FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9435, 617 aa 1>>>pF1KE9435 617 - 617 aa - 617 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 10.3700+/-0.000519; mu= -4.2858+/- 0.032 mean_var=318.2556+/-65.235, 0's: 0 Z-trim(117.2): 581 B-trim: 0 in 0/54 Lambda= 0.071893 statistics sampled from 28304 (28958) to 28304 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.34), width: 16 Scan time: 11.240 The best scores are: opt bits E(85289) NP_004215 (OMIM: 300207) melatonin-related recepto ( 617) 4186 448.6 2.9e-125 XP_011529518 (OMIM: 300207) PREDICTED: melatonin-r ( 370) 2520 275.6 2e-73 NP_005949 (OMIM: 600665) melatonin receptor type 1 ( 350) 1153 133.8 9.4e-31 NP_005950 (OMIM: 125853,600804) melatonin receptor ( 362) 1106 129.0 2.8e-29 XP_011541141 (OMIM: 125853,600804) PREDICTED: mela ( 362) 1106 129.0 2.8e-29 XP_016873266 (OMIM: 125853,600804) PREDICTED: mela ( 320) 992 117.1 9.4e-26 XP_011530304 (OMIM: 600665) PREDICTED: melatonin r ( 265) 895 107.0 8.7e-23 NP_001008505 (OMIM: 600018) mu-type opioid recepto ( 446) 475 63.6 1.7e-09 NP_001008503 (OMIM: 600018) mu-type opioid recepto ( 418) 471 63.2 2.1e-09 NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 468 62.8 2.5e-09 NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 468 62.8 2.5e-09 NP_001138755 (OMIM: 600018) mu-type opioid recepto ( 397) 468 62.8 2.5e-09 NP_000905 (OMIM: 600018) mu-type opioid receptor i ( 400) 468 62.8 2.5e-09 NP_001138756 (OMIM: 600018) mu-type opioid recepto ( 403) 468 62.8 2.6e-09 NP_001138754 (OMIM: 600018) mu-type opioid recepto ( 406) 468 62.9 2.6e-09 NP_001272452 (OMIM: 600018) mu-type opioid recepto ( 414) 468 62.9 2.6e-09 NP_001138758 (OMIM: 600018) mu-type opioid recepto ( 420) 468 62.9 2.6e-09 NP_001138751 (OMIM: 600018) mu-type opioid recepto ( 493) 468 62.9 3e-09 NP_001272453 (OMIM: 600018) mu-type opioid recepto ( 493) 468 62.9 3e-09 NP_001138753 (OMIM: 600018) mu-type opioid recepto ( 319) 418 57.6 7.8e-08 XP_011534164 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08 XP_011534158 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08 XP_016866394 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08 XP_011534155 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08 XP_016866392 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08 XP_011534153 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08 XP_016866393 (OMIM: 600018) PREDICTED: mu-type opi ( 346) 417 57.5 8.9e-08 NP_001272456 (OMIM: 600018) mu-type opioid recepto ( 292) 410 56.7 1.3e-07 NP_001138752 (OMIM: 600018) mu-type opioid recepto ( 300) 410 56.7 1.3e-07 NP_001138759 (OMIM: 600018) mu-type opioid recepto ( 300) 410 56.7 1.3e-07 NP_001272455 (OMIM: 600018) mu-type opioid recepto ( 300) 410 56.7 1.3e-07 XP_016866395 (OMIM: 600018) PREDICTED: mu-type opi ( 300) 410 56.7 1.3e-07 NP_001272457 (OMIM: 600018) mu-type opioid recepto ( 314) 410 56.7 1.4e-07 NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 411 56.9 1.5e-07 NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 411 56.9 1.6e-07 NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 407 56.5 1.8e-07 NP_003848 (OMIM: 603691) galanin receptor type 2 [ ( 387) 401 55.9 3.1e-07 NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 397 55.4 3.9e-07 NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 397 55.4 3.9e-07 NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 396 55.4 4.4e-07 NP_005288 (OMIM: 601751) melanin-concentrating hor ( 422) 394 55.2 5.4e-07 NP_001186948 (OMIM: 602548) nociceptin receptor is ( 370) 392 54.9 5.7e-07 NP_000904 (OMIM: 602548) nociceptin receptor isofo ( 370) 392 54.9 5.7e-07 XP_016883343 (OMIM: 602548) PREDICTED: nociceptin ( 370) 392 54.9 5.7e-07 NP_872588 (OMIM: 602548) nociceptin receptor isofo ( 370) 392 54.9 5.7e-07 XP_011527130 (OMIM: 602548) PREDICTED: nociceptin ( 388) 392 55.0 5.9e-07 XP_016883341 (OMIM: 602548) PREDICTED: nociceptin ( 388) 392 55.0 5.9e-07 XP_016883342 (OMIM: 602548) PREDICTED: nociceptin ( 388) 392 55.0 5.9e-07 NP_001305782 (OMIM: 602548) nociceptin receptor is ( 399) 392 55.0 6e-07 NP_001049 (OMIM: 162323) substance-P receptor isof ( 407) 390 54.8 7e-07 >>NP_004215 (OMIM: 300207) melatonin-related receptor [H (617 aa) initn: 4186 init1: 4186 opt: 4186 Z-score: 2369.9 bits: 448.6 E(85289): 2.9e-125 Smith-Waterman score: 4186; 99.8% identity (100.0% similar) in 617 aa overlap (1-617:1-617) 10 20 30 40 50 60 pF1KE9 MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 NSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 AIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 NYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 NYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQLAEVRNFLTMF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 VIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNEN 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 FRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 TPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAASGHLKP 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 VSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSVHFKPDSVHFKPASSNPKPITGH 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE9 HVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTTADYPKPATTSHPKPTAADNPELS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE9 ASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAASQLESDTIADLPDPTVVTTSTNDY 550 560 570 580 590 600 610 pF1KE9 HDVVVVDVEDDPDEMAV :::::.::::::::::: NP_004 HDVVVIDVEDDPDEMAV 610 >>XP_011529518 (OMIM: 300207) PREDICTED: melatonin-relat (370 aa) initn: 2520 init1: 2520 opt: 2520 Z-score: 1439.0 bits: 275.6 E(85289): 2e-73 Smith-Waterman score: 2520; 99.5% identity (100.0% similar) in 370 aa overlap (248-617:1-370) 220 230 240 250 260 270 pF1KE9 ARDPAGQNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYL .::::::::::::::::::::::::::::: XP_011 MCWCPINVLTVLVAVSPKEMAGKIPNWLYL 10 20 30 280 290 300 310 320 330 pF1KE9 AAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAYFIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLAR 40 50 60 70 80 90 340 350 360 370 380 390 pF1KE9 ARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ARAHARDQAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYR 100 110 120 130 140 150 400 410 420 430 440 450 pF1KE9 KSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDS 160 170 180 190 200 210 460 470 480 490 500 510 pF1KE9 VHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VHFKPDSVHFKPASSNPKPITGHHVSAGSHSKSAFSAATSHPKPTTGHIKPATSHAEPTT 220 230 240 250 260 270 520 530 540 550 560 570 pF1KE9 ADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ADYPKPATTSHPKPTAADNPELSASHCPEIPAIAHPVSDDSDLPESASSPAAGPTKPAAS 280 290 300 310 320 330 580 590 600 610 pF1KE9 QLESDTIADLPDPTVVTTSTNDYHDVVVVDVEDDPDEMAV ::::::::::::::::::::::::::::.::::::::::: XP_011 QLESDTIADLPDPTVVTTSTNDYHDVVVIDVEDDPDEMAV 340 350 360 370 >>NP_005949 (OMIM: 600665) melatonin receptor type 1A [H (350 aa) initn: 1145 init1: 791 opt: 1153 Z-score: 673.1 bits: 133.8 E(85289): 9.4e-31 Smith-Waterman score: 1153; 51.5% identity (79.7% similar) in 305 aa overlap (24-326:23-327) 10 20 30 40 50 60 pF1KE9 MGPTLAVPTPYGCIGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMVILAVTKNKKLR : : . :....:::::..:: .:::.: .::::: NP_005 MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLR 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 NSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIV :.::::::::.:::..::::::::.: .. .::.:. :.::. ::. ::::.::::::. NP_005 NAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNIT 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 AIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIF .:::::::::::::.:....: .:. :... :..:. :::::. ::..:::: :.: : NP_005 GIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTF 120 130 140 150 160 170 190 200 210 220 230 pF1KE9 NYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARD--PAGQNPDNQLAEVRNFLT . ..:...: .::..:..:: :::.::: :: .:. ..: . . :::.: NP_005 AQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVT 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 MFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLN :::.:.:::.:: :.: . . :: .: :. .::.::..:.:..:::::::::.:::::: NP_005 MFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLN 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE9 ENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAV .:::.:: :. .. .:: .:. NP_005 QNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV 300 310 320 330 340 350 >>NP_005950 (OMIM: 125853,600804) melatonin receptor typ (362 aa) initn: 1092 init1: 749 opt: 1106 Z-score: 646.5 bits: 129.0 E(85289): 2.8e-29 Smith-Waterman score: 1106; 48.3% identity (78.7% similar) in 315 aa overlap (6-315:17-329) 10 20 30 40 pF1KE9 MGPTLAVPTPYGCIGCKLP-QPEYPPALIIFMFCAMVITIVVDLIGNSM :: .. : : . :: . . ....: .::..:: . NP_005 MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 VILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFIT :::.: .:.::::.::.:.:::..::..::.:::::.: :. :: :.. .:. .:. NP_005 VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 GLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT ::::.::.:::.:::::::::::::. :.::. .: ... . :..::.:.:::...:. NP_005 GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 IEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDN .::::: :.: : . .:...: :::.::. .:.:::.:::. :: :: : .:.. NP_005 LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKA--KPES 190 200 210 220 230 230 240 250 260 270 280 pF1KE9 QL----AEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAY .: ...:.::::::.:..::.:: :.: . . ::..:.::: .::. :....:..:: NP_005 RLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAY 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 FNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARD :::::::..:::::.:::::: :. :. .: NP_005 FNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQ 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE9 QAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHH NP_005 ADAL 360 >>XP_011541141 (OMIM: 125853,600804) PREDICTED: melatoni (362 aa) initn: 1092 init1: 749 opt: 1106 Z-score: 646.5 bits: 129.0 E(85289): 2.8e-29 Smith-Waterman score: 1106; 48.3% identity (78.7% similar) in 315 aa overlap (6-315:17-329) 10 20 30 40 pF1KE9 MGPTLAVPTPYGCIGCKLP-QPEYPPALIIFMFCAMVITIVVDLIGNSM :: .. : : . :: . . ....: .::..:: . XP_011 MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 VILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFIT :::.: .:.::::.::.:.:::..::..::.:::::.: :. :: :.. .:. .:. XP_011 VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 GLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT ::::.::.:::.:::::::::::::. :.::. .: ... . :..::.:.:::...:. XP_011 GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 IEYDPRTYTCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDN .::::: :.: : . .:...: :::.::. .:.:::.:::. :: :: : .:.. XP_011 LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKA--KPES 190 200 210 220 230 230 240 250 260 270 280 pF1KE9 QL----AEVRNFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAY .: ...:.::::::.:..::.:: :.: . . ::..:.::: .::. :....:..:: XP_011 RLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAY 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 FNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARD :::::::..:::::.:::::: :. :. .: XP_011 FNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQ 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE9 QAREQDRAHACPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHH XP_011 ADAL 360 >>XP_016873266 (OMIM: 125853,600804) PREDICTED: melatoni (320 aa) initn: 976 init1: 633 opt: 992 Z-score: 583.4 bits: 117.1 E(85289): 9.4e-26 Smith-Waterman score: 992; 49.1% identity (80.1% similar) in 277 aa overlap (44-315:13-287) 20 30 40 50 60 70 pF1KE9 IGCKLPQPEYPPALIIFMFCAMVITIVVDLIGNSMV-ILAVTKNKKLRNSGNIFVVSLSV .: ::. .. .. : . ::.:.:::.. XP_016 MATVFFCFPNSSMGISMAGAMSFIHHCVLLECGNLFLVSLAL 10 20 30 40 80 90 100 110 120 130 pF1KE9 ADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFITGLSVVGSIFNIVAIAINRYCYICH ::..::.:::::.: :. :: :.. .:. .:. ::::.::.:::.:::::::::::: XP_016 ADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICH 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE9 SLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTYTCIFNYLNNPVFTVTI :. :.::. .: ... . :..::.:.:::...:..::::: :.: : . .:... XP_016 SMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAV 110 120 130 140 150 160 200 210 220 230 240 pF1KE9 VCIHFVLPLLIVGFCYVRIWTKVLAARDPAGQNPDNQL----AEVRNFLTMFVIFLLFAV : :::.::. .:.:::.:::. :: :: : .:...: ...:.::::::.:..::. XP_016 VVIHFLLPIAVVSFCYLRIWVLVLQARRKA--KPESRLCLKPSDLRSFLTMFVVFVIFAI 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE9 CWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIYGLLNENFRREYWTI :: :.: . . ::..:.::: .::. :....:..:::::::::..:::::.:::::: : XP_016 CWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRI 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE9 FHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHACPAVEETPMNVRNV . :. .: XP_016 LLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQADAL 290 300 310 320 >>XP_011530304 (OMIM: 600665) PREDICTED: melatonin recep (265 aa) initn: 888 init1: 534 opt: 895 Z-score: 530.1 bits: 107.0 E(85289): 8.7e-23 Smith-Waterman score: 895; 49.6% identity (78.1% similar) in 242 aa overlap (89-326:1-242) 60 70 80 90 100 110 pF1KE9 LRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSI--GGWDLSQLQCQMVGFITGLSVVGSI ::: .::.:. :.::. ::. ::::.::: XP_011 MSIFNNGWNLGYLHCQVSGFLMGLSVIGSI 10 20 30 120 130 140 150 160 170 pF1KE9 FNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGTIEYDPRTY :::..:::::::::::::.:....: .:. :... :..:. :::::. ::..:::: : XP_011 FNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIY 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE9 TCIFNYLNNPVFTVTIVCIHFVLPLLIVGFCYVRIWTKVLAARD--PAGQNPDNQLAEVR .: : . ..:...: .::..:..:: :::.::: :: .:. ..: . . : XP_011 SCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFR 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE9 NFLTMFVIFLLFAVCWCPINVLTVLVAVSPKEMAGKIPNWLYLAAYFIAYFNSCLNAVIY ::.::::.:.:::.:: :.: . . :: .: :. .::.::..:.:..:::::::::.:: XP_011 NFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIY 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE9 GLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARAHARDQAREQDRAHA ::::.:::.:: :. .. .:: .:. XP_011 GLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV 220 230 240 250 260 360 370 380 390 400 410 pF1KE9 CPAVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRKSASTHHKSVFSHSKAA >>NP_001008505 (OMIM: 600018) mu-type opioid receptor is (446 aa) initn: 383 init1: 136 opt: 475 Z-score: 291.6 bits: 63.6 E(85289): 1.7e-09 Smith-Waterman score: 475; 27.2% identity (58.5% similar) in 371 aa overlap (21-372:61-414) 10 20 30 40 pF1KE9 MGPTLAVPTPYGCIGCKLPQPEYPPALI--IFMFCAMVITIVVDLIGNSM : :..: : .. . :. :: :.:: . NP_001 WVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFL 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE9 VILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFIT :. .... :.... ::.. .:..:: : : :.. . .: : .. . :..: : NP_001 VMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 100 110 120 130 140 110 120 130 140 150 160 pF1KE9 GLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT .. :::.. .....:: .:: .. . . ::. : : .::.. :: :...: NP_001 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMAT 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE9 IEYDPRTYTCIFNYLNNPVF---TVTIVCIH---FVLPLLIVGFCYVRIWTKVLAARDPA .: . : ... ..:.. .. .:. :..:.::. :: . .. ..: . NP_001 TKYRQGSIDCTLTF-SHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLS 210 220 230 240 250 260 230 240 250 260 270 280 pF1KE9 G-QNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVA-VSPKEMAGKIPNWLYLAAY : .. : .: .. .. .:. .: ::: ::.. ... : :. : . . .: . : NP_001 GSKEKDRNLRRITRMV--LVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIA- 270 280 290 300 310 320 290 300 310 320 330 340 pF1KE9 FIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARA ..: ::::: :.:..:.:::.: . :. : : :.:.... .: .: NP_001 -LGYTNSCLNPVLYAFLDENFKRCF-------REFCIPTS---SNIEQQNSTRIRQNTRD 330 340 350 360 370 350 360 370 380 390 pF1KE9 HARDQAREQDRA-HAC-P-------AVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSR : . : ::. : : : :.:. . : :: : NP_001 HP-STANTVDRTNHQCLPIPSLSCWALEQGCLVVYPGPLQGPLVRYDLPAILHSSCLRGN 380 390 400 410 420 430 400 410 420 430 440 450 pF1KE9 SSSAYRKSASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSV NP_001 TAPSPSGGAFLLS 440 >>NP_001008503 (OMIM: 600018) mu-type opioid receptor is (418 aa) initn: 408 init1: 136 opt: 471 Z-score: 289.8 bits: 63.2 E(85289): 2.1e-09 Smith-Waterman score: 471; 26.9% identity (59.3% similar) in 361 aa overlap (21-369:61-404) 10 20 30 40 pF1KE9 MGPTLAVPTPYGCIGCKLPQPEYPPALI--IFMFCAMVITIVVDLIGNSM : :..: : .. . :. :: :.:: . NP_001 WVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFL 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE9 VILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFIT :. .... :.... ::.. .:..:: : : :.. . .: : .. . :..: : NP_001 VMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 100 110 120 130 140 110 120 130 140 150 160 pF1KE9 GLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT .. :::.. .....:: .:: .. . . ::. : : .::.. :: :...: NP_001 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMAT 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE9 IEYDPRTYTCIFNYLNNPVF---TVTIVCIH---FVLPLLIVGFCYVRIWTKVLAARDPA .: . : ... ..:.. .. .:. :..:.::. :: . .. ..: . NP_001 TKYRQGSIDCTLTF-SHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLS 210 220 230 240 250 260 230 240 250 260 270 280 pF1KE9 G-QNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVA-VSPKEMAGKIPNWLYLAAY : .. : .: .. .. .:. .: ::: ::.. ... : :. : . . .: . : NP_001 GSKEKDRNLRRITRMV--LVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIA- 270 280 290 300 310 320 290 300 310 320 330 340 pF1KE9 FIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARA ..: ::::: :.:..:.:::.: . :. : : :.:.... .: .: NP_001 -LGYTNSCLNPVLYAFLDENFKRCF-------REFCIPTS---SNIEQQNSTRIRQNTRD 330 340 350 360 370 350 360 370 380 390 pF1KE9 HARDQAREQDRAHACP--AVEETPMNVRNVPLPGDAAAGHPDRASGHPKPHSRSSSAYRK : . : ::.. : :: . . .: : NP_001 HP-STANTVDRTNHQPPLAVSMAQIFTRYPPPTHREKTCNDYMKR 380 390 400 410 400 410 420 430 440 450 pF1KE9 SASTHHKSVFSHSKAASGHLKPVSGHSKPASGHPKSATVYPKPASVHFKADSVHFKGDSV >>NP_001138757 (OMIM: 600018) mu-type opioid receptor is (389 aa) initn: 383 init1: 136 opt: 468 Z-score: 288.5 bits: 62.8 E(85289): 2.5e-09 Smith-Waterman score: 468; 27.5% identity (62.4% similar) in 295 aa overlap (21-305:61-349) 10 20 30 40 pF1KE9 MGPTLAVPTPYGCIGCKLPQPEYPPALI--IFMFCAMVITIVVDLIGNSM : :..: : .. . :. :: :.:: . NP_001 WVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFL 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE9 VILAVTKNKKLRNSGNIFVVSLSVADMLVAIYPYPLMLHAMSIGGWDLSQLQCQMVGFIT :. .... :.... ::.. .:..:: : : :.. . .: : .. . :..: : NP_001 VMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGTILCKIVISID 100 110 120 130 140 110 120 130 140 150 160 pF1KE9 GLSVVGSIFNIVAIAINRYCYICHSLQYERIFSVRNTCIYLVITWIMTVLAVLPNMYIGT .. :::.. .....:: .:: .. . . ::. : : .::.. :: :...: NP_001 YYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMAT 150 160 170 180 190 200 170 180 190 200 210 220 pF1KE9 IEYDPRTYTCIFNYLNNPVF---TVTIVCIH---FVLPLLIVGFCYVRIWTKVLAARDPA .: . : ... ..:.. .. .:. :..:.::. :: . .. ..: . NP_001 TKYRQGSIDCTLTF-SHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLS 210 220 230 240 250 260 230 240 250 260 270 280 pF1KE9 G-QNPDNQLAEVRNFLTMFVIFLLFAVCWCPINVLTVLVA-VSPKEMAGKIPNWLYLAAY : .. : .: .. .. .:. .: ::: ::.. ... : :. : . . .: . : NP_001 GSKEKDRNLRRITRMV--LVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIA- 270 280 290 300 310 320 290 300 310 320 330 340 pF1KE9 FIAYFNSCLNAVIYGLLNENFRREYWTIFHAMRHPIIFFSGLISDIREMQEARTLARARA ..: ::::: :.:..:.:::.: . NP_001 -LGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDR 330 340 350 360 370 380 617 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 10:49:10 2016 done: Sun Nov 6 10:49:12 2016 Total Scan time: 11.240 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]