FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1908, 415 aa 1>>>pF1KE1908 415 - 415 aa - 415 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9115+/-0.000445; mu= 19.3158+/- 0.027 mean_var=75.6129+/-15.408, 0's: 0 Z-trim(109.6): 308 B-trim: 22 in 1/53 Lambda= 0.147495 statistics sampled from 17440 (17755) to 17440 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.552), E-opt: 0.2 (0.208), width: 16 Scan time: 8.070 The best scores are: opt bits E(85289) NP_004373 (OMIM: 122561) corticotropin-releasing f ( 415) 2827 611.6 1.1e-174 NP_001138620 (OMIM: 122561) corticotropin-releasin ( 401) 2422 525.4 9.5e-149 NP_001138619 (OMIM: 122561) corticotropin-releasin ( 375) 2279 495.0 1.3e-139 NP_001289949 (OMIM: 122561) corticotropin-releasin ( 314) 2074 451.3 1.6e-126 NP_001189404 (OMIM: 602034) corticotropin-releasin ( 438) 2049 446.1 7.9e-125 NP_001189411 (OMIM: 602034) corticotropin-releasin ( 410) 2027 441.4 1.9e-123 NP_001189410 (OMIM: 602034) corticotropin-releasin ( 397) 2016 439.0 9.6e-123 XP_016867241 (OMIM: 602034) PREDICTED: corticotrop ( 397) 2016 439.0 9.6e-123 NP_001874 (OMIM: 602034) corticotropin-releasing f ( 411) 2016 439.1 9.8e-123 NP_001138618 (OMIM: 122561) corticotropin-releasin ( 444) 1852 404.2 3.3e-112 XP_011513430 (OMIM: 602034) PREDICTED: corticotrop ( 370) 1748 382.0 1.3e-105 NP_001189412 (OMIM: 602034) corticotropin-releasin ( 387) 1748 382.0 1.4e-105 XP_011513431 (OMIM: 602034) PREDICTED: corticotrop ( 387) 1748 382.0 1.4e-105 NP_001289947 (OMIM: 122561) corticotropin-releasin ( 240) 1642 359.3 6e-99 XP_016867240 (OMIM: 602034) PREDICTED: corticotrop ( 558) 1412 310.7 6e-84 XP_011513429 (OMIM: 602034) PREDICTED: corticotrop ( 559) 1401 308.3 3e-83 XP_005265495 (OMIM: 192321) PREDICTED: vasoactive ( 416) 721 163.5 8.9e-40 NP_001238811 (OMIM: 192321) vasoactive intestinal ( 416) 721 163.5 8.9e-40 XP_011532381 (OMIM: 192321) PREDICTED: vasoactive ( 416) 721 163.5 8.9e-40 NP_001238814 (OMIM: 192321) vasoactive intestinal ( 430) 721 163.5 9.1e-40 NP_004615 (OMIM: 192321) vasoactive intestinal pol ( 457) 721 163.5 9.5e-40 XP_005265494 (OMIM: 192321) PREDICTED: vasoactive ( 456) 718 162.9 1.5e-39 NP_001158210 (OMIM: 114131,166710) calcitonin rece ( 474) 716 162.5 2e-39 NP_001733 (OMIM: 114131,166710) calcitonin recepto ( 474) 716 162.5 2e-39 NP_002971 (OMIM: 182098) secretin receptor precurs ( 440) 715 162.2 2.2e-39 XP_005265496 (OMIM: 192321) PREDICTED: vasoactive ( 410) 712 161.6 3.3e-39 NP_001238813 (OMIM: 192321) vasoactive intestinal ( 409) 709 160.9 5.2e-39 XP_016860159 (OMIM: 182098) PREDICTED: secretin re ( 435) 700 159.1 2e-38 XP_011509923 (OMIM: 182098) PREDICTED: secretin re ( 445) 700 159.1 2.1e-38 XP_016860161 (OMIM: 182098) PREDICTED: secretin re ( 377) 690 156.9 8e-38 NP_001258680 (OMIM: 114190) calcitonin gene-relate ( 461) 672 153.1 1.3e-36 NP_005786 (OMIM: 114190) calcitonin gene-related p ( 461) 672 153.1 1.3e-36 XP_005246289 (OMIM: 114190) PREDICTED: calcitonin ( 472) 672 153.1 1.3e-36 XP_005246291 (OMIM: 114190) PREDICTED: calcitonin ( 472) 672 153.1 1.3e-36 XP_005246288 (OMIM: 114190) PREDICTED: calcitonin ( 472) 672 153.1 1.3e-36 XP_016858640 (OMIM: 114190) PREDICTED: calcitonin ( 472) 672 153.1 1.3e-36 NP_001186566 (OMIM: 102981) pituitary adenylate cy ( 447) 665 151.6 3.6e-36 XP_005249618 (OMIM: 601970) PREDICTED: vasoactive ( 463) 664 151.4 4.3e-36 NP_000814 (OMIM: 139191,612781) growth hormone-rel ( 423) 657 149.9 1.1e-35 NP_003373 (OMIM: 601970) vasoactive intestinal pol ( 438) 657 149.9 1.2e-35 XP_006716170 (OMIM: 601970) PREDICTED: vasoactive ( 455) 641 146.5 1.3e-34 XP_016860160 (OMIM: 182098) PREDICTED: secretin re ( 409) 632 144.6 4.4e-34 XP_005249675 (OMIM: 102981) PREDICTED: pituitary a ( 411) 615 140.9 5.4e-33 NP_001109 (OMIM: 102981) pituitary adenylate cycla ( 468) 615 141.0 6e-33 XP_011513565 (OMIM: 139191,612781) PREDICTED: grow ( 359) 574 132.2 2.1e-30 NP_001158209 (OMIM: 114131,166710) calcitonin rece ( 508) 570 131.5 4.8e-30 XP_006716171 (OMIM: 601970) PREDICTED: vasoactive ( 392) 563 129.9 1.1e-29 NP_001295188 (OMIM: 601970) vasoactive intestinal ( 422) 558 128.8 2.5e-29 XP_011514852 (OMIM: 601970) PREDICTED: vasoactive ( 439) 542 125.4 2.7e-28 XP_005263787 (OMIM: 182098) PREDICTED: secretin re ( 262) 526 121.8 2e-27 >>NP_004373 (OMIM: 122561) corticotropin-releasing facto (415 aa) initn: 2827 init1: 2827 opt: 2827 Z-score: 3257.1 bits: 611.6 E(85289): 1.1e-174 Smith-Waterman score: 2827; 100.0% identity (100.0% similar) in 415 aa overlap (1-415:1-415) 10 20 30 40 50 60 pF1KE1 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS 310 320 330 340 350 360 370 380 390 400 410 pF1KE1 VFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 VFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV 370 380 390 400 410 >>NP_001138620 (OMIM: 122561) corticotropin-releasing fa (401 aa) initn: 2422 init1: 2422 opt: 2422 Z-score: 2791.5 bits: 525.4 E(85289): 9.5e-149 Smith-Waterman score: 2690; 96.6% identity (96.6% similar) in 415 aa overlap (1-415:1-401) 10 20 30 40 50 60 pF1KE1 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQ----- 310 320 330 340 350 370 380 390 400 410 pF1KE1 VFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV :::::::::::::::::::::::::::::::::::::::::::::: NP_001 ---------VRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV 360 370 380 390 400 >>NP_001138619 (OMIM: 122561) corticotropin-releasing fa (375 aa) initn: 2279 init1: 2279 opt: 2279 Z-score: 2627.4 bits: 495.0 E(85289): 1.3e-139 Smith-Waterman score: 2437; 90.1% identity (90.4% similar) in 415 aa overlap (1-415:1-375) 10 20 30 40 50 60 pF1KE1 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA :::::::::::::::::::::::::::::::::::::::: NP_001 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNIS-------------------- 10 20 30 40 70 80 90 100 110 120 pF1KE1 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV .::::::::::::::::::::::::::::::::::::::: NP_001 --------------------DNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV 50 60 70 80 130 140 150 160 170 180 pF1KE1 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEV 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE1 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPF 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE1 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRA 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE1 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 STTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVS 270 280 290 300 310 320 370 380 390 400 410 pF1KE1 VFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV 330 340 350 360 370 >>NP_001289949 (OMIM: 122561) corticotropin-releasing fa (314 aa) initn: 2074 init1: 2074 opt: 2074 Z-score: 2392.7 bits: 451.3 E(85289): 1.6e-126 Smith-Waterman score: 2074; 99.7% identity (100.0% similar) in 307 aa overlap (109-415:8-314) 80 90 100 110 120 130 pF1KE1 TTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAF .::::::::::::::::::::::::::::: NP_001 MVSATIPQKKSKVHYHVAVIINYLGHCISLVALLVAF 10 20 30 140 150 160 170 180 190 pF1KE1 VLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYF 40 50 60 70 80 90 200 210 220 230 240 250 pF1KE1 HVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKC 100 110 120 130 140 150 260 270 280 290 300 310 pF1KE1 WFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLV 160 170 180 190 200 210 320 330 340 350 360 370 pF1KE1 LLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRW 220 230 240 250 260 270 380 390 400 410 pF1KE1 HRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV ::::::::::::::::::::::::::::::::::::: NP_001 HRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV 280 290 300 310 >>NP_001189404 (OMIM: 602034) corticotropin-releasing fa (438 aa) initn: 1667 init1: 1667 opt: 2049 Z-score: 2362.0 bits: 446.1 E(85289): 7.9e-125 Smith-Waterman score: 2049; 71.9% identity (90.9% similar) in 395 aa overlap (24-415:45-438) 10 20 30 40 50 pF1KE1 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISG--LQCNASVDLI .: .:.:... .:.:: ::...: : NP_001 HLLLCLLCLLPPPLQYAAGQSQMPKDQPLWALLEQYCHTIMTLTNLSGPYSYCNTTLDQI 20 30 40 50 60 70 60 70 80 90 100 110 pF1KE1 GTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNE-EK ::::::: :: :: :::: .: ::.:::: :.::::: ::.::...:::.:. ::.. .. NP_001 GTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQR 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE1 KSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWF : .::..:...::::::.:..::..::.::: :::::::::.::::::..:::::. :: NP_001 KYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWF 140 150 160 170 180 190 180 190 200 210 220 230 pF1KE1 VVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWM ..:: .. :::.:: ::: .:. .::: :::::::: ::::::::::.::::.:::: . NP_001 LLQL-VDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCL 200 210 220 230 240 250 240 250 260 270 280 290 pF1KE1 FICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNI :. ::: .:::::::::::::::.::.:::::.:: .:::::::.::::::::.::::: NP_001 FLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNI 260 270 280 290 300 310 300 310 320 330 340 350 pF1KE1 VRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSF :::::::::::::::::::::::::::::::::::::::::::::::..:...::::::: NP_001 VRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSF 320 330 340 350 360 370 360 370 380 390 400 410 pF1KE1 LESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIK :.:::::::::::::.:.:::::.:::::::::.::.:. .::::::::::::.:::::: NP_001 LQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIK 380 390 400 410 420 430 pF1KE1 QSTAV :..:: NP_001 QTAAV >>NP_001189411 (OMIM: 602034) corticotropin-releasing fa (410 aa) initn: 2026 init1: 1368 opt: 2027 Z-score: 2337.1 bits: 441.4 E(85289): 1.9e-123 Smith-Waterman score: 2027; 74.7% identity (92.7% similar) in 372 aa overlap (44-415:40-410) 20 30 40 50 60 70 pF1KE1 LLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFY ::...: :::::::: :: :: :::: .: NP_001 LEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFN 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE1 GVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVA ::.:::: :.::::: ::.::...:::.:. ::....: .::..:...::::::.:..: NP_001 GVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKRKYDLHYRIALVVNYLGHCVSVAA 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE1 LLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTA :..::.::: :::::::::.::::::..:::::. ::..:: .. :::.:: ::: .:. NP_001 LVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQL-VDHEVHESNEVWCRCITT 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE1 AYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYY .::: :::::::: ::::::::::.::::.:::: .:. ::: .::::::::::::::: NP_001 IFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLYY 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE1 DNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAV .::.:::::.:: .:::::::.::::::::.:::::::::::::::::::::::::::: NP_001 ENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAV 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE1 KATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSA ::::::::::::::::::::::::..:...::::::::.:::::::::::::.:.::::: NP_001 KATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSA 310 320 330 340 350 360 380 390 400 410 pF1KE1 IRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV .:::::::::.::.:. .::::::::::::.:::::::..:: NP_001 VRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV 370 380 390 400 410 >>NP_001189410 (OMIM: 602034) corticotropin-releasing fa (397 aa) initn: 1667 init1: 1667 opt: 2016 Z-score: 2324.6 bits: 439.0 E(85289): 9.6e-123 Smith-Waterman score: 2016; 74.5% identity (92.5% similar) in 373 aa overlap (44-415:26-397) 20 30 40 50 60 70 pF1KE1 LLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFY ::...: :::::::: :: :: :::: .: NP_001 MGREPWPEDRDLGFPQLFCQGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFN 10 20 30 40 50 80 90 100 110 120 130 pF1KE1 GVRYNTTNNGYRECLANGSWAARVNYSECQEILNE-EKKSKVHYHVAVIINYLGHCISLV ::.:::: :.::::: ::.::...:::.:. ::.. ..: .::..:...::::::.:.. NP_001 GVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVA 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE1 ALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVT ::..::.::: :::::::::.::::::..:::::. ::..:: .. :::.:: ::: .: NP_001 ALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQL-VDHEVHESNEVWCRCIT 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE1 AAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLY . .::: :::::::: ::::::::::.::::.:::: .:. ::: .:::::::::::::: NP_001 TIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLY 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE1 YDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKA :.::.:::::.:: .:::::::.::::::::.::::::::::::::::::::::::::: NP_001 YENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKA 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE1 VKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRS :::::::::::::::::::::::::..:...::::::::.:::::::::::::.:.:::: NP_001 VKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRS 300 310 320 330 340 350 380 390 400 410 pF1KE1 AIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV :.:::::::::.::.:. .::::::::::::.:::::::..:: NP_001 AVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV 360 370 380 390 >>XP_016867241 (OMIM: 602034) PREDICTED: corticotropin-r (397 aa) initn: 1667 init1: 1667 opt: 2016 Z-score: 2324.6 bits: 439.0 E(85289): 9.6e-123 Smith-Waterman score: 2016; 74.5% identity (92.5% similar) in 373 aa overlap (44-415:26-397) 20 30 40 50 60 70 pF1KE1 LLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFY ::...: :::::::: :: :: :::: .: XP_016 MGREPWPEDRDLGFPQLFCQGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFN 10 20 30 40 50 80 90 100 110 120 130 pF1KE1 GVRYNTTNNGYRECLANGSWAARVNYSECQEILNE-EKKSKVHYHVAVIINYLGHCISLV ::.:::: :.::::: ::.::...:::.:. ::.. ..: .::..:...::::::.:.. XP_016 GVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVA 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE1 ALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVT ::..::.::: :::::::::.::::::..:::::. ::..:: .. :::.:: ::: .: XP_016 ALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQL-VDHEVHESNEVWCRCIT 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE1 AAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLY . .::: :::::::: ::::::::::.::::.:::: .:. ::: .:::::::::::::: XP_016 TIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLY 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE1 YDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKA :.::.:::::.:: .:::::::.::::::::.::::::::::::::::::::::::::: XP_016 YENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKA 240 250 260 270 280 290 320 330 340 350 360 370 pF1KE1 VKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRS :::::::::::::::::::::::::..:...::::::::.:::::::::::::.:.:::: XP_016 VKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRS 300 310 320 330 340 350 380 390 400 410 pF1KE1 AIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV :.:::::::::.::.:. .::::::::::::.:::::::..:: XP_016 AVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV 360 370 380 390 >>NP_001874 (OMIM: 602034) corticotropin-releasing facto (411 aa) initn: 1667 init1: 1667 opt: 2016 Z-score: 2324.5 bits: 439.1 E(85289): 9.8e-123 Smith-Waterman score: 2016; 74.5% identity (92.5% similar) in 373 aa overlap (44-415:40-411) 20 30 40 50 60 70 pF1KE1 LLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFY ::...: :::::::: :: :: :::: .: NP_001 LEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFN 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE1 GVRYNTTNNGYRECLANGSWAARVNYSECQEILNE-EKKSKVHYHVAVIINYLGHCISLV ::.:::: :.::::: ::.::...:::.:. ::.. ..: .::..:...::::::.:.. NP_001 GVKYNTTRNAYRECLENGTWASKINYSQCEPILDDKQRKYDLHYRIALVVNYLGHCVSVA 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE1 ALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVT ::..::.::: :::::::::.::::::..:::::. ::..:: .. :::.:: ::: .: NP_001 ALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFLLQL-VDHEVHESNEVWCRCIT 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE1 AAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLY . .::: :::::::: ::::::::::.::::.:::: .:. ::: .:::::::::::::: NP_001 TIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLFIGWCIPFPIIVAWAIGKLY 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE1 YDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKA :.::.:::::.:: .:::::::.::::::::.::::::::::::::::::::::::::: NP_001 YENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKA 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE1 VKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRS :::::::::::::::::::::::::..:...::::::::.:::::::::::::.:.:::: NP_001 VKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRS 310 320 330 340 350 360 380 390 400 410 pF1KE1 AIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV :.:::::::::.::.:. .::::::::::::.:::::::..:: NP_001 AVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTAAV 370 380 390 400 410 >>NP_001138618 (OMIM: 122561) corticotropin-releasing fa (444 aa) initn: 1852 init1: 1852 opt: 1852 Z-score: 2135.4 bits: 404.2 E(85289): 3.3e-112 Smith-Waterman score: 2759; 93.5% identity (93.5% similar) in 444 aa overlap (1-415:1-444) 10 20 30 40 50 60 pF1KE1 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV 70 80 90 100 110 120 130 140 150 pF1KE1 IINYLGHCISLVALLVAFVLFLRLR-----------------------------SIRCLR ::::::::::::::::::::::::: :::::: NP_001 IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE1 NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE1 YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE1 YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE1 VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV 370 380 390 400 410 420 400 410 pF1KE1 ARAMSIPTSPTRVSFHSIKQSTAV :::::::::::::::::::::::: NP_001 ARAMSIPTSPTRVSFHSIKQSTAV 430 440 415 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 11:03:42 2016 done: Sun Nov 6 11:03:43 2016 Total Scan time: 8.070 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]