FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5623, 474 aa 1>>>pF1KE5623 474 - 474 aa - 474 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0163+/-0.000443; mu= 21.1241+/- 0.028 mean_var=147.5643+/-39.215, 0's: 0 Z-trim(112.6): 219 B-trim: 2314 in 2/53 Lambda= 0.105580 statistics sampled from 21284 (21651) to 21284 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.621), E-opt: 0.2 (0.254), width: 16 Scan time: 7.230 The best scores are: opt bits E(85289) XP_016858811 (OMIM: 608888) PREDICTED: RNA-binding ( 474) 3156 493.4 5.7e-139 NP_694453 (OMIM: 608888) RNA-binding protein 45 [H ( 474) 3156 493.4 5.7e-139 XP_005246344 (OMIM: 608888) PREDICTED: RNA-binding ( 476) 3142 491.3 2.5e-138 XP_016858809 (OMIM: 608888) PREDICTED: RNA-binding ( 617) 2480 390.6 6.5e-108 XP_016858810 (OMIM: 608888) PREDICTED: RNA-binding ( 617) 2480 390.6 6.5e-108 XP_016881329 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 496) 306 59.3 2.8e-08 NP_001020259 (OMIM: 612679) CUGBP Elav-like family ( 484) 291 57.0 1.4e-07 NP_001020258 (OMIM: 612679) CUGBP Elav-like family ( 485) 288 56.5 1.9e-07 NP_001278035 (OMIM: 612678) CUGBP Elav-like family ( 464) 284 55.9 2.8e-07 XP_016881330 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 485) 284 55.9 2.8e-07 NP_064565 (OMIM: 612679) CUGBP Elav-like family me ( 486) 281 55.5 3.9e-07 XP_016881334 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 483) 276 54.7 6.6e-07 NP_001317532 (OMIM: 612679) CUGBP Elav-like family ( 484) 276 54.7 6.6e-07 XP_011524394 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 457) 274 54.4 7.9e-07 XP_016881333 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 484) 273 54.3 9.1e-07 XP_016881331 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 485) 273 54.3 9.1e-07 XP_016881348 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 455) 272 54.1 9.8e-07 XP_016881347 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 456) 272 54.1 9.8e-07 XP_016881344 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 456) 272 54.1 9.8e-07 XP_011507413 (OMIM: 612678) PREDICTED: CUGBP Elav- ( 414) 271 53.8 1e-06 NP_001166120 (OMIM: 612678) CUGBP Elav-like family ( 415) 271 53.9 1e-06 XP_011524393 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 458) 271 53.9 1.1e-06 NP_009116 (OMIM: 612678) CUGBP Elav-like family me ( 465) 271 53.9 1.1e-06 XP_016881354 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 446) 270 53.7 1.2e-06 XP_016881350 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 447) 270 53.7 1.2e-06 XP_016881351 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 447) 270 53.7 1.2e-06 NP_001020260 (OMIM: 612679) CUGBP Elav-like family ( 448) 270 53.8 1.2e-06 XP_016881341 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 474) 270 53.8 1.2e-06 XP_016881339 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 475) 270 53.8 1.2e-06 XP_016881335 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 476) 270 53.8 1.2e-06 XP_011524389 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 494) 270 53.8 1.3e-06 XP_016881345 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 456) 269 53.6 1.3e-06 XP_016881343 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 457) 269 53.6 1.3e-06 XP_016881342 (OMIM: 612679) PREDICTED: CUGBP Elav- ( 457) 269 53.6 1.3e-06 NP_001166155 (OMIM: 612681) CUGBP Elav-like family ( 454) 256 51.6 5.3e-06 NP_443072 (OMIM: 612681) CUGBP Elav-like family me ( 481) 256 51.7 5.4e-06 NP_001166144 (OMIM: 612680) CUGBP Elav-like family ( 409) 253 51.1 6.9e-06 XP_006722895 (OMIM: 612680) PREDICTED: CUGBP Elav- ( 485) 253 51.2 7.5e-06 NP_068757 (OMIM: 612680) CUGBP Elav-like family me ( 485) 253 51.2 7.5e-06 XP_016872622 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 483) 252 51.1 8.3e-06 XP_016872623 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 483) 252 51.1 8.3e-06 NP_941989 (OMIM: 601074) CUGBP Elav-like family me ( 483) 252 51.1 8.3e-06 XP_011518161 (OMIM: 601074) PREDICTED: CUGBP Elav- ( 483) 252 51.1 8.3e-06 XP_006722896 (OMIM: 612680) PREDICTED: CUGBP Elav- ( 484) 251 50.9 9.3e-06 XP_016868729 (OMIM: 604819,615583) PREDICTED: poly ( 499) 236 48.6 4.6e-05 NP_001258029 (OMIM: 604819,615583) poly(U)-binding ( 499) 236 48.6 4.6e-05 NP_001258026 (OMIM: 604819,615583) poly(U)-binding ( 513) 236 48.7 4.6e-05 XP_016868728 (OMIM: 604819,615583) PREDICTED: poly ( 516) 236 48.7 4.7e-05 NP_001129505 (OMIM: 604819,615583) poly(U)-binding ( 516) 236 48.7 4.7e-05 NP_001258028 (OMIM: 604819,615583) poly(U)-binding ( 530) 236 48.7 4.7e-05 >>XP_016858811 (OMIM: 608888) PREDICTED: RNA-binding pro (474 aa) initn: 3156 init1: 3156 opt: 3156 Z-score: 2615.9 bits: 493.4 E(85289): 5.7e-139 Smith-Waterman score: 3156; 100.0% identity (100.0% similar) in 474 aa overlap (1-474:1-474) 10 20 30 40 50 60 pF1KE5 MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 HTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 TRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIEN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 CDRSFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPFEQQSEFSSFDKNDSRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CDRSFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPFEQQSEFSSFDKNDSRG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 QEAISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QEAISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 KYKLHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQFMQFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KYKLHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQFMQFGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 SSGSQLPQIQTDVVLPSCKKKAPAETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SSGSQLPQIQTDVVLPSCKKKAPAETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVY 370 380 390 400 410 420 430 440 450 460 470 pF1KE5 LVSGKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSGKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY 430 440 450 460 470 >>NP_694453 (OMIM: 608888) RNA-binding protein 45 [Homo (474 aa) initn: 3156 init1: 3156 opt: 3156 Z-score: 2615.9 bits: 493.4 E(85289): 5.7e-139 Smith-Waterman score: 3156; 100.0% identity (100.0% similar) in 474 aa overlap (1-474:1-474) 10 20 30 40 50 60 pF1KE5 MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 HTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 HTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 TRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 TRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIEN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 CDRSFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPFEQQSEFSSFDKNDSRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 CDRSFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPFEQQSEFSSFDKNDSRG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 QEAISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 QEAISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 KYKLHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQFMQFGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 KYKLHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQFMQFGG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 SSGSQLPQIQTDVVLPSCKKKAPAETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 SSGSQLPQIQTDVVLPSCKKKAPAETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVY 370 380 390 400 410 420 430 440 450 460 470 pF1KE5 LVSGKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_694 LVSGKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY 430 440 450 460 470 >>XP_005246344 (OMIM: 608888) PREDICTED: RNA-binding pro (476 aa) initn: 3142 init1: 1659 opt: 3142 Z-score: 2604.4 bits: 491.3 E(85289): 2.5e-138 Smith-Waterman score: 3142; 99.6% identity (99.6% similar) in 476 aa overlap (1-474:1-476) 10 20 30 40 50 60 pF1KE5 MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 HTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 TRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIEN 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 CDRSFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPF--EQQSEFSSFDKNDS :::::::::::::::::::::::::::::::::::::::::::: :::::::::::::: XP_005 CDRSFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPFVGEQQSEFSSFDKNDS 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE5 RGQEAISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RGQEAISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAI 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE5 YAKYKLHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQFMQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YAKYKLHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQFMQF 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE5 GGSSGSQLPQIQTDVVLPSCKKKAPAETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGSSGSQLPQIQTDVVLPSCKKKAPAETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIE 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 VYLVSGKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VYLVSGKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY 430 440 450 460 470 >>XP_016858809 (OMIM: 608888) PREDICTED: RNA-binding pro (617 aa) initn: 2474 init1: 2474 opt: 2480 Z-score: 2058.3 bits: 390.6 E(85289): 6.5e-108 Smith-Waterman score: 2480; 99.0% identity (99.5% similar) in 381 aa overlap (94-474:238-617) 70 80 90 100 110 120 pF1KE5 ESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEELTRI :.: : .::::::::::::::::::::::: XP_016 FTAKLVLAYFEYFSDLPLSDAQISIYKKRKNSTFP-QVFIAQSRSSGSHRDVEDEELTRI 210 220 230 240 250 260 130 140 150 160 170 180 pF1KE5 FVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDR 270 280 290 300 310 320 190 200 210 220 230 240 pF1KE5 SFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPFEQQSEFSSFDKNDSRGQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPFEQQSEFSSFDKNDSRGQEA 330 340 350 360 370 380 250 260 270 280 290 300 pF1KE5 ISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYK 390 400 410 420 430 440 310 320 330 340 350 360 pF1KE5 LHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQFMQFGGSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQFMQFGGSSG 450 460 470 480 490 500 370 380 390 400 410 420 pF1KE5 SQLPQIQTDVVLPSCKKKAPAETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVYLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQLPQIQTDVVLPSCKKKAPAETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVYLVS 510 520 530 540 550 560 430 440 450 460 470 pF1KE5 GKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY 570 580 590 600 610 >-- initn: 720 init1: 692 opt: 694 Z-score: 588.1 bits: 118.6 E(85289): 5.1e-26 Smith-Waterman score: 694; 83.5% identity (88.2% similar) in 127 aa overlap (1-127:1-124) 10 20 30 40 50 60 pF1KE5 MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 HTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEEL ::::::::::::::::::::::::::::::::::::::::: . .:: : : XP_016 HTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVRVP---GSGCPRGKEWASW 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 TRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIEN : . ... XP_016 TSLHLLLCRGEGGVEHPFPAADQTAPGLGTGAALRRGSPPTKLRRVAGKGTGCGVFAPRE 120 130 140 150 160 170 >>XP_016858810 (OMIM: 608888) PREDICTED: RNA-binding pro (617 aa) initn: 2474 init1: 2474 opt: 2480 Z-score: 2058.3 bits: 390.6 E(85289): 6.5e-108 Smith-Waterman score: 2480; 99.0% identity (99.5% similar) in 381 aa overlap (94-474:238-617) 70 80 90 100 110 120 pF1KE5 ESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEELTRI :.: : .::::::::::::::::::::::: XP_016 FTAKLVLAYFEYFSDLPLSDAQISIYKKRKNSTFP-QVFIAQSRSSGSHRDVEDEELTRI 210 220 230 240 250 260 130 140 150 160 170 180 pF1KE5 FVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDR 270 280 290 300 310 320 190 200 210 220 230 240 pF1KE5 SFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPFEQQSEFSSFDKNDSRGQEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SFRAILAEPKNKASESSEQDYYSNMRQEALGHEPRVNMFPFEQQSEFSSFDKNDSRGQEA 330 340 350 360 370 380 250 260 270 280 290 300 pF1KE5 ISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYK 390 400 410 420 430 440 310 320 330 340 350 360 pF1KE5 LHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQFMQFGGSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHGFQYPPGNRIGVSFIDDGSNATDLLRKMATQMVAAQLASMVWNNPSQQQFMQFGGSSG 450 460 470 480 490 500 370 380 390 400 410 420 pF1KE5 SQLPQIQTDVVLPSCKKKAPAETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVYLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQLPQIQTDVVLPSCKKKAPAETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLIEVYLVS 510 520 530 540 550 560 430 440 450 460 470 pF1KE5 GKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY ::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GKNVGYAKYADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY 570 580 590 600 610 >-- initn: 720 init1: 692 opt: 694 Z-score: 588.1 bits: 118.6 E(85289): 5.1e-26 Smith-Waterman score: 694; 83.5% identity (88.2% similar) in 127 aa overlap (1-127:1-124) 10 20 30 40 50 60 pF1KE5 MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDEAGSSASGGGFRPGVDSLDEPPNSRIFLVISKYTPESVLRERFSPFGDIQDIWVVRDK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 HTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEEL ::::::::::::::::::::::::::::::::::::::::: . .:: : : XP_016 HTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVRVP---GSGCPRGKEWASW 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 TRIFVMIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAIEN : . ... XP_016 TSLHLLLCRGEGGVEHPFPAADQTAPGLGTGAALRRGSPPTKLRRVAGKGTGCGVFAPRE 120 130 140 150 160 170 >>XP_016881329 (OMIM: 612679) PREDICTED: CUGBP Elav-like (496 aa) initn: 191 init1: 114 opt: 306 Z-score: 269.6 bits: 59.3 E(85289): 2.8e-08 Smith-Waterman score: 336; 23.8% identity (53.5% similar) in 501 aa overlap (2-465:14-491) 10 20 30 pF1KE5 MDEAGSSASGGGFRPG----VDSLDEPPNS------------RIFL-V :.:. :..: : :: ...:.. :.. ..:. XP_016 MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 ISKYTPESVLRERFSPFGDIQDIWVVRDKHTKESKGIAFVKFARSSQACRAMEEMHGQCL : . :. :. : :: : .. :..:. : :: ::. . . .: .:. .: : XP_016 IPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKT 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 GPNDTKPIKVFIAQSRSSGSHRDVEDEELTRIFV-MIPKSYTEEDLREKFKVYGDIEYCS :. ..::.: :.:.: : ::..: :: :. :. .:.:.:. :...:.:: :. XP_016 LPGMNRPIQVKPADSESRG-----EDRKL---FVGMLNKQQSEDDVRRLFEAFGNIEECT 130 140 150 160 170 160 170 180 190 200 pF1KE5 IIKNKVTGESKGLGYVRYLKPSQAAQAIENCDRSFRAILAEPKNKASESSEQDYYSNMR- :... :.::: ..:.: . ..: :: : .. ... . .. . . .. : .:: XP_016 ILRGP-DGNSKGCAFVKYSSHAEAQAAI-NALHGSQTMPGASSSLVVKFADTDKERTMRR 180 190 200 210 220 230 210 220 230 240 250 260 pF1KE5 -QEALGHEPRVN--MFPFEQQSEFS-SFDKNDSRGQEAISKRLSVVSRVPFTEEQLFSIF :. :. : .:: . .. .. .... . .... . . :. :. .. XP_016 MQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNPMAAFAAAQMQQMA 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE5 DI-VPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYKLHGFQ-YPPGNRIGVSFIDDG . . :: . .. :.. .. .: . ..:: :: .: XP_016 ALNMNGLAAAPMTPTSGGSTPPGITA--PAVPSIPSPIGVNGFTGLPPQA--------NG 300 310 320 330 340 330 340 350 360 370 380 pF1KE5 SNATDLLRKMATQMVAAQLASMVWNNPSQQQF---MQFGGSSGSQLPQIQTDVVLPSCKK . :.. . . . :: : . .: :: . .:..: .. : . ..:. XP_016 QPAAEAVFANGIHPYPAQ--SPTAADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPPP 350 360 370 380 390 390 400 410 420 430 pF1KE5 KAPA---ETPVKERLFIVFNPHPLPLDVLEDIFCRFGNLI--EVYLVSGKN----VGYAK : : : ::: :. . : ..: :::.: .:.. . : :... XP_016 MIPQQQREGPEGCNLFIYHLPQEFGDAELMQMFLPFGNVISSKVFVDRATNQSKCFGFVS 400 410 420 430 440 450 440 450 460 470 pF1KE5 YADRISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY . . ::. :: ...: .. ::::.: :.. XP_016 FDNPASAQTAIQAMNGFQIGMKRLKVQLK-RPKDANRPY 460 470 480 490 >>NP_001020259 (OMIM: 612679) CUGBP Elav-like family mem (484 aa) initn: 215 init1: 114 opt: 291 Z-score: 257.3 bits: 57.0 E(85289): 1.4e-07 Smith-Waterman score: 307; 22.9% identity (52.9% similar) in 497 aa overlap (2-465:14-479) 10 20 30 pF1KE5 MDEAGSSASGGGFRPG----VDSLDEPPNS------------RIFL-V :.:. :..: : :: ...:.. :.. ..:. NP_001 MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 ISKYTPESVLRERFSPFGDIQDIWVVRDKHTKESKGIAFVKFARSSQACRAMEEMHGQCL : . :. :. : :: : .. :..:. : :: ::. . . .: .:. .: : NP_001 IPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKT 70 80 90 100 110 120 100 110 120 130 140 pF1KE5 GPNDTKPIKVFIAQSRSSGSHRDVEDEELTR-IFV-MIPKSYTEEDLREKFKVYGDIEYC :. ..::.: :.:.: :. ... : .:: :. :. .:.:.:. :...:.:: : NP_001 LPGMNRPIQVKPADSESRGGSSCLRQPPSHRKLFVGMLNKQQSEDDVRRLFEAFGNIEEC 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE5 SIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDRSFRAILAEPKNKASESSEQDYYSNMR .:... :.::: ..:.: . ..: :: : .. ... . .. . . .. : .:: NP_001 TILRGP-DGNSKGCAFVKYSSHAEAQAAI-NALHGSQTMPGASSSLVVKFADTDKERTMR 190 200 210 220 230 210 220 230 240 250 260 pF1KE5 --QEALGHEPRVN--MFPFEQQSEFSSFDKNDSRGQEAISKRLSVVSRVPFTEEQLFSIF :. :. : .:: . ... .... . .... . . :. :. .. NP_001 RMQQMAGQMGMFNPMAIPFGAYGAYAQAMQQQAALMASVAQGGYLNPMAAFAAAQMQQMA 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE5 DI-VPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYKLHGFQ-YPPGNRIGVSFIDDG . . :: . .. :.. .. .: . ..:: :: .: NP_001 ALNMNGLAAAPMTPTSGGSTPPGITA--PAVPSIPSPIGVNGFTGLPPQA--------NG 300 310 320 330 340 330 340 350 360 370 380 pF1KE5 SNATDLLRKMATQMVAAQLASMVWNNPSQQQF---MQFGGSSGSQLPQIQTDVVLPSCKK . :.. . . . :: : . .: :: . .:..: .. : . ..:. NP_001 QPAAEAVFANGIHPYPAQ--SPTAADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPPP 350 360 370 380 390 400 390 400 410 420 430 pF1KE5 KAPA---ETPVKERLFIVFNPHPLPLDVLEDIFCRFGN--LIEVYLVSGKNVGYAKYADR : : : ::: . :: . ::. :....: :.... . NP_001 MIPQQQREGPEGCNLFI----YHLPQE--------FGDAELMQMFL----PFGFVSFDNP 410 420 430 440 450 440 450 460 470 pF1KE5 ISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY ::. :: ...: .. ::::.: :.. NP_001 ASAQTAIQAMNGFQIGMKRLKVQLK-RPKDANRPY 460 470 480 >>NP_001020258 (OMIM: 612679) CUGBP Elav-like family mem (485 aa) initn: 215 init1: 114 opt: 288 Z-score: 254.8 bits: 56.5 E(85289): 1.9e-07 Smith-Waterman score: 304; 22.7% identity (53.0% similar) in 498 aa overlap (2-465:14-480) 10 20 30 pF1KE5 MDEAGSSASGGGFRPG----VDSLDEPPNS------------RIFL-V :.:. :..: : :: ...:.. :.. ..:. NP_001 MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 ISKYTPESVLRERFSPFGDIQDIWVVRDKHTKESKGIAFVKFARSSQACRAMEEMHGQCL : . :. :. : :: : .. :..:. : :: ::. . . .: .:. .: : NP_001 IPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKT 70 80 90 100 110 120 100 110 120 130 140 pF1KE5 GPNDTKPIKVFIAQSRSSGSHRDVEDE--ELTRIFV-MIPKSYTEEDLREKFKVYGDIEY :. ..::.: :.:.: :. ... . ..:: :. :. .:.:.:. :...:.:: NP_001 LPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQQSEDDVRRLFEAFGNIEE 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE5 CSIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDRSFRAILAEPKNKASESSEQDYYSNM :.:... :.::: ..:.: . ..: :: : .. ... . .. . . .. : .: NP_001 CTILRGP-DGNSKGCAFVKYSSHAEAQAAI-NALHGSQTMPGASSSLVVKFADTDKERTM 190 200 210 220 230 210 220 230 240 250 260 pF1KE5 R--QEALGHEPRVN--MFPFEQQSEFSSFDKNDSRGQEAISKRLSVVSRVPFTEEQLFSI : :. :. : .:: . ... .... . .... . . :. :. .. NP_001 RRMQQMAGQMGMFNPMAIPFGAYGAYAQAMQQQAALMASVAQGGYLNPMAAFAAAQMQQM 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE5 FDI-VPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYKLHGFQ-YPPGNRIGVSFIDD . . :: . .. :.. .. .: . ..:: :: . NP_001 AALNMNGLAAAPMTPTSGGSTPPGITA--PAVPSIPSPIGVNGFTGLPPQA--------N 300 310 320 330 340 330 340 350 360 370 pF1KE5 GSNATDLLRKMATQMVAAQLASMVWNNPSQQQF---MQFGGSSGSQLPQIQTDVVLPSCK :. :.. . . . :: : . .: :: . .:..: .. : . ..:. NP_001 GQPAAEAVFANGIHPYPAQ--SPTAADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPP 350 360 370 380 390 400 380 390 400 410 420 430 pF1KE5 KKAPA---ETPVKERLFIVFNPHPLPLDVLEDIFCRFGN--LIEVYLVSGKNVGYAKYAD : : : ::: . :: . ::. :....: :.... . NP_001 PMIPQQQREGPEGCNLFI----YHLPQE--------FGDAELMQMFL----PFGFVSFDN 410 420 430 440 450 440 450 460 470 pF1KE5 RISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY ::. :: ...: .. ::::.: :.. NP_001 PASAQTAIQAMNGFQIGMKRLKVQLK-RPKDANRPY 460 470 480 >>NP_001278035 (OMIM: 612678) CUGBP Elav-like family mem (464 aa) initn: 176 init1: 117 opt: 284 Z-score: 251.7 bits: 55.9 E(85289): 2.8e-07 Smith-Waterman score: 317; 24.3% identity (53.3% similar) in 478 aa overlap (20-465:1-459) 10 20 30 40 50 pF1KE5 MDEAGSSASGGGFRPGVDSLDEPPNSRIFL-VISKYTPESVLRERFSPFGDIQDIWVVRD . :: ..:. : .. :. :. : :: : .. :..: NP_001 MKEPDAIKLFVGQIPRHLEEKDLKPIFEQFGRIFELTVIKD 10 20 30 40 60 70 80 90 100 110 pF1KE5 KHTKESKGIAFVKFARSSQACRAMEEMHGQCLGPNDTKPIKVFIAQSRSSGSHRDVEDEE :.: :: ::. . ..: .:. .: : :. ..::.: :.:.: : ::.. NP_001 KYTGLHKGCAFLTYCARDSALKAQSALHEQKTLPGMNRPIQVKPADSESRG-----EDRK 50 60 70 80 90 120 130 140 150 160 170 pF1KE5 LTRIFV-MIPKSYTEEDLREKFKVYGDIEYCSIIKNKVTGESKGLGYVRYLKPSQAAQAI : :: :. :. :.::.:. :. .: :. :..... : ::: ..:.. ..: :: NP_001 L---FVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGP-DGTSKGCAFVKFQTHAEAQAAI 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE5 ENCDRSFRAILAEPKN---KASESSEQDYYSNMRQEALGHEPRVNMF-PFEQQ-SEFSSF : .: :.. . .. : ... .. :.: : ...:: :. : . .:.. NP_001 -NTLHSSRTLPGASSSLVVKFADTEKERGLRRMQQVAT----QLGMFSPIALQFGAYSAY 160 170 180 190 200 240 250 260 270 280 pF1KE5 DKNDSRGQEAI----SKRLSVVSRVPFTEEQLFSIFDIVPGLEYCEVQRDPYSNYGHGVV . . : :. : :: .. . .. : .. .. . :: . : :. . . NP_001 TQALMQQQAALVAAHSAYLSPMATMAAVQMQHMAAIN-ANGLIATPIT--PSSGTSTPPA 210 220 230 240 250 260 290 300 310 320 330 pF1KE5 QYFNVASAIYAKYKLHGFQ----YPPGNRIGVSFIDDG---------SNATDLLRKM--A . .::: : ..:.. : :. .. .: . .: :.. . NP_001 IAATPVSAIPAALGVNGYSPVPTQPTGQPAPDALYPNGVHPYPAQSPAAPVDPLQQAYAG 270 280 290 300 310 320 340 350 360 370 380 390 pF1KE5 TQMVAAQLASMVWNNPSQQQFMQFGGSSGSQLPQIQTDVVLPSCKKKAPAETPVKERLFI : .: :.. :. : . ... :: : . . ... : : .:: NP_001 MQHYTAYPAAYSLVAPAFPQPPALVAQQPPPPPQ-QQQQQQQQQQQQQQREGPDGCNIFI 330 340 350 360 370 380 400 410 420 430 440 pF1KE5 VFNPHPLPLDVLEDIFCRFGNLI--EVYLVSGKN----VGYAKYADRISANDAIATLHGK :. . . . ..: ::..: .:.. . : :.... . ::. :: ...: NP_001 YHLPQEFTDSEILQMFVPFGHVISAKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGF 390 400 410 420 430 440 450 460 470 pF1KE5 ILNGVRLKVMLADSPREESNKRQRTY .. ::::.: :.. NP_001 QIGMKRLKVQLK-RPKDANRPY 450 460 >>XP_016881330 (OMIM: 612679) PREDICTED: CUGBP Elav-like (485 aa) initn: 215 init1: 114 opt: 284 Z-score: 251.6 bits: 55.9 E(85289): 2.8e-07 Smith-Waterman score: 300; 22.9% identity (53.0% similar) in 498 aa overlap (2-465:14-480) 10 20 30 pF1KE5 MDEAGSSASGGGFRPG----VDSLDEPPNS------------RIFL-V :.:. :..: : :: ...:.. :.. ..:. XP_016 MYIKMATLANGQADNASLSTNGLGSSPGSAGHMNGLSHSPGNPSTIPMKDHDAIKLFIGQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 ISKYTPESVLRERFSPFGDIQDIWVVRDKHTKESKGIAFVKFARSSQACRAMEEMHGQCL : . :. :. : :: : .. :..:. : :: ::. . . .: .:. .: : XP_016 IPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGCAFLTYCERESALKAQSALHEQKT 70 80 90 100 110 120 100 110 120 130 140 pF1KE5 GPNDTKPIKVFIAQSRSSGSHRDVEDEELTR-IFV-MIPKSYTEEDLREKFKVYGDIEYC :. ..::.: :.:.: :. ... : .:: :. :. .:.:.:. :...:.:: : XP_016 LPGMNRPIQVKPADSESRGGSSCLRQPPSHRKLFVGMLNKQQSEDDVRRLFEAFGNIEEC 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE5 SIIKNKVTGESKGLGYVRYLKPSQAAQAIENCDRSFRAILAEPKNKASESSEQDYYSNMR .:... :.::: ..:.: . ..: :: : .. ... . .. . . .. : .:: XP_016 TILRGP-DGNSKGCAFVKYSSHAEAQAAI-NALHGSQTMPGASSSLVVKFADTDKERTMR 190 200 210 220 230 210 220 230 240 250 260 pF1KE5 --QEALGHEPRVN--MFPFEQQSEFS-SFDKNDSRGQEAISKRLSVVSRVPFTEEQLFSI :. :. : .:: . .. .. .... . .... . . :. :. .. XP_016 RMQQMAGQMGMFNPMAIPFGAYGAYAQALMQQQAALMASVAQGGYLNPMAAFAAAQMQQM 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE5 FDI-VPGLEYCEVQRDPYSNYGHGVVQYFNVASAIYAKYKLHGFQ-YPPGNRIGVSFIDD . . :: . .. :.. .. .: . ..:: :: . XP_016 AALNMNGLAAAPMTPTSGGSTPPGITA--PAVPSIPSPIGVNGFTGLPPQA--------N 300 310 320 330 340 330 340 350 360 370 pF1KE5 GSNATDLLRKMATQMVAAQLASMVWNNPSQQQF---MQFGGSSGSQLPQIQTDVVLPSCK :. :.. . . . :: : . .: :: . .:..: .. : . ..:. XP_016 GQPAAEAVFANGIHPYPAQ--SPTAADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPP 350 360 370 380 390 400 380 390 400 410 420 430 pF1KE5 KKAPA---ETPVKERLFIVFNPHPLPLDVLEDIFCRFGN--LIEVYLVSGKNVGYAKYAD : : : ::: . :: . ::. :....: :.... . XP_016 PMIPQQQREGPEGCNLFI----YHLPQE--------FGDAELMQMFL----PFGFVSFDN 410 420 430 440 450 440 450 460 470 pF1KE5 RISANDAIATLHGKILNGVRLKVMLADSPREESNKRQRTY ::. :: ...: .. ::::.: :.. XP_016 PASAQTAIQAMNGFQIGMKRLKVQLK-RPKDANRPY 460 470 480 474 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:15:59 2016 done: Tue Nov 8 05:16:00 2016 Total Scan time: 7.230 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]