7e-36 XP_016874323 (OMIM: 608246) PREDICTED: keratin, ty ( 442) 1658 149.9 1.8e-35 XP_016874325 (OMIM: 608246) PREDICTED: keratin, ty ( 419) 1652 149.3 2.5e-35 NP_002264 (OMIM: 148060) keratin, type II cytoskel ( 483) 1653 149.5 2.6e-35 NP_001243222 (OMIM: 148060) keratin, type II cytos ( 483) 1653 149.5 2.6e-35 NP_001243211 (OMIM: 148060) keratin, type II cytos ( 511) 1653 149.5 2.7e-35 NP_005547 (OMIM: 148059) keratin, type II cytoskel ( 469) 1615 146.4 2.1e-34 NP_775487 (OMIM: 611159) keratin, type II cytoskel ( 520) 1534 139.9 2.1e-32 NP_149034 (OMIM: 602766) keratin, type II cuticula ( 600) 1533 139.9 2.5e-32 XP_011536637 (OMIM: 602766) PREDICTED: keratin, ty ( 600) 1533 139.9 2.5e-32 XP_011536627 (OMIM: 148059) PREDICTED: keratin, ty ( 445) 1512 138.0 6.7e-32 XP_016874324 (OMIM: 608246) PREDICTED: keratin, ty ( 439) 1433 131.6 5.6e-30 XP_016874322 (OMIM: 608246) PREDICTED: keratin, ty ( 445) 1433 131.6 5.7e-30 NP_002274 (OMIM: 602032,602767) keratin, type II c ( 507) 1389 128.1 7.3e-29 NP_002272 (OMIM: 158000,602153) keratin, type II c ( 505) 1370 126.6 2.1e-28 NP_001307127 (OMIM: 158000,601928) keratin, type I ( 486) 1351 125.0 6e-28 XP_016874785 (OMIM: 158000,601928) PREDICTED: kera ( 486) 1351 125.0 6e-28 XP_005268923 (OMIM: 158000,601928) PREDICTED: kera ( 563) 1351 125.1 6.6e-28 NP_149022 (OMIM: 601078) keratin, type II cuticula ( 513) 1342 124.3 1e-27 NP_002273 (OMIM: 158000,602765) keratin, type II c ( 493) 1341 124.2 1.1e-27 XP_011536590 (OMIM: 611158) PREDICTED: keratin, ty ( 345) 1304 121.0 6.9e-27 NP_001287743 (OMIM: 611159) keratin, type II cytos ( 410) 1244 116.3 2.2e-25 NP_001139698 (OMIM: 608246) keratin, type II cytos ( 469) 1146 108.4 5.9e-23 NP_872313 (OMIM: 611161) keratin, type II cytoskel ( 452) 1053 100.8 1.1e-20 NP_001074961 (OMIM: 611161) keratin, type II cytos ( 422) 1051 100.6 1.2e-20 XP_016874783 (OMIM: 148059) PREDICTED: keratin, ty ( 292) 1032 98.9 2.7e-20 NP_000412 (OMIM: 113800,148080,607602,609165) kera ( 584) 1033 99.4 3.9e-20 XP_005257400 (OMIM: 113800,148080,607602,609165) P ( 624) 1033 99.4 4e-20 XP_016874326 (OMIM: 608246) PREDICTED: keratin, ty ( 271) 1018 97.7 5.6e-20 XP_011536559 (OMIM: 608247) PREDICTED: keratin, ty ( 508) 999 96.5 2.4e-19 XP_011536591 (OMIM: 611158) PREDICTED: keratin, ty ( 322) 959 93.0 1.7e-18 XP_011536312 (OMIM: 611159) PREDICTED: keratin, ty ( 488) 871 86.1 3.1e-16 NP_001287739 (OMIM: 602032,602767) keratin, type I ( 295) 858 84.8 4.8e-16 >>NP_476429 (OMIM: 122100,148043) keratin, type II cytos (628 aa) initn: 4128 init1: 4128 opt: 4128 Z-score: 1838.0 bits: 350.3 E(85289): 1.2e-95 Smith-Waterman score: 4128; 100.0% identity (100.0% similar) in 628 aa overlap (1-628:1-628) 10 20 30 40 50 60 pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSRMSCVAHSGGAGGGAYGFRSGAGGFGSRSLYNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 MSRQASKTSGGGSQGFSGRSAVVSGSSRMSCVAHSGGAGGGAYGFRSGAGGFGSRSLYNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMGGGFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 GGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMGGGFG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 GAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQSLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 GAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQSLL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 QPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 QPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSS 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 ISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 ISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 ENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 ENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSMD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 NNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEIIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 NNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEIIE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE6 LNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 LNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLAR 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE6 LLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGYGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 LLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGYGG 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE6 GYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGARYGVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 GYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGARYGVS 550 560 570 580 590 600 610 620 pF1KE6 GGGFSSASNRGGSIKFSQSSQSSQRYSR :::::::::::::::::::::::::::: NP_476 GGGFSSASNRGGSIKFSQSSQSSQRYSR 610 620 >>NP_056932 (OMIM: 616671) keratin, type II cytoskeletal (638 aa) initn: 2604 init1: 1692 opt: 2559 Z-score: 1150.6 bits: 223.1 E(85289): 2.4e-57 Smith-Waterman score: 3018; 74.3% identity (86.7% similar) in 654 aa overlap (1-627:1-636) 10 20 30 40 50 pF1KE6 MSRQASKTS-GGGSQGFSGRSAVVSGSSRMSCVAHSGGAGGGAYGFRSGAGGFGSRSLYN :.::. : : .: :::::::::::::::::::::.:::::::: :::::::.:::::::: NP_056 MNRQVCKKSFSGRSQGFSGRSAVVSGSSRMSCVARSGGAGGGACGFRSGAGSFGSRSLYN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 LGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMGGGF ::.:::::::::::.:::::::::::::.::::::::: ::..:::::::::.:.:: NP_056 LGSNKSISISVAAGSSRAGGFGGGRSSCGFAGGYGGGF----GGSYGGGFGGGRGVGSGF 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 GGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQSL :::::::::::::: : :::::.::: :::::::::::::::: .:::: NP_056 GGAGGFGGAGGFGGPGVFGGPGSFGG------------PGGFGPGGFPGGIQEVIVNQSL 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 LQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTS :::::::::::::::::::::::::::::::::::::::::::::::::::.::::: :. NP_056 LQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTG 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 SISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTA :: ..::: ::..:..: . ::..::::: :..:::.:.::::::::::::::::::: NP_056 --SGPSSLEPCFESYISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTA 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 AENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSM :::::: ::::::.:.:::::::::::.: ::..::::::. :::::::: ::::::::: NP_056 AENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVLSM 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE6 DNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEII :::: ::: :::::::::::.::::::.:::::::::::::::::::::::::::::::. NP_056 DNNRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIM 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE6 ELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDLA ::::::::::::::.:::::::::::::::::.:::::::::::::.::.:::.:::::: NP_056 ELNRMIQRLRAEIENVKKQNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLA 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE6 RLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGYG ::::::::::::::::::::::::::::::: :::::: ::: :::::. :......: . NP_056 RLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGECQSAVCISVVSNVTSTSGSSGSS 470 480 490 500 510 520 540 550 560 570 580 pF1KE6 GGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGG------------- : ::..:. .::...:..:.:. : : .:: :.:.:: ::: .:: NP_056 RGVFGGVSGSGSGGYKGGSSSSSSSGYGVSGGSGSGYGGVSSGSTGGRGSSGSYQSSSSG 530 540 550 560 570 580 590 600 610 620 pF1KE6 -------------SGFGSISGARYGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR ::.:: ::. .:.:..:... . ::.:::...:::. : NP_056 SRLGGAGSISVSHSGMGSSSGSIQTSGGSGYKSGGGGSTSIRFSQTTSSSQHSSTK 590 600 610 620 630 >>NP_000415 (OMIM: 131760,131800,131900,131960,148040,17 (590 aa) initn: 1535 init1: 1535 opt: 2280 Z-score: 1028.8 bits: 200.4 E(85289): 1.5e-50 Smith-Waterman score: 2423; 64.6% identity (82.1% similar) in 636 aa overlap (1-625:1-586) 10 20 30 40 50 pF1KE6 MSRQASKT-SGGGSQGFSGRSAVVSGSSRMS--CVAHSGGAGGGAYGFRS-----GAGGF ::::.: . .:::..:: ::.. . :: : :..:::.:::..: : :.::. NP_000 MSRQSSVSFRSGGSRSFSTASAITPSVSRTSFTSVSRSGGGGGGGFGRVSLAGACGVGGY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 GSRSLYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGG ::::::::::.: ::::...:. : .: ::.: :::. ::::: NP_000 GSRSLYNLGGSKRISISTSGGSFR------NR------------FGAGAGGGY--GFGGG 70 80 90 100 120 130 140 150 160 170 pF1KE6 RGMGGGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQE : : :::: :..:::: .:: .::: ::::::: : :::::: NP_000 AGSGFGFGG----GAGGGFG----LGGGAGFG--GGFGGPGFPVCP--------PGGIQE 110 120 130 140 180 190 200 210 220 230 pF1KE6 VTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNL ::.::::: :::..:::.: .:...:::::::::::::::::::::::::::::.:::.: NP_000 VTVNQSLLTPLNLQIDPSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTL 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE6 LQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYED ::.:::... .:::::::..:: :: ::.:.::::::::::.::.:::::::.:::: NP_000 LQEQGTKTV--RQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYED 210 220 230 240 250 260 300 310 320 330 340 350 pF1KE6 EINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISD ::::::.:::::: ::::::.::::::::.::::::.:::.:.. ..::::::::.:.:: NP_000 EINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSD 270 280 290 300 310 320 360 370 380 390 400 410 pF1KE6 TSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLR :::::::::::.::::::::::.::::.::.::..:::. :::: ::: :::::::::: NP_000 TSVVLSMDNNRNLDLDSIIAEVKAQYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLR 330 340 350 360 370 380 420 430 440 450 460 470 pF1KE6 NTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQ ::: :: :.:::::::::::..:::: ::::.:::.:::.::.::::: :: ::. ::: NP_000 NTKHEISEMNRMIQRLRAEIDNVKKQCANLQNAIADAEQRGELALKDARNKLAELEEALQ 390 400 410 420 430 440 480 490 500 510 520 530 pF1KE6 QAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTS .::.:.:::::.::::::.::::::::::::::::::: :.::: . :.::::.::..: NP_000 KAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTSSVSS 450 460 470 480 490 500 540 550 560 570 580 pF1KE6 A--SAGGYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGG-GIGGGFGGGSSGFSGGSGF . :..::::: :::.:::::::. :::.::: .. ..:: :.:::.. :.::::..:: NP_000 GYGSGSGYGGGLGGGLGGGLGGGL-AGGSSGSYYSSSSGGVGLGGGLSVGGSGFSASSGR 510 520 530 540 550 590 600 610 620 pF1KE6 GSISGARYGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR : :. .: :::: :: :.:: ....::.. NP_000 G--LGVGFG-SGGGSSS------SVKFVSTTSSSRKSFKS 560 570 580 590 >>NP_000414 (OMIM: 146800,600194) keratin, type II cytos (639 aa) initn: 2070 init1: 1442 opt: 2257 Z-score: 1018.3 bits: 198.6 E(85289): 5.6e-50 Smith-Waterman score: 2379; 64.8% identity (80.3% similar) in 631 aa overlap (10-613:16-606) 10 20 30 40 pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSR-----MSCVAHSGGAGGGAYGFRSGA ::: .:::. ::::::.:: .::... ::.::: : :. NP_000 MSCQISCKSRGRGGGGGGFRGFSSGSAVVSGGSRRSTSSFSCLSRHGGGGGG---F--GG 10 20 30 40 50 50 60 70 80 90 100 pF1KE6 GGFGSRSLYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGG- :::::::: .:::.::::::::.:: ::::. :::.:: ::::::: NP_000 GGFGSRSLVGLGGTKSISISVAGGG---GGFGA-------AGGFGG-----RGGGFGGGS 60 70 80 90 100 110 120 130 140 150 160 pF1KE6 -FGGGRGM-GGGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGF :::: :. :::::: ::::: : ::: :::::: :: :: ::::::::. NP_000 SFGGGSGFSGGGFGG-GGFGG-GRFGG---FGGPGGVGGLGG---------PGGFGPGGY 110 120 130 140 170 180 190 200 210 220 pF1KE6 PGGIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVL ::::.::..::::::::::..::.: .::::::::::::::::::::::::::::::.:: NP_000 PGGIHEVSVNQSLLQPLNVKVDPEIQNVKAQEREQIKTLNNKFASFIDKVRFLEQQNQVL 150 160 170 180 190 200 230 240 250 260 270 280 pF1KE6 ETKWNLLQQQ--GTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVE .:::.::::. :: : ::::.:...:. :. :::.. .:: .:::.::.:::: NP_000 QTKWELLQQMNVGTRPI----NLEPIFQGYIDSLKRYLDGLTAERTSQNSELNNMQDLVE 210 220 230 240 250 260 290 300 310 320 330 340 pF1KE6 DFKKKYEDEINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELS :.::::::::::::::::.:::::::::.::: :::::.::: : .::.::..:::::.: NP_000 DYKKKYEDEINKRTAAENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEFLKVLYDAEIS 270 280 290 300 310 320 350 360 370 380 390 400 pF1KE6 QMQSHISDTSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTA :... ..::.:.:::::.:.::::::::::.::::.:::::: ::::::..: :::.:. NP_000 QIHQSVTDTNVILSMDNSRNLDLDSIIAEVKAQYEEIAQRSKEEAEALYHSKYEELQVTV 330 340 350 360 370 380 410 420 430 440 450 460 pF1KE6 GRHGDDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKL :::::.:.. : :: ::::.::::..:: :::: :.: :::.:::.:: ::::: :: NP_000 GRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAEQRGEHALKDARNKL 390 400 410 420 430 440 470 480 490 500 510 520 pF1KE6 QELQAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSIS ..:. ::::::.:::::::::::::::::::::::::::::::::: ::::. : :..: NP_000 NDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDLSSNVTVS 450 460 470 480 490 500 530 540 550 560 570 pF1KE6 VVSSSTTS--ASAGGYGGGYGGGMGGGLGGGFSAG------GG--SGSGFGRGGGGGI-G :.::. .: :: ...::. :: :.. :::.:.: :: ::: : ::::.: : NP_000 VTSSTISSNVASKAAFGGS--GGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSISG 510 520 530 540 550 560 580 590 600 610 620 pF1KE6 GGFG-----GGSSGFSGGSGFGSISGARYGVSGGGFSSAS-NRGGSIKFSQSSQSSQRYS ::.: :: : .::: :::::. :: .:: ::.. .:::: NP_000 GGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSS 570 580 590 600 610 620 pF1KE6 R NP_000 SVKGSSGEAFGSSVTFSFR 630 >>NP_006112 (OMIM: 113800,139350,144200,146590,600962,60 (644 aa) initn: 1563 init1: 1563 opt: 2257 Z-score: 1018.3 bits: 198.6 E(85289): 5.6e-50 Smith-Waterman score: 2366; 64.8% identity (81.5% similar) in 628 aa overlap (1-613:1-591) 10 20 30 40 pF1KE6 MSRQASKTSG---GGSQGFS-GRSAVVSGSSRM--SCVAHSGGAGG-----GAYGFRSGA :::: :. :: :: ::: : ..... . : : . .:::.:: :. : :: NP_006 MSRQFSSRSGYRSGG--GFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGA 10 20 30 40 50 50 60 70 80 90 100 pF1KE6 GG-FGSRSLYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGG :: :::::: ::::.:::::::: ::.:..::::: :::: :.::: : NP_006 GGGFGSRSLVNLGGSKSISISVARGGGRGSGFGGG---------YGGG---GFGGG---G 60 70 80 90 100 110 120 130 140 150 160 pF1KE6 FGGGRGMGGGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPG :::: :.::: :.::::: :. :.::::: ::::: ::.:: :.:: :: NP_006 FGGG-GFGGGGIGGGGFGGFGS--GGGGFGG-GGFGG-GGYGG--------GYGPVCPPG 110 120 130 140 150 170 180 190 200 210 220 pF1KE6 GIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLET :::::::::::::::::::::.: .::..::::::.:::.:::::::::::::::.::.: NP_006 GIQEVTINQSLLQPLNVEIDPEIQKVKSREREQIKSLNNQFASFIDKVRFLEQQNQVLQT 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE6 KWNLLQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKK ::.:::: :: . :.:::: ::. :: :: .:.. ....:::::::::.:.:::... NP_006 KWELLQQVDTS--TRTHNLEPYFESFINNLRRRVDQLKSDQSRLDSELKNMQDMVEDYRN 220 230 240 250 260 290 300 310 320 330 340 pF1KE6 KYEDEINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQS :::::::::: :::::::.:::::.:::.::.::::.: : .::::: .::.:::::::. NP_006 KYEDEINKRTNAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQAELSQMQT 270 280 290 300 310 320 350 360 370 380 390 400 pF1KE6 HISDTSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHG .::.:.:.::::::::::::::::::.::::::::.::::::.:::.: ::: :::::: NP_006 QISETNVILSMDNNRSLDLDSIIAEVKAQYEDIAQKSKAEAESLYQSKYEELQITAGRHG 330 340 350 360 370 380 410 420 430 440 450 460 pF1KE6 DDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQ :..::.: :: ::::.:::::.::..:::: .::: .:..:::.:: :::::. ::..:. NP_006 DSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQRGENALKDAKNKLNDLE 390 400 410 420 430 440 470 480 490 500 510 520 pF1KE6 AALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSS ::::::.::::::::::::::.:::::.:::::: :::::: :::::: ::.:: :. NP_006 DALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMSGECAPNVSVSV-ST 450 460 470 480 490 500 530 540 550 560 570 580 pF1KE6 STTSASAGGYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIG-GGFG-GGSSGFSGG : :. :.:: :: :::.:.: :.....:::: .: ::::: : :..: :::: ::: NP_006 SHTTISGGGSRGGGGGGYGSG-GSSYGSGGGS---YGSGGGGGGGRGSYGSGGSSYGSGG 510 520 530 540 550 560 590 600 610 620 pF1KE6 SGFGSISGAR-YGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR ...:: .:. .: :.: ::.. :::: NP_006 GSYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGGGSSGGRGSGGGSSGGSIGGRGSSSGGV 570 580 590 600 610 620 >>NP_005545 (OMIM: 148041,615726) keratin, type II cytos (564 aa) initn: 2038 init1: 1559 opt: 2169 Z-score: 980.4 bits: 191.4 E(85289): 7.2e-48 Smith-Waterman score: 2249; 64.0% identity (80.5% similar) in 606 aa overlap (7-610:9-560) 10 20 30 40 50 pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSR--MSCVAHSGGAGGGAYGFRSGAGGFGSRS .. ... .:::. :: . : :: .: :. : . :.:. : :..:::::: NP_005 MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSVSVSRSRGSGGLGGACGGAGFGSRS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 LYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMG ::.:::.: ::: ::: :::..:::: : ::..: :::. : NP_005 LYGLGGSKRISI------------GGG--SCAISGGYG----SRAGGSYG--FGGA---G 70 80 90 120 130 140 150 160 170 pF1KE6 GGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTIN .:: ::::..:.: :: :: : .::::::: : ::::::::.: NP_005 SGF----GFGGGAGIG----FGLGGGAGLAGGFGGPGFPVCP--------PGGIQEVTVN 100 110 120 130 140 180 190 200 210 220 230 pF1KE6 QSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQ :::: :::..::: : .:.:.:::::::::::::::::::::::::::::::::.:::.: NP_005 QSLLTPLNLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQ 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE6 GTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINK ::... .:::::::..:: :: ::.:.::::::::::..:.:::::::.:::::::: NP_005 GTKTV--RQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINK 210 220 230 240 250 300 310 320 330 340 350 pF1KE6 RTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVV ::::::::::::::::.:::::::::::.:.: :::.:::.::::::::::.:::::::: NP_005 RTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVV 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE6 LSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKS :::::::.::::::::::.::::.:::::.::::. :::: :::.:::::::::::::. NP_005 LSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQ 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE6 EIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKD :: :.::::::::.::. :::: ::::.:::.:::.::::::::. ::. :. :::.::. NP_005 EIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQ 380 390 400 410 420 430 480 490 500 510 520 530 pF1KE6 DLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAG ::::::..:::::::::::::::::::::::::: :..:: . :.::::.:...: NP_005 DLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSS---- 440 450 460 470 480 490 540 550 560 570 580 590 pF1KE6 GYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGAR ::::. : : : ::::: :... :.: :.::::.. ::: . :.:..:..:. NP_005 GYGGASGVGSGLGLGGG--------SSYSYGSGLGVGGGFSS-SSGRAIGGGLSSVGGGS 500 510 520 530 540 600 610 620 pF1KE6 YGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR .. ::.: . NP_005 STIKYTTTSSSSRKSYKH 550 560 >>NP_005546 (OMIM: 148042,615728) keratin, type II cytos (564 aa) initn: 2033 init1: 1558 opt: 2167 Z-score: 979.5 bits: 191.3 E(85289): 8.1e-48 Smith-Waterman score: 2251; 63.9% identity (80.4% similar) in 606 aa overlap (7-610:9-560) 10 20 30 40 50 pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSR--MSCVAHSGGAGGGAYGFRSGAGGFGSRS .. ... .:::. :: . : :: .: .. : . :.:. : :..:::::: NP_005 MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSRSRGSGGLGGACGGAGFGSRS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 LYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMG ::.:::.: ::: ::: :::..:::: : ::..: :::. : NP_005 LYGLGGSKRISI------------GGG--SCAISGGYG----SRAGGSYG--FGGA---G 70 80 90 120 130 140 150 160 170 pF1KE6 GGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTIN .:: ::::..:.: :: :: : .::::::: : ::::::::.: NP_005 SGF----GFGGGAGIG----FGLGGGAGLAGGFGGPGFPVCP--------PGGIQEVTVN 100 110 120 130 140 180 190 200 210 220 230 pF1KE6 QSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQ :::: :::..::: : .:.:.:::::::::::::::::::::::::::::.:::.:::.: NP_005 QSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQ 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE6 GTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINK ::... .:::::::..:: :: ::::.::::::::::.::.:::::.:.:::::::: NP_005 GTKTV--RQNLEPLFEQYINNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINK 210 220 230 240 250 300 310 320 330 340 350 pF1KE6 RTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVV ::::::::::::::::.:::::::::::.:.: :::.:::.::::::::::.:::::::: NP_005 RTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVV 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE6 LSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKS :::::::.::::::::::.::::.:::::.::::. :::: ::: :::::::::::::. NP_005 LSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQ 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE6 EIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKD :: :.::::::::.::. :::: ::::.:::.:::.::::::::. ::. :. :::.::. NP_005 EIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQ 380 390 400 410 420 430 480 490 500 510 520 530 pF1KE6 DLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAG ::::::..:::::::::::::::::::::::::: :..:: . :.::::.:...: NP_005 DLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVVQSTVSS---- 440 450 460 470 480 490 540 550 560 570 580 590 pF1KE6 GYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGAR ::::. : : : ::::: :... :.: :.::::.. ::: . :.:..:..:. NP_005 GYGGASGVGSGLGLGGG--------SSYSYGSGLGVGGGFSS-SSGRATGGGLSSVGGGS 500 510 520 530 540 600 610 620 pF1KE6 YGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR .. ::.: . NP_005 STIKYTTTSSSSRKSYKH 550 560 >>NP_775109 (OMIM: 612315,615735) keratin, type II cytos (564 aa) initn: 2025 init1: 1550 opt: 2157 Z-score: 975.1 bits: 190.4 E(85289): 1.4e-47 Smith-Waterman score: 2237; 63.5% identity (80.4% similar) in 606 aa overlap (7-610:9-560) 10 20 30 40 50 pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSR--MSCVAHSGGAGGGAYGFRSGAGGFGSRS .. ... .:::. :: . : :: .: .. : . :.:. : :..:::::: NP_775 MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSRSRGSGGLGGACGGAGFGSRS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 LYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMG ::.:::.: ::: ::: :::..:::: : ::..: :::. : NP_775 LYGLGGSKRISI------------GGG--SCAISGGYG----SRAGGSYG--FGGA---G 70 80 90 120 130 140 150 160 170 pF1KE6 GGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTIN .:: ::::..:.: :: :: : .::::::: : ::::::::.: NP_775 SGF----GFGGGAGIG----FGLGGGAGLAGGFGGPGFPVCP--------PGGIQEVTVN 100 110 120 130 140 180 190 200 210 220 230 pF1KE6 QSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQ :::: :::..::: : .:.:.:::::::::::::::::::::::::::::.:::.:::.: NP_775 QSLLTPLNLQIDPAIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQ 150 160 170 180 190 200 240 250 260 270 280 290 pF1KE6 GTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINK ::... .:::::::..:: :: ::.:.::::::::::.::.:::::.:.:::::::: NP_775 GTKTV--RQNLEPLFEQYINNLRRQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINK 210 220 230 240 250 300 310 320 330 340 350 pF1KE6 RTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVV ::::::::::::::::.:::::::::::.:.: :::.:::.::::::::::.:::::::: NP_775 RTAAENEFVTLKKDVDAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVV 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE6 LSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKS :::::::.::::::::::.::::.:::::.::::. :::: :::.:::::::::::::. NP_775 LSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQ 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE6 EIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKD :: :.::::::::.::. :::: :.::.:::.:::.::::::::. ::. :. :::.::. NP_775 EIAEINRMIQRLRSEIDHVKKQCASLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQ 380 390 400 410 420 430 480 490 500 510 520 530 pF1KE6 DLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAG ::::::..:::::::::::::::::::::::::: :..:: . :..:::.:. .: NP_775 DLARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNVSVVQSTISS---- 440 450 460 470 480 490 540 550 560 570 580 590 pF1KE6 GYGGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGAR ::::. : : : ::::: :... :.: ::::::.. ::: . :.:..:..:. NP_775 GYGGASGVGSGLGLGGG--------SSYSYGSGLGIGGGFSS-SSGRAIGGGLSSVGGGS 500 510 520 530 540 600 610 620 pF1KE6 YGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR .. ::.: . NP_775 STIKYTTTSSSSRKSYKH 550 560 >>NP_002263 (OMIM: 123940,193900) keratin, type II cytos (520 aa) initn: 1806 init1: 1400 opt: 2034 Z-score: 921.6 bits: 180.4 E(85289): 1.4e-44 Smith-Waterman score: 2111; 65.5% identity (80.5% similar) in 560 aa overlap (11-568:10-500) 10 20 30 40 50 pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSR--MSCVAHSGGAGGGAYGFRSGAGGFGSRSLY :: .::: ::.:.:..: .: :. ::::: : ..::::::::: NP_002 MIARQQCVRGGPRGFSCGSAIVGGGKRGAFSSVSMSGGAG------RCSSGGFGSRSLY 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 NLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGGGFGGGRGMGGG :: ::::::.::: ::: : .: NP_002 NLRGNKSISMSVA--GSRQG-------AC------------------------------- 60 70 120 130 140 150 160 170 pF1KE6 FGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQS :::::::: .:::: :::: :.:.:. :::: :.: :::::::::: NP_002 FGGAGGFG-TGGFG--GGFG--GSFSGK---GGPGFPVCPAG--------GIQEVTINQS 80 90 100 110 180 190 200 210 220 230 pF1KE6 LLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGT :: ::.:::::.: .:...:::::: ::::::::::::.::::::::::::::::::: : NP_002 LLTPLHVEIDPEIQKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTT 120 130 140 150 160 170 240 250 260 270 280 290 pF1KE6 SSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRT .. : .:::::::.... ::. ::.. ...:::.::::.:.: ::::: :::.:::::: NP_002 TTSS--KNLEPLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRT 180 190 200 210 220 230 300 310 320 330 340 350 pF1KE6 AAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLS ::::.::.::::::.::.:::::.::::.: :::.::..::::::::::.:.:::::::: NP_002 AAENDFVVLKKDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLS 240 250 260 270 280 290 360 370 380 390 400 410 pF1KE6 MDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEI :::::.:::::::::::::::.::::::::::::::::. .:: .. .:::.:.:::::: NP_002 MDNNRNLDLDSIIAEVRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEI 300 310 320 330 340 350 420 430 440 450 460 470 pF1KE6 IELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQELQAALQQAKDDL ::::::::::::::..::: .::...:.:::.:: :::::..: ::.:::::::..: NP_002 AELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGENALKDAHSKRVELEAALQQAKEEL 360 370 380 390 400 410 480 490 500 510 520 530 pF1KE6 ARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVSSSTTSASAGGY ::.::.:::::.::::::.:::::::::::::::::::: :::::::::.:: :.:: NP_002 ARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGST---STGGI 420 430 440 450 460 470 540 550 560 570 580 590 pF1KE6 GGGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSGFSGGSGFGSISGARYG .:: :.: : ::..:: :.::::::: :: NP_002 SGGLGSGSGFGLSSGF--GSGSGSGFGFGGSVSGSSSSKIISTTTLNKRR 480 490 500 510 520 >>NP_778253 (OMIM: 611158) keratin, type II cytoskeletal (578 aa) initn: 1934 init1: 1301 opt: 1975 Z-score: 895.2 bits: 175.7 E(85289): 4e-43 Smith-Waterman score: 2064; 60.4% identity (78.5% similar) in 596 aa overlap (1-591:14-559) 10 20 30 40 pF1KE6 MSRQASKTSGGGSQGFSGRSAVVSGSSRMSCVAHSGGAGGGAYGFRS :::.. .::.....: .: :: :: : :. : :::.::... NP_778 MSHQFSSQSAFSSMSRRVYSTSSSAGSG-GGSPAV--GSV---CYAR-GRCGGGGYGIHG 10 20 30 40 50 50 60 70 80 90 100 pF1KE6 GAGGFGSRSLYNLGGNKSISISVAAGGSRAGGFGGGRSSCAFAGGYGGGFGSGYGGGFGG ::::::::::::..::::.. :::. .: ::: : NP_778 --RGFGSRSLYNLGGSRSISINLM-----------GRSTSGFC--QGGGVG--------- 60 70 80 110 120 130 140 150 160 pF1KE6 GFGGGRGMGGGFGGAGGFGGAGGFGGAGGFGGPGGFGGSGGFGGPGSLGSPGGFGPGGFP :::::::.: : ::::::: ::::::: :: :. :: ::::: : NP_778 GFGGGRGFGVGSTGAGGFGG-GGFGGAG-------FGTSN-FGL-------GGFGPYCPP 90 100 110 120 130 170 180 190 200 210 220 pF1KE6 GGIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLE :::::::::::::.::..:.::.: ..:.:::::: .:::::::::::::::::::.::. NP_778 GGIQEVTINQSLLEPLHLEVDPEIQRIKTQEREQIMVLNNKFASFIDKVRFLEQQNQVLQ 140 150 160 170 180 190 230 240 250 260 270 280 pF1KE6 TKWNLLQQQGTSSISGTNNLEPLFENHINYLRSYLDNILGERGRLDSELKNMEDLVEDFK :::.:::: .:: .::::::::.::.:. :: .: . .:. : ..:...:.:.:::.: NP_778 TKWELLQQVNTS--TGTNNLEPLLENYIGDLRRQVDLLSAEQMRQNAEVRSMQDVVEDYK 200 210 220 230 240 250 290 300 310 320 330 340 pF1KE6 KKYEDEINKRTAAENEFVTLKKDVDSAYMNKVELQAKVDALIDEIDFLRTLYDAELSQMQ .::::::::::..::.::.::::::.::..::.:...::.: :..::. :. .::::.: NP_778 SKYEDEINKRTGSENDFVVLKKDVDAAYVSKVDLESRVDTLTGEVNFLKYLFLTELSQVQ 260 270 280 290 300 310 350 360 370 380 390 400 pF1KE6 SHISDTSVVLSMDNNRSLDLDSIIAEVRAQYEDIAQRSKAEAEALYQTKLGELQTTAGRH .:::::.:.::::::::::::::: ::.::: :::::: ::::::::: ::: ::::: NP_778 THISDTNVILSMDNNRSLDLDSIIDAVRTQYELIAQRSKDEAEALYQTKYQELQITAGRH 320 330 340 350 360 370 410 420 430 440 450 460 pF1KE6 GDDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAEAEQHGEMALKDANAKLQEL ::::.:.: :: :::: .:::.::: .:::: ..:. :..::..::.::.:: :::.: NP_778 GDDLKNSKMEIAELNRTVQRLQAEISNVKKQIEQMQSLISDAEERGEQALQDAWQKLQDL 380 390 400 410 420 430 470 480 490 500 510 520 pF1KE6 QAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSISVVS . ::::.:..::::::::: ...:::.:::::::::.:::::: ::::: : ::::: . NP_778 EEALQQSKEELARLLRDYQAMLGVKLSLDVEIATYRQLLEGEESRMSGELQSHVSISVQN 440 450 460 470 480 490 530 540 550 560 570 580 pF1KE6 SSTT-SASAGG---YG-GGYGGGMGGGLGGGFSAGGGSGSGFGRGGGGGIGGGFGGGSSG :... ...::: :: :::::: ::: ::: : ::.. : . ::: : : : :::: : NP_778 SQVSVNGGAGGGGSYGSGGYGGGSGGGYGGGRSYRGGGARGRS-GGGYGSGCGGGGGSYG 500 510 520 530 540 550 590 600 610 620 pF1KE6 FSGGSGFGSISGARYGVSGGGFSSASNRGGSIKFSQSSQSSQRYSR :: :: :: NP_778 GSGRSGRGSSRVQIIQTSTNTSHRRILE 560 570 628 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:56:33 2016 done: Tue Nov 8 15:56:34 2016 Total Scan time: 9.860 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]