FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4078, 412 aa 1>>>pF1KE4078 412 - 412 aa - 412 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6569+/-0.00035; mu= 15.8452+/- 0.022 mean_var=111.9988+/-25.004, 0's: 0 Z-trim(115.9): 192 B-trim: 293 in 1/50 Lambda= 0.121190 statistics sampled from 26442 (26736) to 26442 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.68), E-opt: 0.2 (0.313), width: 16 Scan time: 8.060 The best scores are: opt bits E(85289) NP_071322 (OMIM: 608071) F-box/WD repeat-containin ( 412) 2858 510.8 2.4e-144 NP_001310470 (OMIM: 608071) F-box/WD repeat-contai ( 325) 2279 409.5 6.1e-114 XP_016872059 (OMIM: 608071) PREDICTED: F-box/WD re ( 284) 1762 319.1 9e-87 XP_005270110 (OMIM: 608071) PREDICTED: F-box/WD re ( 436) 1762 319.2 1.2e-86 XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD re ( 540) 210 48.0 6.8e-05 NP_001013433 (OMIM: 606278) F-box/WD repeat-contai ( 589) 210 48.0 7.2e-05 NP_060785 (OMIM: 606278) F-box/WD repeat-containin ( 627) 210 48.1 7.5e-05 XP_011530388 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 210 48.1 7.9e-05 XP_011530389 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 210 48.1 7.9e-05 XP_011530386 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 210 48.1 8.1e-05 NP_361014 (OMIM: 606278) F-box/WD repeat-containin ( 707) 210 48.1 8.1e-05 XP_011530385 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 210 48.1 8.1e-05 XP_011530387 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 210 48.1 8.1e-05 XP_016863851 (OMIM: 606278) PREDICTED: F-box/WD re ( 707) 210 48.1 8.1e-05 NP_001188493 (OMIM: 605961) pleiotropic regulator ( 505) 196 45.5 0.00035 NP_002660 (OMIM: 605961) pleiotropic regulator 1 i ( 514) 196 45.5 0.00036 NP_006089 (OMIM: 176981) receptor of activated pro ( 317) 190 44.3 0.00053 NP_001309195 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 189 44.0 0.00055 NP_001309196 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 189 44.0 0.00055 NP_001231855 (OMIM: 607795,615922) U4/U6 small nuc ( 521) 189 44.3 0.00084 NP_004688 (OMIM: 607795,615922) U4/U6 small nuclea ( 522) 189 44.3 0.00084 XP_016864369 (OMIM: 604734) PREDICTED: WD repeat-c ( 659) 182 43.2 0.0023 NP_001315 (OMIM: 600369) cleavage stimulation fact ( 431) 179 42.5 0.0025 NP_001028693 (OMIM: 600369) cleavage stimulation f ( 431) 179 42.5 0.0025 XP_011526902 (OMIM: 600369) PREDICTED: cleavage st ( 431) 179 42.5 0.0025 NP_001028694 (OMIM: 600369) cleavage stimulation f ( 431) 179 42.5 0.0025 XP_016863186 (OMIM: 609005) PREDICTED: WD repeat-c ( 982) 180 43.0 0.0039 XP_005262782 (OMIM: 609005) PREDICTED: WD repeat-c (1216) 180 43.1 0.0045 NP_851782 (OMIM: 609005) WD repeat-containing prot (1283) 180 43.1 0.0047 XP_011529884 (OMIM: 609005) PREDICTED: WD repeat-c (1290) 180 43.1 0.0047 XP_016863179 (OMIM: 609005) PREDICTED: WD repeat-c (1307) 180 43.1 0.0047 XP_016863178 (OMIM: 609005) PREDICTED: WD repeat-c (1307) 180 43.1 0.0047 XP_016863175 (OMIM: 609005) PREDICTED: WD repeat-c (1314) 180 43.2 0.0047 XP_016863176 (OMIM: 609005) PREDICTED: WD repeat-c (1314) 180 43.2 0.0047 XP_016863177 (OMIM: 609005) PREDICTED: WD repeat-c (1314) 180 43.2 0.0047 NP_733828 (OMIM: 609005) WD repeat-containing prot (1322) 180 43.2 0.0047 NP_001186104 (OMIM: 612190) target of rapamycin co ( 325) 167 40.2 0.0088 >>NP_071322 (OMIM: 608071) F-box/WD repeat-containing pr (412 aa) initn: 2858 init1: 2858 opt: 2858 Z-score: 2712.5 bits: 510.8 E(85289): 2.4e-144 Smith-Waterman score: 2858; 100.0% identity (100.0% similar) in 412 aa overlap (1-412:1-412) 10 20 30 40 50 60 pF1KE4 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 GDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 IQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 IQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 YESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 YESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGV 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 VRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 VRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP 370 380 390 400 410 >>NP_001310470 (OMIM: 608071) F-box/WD repeat-containing (325 aa) initn: 2279 init1: 2279 opt: 2279 Z-score: 2166.6 bits: 409.5 E(85289): 6.1e-114 Smith-Waterman score: 2279; 100.0% identity (100.0% similar) in 325 aa overlap (88-412:1-325) 60 70 80 90 100 110 pF1KE4 LRRFTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWR :::::::::::::::::::::::::::::: NP_001 MTSVPVKERVKVSQNWRLGRCREGILLKWR 10 20 30 120 130 140 150 160 170 pF1KE4 CSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CSQMPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIV 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE4 SAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAGGDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQC 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE4 LHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LHTIQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVL 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE4 DVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSY 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE4 YGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP 280 290 300 310 320 >>XP_016872059 (OMIM: 608071) PREDICTED: F-box/WD repeat (284 aa) initn: 1799 init1: 1758 opt: 1762 Z-score: 1678.8 bits: 319.1 E(85289): 9e-87 Smith-Waterman score: 1762; 95.3% identity (96.4% similar) in 275 aa overlap (1-275:1-270) 10 20 30 40 50 60 pF1KE4 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 IQTEDRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPGAGVLDVM ::::::::::::::::: ::.. . ::: XP_016 IQTEDRVWSIAISPLLS---TGASTVRDVT--RIWLKTSRGFKSNRFKF 250 260 270 280 310 320 330 340 350 360 pF1KE4 YESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLATGSSYYGV >>XP_005270110 (OMIM: 608071) PREDICTED: F-box/WD repeat (436 aa) initn: 1867 init1: 1758 opt: 1762 Z-score: 1676.5 bits: 319.2 E(85289): 1.2e-86 Smith-Waterman score: 2800; 94.5% identity (94.5% similar) in 436 aa overlap (1-412:1-436) 10 20 30 40 50 60 pF1KE4 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDVCHFVLANSHIVSAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 GDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GDGKIGIHKIHSTFTVKYSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRLGQCLHT 190 200 210 220 230 240 250 260 270 pF1KE4 IQTEDRVWSIAISPLLS------------------------SFVTGTACCGHFSPLRIWD ::::::::::::::::: ::::::::::::::::::: XP_005 IQTEDRVWSIAISPLLSTGASTVRDVTRIWLKTSRGFKSNSSFVTGTACCGHFSPLRIWD 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE4 LNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNSGQLMTHLGSDFPPGAGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPH 310 320 330 340 350 360 340 350 360 370 380 390 pF1KE4 DSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSTLYCLQTDGNHLLATGSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHL 370 380 390 400 410 420 400 410 pF1KE4 YAALSYNLHVLDFQNP :::::::::::::::: XP_005 YAALSYNLHVLDFQNP 430 >>XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD repeat (540 aa) initn: 340 init1: 110 opt: 210 Z-score: 208.9 bits: 48.0 E(85289): 6.8e-05 Smith-Waterman score: 302; 28.1% identity (53.4% similar) in 352 aa overlap (31-375:117-410) 10 20 30 40 50 60 pF1KE4 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR ::.:: : . :.:. . : . ::.::. : XP_011 DELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRI 90 100 110 120 130 140 70 80 90 100 110 120 pF1KE4 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ .. .::::. . : : . .:.: :: . :.. . XP_011 LAEDNLLWREKCKEE--------GID--EPLHIKRR-KV--------IKPGFI------H 150 160 170 180 130 140 150 160 170 pF1KE4 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDV--CHFVLANSHIVS :: : :: : . .. : . : : :. :::. : : . . ...::: XP_011 SPW-----KSAYIRQHRIDTNWR-RGELKS----P-KVLKGHDDHVITC-LQFCGNRIVS 190 200 210 220 180 190 200 210 220 230 pF1KE4 AGGDGKIGIHKIHSTFTVK----YSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL .. :. . :. :. : : .: : . . .::.::: ::: ::: ... XP_011 GSDDNTL---KVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVW---NAET 230 240 250 260 270 280 240 250 260 270 280 290 pF1KE4 GQCLHTIQTE-DRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPG :.:.::. . . : . . . :.:. . . ::.::...:: . : . XP_011 GECIHTLYGHTSTVRCMHLHE--KRVVSGS----RDATLRVWDIETGQCLHVLMGHV--- 290 300 310 320 330 300 310 320 330 340 350 pF1KE4 AGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLAT :.: :.:.. ..: .:: .:. :: .: . : .. . : . .: :: :: :... XP_011 AAVRCVQYDGR-RVVSGAYDFMVKVWDPETET--C-LHTLQGHTNRVYSLQFDGIHVVS- 340 350 360 370 380 360 370 380 390 400 410 pF1KE4 GSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP .: .:.:: . :.:.. XP_011 -GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQ 390 400 410 420 430 440 >>NP_001013433 (OMIM: 606278) F-box/WD repeat-containing (589 aa) initn: 340 init1: 110 opt: 210 Z-score: 208.4 bits: 48.0 E(85289): 7.2e-05 Smith-Waterman score: 302; 28.1% identity (53.4% similar) in 352 aa overlap (31-375:166-459) 10 20 30 40 50 60 pF1KE4 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR ::.:: : . :.:. . : . ::.::. : NP_001 DELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRI 140 150 160 170 180 190 70 80 90 100 110 120 pF1KE4 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ .. .::::. . : : . .:.: :: . :.. . NP_001 LAEDNLLWREKCKEE--------GID--EPLHIKRR-KV--------IKPGFI------H 200 210 220 230 130 140 150 160 170 pF1KE4 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDV--CHFVLANSHIVS :: : :: : . .. : . : : :. :::. : : . . ...::: NP_001 SPW-----KSAYIRQHRIDTNWR-RGELKS----P-KVLKGHDDHVITC-LQFCGNRIVS 240 250 260 270 180 190 200 210 220 230 pF1KE4 AGGDGKIGIHKIHSTFTVK----YSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL .. :. . :. :. : : .: : . . .::.::: ::: ::: ... NP_001 GSDDNTL---KVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVW---NAET 280 290 300 310 320 330 240 250 260 270 280 290 pF1KE4 GQCLHTIQTE-DRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPG :.:.::. . . : . . . :.:. . . ::.::...:: . : . NP_001 GECIHTLYGHTSTVRCMHLHE--KRVVSGS----RDATLRVWDIETGQCLHVLMGHV--- 340 350 360 370 380 300 310 320 330 340 350 pF1KE4 AGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLAT :.: :.:.. ..: .:: .:. :: .: . : .. . : . .: :: :: :... NP_001 AAVRCVQYDGR-RVVSGAYDFMVKVWDPETET--C-LHTLQGHTNRVYSLQFDGIHVVS- 390 400 410 420 430 360 370 380 390 400 410 pF1KE4 GSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP .: .:.:: . :.:.. NP_001 -GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQ 440 450 460 470 480 490 >>NP_060785 (OMIM: 606278) F-box/WD repeat-containing pr (627 aa) initn: 340 init1: 110 opt: 210 Z-score: 208.1 bits: 48.1 E(85289): 7.5e-05 Smith-Waterman score: 302; 28.1% identity (53.4% similar) in 352 aa overlap (31-375:204-497) 10 20 30 40 50 60 pF1KE4 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR ::.:: : . :.:. . : . ::.::. : NP_060 DELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRI 180 190 200 210 220 230 70 80 90 100 110 120 pF1KE4 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ .. .::::. . : : . .:.: :: . :.. . NP_060 LAEDNLLWREKCKEE--------GID--EPLHIKRR-KV--------IKPGFI------H 240 250 260 130 140 150 160 170 pF1KE4 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDV--CHFVLANSHIVS :: : :: : . .. : . : : :. :::. : : . . ...::: NP_060 SPW-----KSAYIRQHRIDTNWR-RGELKS----P-KVLKGHDDHVITC-LQFCGNRIVS 270 280 290 300 310 180 190 200 210 220 230 pF1KE4 AGGDGKIGIHKIHSTFTVK----YSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL .. :. . :. :. : : .: : . . .::.::: ::: ::: ... NP_060 GSDDNTL---KVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVW---NAET 320 330 340 350 360 370 240 250 260 270 280 290 pF1KE4 GQCLHTIQTE-DRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPG :.:.::. . . : . . . :.:. . . ::.::...:: . : . NP_060 GECIHTLYGHTSTVRCMHLHE--KRVVSGS----RDATLRVWDIETGQCLHVLMGHV--- 380 390 400 410 420 300 310 320 330 340 350 pF1KE4 AGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLAT :.: :.:.. ..: .:: .:. :: .: . : .. . : . .: :: :: :... NP_060 AAVRCVQYDGR-RVVSGAYDFMVKVWDPETET--C-LHTLQGHTNRVYSLQFDGIHVVS- 430 440 450 460 470 360 370 380 390 400 410 pF1KE4 GSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP .: .:.:: . :.:.. NP_060 -GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQ 480 490 500 510 520 530 >>XP_011530388 (OMIM: 606278) PREDICTED: F-box/WD repeat (679 aa) initn: 340 init1: 110 opt: 210 Z-score: 207.6 bits: 48.1 E(85289): 7.9e-05 Smith-Waterman score: 302; 28.1% identity (53.4% similar) in 352 aa overlap (31-375:256-549) 10 20 30 40 50 60 pF1KE4 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR ::.:: : . :.:. . : . ::.::. : XP_011 DELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRI 230 240 250 260 270 280 70 80 90 100 110 120 pF1KE4 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ .. .::::. . : : . .:.: :: . :.. . XP_011 LAEDNLLWREKCKEE--------GID--EPLHIKRR-KV--------IKPGFI------H 290 300 310 320 130 140 150 160 170 pF1KE4 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDV--CHFVLANSHIVS :: : :: : . .. : . : : :. :::. : : . . ...::: XP_011 SPW-----KSAYIRQHRIDTNWR-RGELKS----P-KVLKGHDDHVITC-LQFCGNRIVS 330 340 350 360 180 190 200 210 220 230 pF1KE4 AGGDGKIGIHKIHSTFTVK----YSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL .. :. . :. :. : : .: : . . .::.::: ::: ::: ... XP_011 GSDDNTL---KVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVW---NAET 370 380 390 400 410 420 240 250 260 270 280 290 pF1KE4 GQCLHTIQTE-DRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPG :.:.::. . . : . . . :.:. . . ::.::...:: . : . XP_011 GECIHTLYGHTSTVRCMHLHE--KRVVSGS----RDATLRVWDIETGQCLHVLMGHV--- 430 440 450 460 470 300 310 320 330 340 350 pF1KE4 AGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLAT :.: :.:.. ..: .:: .:. :: .: . : .. . : . .: :: :: :... XP_011 AAVRCVQYDGR-RVVSGAYDFMVKVWDPETET--C-LHTLQGHTNRVYSLQFDGIHVVS- 480 490 500 510 520 360 370 380 390 400 410 pF1KE4 GSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP .: .:.:: . :.:.. XP_011 -GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQ 530 540 550 560 570 580 >>XP_011530389 (OMIM: 606278) PREDICTED: F-box/WD repeat (679 aa) initn: 340 init1: 110 opt: 210 Z-score: 207.6 bits: 48.1 E(85289): 7.9e-05 Smith-Waterman score: 302; 28.1% identity (53.4% similar) in 352 aa overlap (31-375:256-549) 10 20 30 40 50 60 pF1KE4 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR ::.:: : . :.:. . : . ::.::. : XP_011 DELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRI 230 240 250 260 270 280 70 80 90 100 110 120 pF1KE4 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ .. .::::. . : : . .:.: :: . :.. . XP_011 LAEDNLLWREKCKEE--------GID--EPLHIKRR-KV--------IKPGFI------H 290 300 310 320 130 140 150 160 170 pF1KE4 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDV--CHFVLANSHIVS :: : :: : . .. : . : : :. :::. : : . . ...::: XP_011 SPW-----KSAYIRQHRIDTNWR-RGELKS----P-KVLKGHDDHVITC-LQFCGNRIVS 330 340 350 360 180 190 200 210 220 230 pF1KE4 AGGDGKIGIHKIHSTFTVK----YSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL .. :. . :. :. : : .: : . . .::.::: ::: ::: ... XP_011 GSDDNTL---KVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVW---NAET 370 380 390 400 410 420 240 250 260 270 280 290 pF1KE4 GQCLHTIQTE-DRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPG :.:.::. . . : . . . :.:. . . ::.::...:: . : . XP_011 GECIHTLYGHTSTVRCMHLHE--KRVVSGS----RDATLRVWDIETGQCLHVLMGHV--- 430 440 450 460 470 300 310 320 330 340 350 pF1KE4 AGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLAT :.: :.:.. ..: .:: .:. :: .: . : .. . : . .: :: :: :... XP_011 AAVRCVQYDGR-RVVSGAYDFMVKVWDPETET--C-LHTLQGHTNRVYSLQFDGIHVVS- 480 490 500 510 520 360 370 380 390 400 410 pF1KE4 GSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP .: .:.:: . :.:.. XP_011 -GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQ 530 540 550 560 570 580 >>XP_011530386 (OMIM: 606278) PREDICTED: F-box/WD repeat (707 aa) initn: 340 init1: 110 opt: 210 Z-score: 207.4 bits: 48.1 E(85289): 8.1e-05 Smith-Waterman score: 302; 28.1% identity (53.4% similar) in 352 aa overlap (31-375:284-577) 10 20 30 40 50 60 pF1KE4 MAAAAGEEEEEEEAARESAARPAAGPALWRLPEELLLLICSYLDMRALGRLAQVCRWLRR ::.:: : . :.:. . : . ::.::. : XP_011 DELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRI 260 270 280 290 300 310 70 80 90 100 110 120 pF1KE4 FTSCDLLWRRIARASLNSGFTRLGTDLMTSVPVKERVKVSQNWRLGRCREGILLKWRCSQ .. .::::. . : : . .:.: :: . :.. . XP_011 LAEDNLLWREKCKEE--------GID--EPLHIKRR-KV--------IKPGFI------H 320 330 340 130 140 150 160 170 pF1KE4 MPWMQLEDDSLYISQANFILAYQFRPDGASLNRRPLGVFAGHDEDV--CHFVLANSHIVS :: : :: : . .. : . : : :. :::. : : . . ...::: XP_011 SPW-----KSAYIRQHRIDTNWR-RGELKS----P-KVLKGHDDHVITC-LQFCGNRIVS 350 360 370 380 390 180 190 200 210 220 230 pF1KE4 AGGDGKIGIHKIHSTFTVK----YSAHEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL .. :. . :. :. : : .: : . . .::.::: ::: ::: ... XP_011 GSDDNTL---KVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVW---NAET 400 410 420 430 440 450 240 250 260 270 280 290 pF1KE4 GQCLHTIQTE-DRVWSIAISPLLSSFVTGTACCGHFSPLRIWDLNSGQLMTHLGSDFPPG :.:.::. . . : . . . :.:. . . ::.::...:: . : . XP_011 GECIHTLYGHTSTVRCMHLHE--KRVVSGS----RDATLRVWDIETGQCLHVLMGHV--- 460 470 480 490 500 300 310 320 330 340 350 pF1KE4 AGVLDVMYESPFTLLSCGYDTYVRYWDLRTSVRKCVMEWEEPHDSTLYCLQTDGNHLLAT :.: :.:.. ..: .:: .:. :: .: . : .. . : . .: :: :: :... XP_011 AAVRCVQYDGR-RVVSGAYDFMVKVWDPETET--C-LHTLQGHTNRVYSLQFDGIHVVS- 510 520 530 540 550 360 370 380 390 400 410 pF1KE4 GSSYYGVVRLWDRRQRACLHAFPLTSTPLSSPVYCLRLTTKHLYAALSYNLHVLDFQNP .: .:.:: . :.:.. XP_011 -GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQ 560 570 580 590 600 610 412 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 03:58:47 2016 done: Sun Nov 6 03:58:49 2016 Total Scan time: 8.060 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]