FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1869, 390 aa 1>>>pF1KE1869 390 - 390 aa - 390 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1922+/-0.000287; mu= 18.5981+/- 0.018 mean_var=76.2215+/-15.262, 0's: 0 Z-trim(118.5): 68 B-trim: 1655 in 1/55 Lambda= 0.146905 statistics sampled from 31466 (31550) to 31466 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.727), E-opt: 0.2 (0.37), width: 16 Scan time: 9.470 The best scores are: opt bits E(85289) NP_000651 (OMIM: 131300,190180,219700) transformin ( 390) 2658 572.3 6.8e-163 XP_011525544 (OMIM: 131300,190180,219700) PREDICTE ( 391) 2646 569.8 4e-162 NP_003230 (OMIM: 107970,190230,615582) transformin ( 412) 700 157.4 5.9e-38 NP_001316868 (OMIM: 107970,190230,615582) transfor ( 412) 700 157.4 5.9e-38 NP_003229 (OMIM: 190220,614816) transforming growt ( 414) 699 157.1 6.8e-38 NP_001129071 (OMIM: 190220,614816) transforming gr ( 442) 699 157.2 7.2e-38 NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 327 78.3 3.6e-14 NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 317 76.2 1.6e-13 XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 317 76.2 1.6e-13 XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 317 76.2 1.8e-13 XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 317 76.3 2e-13 NP_001316867 (OMIM: 107970,190230,615582) transfor ( 309) 304 73.3 8.7e-13 NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 293 71.1 5.4e-12 XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 293 71.1 5.4e-12 NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 290 70.4 7.5e-12 NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 290 70.4 7.9e-12 XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 275 67.1 5.1e-11 NP_005529 (OMIM: 601233) inhibin beta C chain prep ( 352) 262 64.5 4.6e-10 NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 261 64.3 5.9e-10 XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 256 63.1 8.2e-10 NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 259 63.9 8.7e-10 XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 255 63.0 1.3e-09 XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 255 63.0 1.3e-09 XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 255 63.0 1.4e-09 NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 255 63.0 1.4e-09 NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 255 63.0 1.4e-09 XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 255 63.0 1.4e-09 NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 251 62.3 3.1e-09 NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 241 60.0 1e-08 NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 239 59.6 1.4e-08 NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 236 59.0 2.4e-08 NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 232 58.2 4.6e-08 NP_004855 (OMIM: 605312) growth/differentiation fa ( 308) 219 55.3 2.3e-07 NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 219 55.4 3.1e-07 NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 215 54.6 5.3e-07 NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 210 53.5 1.2e-06 NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 208 53.1 1.7e-06 XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 208 53.1 1.7e-06 NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 208 53.1 1.7e-06 NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 201 51.4 2.4e-06 NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 201 51.5 3.5e-06 NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 175 46.1 0.00021 NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 172 45.5 0.00029 NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 163 43.5 0.001 NP_000470 (OMIM: 261550,600957) muellerian-inhibit ( 560) 158 42.6 0.0028 NP_001165896 (OMIM: 601877) left-right determinati ( 332) 148 40.3 0.0082 NP_003231 (OMIM: 601877) left-right determination ( 366) 148 40.3 0.0089 >>NP_000651 (OMIM: 131300,190180,219700) transforming gr (390 aa) initn: 2658 init1: 2658 opt: 2658 Z-score: 3045.5 bits: 572.3 E(85289): 6.8e-163 Smith-Waterman score: 2658; 99.7% identity (99.7% similar) in 390 aa overlap (1-390:1-390) 10 20 30 40 50 60 pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQA 310 320 330 340 350 360 370 380 390 pF1KE1 LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS :::::::::::::::::::::::::::::: NP_000 LEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 370 380 390 >>XP_011525544 (OMIM: 131300,190180,219700) PREDICTED: t (391 aa) initn: 1580 init1: 1557 opt: 2646 Z-score: 3031.7 bits: 569.8 E(85289): 4e-162 Smith-Waterman score: 2646; 99.5% identity (99.5% similar) in 391 aa overlap (1-390:1-391) 10 20 30 40 50 60 pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA ::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWR 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDIN-GF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_011 YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINAGF 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE1 TTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLY 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE1 IDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQ 310 320 330 340 350 360 360 370 380 390 pF1KE1 ALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS ::::::::::::::::::::::::::::::: XP_011 ALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS 370 380 390 >>NP_003230 (OMIM: 107970,190230,615582) transforming gr (412 aa) initn: 1022 init1: 669 opt: 700 Z-score: 802.4 bits: 157.4 E(85289): 5.9e-38 Smith-Waterman score: 1093; 46.3% identity (67.6% similar) in 410 aa overlap (15-390:9-412) 10 20 30 40 50 60 pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA :. : .:. . . .:::: :.:. .:.::.:::::::::::::. NP_003 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLT 10 20 30 40 50 70 80 90 100 110 pF1KE1 SPPSQGEVPPGPLPEAVLALYNSTRD---RVAGESAE--PEPEPEADYYAKEVTRVLMVE ::: . .: :::::::::. .. :: : . . :..:::::. . :.. NP_003 SPPEPTVMTH--VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQ 60 70 80 90 100 110 120 130 140 150 160 pF1KE1 ---THNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRL----KLKVEQHV :::. : : ... : :.: ... . : :::.:.::. . . ::.. NP_003 GLAEHNELAVCPKGITSKVFRF-NVSSVEKNRTN---LFRAEFRVLRVPNPSSKRNEQRI 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 ELYQKYSNN----SWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCS ::.: . . ::.... : . :::::::: .::.:: : :...: :: NP_003 ELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCP 170 180 190 200 210 220 230 240 250 260 pF1KE1 C-------DSRDN---TLQVDINGFTTGR---RGDLATIHGM---NRPFLLLMATPLERA : : .: .... ..: . ::::. .. . . : :.:: : .: NP_003 CHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRL 230 240 250 260 270 280 270 280 290 300 310 320 pF1KE1 QH--LQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPC .. ..:..::::::::: . :.::::: ::::::.::::::.::::::.:::: ::: NP_003 DNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPC 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE1 PYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRS ::. : :: .: ::.::: :: :::.:::::: :::: :.::::: :::::::::.:.: NP_003 PYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKS 350 360 370 380 390 400 390 pF1KE1 CKCS :::: NP_003 CKCS 410 >>NP_001316868 (OMIM: 107970,190230,615582) transforming (412 aa) initn: 1022 init1: 669 opt: 700 Z-score: 802.4 bits: 157.4 E(85289): 5.9e-38 Smith-Waterman score: 1093; 46.3% identity (67.6% similar) in 410 aa overlap (15-390:9-412) 10 20 30 40 50 60 pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA :. : .:. . . .:::: :.:. .:.::.:::::::::::::. NP_001 MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLT 10 20 30 40 50 70 80 90 100 110 pF1KE1 SPPSQGEVPPGPLPEAVLALYNSTRD---RVAGESAE--PEPEPEADYYAKEVTRVLMVE ::: . .: :::::::::. .. :: : . . :..:::::. . :.. NP_001 SPPEPTVMTH--VPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQ 60 70 80 90 100 110 120 130 140 150 160 pF1KE1 ---THNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRL----KLKVEQHV :::. : : ... : :.: ... . : :::.:.::. . . ::.. NP_001 GLAEHNELAVCPKGITSKVFRF-NVSSVEKNRTN---LFRAEFRVLRVPNPSSKRNEQRI 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 ELYQKYSNN----SWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCS ::.: . . ::.... : . :::::::: .::.:: : :...: :: NP_001 ELFQILRPDEHIAKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCP 170 180 190 200 210 220 230 240 250 260 pF1KE1 C-------DSRDN---TLQVDINGFTTGR---RGDLATIHGM---NRPFLLLMATPLERA : : .: .... ..: . ::::. .. . . : :.:: : .: NP_001 CHTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRL 230 240 250 260 270 280 270 280 290 300 310 320 pF1KE1 QH--LQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPC .. ..:..::::::::: . :.::::: ::::::.::::::.::::::.:::: ::: NP_001 DNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPC 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE1 PYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRS ::. : :: .: ::.::: :: :::.:::::: :::: :.::::: :::::::::.:.: NP_001 PYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKS 350 360 370 380 390 400 390 pF1KE1 CKCS :::: NP_001 CKCS 410 >>NP_003229 (OMIM: 190220,614816) transforming growth fa (414 aa) initn: 1019 init1: 653 opt: 699 Z-score: 801.3 bits: 157.1 E(85289): 6.8e-38 Smith-Waterman score: 1086; 45.1% identity (67.0% similar) in 412 aa overlap (18-390:9-414) 10 20 30 40 50 60 pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA .:.: : .::::.:.::. :::::::::::::::.:. NP_003 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLT 10 20 30 40 50 70 80 90 100 110 pF1KE1 SPPSQGEVP-PGPLPEAVLALYNSTRD----RVAGESAEPEPE-PEADYYAKEVTRVLM- ::: . : : .: :...:::::: ... ..: : : . .:::::: .. : NP_003 SPPE--DYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMP 60 70 80 90 100 120 130 140 150 160 pF1KE1 --VETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRL---KLKV-EQH ..: : : . : . :..: ... . . : .::.:..:: : .: ::. NP_003 PFFPSENAIPPTFYRPYFRI-VRFDVSAMEKNASN---LVKAEFRVFRLQNPKARVPEQR 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 VELYQ-----KYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAH .:::: .. . ::...... :::::::: .:..:: . . ::..: : NP_003 IELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLH 170 180 190 200 210 220 230 240 250 260 pF1KE1 CSC-----------DSRDNTLQV---DINGFTTGRRGDLATIHGMNR------PFLLLMA : : .... :.. :.: .: :: ::.. . : :::: NP_003 CPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLML 230 240 250 260 270 280 270 280 290 300 310 320 pF1KE1 TPLERAQHLQSSRHR-RALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANF : : . :..:.. ::::. ::: ... :::.: :::::..:::::::::::::.::: NP_003 LPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANF 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE1 CLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSN : : :::.:: :::.:.::.::: :: :::.:::: : :::: :.::.:. ::.::::: NP_003 CAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSN 350 360 370 380 390 400 390 pF1KE1 MIVRSCKCS :::.::::: NP_003 MIVKSCKCS 410 >>NP_001129071 (OMIM: 190220,614816) transforming growth (442 aa) initn: 1040 init1: 653 opt: 699 Z-score: 800.9 bits: 157.2 E(85289): 7.2e-38 Smith-Waterman score: 1025; 43.4% identity (63.7% similar) in 424 aa overlap (30-390:21-442) 10 20 30 40 50 60 pF1KE1 MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLA ::::.:.::. :::::::::::::::.:. NP_001 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLT 10 20 30 40 50 70 80 90 100 110 pF1KE1 SPPSQGEVP-PGPLPEAVLALYNSTRD----RVAGESAEPEPE-PEADYYAKEVTRVLM- ::: . : : .: :...:::::: ... ..: : : . .:::::: .. : NP_001 SPPE--DYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMP 60 70 80 90 100 120 130 140 pF1KE1 ----VETHNEIYDKFKQSTHSI----------YM----------FFNTSELREAVPEPVL :: . . :. :. :. .: .. .. : NP_001 PFFPSETVCPVVTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA 110 120 130 140 150 160 150 160 170 180 190 pF1KE1 --LSRAELRLLRL---KLKV-EQHVELYQ-----KYSNNSWRYLSNRLLAPSDSPEWLSF : .::.:..:: : .: ::..:::: .. . ::...... ::::: NP_001 SNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSF 170 180 190 200 210 220 200 210 220 230 240 pF1KE1 DVTGVVRQWLSRGGEIEGFRLSAHCSC-----------DSRDNTLQV---DINGFTTGRR ::: .:..:: . . ::..: :: : .... :.. :.: .: NP_001 DVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTS 230 240 250 260 270 280 250 260 270 280 290 pF1KE1 GDLATIHGMNR------PFLLLMATPLERAQHLQSSRHR-RALDTNYCFSSTEKNCCVRQ :: ::.. . : :::: : : . :..:.. ::::. ::: ... :::.: NP_001 GDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRP 290 300 310 320 330 340 300 310 320 330 340 350 pF1KE1 LYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCV :::::..:::::::::::::.:::: : :::.:: :::.:.::.::: :: :::.:::: NP_001 LYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCV 350 360 370 380 390 400 360 370 380 390 pF1KE1 PQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS : :::: :.::.:. ::.::::::::.::::: NP_001 SQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS 410 420 430 440 >>NP_001191 (OMIM: 112261,112600,235200) bone morphogene (396 aa) initn: 269 init1: 114 opt: 327 Z-score: 375.4 bits: 78.3 E(85289): 3.6e-14 Smith-Waterman score: 339; 27.9% identity (53.4% similar) in 427 aa overlap (4-389:3-395) 10 20 30 40 50 pF1KE1 MPPSGLRLLL-LLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRG-------- .: : :: :::: :: : :::: :: .:: : : NP_001 MVAGTRCLLALLLPQ----VLLGG--AAGLVP------ELGRRKFAAASSGRPSSQPSD 10 20 30 40 60 70 80 90 100 pF1KE1 QILSK--LRLASPPSQGEVPPGPLPEAVLALYN-STRDRVAGESAEPEPEPEADYYAKEV ..::. ::: : . . : : .::. : . : .:. . : :. . . :... NP_001 EVLSEFELRLLSMFGLKQRPT-PSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRA 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE1 TRVLMVETHNEIYDKFKQSTHSI--YMFFNTSELREAVPEPVLLSRAELRLLRLKLK--- . : . :.: ... ... . .::: : ..: ... :::...: ... NP_001 NTVRSFH-HEESLEELPETSGKTTRRFFFNLS----SIPTEEFITSAELQVFREQMQDAL 110 120 130 140 150 160 170 180 190 200 210 pF1KE1 -----VEQHVELYQ---KYSNNSW----RYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRG ......:. . :: : :..::. . : .: ::::: .: .: ..: NP_001 GNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNAS-RWESFDVTPAVMRWTAQG 170 180 190 200 210 220 220 230 240 250 260 pF1KE1 GEIEGFRLS-AHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMAT-----PL .:: . :: . . .: :. . . . : ::.:. .. :: NP_001 HANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQI----RPLLVTFGHDGKGHPL 230 240 250 260 270 270 280 290 300 310 320 pF1KE1 ERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQ-LYIDFRKDLGWK-WIHEPKGYHANFCL .. .. :.....: . :. : :. ::.:: .:.::. :: : :::: .: NP_001 HKREKRQAKHKQR---------KRLKSSCKRHPLYVDF-SDVGWNDWIVAPPGYHAFYCH 280 290 300 310 320 330 340 350 360 370 pF1KE1 GPCPYIWS--LD-TQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYY-VGRKPKVEQL : ::. . :. :... : .: :. : : :::: : . ..: ..: ... NP_001 GECPFPLADHLNSTNHAIVQTLVNSVNSKIPKA-CCVPTELSAISMLYLDENEKVVLKNY 330 340 350 360 370 380 380 390 pF1KE1 SNMIVRSCKCS ..:.:..: : NP_001 QDMVVEGCGCR 390 >>NP_002183 (OMIM: 147290) inhibin beta A chain prepropr (426 aa) initn: 322 init1: 143 opt: 317 Z-score: 363.5 bits: 76.2 E(85289): 1.6e-13 Smith-Waterman score: 352; 26.6% identity (49.7% similar) in 447 aa overlap (1-390:1-426) 10 20 30 40 pF1KE1 MPPSGLRLLLLLLPLLWLLVL---TPGRP----AAGLSTCKTI----DMELVKRKRIEAI :: :: .: : :..: ::: : .: :. . . .::. NP_002 MPLLWLRGFL--LASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAV 10 20 30 40 50 50 60 70 80 90 100 pF1KE1 RGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVT . .::. :.: . :. . :.:.: :: :. : .:. .: : .... NP_002 KKHILNMLHLKKRPDVTQ----PVPKA--ALLNAIRKLHVGKVGENGYVEIEDDIGRRAE 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 RVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLL-------RLKL ..: .:: ...: . :. : .:. :. :::. :. : . NP_002 MNELMEQTSEIITFAESGTARKTLHFEIS--KEGSDLSVV-ERAEVWLFLKVPKANRTRT 120 130 140 150 160 170 180 190 200 pF1KE1 KVEQHVELYQKYSNNSWR-----------------YLSNRLLAPSDSPEWLSFDVTGVVR :: .. ::. ..: ::.... : : : :.. .. NP_002 KVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKST-WHVFPVSSSIQ 170 180 190 200 210 220 210 220 230 240 250 pF1KE1 QWLSRGGEIEGFRLSAHCSCDSRDNTLQV-------------DINGFTTGRRGDLATIHG . :..: :.. . .:. .: . .: : : . NP_002 RLLDQGKSSLDVRIACE-QCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQ 230 240 250 260 270 280 260 270 280 290 300 310 pF1KE1 MNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WI .::::.:.: : : :.::.:. : .. . :: .:....: ::.::. :: NP_002 SHRPFLMLQARQSEDHPH---RRRRRGLE---C-DGKVNICCKKQFFVSF-KDIGWNDWI 290 300 310 320 330 320 330 340 350 360 pF1KE1 HEPKGYHANFCLGPCP-YIWSLDTQ----YSKVLALYNQ--HNPGASAAPCCVPQALEPL :.:::::.: : :: .: . . . .: :. : . :.: :. :::: :.:. NP_002 IAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPM 340 350 360 370 380 390 370 380 390 pF1KE1 PIVYYV-GRKPKVEQLSNMIVRSCKCS ..:: :.. ....::::. : :: NP_002 SMLYYDDGQNIIKKDIQNMIVEECGCS 400 410 420 >>XP_016867665 (OMIM: 147290) PREDICTED: inhibin beta A (426 aa) initn: 322 init1: 143 opt: 317 Z-score: 363.5 bits: 76.2 E(85289): 1.6e-13 Smith-Waterman score: 352; 26.6% identity (49.7% similar) in 447 aa overlap (1-390:1-426) 10 20 30 40 pF1KE1 MPPSGLRLLLLLLPLLWLLVL---TPGRP----AAGLSTCKTI----DMELVKRKRIEAI :: :: .: : :..: ::: : .: :. . . .::. XP_016 MPLLWLRGFL--LASCWIIVRSSPTPGSEGHSAAPDCPSCALAALPKDVPNSQPEMVEAV 10 20 30 40 50 50 60 70 80 90 100 pF1KE1 RGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVT . .::. :.: . :. . :.:.: :: :. : .:. .: : .... XP_016 KKHILNMLHLKKRPDVTQ----PVPKA--ALLNAIRKLHVGKVGENGYVEIEDDIGRRAE 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 RVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLL-------RLKL ..: .:: ...: . :. : .:. :. :::. :. : . XP_016 MNELMEQTSEIITFAESGTARKTLHFEIS--KEGSDLSVV-ERAEVWLFLKVPKANRTRT 120 130 140 150 160 170 180 190 200 pF1KE1 KVEQHVELYQKYSNNSWR-----------------YLSNRLLAPSDSPEWLSFDVTGVVR :: .. ::. ..: ::.... : : : :.. .. XP_016 KVTIRLFQQQKHPQGSLDTGEEAEEVGLKGERSELLLSEKVVDARKST-WHVFPVSSSIQ 170 180 190 200 210 220 210 220 230 240 250 pF1KE1 QWLSRGGEIEGFRLSAHCSCDSRDNTLQV-------------DINGFTTGRRGDLATIHG . :..: :.. . .:. .: . .: : : . XP_016 RLLDQGKSSLDVRIACE-QCQESGASLVLLGKKKKKEEEGEGKKKGGGEGGAGADEEKEQ 230 240 250 260 270 280 260 270 280 290 300 310 pF1KE1 MNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWK-WI .::::.:.: : : :.::.:. : .. . :: .:....: ::.::. :: XP_016 SHRPFLMLQARQSEDHPH---RRRRRGLE---C-DGKVNICCKKQFFVSF-KDIGWNDWI 290 300 310 320 330 320 330 340 350 360 pF1KE1 HEPKGYHANFCLGPCP-YIWSLDTQ----YSKVLALYNQ--HNPGASAAPCCVPQALEPL :.:::::.: : :: .: . . . .: :. : . :.: :. :::: :.:. XP_016 IAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPM 340 350 360 370 380 390 370 380 390 pF1KE1 PIVYYV-GRKPKVEQLSNMIVRSCKCS ..:: :.. ....::::. : :: XP_016 SMLYYDDGQNIIKKDIQNMIVEECGCS 400 410 420 >>XP_016867664 (OMIM: 147290) PREDICTED: inhibin beta A (483 aa) initn: 293 init1: 143 opt: 317 Z-score: 362.8 bits: 76.2 E(85289): 1.8e-13 Smith-Waterman score: 352; 26.6% identity (49.7% similar) in 447 aa overlap (1-390:58-483) 10 20 pF1KE1 MPPSGLRLLLLLLPLLWLLVL---TPGRP- :: :: .: : :..: ::: XP_016 KSTHTKKPAREGGGKAGPFKKAITTTFAARMPLLWLRGFL--LASCWIIVRSSPTPGSEG 30 40 50 60 70 80 30 40 50 60 70 pF1KE1 ---AAGLSTCKTI----DMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLA : .: :. . . .::.. .::. :.: . :. . :.:.: : XP_016 HSAAPDCPSCALAALPKDVPNSQPEMVEAVKKHILNMLHLKKRPDVTQ----PVPKA--A 90 100 110 120 130 80 90 100 110 120 130 pF1KE1 LYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSE : :. : .:. .: : .... ..: .:: ...: . :. : XP_016 LLNAIRKLHVGKVGENGYVEIEDDIGRRAEMNELMEQTSEIITFAESGTARKTLHFEIS- 140 150 160 170 180 190 140 150 160 170 180 pF1KE1 LREAVPEPVLLSRAELRLL-------RLKLKVEQHVELYQKYSNNSWR------------ .:. :. :::. :. : . :: .. ::. ..: XP_016 -KEGSDLSVV-ERAEVWLFLKVPKANRTRTKVTIRLFQQQKHPQGSLDTGEEAEEVGLKG 200 210 220 230 240 250 190 200 210 220 230 pF1KE1 -----YLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQV- ::.... : : : :.. ... :..: :.. . .:. .: . XP_016 ERSELLLSEKVVDARKST-WHVFPVSSSIQRLLDQGKSSLDVRIACE-QCQESGASLVLL 260 270 280 290 300 310 240 250 260 270 280 pF1KE1 ------------DINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDT .: : : . .::::.:.: : : :.::.:. XP_016 GKKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPH---RRRRRGLE- 320 330 340 350 360 370 290 300 310 320 330 pF1KE1 NYCFSSTEKNCCVRQLYIDFRKDLGWK-WIHEPKGYHANFCLGPCP-YIWSLDTQ----Y : .. . :: .:....: ::.::. :: :.:::::.: : :: .: . . . . XP_016 --C-DGKVNICCKKQFFVSF-KDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFH 380 390 400 410 420 340 350 360 370 380 390 pF1KE1 SKVLALYNQ--HNPGASAAPCCVPQALEPLPIVYYV-GRKPKVEQLSNMIVRSCKCS : :. : . :.: :. :::: :.:. ..:: :.. ....::::. : :: XP_016 STVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCS 430 440 450 460 470 480 390 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 12:11:48 2016 done: Sun Nov 6 12:11:49 2016 Total Scan time: 9.470 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]