FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6257, 247 aa 1>>>pF1KE6257 247 - 247 aa - 247 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1085+/-0.000429; mu= 14.9828+/- 0.026 mean_var=62.5542+/-13.373, 0's: 0 Z-trim(110.4): 27 B-trim: 747 in 1/56 Lambda= 0.162161 statistics sampled from 18717 (18732) to 18717 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.579), E-opt: 0.2 (0.22), width: 16 Scan time: 4.580 The best scores are: opt bits E(85289) NP_057106 (OMIM: 607629) gamma-secretase subunit A ( 247) 1609 385.3 5.6e-107 NP_001071096 (OMIM: 607629) gamma-secretase subuni ( 265) 1598 382.7 3.5e-106 NP_112591 (OMIM: 607630) gamma-secretase subunit A ( 257) 1005 244.0 2e-64 NP_001230700 (OMIM: 607629) gamma-secretase subuni ( 190) 999 242.5 4.1e-64 XP_016856906 (OMIM: 607629) PREDICTED: gamma-secre ( 208) 988 239.9 2.6e-63 XP_011520407 (OMIM: 607630) PREDICTED: gamma-secre ( 235) 863 210.7 1.8e-54 NP_001230701 (OMIM: 607629) gamma-secretase subuni ( 195) 837 204.6 1.1e-52 NP_001139118 (OMIM: 607630) gamma-secretase subuni ( 216) 486 122.5 6.1e-28 >>NP_057106 (OMIM: 607629) gamma-secretase subunit APH-1 (247 aa) initn: 1609 init1: 1609 opt: 1609 Z-score: 2041.7 bits: 385.3 E(85289): 5.6e-107 Smith-Waterman score: 1609; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:1-247) 10 20 30 40 50 60 pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ 190 200 210 220 230 240 pF1KE6 RSLLCKD ::::::: NP_057 RSLLCKD >>NP_001071096 (OMIM: 607629) gamma-secretase subunit AP (265 aa) initn: 1598 init1: 1598 opt: 1598 Z-score: 2027.3 bits: 382.7 E(85289): 3.5e-106 Smith-Waterman score: 1598; 99.6% identity (100.0% similar) in 246 aa overlap (1-246:1-246) 10 20 30 40 50 60 pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ 190 200 210 220 230 240 pF1KE6 RSLLCKD :::::. NP_001 RSLLCRRQEDSRVMVYSALRIPPED 250 260 >>NP_112591 (OMIM: 607630) gamma-secretase subunit APH-1 (257 aa) initn: 978 init1: 536 opt: 1005 Z-score: 1277.7 bits: 244.0 E(85289): 2e-64 Smith-Waterman score: 1005; 59.1% identity (83.0% similar) in 247 aa overlap (1-247:1-246) 10 20 30 40 50 60 pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT : :::::::.:.:::::.::...:.: .:::.:.:.:::::::::::..:.:::. . NP_112 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV : .:. : :::::: ::: .::.::::::::::::.::: :.. :.. :.: .::: NP_112 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINP-GETAPSMRLLAYV 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD :::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.:::: NP_112 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFD 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ .::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::.. NP_112 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK 180 190 200 210 220 230 pF1KE6 RSLLCKD :::.: NP_112 LCLLCQDKNFLLYNQRSR 240 250 >>NP_001230700 (OMIM: 607629) gamma-secretase subunit AP (190 aa) initn: 1233 init1: 999 opt: 999 Z-score: 1272.1 bits: 242.5 E(85289): 4.1e-64 Smith-Waterman score: 1123; 76.9% identity (76.9% similar) in 247 aa overlap (1-247:1-190) 10 20 30 40 50 60 pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT :::::::::::::::::::::::::::::::::::::: NP_001 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG---------------------- 10 20 30 70 80 90 100 110 120 pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV ::::::::::::::::::::::::: NP_001 -----------------------------------KADEGLASLSEDGRSPISIRQMAYV 40 50 60 130 140 150 160 170 180 pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 70 80 90 100 110 120 190 200 210 220 230 240 pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ 130 140 150 160 170 180 pF1KE6 RSLLCKD ::::::: NP_001 RSLLCKD 190 >>XP_016856906 (OMIM: 607629) PREDICTED: gamma-secretase (208 aa) initn: 1222 init1: 988 opt: 988 Z-score: 1257.6 bits: 239.9 E(85289): 2.6e-63 Smith-Waterman score: 1112; 76.4% identity (76.8% similar) in 246 aa overlap (1-246:1-189) 10 20 30 40 50 60 pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT :::::::::::::::::::::::::::::::::::::: XP_016 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG---------------------- 10 20 30 70 80 90 100 110 120 pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV ::::::::::::::::::::::::: XP_016 -----------------------------------KADEGLASLSEDGRSPISIRQMAYV 40 50 60 130 140 150 160 170 180 pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 70 80 90 100 110 120 190 200 210 220 230 240 pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ 130 140 150 160 170 180 pF1KE6 RSLLCKD :::::. XP_016 RSLLCRRQEDSRVMVYSALRIPPED 190 200 >>XP_011520407 (OMIM: 607630) PREDICTED: gamma-secretase (235 aa) initn: 836 init1: 456 opt: 863 Z-score: 1098.8 bits: 210.7 E(85289): 1.8e-54 Smith-Waterman score: 863; 62.7% identity (86.1% similar) in 201 aa overlap (1-201:1-200) 10 20 30 40 50 60 pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT : :::::::.:.:::::.::...:.: .:::.:.:.:::::::::::..:.:::. . XP_011 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV : .:. : :::::: ::: .::.::::::::::::.::: :.. :.. :.: .::: XP_011 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINP-GETAPSMRLLAYV 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD :::.:::.::::: .: :.:.::::.:::::::: .:: :::.: .:::::.:::.:::: XP_011 SGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFD 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ .::.... : .:. .:::.: XP_011 GCEKKKWGILLIVLLTHLLVSAQVSLENCSFSVTAAWKSCVFQTRHHDWTLFLALV 180 190 200 210 220 230 >>NP_001230701 (OMIM: 607629) gamma-secretase subunit AP (195 aa) initn: 1071 init1: 837 opt: 837 Z-score: 1067.1 bits: 204.6 E(85289): 1.1e-52 Smith-Waterman score: 933; 67.9% identity (69.5% similar) in 246 aa overlap (1-246:1-176) 10 20 30 40 50 60 pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT :::::::::::::::::::::::::::::::::::::: NP_001 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAG---------------------- 10 20 30 70 80 90 100 110 120 pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV : .: : . : . NP_001 -RCSA-----------------------------------LPTTS------------CLI 40 50 130 140 150 160 170 180 pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD 60 70 80 90 100 110 190 200 210 220 230 240 pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ 120 130 140 150 160 170 pF1KE6 RSLLCKD :::::. NP_001 RSLLCRRQEDSRVMVYSALRIPPED 180 190 >>NP_001139118 (OMIM: 607630) gamma-secretase subunit AP (216 aa) initn: 771 init1: 456 opt: 486 Z-score: 622.6 bits: 122.5 E(85289): 6.1e-28 Smith-Waterman score: 703; 47.0% identity (68.0% similar) in 247 aa overlap (1-247:1-205) 10 20 30 40 50 60 pF1KE6 MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVT : :::::::.:.:::::.::...:.: .:::.:.:.:::::::::::..:.:::. . NP_001 MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 DRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYV : .:. : :::::: ::: .::.::::::::::::.::: :.. :.. :.: .:: NP_001 DNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINP-GETAPSMRLLAY- 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 SGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFD ::.: .:::::.:::.:::: NP_001 ----------------------------------------AFMTLVIILLHVFWGIVFFD 120 130 190 200 210 220 230 240 pF1KE6 ACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQ .::.... : .:. .:::.:. ::.. .: .: . . : :: :::..:::: ::.. NP_001 GCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLK 140 150 160 170 180 190 pF1KE6 RSLLCKD :::.: NP_001 LCLLCQDKNFLLYNQRSR 200 210 247 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 11:32:33 2016 done: Tue Nov 8 11:32:34 2016 Total Scan time: 4.580 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]