FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4181, 653 aa 1>>>pF1KE4181 653 - 653 aa - 653 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.7143+/-0.000413; mu= 9.5974+/- 0.026 mean_var=185.3900+/-37.817, 0's: 0 Z-trim(118.5): 125 B-trim: 705 in 2/52 Lambda= 0.094196 statistics sampled from 31397 (31527) to 31397 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.701), E-opt: 0.2 (0.37), width: 16 Scan time: 11.530 The best scores are: opt bits E(85289) NP_002224 (OMIM: 176266) potassium voltage-gated c ( 653) 4351 604.2 4.9e-172 NP_002223 (OMIM: 176263) potassium voltage-gated c ( 575) 2243 317.6 7.7e-86 XP_011539701 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83 XP_011539699 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83 NP_004965 (OMIM: 176262,616366) potassium voltage- ( 499) 2188 310.1 1.2e-83 XP_011539700 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83 XP_011539702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83 XP_016856702 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83 XP_011539698 (OMIM: 176262,616366) PREDICTED: pota ( 499) 2188 310.1 1.2e-83 NP_114092 (OMIM: 176268) potassium voltage-gated c ( 456) 1910 272.3 2.7e-72 NP_001191198 (OMIM: 176262,616366) potassium volta ( 356) 1341 194.9 4.3e-49 NP_000208 (OMIM: 160120,176260) potassium voltage- ( 495) 1280 186.7 1.7e-46 NP_002225 (OMIM: 176267,612240) potassium voltage- ( 613) 1216 178.1 8.3e-44 XP_016874761 (OMIM: 176257) PREDICTED: potassium v ( 529) 1199 175.7 3.7e-43 XP_005253743 (OMIM: 176257) PREDICTED: potassium v ( 529) 1199 175.7 3.7e-43 XP_016874759 (OMIM: 176257) PREDICTED: potassium v ( 529) 1199 175.7 3.7e-43 XP_011519257 (OMIM: 176257) PREDICTED: potassium v ( 529) 1199 175.7 3.7e-43 NP_002226 (OMIM: 176257) potassium voltage-gated c ( 529) 1199 175.7 3.7e-43 XP_016874760 (OMIM: 176257) PREDICTED: potassium v ( 529) 1199 175.7 3.7e-43 NP_005540 (OMIM: 602420) potassium voltage-gated c ( 511) 1120 165.0 6.2e-40 NP_004761 (OMIM: 607738) potassium voltage-gated c ( 911) 721 111.0 2e-23 XP_011527101 (OMIM: 600397,616056) PREDICTED: pota ( 858) 716 110.3 3e-23 XP_006723847 (OMIM: 600397,616056) PREDICTED: pota ( 858) 716 110.3 3e-23 NP_004966 (OMIM: 600397,616056) potassium voltage- ( 858) 716 110.3 3e-23 NP_001269357 (OMIM: 603888) potassium voltage-gate ( 491) 701 108.0 8.3e-23 NP_002243 (OMIM: 603888) potassium voltage-gated c ( 491) 701 108.0 8.3e-23 XP_011531127 (OMIM: 603888) PREDICTED: potassium v ( 491) 701 108.0 8.3e-23 XP_016859548 (OMIM: 603888) PREDICTED: potassium v ( 491) 701 108.0 8.3e-23 XP_016869470 (OMIM: 607738) PREDICTED: potassium v ( 666) 647 100.8 1.7e-20 XP_016869471 (OMIM: 607738) PREDICTED: potassium v ( 666) 647 100.8 1.7e-20 XP_011539703 (OMIM: 176265) PREDICTED: potassium v ( 609) 641 100.0 2.8e-20 XP_006710688 (OMIM: 176265) PREDICTED: potassium v ( 618) 641 100.0 2.8e-20 XP_006710690 (OMIM: 176265) PREDICTED: potassium v ( 624) 641 100.0 2.8e-20 NP_001034663 (OMIM: 176265) potassium voltage-gate ( 626) 641 100.0 2.8e-20 NP_004969 (OMIM: 176265) potassium voltage-gated c ( 635) 641 100.0 2.8e-20 XP_011524220 (OMIM: 605696) PREDICTED: potassium v ( 466) 632 98.6 5.3e-20 NP_036415 (OMIM: 605696) potassium voltage-gated c ( 466) 632 98.6 5.3e-20 XP_016881194 (OMIM: 605696) PREDICTED: potassium v ( 466) 632 98.6 5.3e-20 XP_011524222 (OMIM: 605696) PREDICTED: potassium v ( 466) 632 98.6 5.3e-20 XP_016881193 (OMIM: 605696) PREDICTED: potassium v ( 509) 632 98.7 5.7e-20 XP_011518382 (OMIM: 176258,616187) PREDICTED: pota ( 535) 629 98.3 7.8e-20 NP_004967 (OMIM: 176258,616187) potassium voltage- ( 511) 626 97.8 1e-19 NP_001106212 (OMIM: 176258,616187) potassium volta ( 585) 627 98.0 1e-19 XP_006723848 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19 XP_011527106 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19 NP_002228 (OMIM: 603788) potassium voltage-gated c ( 513) 625 97.7 1.1e-19 XP_011527105 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19 XP_011527102 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19 XP_011527104 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19 XP_011527107 (OMIM: 603788) PREDICTED: potassium v ( 513) 625 97.7 1.1e-19 >>NP_002224 (OMIM: 176266) potassium voltage-gated chann (653 aa) initn: 4351 init1: 4351 opt: 4351 Z-score: 3209.5 bits: 604.2 E(85289): 4.9e-172 Smith-Waterman score: 4351; 100.0% identity (100.0% similar) in 653 aa overlap (1-653:1-653) 10 20 30 40 50 60 pF1KE4 MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 SHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 LSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 NVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 LKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 ESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLE 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 NSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 NSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIV 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 GSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSS 550 560 570 580 590 600 610 620 630 640 650 pF1KE4 TSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 TSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV 610 620 630 640 650 >>NP_002223 (OMIM: 176263) potassium voltage-gated chann (575 aa) initn: 1907 init1: 868 opt: 2243 Z-score: 1662.1 bits: 317.6 E(85289): 7.7e-86 Smith-Waterman score: 2252; 63.4% identity (79.9% similar) in 576 aa overlap (90-653:15-575) 60 70 80 90 100 110 pF1KE4 GSHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAH--YRQSSFPHCSDLMPSG-SEEK : ...:: : .: :. : .: NP_002 MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPA 10 20 30 40 120 130 140 150 160 170 pF1KE4 ILRELSEEEE----DEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYS ::: . :. : : . : . : :. . :: . ..: . NP_002 AGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQ----- 50 60 70 80 90 180 190 200 210 220 230 pF1KE4 DCC-ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAI ::: ::::::.::::::::.::: ::::::::::..: .::::::::::::::::::::: NP_002 DCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAI 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE4 LYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKK :::::::::..::::::.:::.::..::::::::. ::::::::.:::: : ::. .:.. NP_002 LYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEE-RPLPRRDFQR 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE4 QIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLL :.::::::::::.::::::::::::::::::::::::::::::..: . : . . NP_002 QVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAG 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE4 NDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVS :.::. . .: . :.::::.:::.::.:::::..:: :::::.: : .::::.::::. NP_002 NSTSGSR---AGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVA 280 290 300 310 320 330 420 430 440 450 460 470 pF1KE4 ILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTL :.::::::::.::..::.: :::::.::::.:::::::::::::::::::::::.:: NP_002 IIPYFITLGTELAERQGNG----QQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTL 340 350 360 370 380 390 480 490 500 510 520 530 pF1KE4 RASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMK .::::::::::::::::::::::::::::::.::. :.:::::::::::::::::::::. NP_002 KASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMH 400 410 420 430 440 450 540 550 560 570 580 590 pF1KE4 PITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPS :.:.:::::::::::::::::::::::::::::::::::::.:::.: ... :: .: : NP_002 PVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQY-MHVGSCQHLSS 460 470 480 490 500 510 600 610 620 630 640 pF1KE4 NLLKKFRSSTSSSLGDKSEYLEMEEG-VKESLCAKEEKCQGKGDDSETDKNN---CSNAK . ...:.. :.: .::::. .::: ...: . :.. . : .:: : : : NP_002 SA-EELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIK 520 530 540 550 560 650 pF1KE4 AVETDV . ::: NP_002 KIFTDV 570 >>XP_011539701 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83 Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468) 120 130 140 150 160 170 pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC : .:: . ::: :. .:: XP_011 MTVATGDPADEAAALPGHPQDT----YDPEADHECC 10 20 30 180 190 200 210 220 230 pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY ::::::.::::::::.::::::::::::::.:: .::::::::::::::::::::::::: XP_011 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL ::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.:: XP_011 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS ::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. : XP_011 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS 160 170 180 190 200 360 370 380 390 400 410 pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY . . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.:: XP_011 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY 210 220 230 240 250 260 420 430 440 450 460 470 pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM ::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.::: XP_011 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 270 280 290 300 310 320 480 490 500 510 520 530 pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV :::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :. XP_011 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI 330 340 350 360 370 380 540 550 560 570 580 590 pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L :::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. : XP_011 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL 390 400 410 420 430 440 600 610 620 630 640 650 pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV :: ::... : ::.:.:..:::..: XP_011 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 450 460 470 480 490 >>XP_011539699 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83 Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468) 120 130 140 150 160 170 pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC : .:: . ::: :. .:: XP_011 MTVATGDPADEAAALPGHPQDT----YDPEADHECC 10 20 30 180 190 200 210 220 230 pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY ::::::.::::::::.::::::::::::::.:: .::::::::::::::::::::::::: XP_011 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL ::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.:: XP_011 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS ::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. : XP_011 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS 160 170 180 190 200 360 370 380 390 400 410 pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY . . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.:: XP_011 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY 210 220 230 240 250 260 420 430 440 450 460 470 pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM ::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.::: XP_011 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 270 280 290 300 310 320 480 490 500 510 520 530 pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV :::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :. XP_011 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI 330 340 350 360 370 380 540 550 560 570 580 590 pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L :::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. : XP_011 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL 390 400 410 420 430 440 600 610 620 630 640 650 pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV :: ::... : ::.:.:..:::..: XP_011 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 450 460 470 480 490 >>NP_004965 (OMIM: 176262,616366) potassium voltage-gate (499 aa) initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83 Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468) 120 130 140 150 160 170 pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC : .:: . ::: :. .:: NP_004 MTVATGDPADEAAALPGHPQDT----YDPEADHECC 10 20 30 180 190 200 210 220 230 pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY ::::::.::::::::.::::::::::::::.:: .::::::::::::::::::::::::: NP_004 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL ::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.:: NP_004 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS ::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. : NP_004 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS 160 170 180 190 200 360 370 380 390 400 410 pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY . . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.:: NP_004 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY 210 220 230 240 250 260 420 430 440 450 460 470 pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM ::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.::: NP_004 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 270 280 290 300 310 320 480 490 500 510 520 530 pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV :::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :. NP_004 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI 330 340 350 360 370 380 540 550 560 570 580 590 pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L :::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. : NP_004 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL 390 400 410 420 430 440 600 610 620 630 640 650 pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV :: ::... : ::.:.:..:::..: NP_004 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 450 460 470 480 490 >>XP_011539700 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83 Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468) 120 130 140 150 160 170 pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC : .:: . ::: :. .:: XP_011 MTVATGDPADEAAALPGHPQDT----YDPEADHECC 10 20 30 180 190 200 210 220 230 pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY ::::::.::::::::.::::::::::::::.:: .::::::::::::::::::::::::: XP_011 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL ::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.:: XP_011 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS ::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. : XP_011 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS 160 170 180 190 200 360 370 380 390 400 410 pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY . . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.:: XP_011 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY 210 220 230 240 250 260 420 430 440 450 460 470 pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM ::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.::: XP_011 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 270 280 290 300 310 320 480 490 500 510 520 530 pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV :::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :. XP_011 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI 330 340 350 360 370 380 540 550 560 570 580 590 pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L :::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. : XP_011 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL 390 400 410 420 430 440 600 610 620 630 640 650 pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV :: ::... : ::.:.:..:::..: XP_011 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 450 460 470 480 490 >>XP_011539702 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83 Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468) 120 130 140 150 160 170 pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC : .:: . ::: :. .:: XP_011 MTVATGDPADEAAALPGHPQDT----YDPEADHECC 10 20 30 180 190 200 210 220 230 pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY ::::::.::::::::.::::::::::::::.:: .::::::::::::::::::::::::: XP_011 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL ::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.:: XP_011 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS ::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. : XP_011 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS 160 170 180 190 200 360 370 380 390 400 410 pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY . . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.:: XP_011 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY 210 220 230 240 250 260 420 430 440 450 460 470 pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM ::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.::: XP_011 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 270 280 290 300 310 320 480 490 500 510 520 530 pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV :::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :. XP_011 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI 330 340 350 360 370 380 540 550 560 570 580 590 pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L :::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. : XP_011 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL 390 400 410 420 430 440 600 610 620 630 640 650 pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV :: ::... : ::.:.:..:::..: XP_011 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 450 460 470 480 490 >>XP_016856702 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83 Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468) 120 130 140 150 160 170 pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC : .:: . ::: :. .:: XP_016 MTVATGDPADEAAALPGHPQDT----YDPEADHECC 10 20 30 180 190 200 210 220 230 pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY ::::::.::::::::.::::::::::::::.:: .::::::::::::::::::::::::: XP_016 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL ::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.:: XP_016 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS ::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. : XP_016 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS 160 170 180 190 200 360 370 380 390 400 410 pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY . . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.:: XP_016 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY 210 220 230 240 250 260 420 430 440 450 460 470 pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM ::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.::: XP_016 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 270 280 290 300 310 320 480 490 500 510 520 530 pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV :::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :. XP_016 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI 330 340 350 360 370 380 540 550 560 570 580 590 pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L :::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. : XP_016 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL 390 400 410 420 430 440 600 610 620 630 640 650 pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV :: ::... : ::.:.:..:::..: XP_016 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 450 460 470 480 490 >>XP_011539698 (OMIM: 176262,616366) PREDICTED: potassiu (499 aa) initn: 1877 init1: 872 opt: 2188 Z-score: 1622.5 bits: 310.1 E(85289): 1.2e-83 Smith-Waterman score: 2200; 71.7% identity (85.3% similar) in 477 aa overlap (146-621:7-468) 120 130 140 150 160 170 pF1KE4 KILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCC : .:: . ::: :. .:: XP_011 MTVATGDPADEAAALPGHPQDT----YDPEADHECC 10 20 30 180 190 200 210 220 230 pF1KE4 ERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYY ::::::.::::::::.::::::::::::::.:: .::::::::::::::::::::::::: XP_011 ERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYY 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 QSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWL ::::::.::::::.:::.::..::.:::::. ::::::...::: : ::::::..:.:: XP_011 QSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEE-RPLPENEFQRQVWL 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 LFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTS ::::::::.::: ::::::.::::::: ::::::: :::. . . : : .. : XP_011 LFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENE-----DMHGSGVTFHTYS 160 170 180 190 200 360 370 380 390 400 410 pF1KE4 APHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPY . . : :.::::::::.::.::::::.:: :::::.: :: :::::::::.:.:: XP_011 NSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPY 210 220 230 240 250 260 420 430 440 450 460 470 pF1KE4 FITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASM ::::::.::.. .. : :::::.::::.:::::::::::::::::::::::.::.::: XP_011 FITLGTELAEKPEDAQ-QGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASM 270 280 290 300 310 320 480 490 500 510 520 530 pF1KE4 RELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITV :::::::::::::::::::::::::::: ..: :::::::::::.::::::::: : :. XP_011 RELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTI 330 340 350 360 370 380 540 550 560 570 580 590 pF1KE4 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNL-L :::::::::::::::::::::::::::::::::::::.:::.: : ..::: .::. : XP_011 GGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQ-VTSCPKIPSSPDL 390 400 410 420 430 440 600 610 620 630 640 650 pF1KE4 KKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV :: ::... : ::.:.:..:::..: XP_011 KKSRSASTIS---KSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV 450 460 470 480 490 >>NP_114092 (OMIM: 176268) potassium voltage-gated chann (456 aa) initn: 1944 init1: 821 opt: 1910 Z-score: 1418.8 bits: 272.3 E(85289): 2.7e-72 Smith-Waterman score: 1910; 69.4% identity (86.4% similar) in 412 aa overlap (174-581:11-415) 150 160 170 180 190 200 pF1KE4 EDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLG ::::.:.::.::::::. .::..::.:::: NP_114 MEPRCPPPCGCCERLVLNVAGLRFETRARTLGRFPDTLLG 10 20 30 40 210 220 230 240 250 260 pF1KE4 DPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGE :: .: ...: : ::::::.::::::.::::::::::.::..::.:.: ::: :: :: NP_114 DPARRGRFYDDARREYFFDRHRPSFDAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGA 50 60 70 80 90 100 270 280 290 300 310 320 pF1KE4 EALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVI :: ..::::: : : ::. : .:.:::::.::::. :: .:.:::::::.:::. NP_114 AALARLREDEGCPVPPE-RPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVV 110 120 130 140 150 330 340 350 360 370 pF1KE4 FCLETLPEFRDDRD---LVMALSAGGHGGLLNDTSA-PHLENSGHTIFNDPFFIVETVCI :::::::.:::::: :. : .:: . :: .: : : . ::::::.:::.:: NP_114 FCLETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPG--NPPRLPFNDPFFVVETLCI 160 170 180 190 200 210 380 390 400 410 420 430 pF1KE4 VWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMS :::::..:: ..:::.:.::::.::.::.:.:::::..:::.::.:.: : ::::: NP_114 CWFSFELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVALGTELARQRGVG----QQAMS 220 230 240 250 260 270 440 450 460 470 480 490 pF1KE4 FAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFA .::::.:::::::::::::::::::::::.::::::::::::::::::::.::::::::: NP_114 LAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFA 280 290 300 310 320 330 500 510 520 530 540 550 pF1KE4 EADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVI :.:. .:: :::..:::::::::::::::: :.:::::::::::::::::::.:::::: NP_114 EVDRVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVI 340 350 360 370 380 390 560 570 580 590 600 610 pF1KE4 VSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVK ::::.::::::::.:: .... NP_114 VSNFSYFYHRETEGEEAGMFSHVDMQPCGPLEGKANGGLVDGEVPELPPPLWAPPGKHLV 400 410 420 430 440 450 653 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:26:51 2016 done: Sun Nov 6 01:26:53 2016 Total Scan time: 11.530 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]