FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9447, 402 aa 1>>>pF1KE9447 402 - 402 aa - 402 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8128+/-0.000382; mu= 16.2534+/- 0.024 mean_var=125.6370+/-30.633, 0's: 0 Z-trim(115.0): 540 B-trim: 2666 in 2/50 Lambda= 0.114424 statistics sampled from 24557 (25253) to 24557 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.296), width: 16 Scan time: 8.400 The best scores are: opt bits E(85289) NP_055137 (OMIM: 606695) opsin-3 [Homo sapiens] ( 402) 2713 459.3 7.5e-129 NP_000530 (OMIM: 136880,180380,610445,613731) rhod ( 348) 596 109.8 1.1e-23 NP_006574 (OMIM: 605224) visual pigment-like recep ( 337) 588 108.4 2.6e-23 NP_001699 (OMIM: 190900,613522) short-wave-sensiti ( 348) 533 99.4 1.5e-20 NP_064445 (OMIM: 300822,303700,303900) long-wave-s ( 364) 523 97.7 4.7e-20 NP_000504 (OMIM: 300821,303700,303800) medium-wave ( 364) 512 95.9 1.7e-19 NP_859528 (OMIM: 609042) opsin-5 [Homo sapiens] ( 354) 491 92.4 1.8e-18 XP_016865905 (OMIM: 609042) PREDICTED: opsin-5 iso ( 408) 491 92.5 2e-18 XP_016865900 (OMIM: 609042) PREDICTED: opsin-5 iso ( 298) 472 89.2 1.4e-17 NP_001040 (OMIM: 182451) somatostatin receptor typ ( 391) 404 78.1 4e-14 NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 389 75.8 2.6e-13 XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 389 75.8 2.8e-13 NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 376 73.5 9.9e-13 NP_001048 (OMIM: 162321) substance-K receptor [Hom ( 398) 361 71.0 5.6e-12 NP_001025186 (OMIM: 606665) melanopsin isoform 2 [ ( 489) 359 70.8 8.1e-12 XP_016872444 (OMIM: 606665) PREDICTED: melanopsin ( 539) 359 70.9 8.6e-12 NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 355 70.0 1e-11 NP_057624 (OMIM: 605569) probable G-protein couple ( 423) 353 69.8 1.5e-11 NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 351 69.4 1.8e-11 NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 348 68.9 2.3e-11 NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 348 68.9 2.3e-11 NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 348 68.9 2.4e-11 NP_000668 (OMIM: 600445) adenosine receptor A3 iso ( 318) 345 68.3 3e-11 XP_016872446 (OMIM: 606665) PREDICTED: melanopsin ( 405) 339 67.4 7e-11 NP_000902 (OMIM: 165195) delta-type opioid recepto ( 372) 333 66.4 1.3e-10 NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 332 66.2 1.5e-10 NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 324 64.9 3.7e-10 XP_011541141 (OMIM: 125853,600804) PREDICTED: mela ( 362) 317 63.7 8.1e-10 NP_005950 (OMIM: 125853,600804) melatonin receptor ( 362) 317 63.7 8.1e-10 NP_001050 (OMIM: 162332,614840) neuromedin-K recep ( 465) 313 63.2 1.5e-09 NP_001012740 (OMIM: 600342,613769) RPE-retinal G p ( 253) 307 61.9 2e-09 NP_001012738 (OMIM: 600342,613769) RPE-retinal G p ( 291) 307 62.0 2.2e-09 NP_003848 (OMIM: 603691) galanin receptor type 2 [ ( 387) 307 62.1 2.7e-09 NP_005949 (OMIM: 600665) melatonin receptor type 1 ( 350) 305 61.7 3.1e-09 NP_002912 (OMIM: 600342,613769) RPE-retinal G prot ( 295) 301 61.0 4.4e-09 XP_016865901 (OMIM: 609042) PREDICTED: opsin-5 iso ( 285) 299 60.6 5.4e-09 XP_016865902 (OMIM: 609042) PREDICTED: opsin-5 iso ( 285) 299 60.6 5.4e-09 NP_000901 (OMIM: 162642) neuropeptide Y receptor t ( 381) 293 59.8 1.3e-08 XP_005263090 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 293 59.8 1.3e-08 XP_005263091 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 293 59.8 1.3e-08 NP_001269833 (OMIM: 165196) kappa-type opioid rece ( 291) 289 59.0 1.7e-08 NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 288 59.0 2.3e-08 NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 288 59.0 2.4e-08 NP_001138755 (OMIM: 600018) mu-type opioid recepto ( 397) 288 59.0 2.4e-08 NP_000905 (OMIM: 600018) mu-type opioid receptor i ( 400) 288 59.0 2.4e-08 NP_001138756 (OMIM: 600018) mu-type opioid recepto ( 403) 288 59.0 2.4e-08 NP_001138754 (OMIM: 600018) mu-type opioid recepto ( 406) 288 59.0 2.4e-08 NP_001272452 (OMIM: 600018) mu-type opioid recepto ( 414) 288 59.0 2.4e-08 NP_001008503 (OMIM: 600018) mu-type opioid recepto ( 418) 288 59.0 2.5e-08 NP_001138758 (OMIM: 600018) mu-type opioid recepto ( 420) 288 59.0 2.5e-08 >>NP_055137 (OMIM: 606695) opsin-3 [Homo sapiens] (402 aa) initn: 2713 init1: 2713 opt: 2713 Z-score: 2434.3 bits: 459.3 E(85289): 7.5e-129 Smith-Waterman score: 2713; 100.0% identity (100.0% similar) in 402 aa overlap (1-402:1-402) 10 20 30 40 50 60 pF1KE9 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 LVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 GSLFGIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GSLFGIVSIATLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 LDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRCVEDLQT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRCVEDLQT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 IQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 IQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 NTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 NTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRP 310 320 330 340 350 360 370 380 390 400 pF1KE9 KKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL :::::::::::::::::::::::::::::::::::::::::: NP_055 KKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL 370 380 390 400 >>NP_000530 (OMIM: 136880,180380,610445,613731) rhodopsi (348 aa) initn: 611 init1: 234 opt: 596 Z-score: 546.4 bits: 109.8 E(85289): 1.1e-23 Smith-Waterman score: 596; 31.6% identity (64.3% similar) in 297 aa overlap (35-325:31-322) 10 20 30 40 50 60 pF1KE9 NRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLV : : . :: . . .:: :.:.: NP_000 MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 LYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLF . . ..:::: . .:.:....::.. : : : :. . :.. .:. .:: .:: ..: NP_000 VTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 GIVSIATLTVLAYERYIRVVHARVINFSW----AWRAITYIWLYSLAWAGAPLLGWNRYI : ... .:.::: :::. :: . :: . : .... :...:: :. :: ::.::: NP_000 GEIALWSLVVLAIERYV-VVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYI 130 140 150 160 170 190 200 210 220 230 pF1KE9 LDVHGLGCTVDWKS--KDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLRCVEDL . .: .:. . ..:. :::...:. ...:. .: :::....... NP_000 PEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAA---- 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 QTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFA : . : ::....: ..:...::.::.:: . : . . .: : . . .:: NP_000 QQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFA 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE9 KSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGD :: ..::::::..: ..:: .: .: NP_000 KSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA 300 310 320 330 340 >>NP_006574 (OMIM: 605224) visual pigment-like receptor (337 aa) initn: 584 init1: 220 opt: 588 Z-score: 539.4 bits: 108.4 E(85289): 2.6e-23 Smith-Waterman score: 592; 32.0% identity (62.5% similar) in 328 aa overlap (35-354:19-329) 10 20 30 40 50 60 pF1KE9 NRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLV .:: .. .: : :.... .:..:: NP_006 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMAGMISIISNIIVLG 10 20 30 40 70 80 90 100 110 120 pF1KE9 LYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGC-VWDGFSGSL .. :...:::::. ...:....:. :: .: .. .: : ..: . .:: :. :.. . NP_006 IFIKYKELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQVYAGLN-IF 50 60 70 80 90 100 130 140 150 160 170 pF1KE9 FGIVSIATLTVLAYERYIRV----VHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRY ::..::. :::.: .::. . : :. . .. : :. .: :: :..:: : NP_006 FGMASIGLLTVVAVDRYLTICLPDVGRRMTTNTYIG-LILGAWINGLFWALMPIIGWASY 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE9 ILDVHGLGCTVDWKSKDANDSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRMLR---CVE : : ::..:...: . :... .. ..::: :. .:: :. ::. :.: NP_006 APDPTGATCTINWRKNDRSFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTE 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 DLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYL .:. .: ..:: .:: ::: : :: ..:. . : . . : ..:.. : NP_006 SLNRDWSDQI-----DVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 FAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKD ::::.: ::: ::: .::::..: .. .:: . .:... : :. .:: NP_006 FAKSSTFYNPCIYVVANKKFRRAMLAMF-----KCQTH-QTMPVTS----ILPMDVSQNP 290 300 310 320 330 360 370 380 390 400 pF1KE9 GDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL NP_006 LASGRI >>NP_001699 (OMIM: 190900,613522) short-wave-sensitive o (348 aa) initn: 470 init1: 180 opt: 533 Z-score: 490.2 bits: 99.4 E(85289): 1.5e-20 Smith-Waterman score: 533; 31.0% identity (62.6% similar) in 313 aa overlap (23-325:19-319) 10 20 30 40 50 60 pF1KE9 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNL :: . ::... . : ..:.. :.: : NP_001 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWA---FYLQAAFMGTVFLIGFPLNA 10 20 30 40 50 70 80 90 100 110 pF1KE9 LVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFV-SCLRNGW-VWDTVGCVWDG .::: ....:: : . .:::.:.. .:. .:.: .:: :: ::. :. :. .: NP_001 MVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASC--NGYFVFGRHVCALEG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 FSGSLFGIVSIATLTVLAYERYIRVVHARVINFSWAWR-AITYI---WLYSLAWAGAPLL : :.. :.:. .:. ::.:::: :. :: .. . :.: . : ... . :.. NP_001 FLGTVAGLVTGWSLAFLAFERYI-VICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 GWNRYILDVHGLGCTV--DWKSKDAN--DSSFVLFLFLGCLVVPLGVIAHCYGHILYSIR ::.:.: . :: :. :: . .. . :.. :::. :..:::..: : ..: : NP_001 GWSRFIPE--GLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLL---R 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 MLRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTI :. : : . : :.....: .:. .: ::..:: .. . .::...: . . NP_001 ALKAVAAQQQ-ESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 SIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPI . .:.:: .:::.:: :: ..:. .....: NP_001 VTIPSFFSKSACIYNPIIYCFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQ 290 300 310 320 330 340 360 370 380 390 400 pF1KE9 VMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL NP_001 VGPN >>NP_064445 (OMIM: 300822,303700,303900) long-wave-sensi (364 aa) initn: 537 init1: 233 opt: 523 Z-score: 481.0 bits: 97.7 E(85289): 4.7e-20 Smith-Waterman score: 523; 31.5% identity (64.0% similar) in 311 aa overlap (23-324:38-337) 10 20 30 40 50 pF1KE9 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIG :: . . :: . .:. .. . . NP_064 QRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRW---VYHLTSVWMIFVV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 LLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTV .: .: :::. .::..:: : . .:::....:: .... :...:. . . .: NP_064 TASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFVLGHP 70 80 90 100 110 120 120 130 140 150 160 pF1KE9 GCVWDGFSGSLFGIVSIATLTVLAYERYIRVVHAR-VINFS--WAWRAITYIWLYSLAWA :: .:.. :: ::... .:.....::.. : . . :. : .:.. :... .:. NP_064 MCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWT 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 GAPLLGWNRYILDVHGL--GCTVDWKSKDANDS--SFVLFLFLGCLVVPLGVIAHCYGHI . :..::.:: ::: .: : : .. . :... :.. : ..::..: :: .. NP_064 APPIFGWSRYW--PHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQV 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 LYSIRML-RCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVI-CFLVVNGHG .:: . . .. .. : : ::....: .:::.. ::: :: . :: ..: : NP_064 WLAIRAVAKQQKESESTQ-----KAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANP-G 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 HLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGS . : .. . :::: :.::::::::: :.:: .:::. NP_064 YAFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVS 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE9 EMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL NP_064 SVSSVSPA 360 >>NP_000504 (OMIM: 300821,303700,303800) medium-wave-sen (364 aa) initn: 523 init1: 223 opt: 512 Z-score: 471.2 bits: 95.9 E(85289): 1.7e-19 Smith-Waterman score: 512; 30.9% identity (64.3% similar) in 311 aa overlap (23-324:38-337) 10 20 30 40 50 pF1KE9 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIG :: . . :: . .:. .. . . NP_000 QRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRW---VYHLTSVWMIFVV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 LLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTV . .: .: :::. .::..:: : . .:::....:: .... :.. :. . . .: NP_000 IASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHP 70 80 90 100 110 120 120 130 140 150 160 pF1KE9 GCVWDGFSGSLFGIVSIATLTVLAYERYIRVVHAR-VINFS--WAWRAITYIWLYSLAWA :: .:.. :: ::... .:.....::.. : . . :. : .:.. :... .:. NP_000 MCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWT 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 GAPLLGWNRYILDVHGL--GCTVDWKSKDANDS--SFVLFLFLGCLVVPLGVIAHCYGHI . :..::.:: ::: .: : : .. . :... :.. : ..::..:. :: .. NP_000 APPIFGWSRYW--PHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQV 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 LYSIRML-RCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVI-CFLVVNGHG .:: . . .. .. : : ::....: .:...: :: :: . :: ..: : NP_000 WLAIRAVAKQQKESESTQ-----KAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANP-G 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 HLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGS . : .. . .:::: :.::::::::: :.:: .:::. NP_000 YPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVS 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE9 EMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL NP_000 SVSSVSPA 360 >>NP_859528 (OMIM: 609042) opsin-5 [Homo sapiens] (354 aa) initn: 492 init1: 228 opt: 491 Z-score: 452.6 bits: 92.4 E(85289): 1.8e-18 Smith-Waterman score: 491; 30.4% identity (63.0% similar) in 276 aa overlap (51-316:43-313) 30 40 50 60 70 80 pF1KE9 AEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLL ::.:.. .: :: . . .. :.... NP_859 RLPHYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMT 20 30 40 50 60 70 90 100 110 120 130 140 pF1KE9 VNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLFGIVSIATLTVLAYERY .:... :: .:. : ::..::. . ::. .:: : :..: .:: :. :.:... .:: NP_859 INLAVCDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRY 80 90 100 110 120 130 150 160 170 180 190 pF1KE9 IRVVHARVINFS-WAWRAITYI-----WLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKS ... . .... : : .:: : :. :. ::.: . :. . : .::.:: NP_859 LKICY---LSYGVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWL 140 150 160 170 180 200 210 220 230 240 250 pF1KE9 KDAN--DSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRML-RCVEDLQT-IQVIKILKYE .:. . :.: ... ::..: .::. : .:. ... . : ... :. ..: : NP_859 AQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVL--E 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE9 KKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYV ::.:. .:. ::. :.:: :. . :. . .:.: :.::: ..:::.:: NP_859 MKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQ 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE9 FMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSS . :: NP_859 VIDYKFACCQTGGLKATKKKSLEGFRLHTVTTVRKSSAVLEIHEEWE 310 320 330 340 350 >>XP_016865905 (OMIM: 609042) PREDICTED: opsin-5 isoform (408 aa) initn: 492 init1: 228 opt: 491 Z-score: 451.9 bits: 92.5 E(85289): 2e-18 Smith-Waterman score: 491; 30.4% identity (63.0% similar) in 276 aa overlap (51-316:43-313) 30 40 50 60 70 80 pF1KE9 AEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLL ::.:.. .: :: . . .. :.... XP_016 RLPHYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSSRRKKKLRPAEIMT 20 30 40 50 60 70 90 100 110 120 130 140 pF1KE9 VNISLSDLLVSLFGVTFTFVSCLRNGWVWDTVGCVWDGFSGSLFGIVSIATLTVLAYERY .:... :: .:. : ::..::. . ::. .:: : :..: .:: :. :.:... .:: XP_016 INLAVCDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRY 80 90 100 110 120 130 150 160 170 180 190 pF1KE9 IRVVHARVINFS-WAWRAITYI-----WLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKS ... . .... : : .:: : :. :. ::.: . :. . : .::.:: XP_016 LKICY---LSYGVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWL 140 150 160 170 180 200 210 220 230 240 250 pF1KE9 KDAN--DSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRML-RCVEDLQT-IQVIKILKYE .:. . :.: ... ::..: .::. : .:. ... . : ... :. ..: : XP_016 AQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVL--E 190 200 210 220 230 240 260 270 280 290 300 310 pF1KE9 KKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYV ::.:. .:. ::. :.:: :. . :. . .:.: :.::: ..:::.:: XP_016 MKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQ 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE9 FMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSS . :: XP_016 VIDYKFACCQTGGLKATKKKSLEGFRLHTVTTVRKSSAVLEIHEEDKGRLWHQLSCGENS 310 320 330 340 350 360 >>XP_016865900 (OMIM: 609042) PREDICTED: opsin-5 isoform (298 aa) initn: 468 init1: 204 opt: 472 Z-score: 436.5 bits: 89.2 E(85289): 1.4e-17 Smith-Waterman score: 472; 31.1% identity (63.8% similar) in 257 aa overlap (70-316:7-257) 40 50 60 70 80 90 pF1KE9 TYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTF ..:: :.... .:... :: .:. : ::. XP_016 MSSRRKKKLR-PAEIMTINLAVCDLGISVVGKPFTI 10 20 30 100 110 120 130 140 150 pF1KE9 VSCLRNGWVWDTVGCVWDGFSGSLFGIVSIATLTVLAYERYIRVVHARVINFS-WAWRAI .::. . ::. .:: : :..: .:: :. :.:... .::... . .... : : XP_016 ISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICY---LSYGVWLKRKH 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE9 TYI-----WLYSLAWAGAPLLGWNRYILDVHGLGCTVDWKSKDAN--DSSFVLFLFLGCL .:: : :. :. ::.: . :. . : .::.:: .:. . :.: ... :: XP_016 AYICLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCL 100 110 120 130 140 150 220 230 240 250 260 pF1KE9 VVPLGVIAHCYGHILYSIRML-RCVEDLQT-IQVIKILKYEKKLAKMCFLMIFTFLVCWM ..: .::. : .:. ... . : ... :. ..: : ::.:. .:. ::. :. XP_016 LLPTAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVL--EMKLTKVAMLICAGFLIAWI 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE9 PYIVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLL :: :. . :. . .:.: :.::: ..:::.:: . :: XP_016 PYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKK 220 230 240 250 260 270 330 340 350 360 370 380 pF1KE9 RCQRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKT XP_016 KSLEGFRLHTVTTVRKSSAVLEIHEEWE 280 290 >>NP_001040 (OMIM: 182451) somatostatin receptor type 1 (391 aa) initn: 285 init1: 105 opt: 404 Z-score: 374.5 bits: 78.1 E(85289): 4e-14 Smith-Waterman score: 404; 26.7% identity (58.8% similar) in 330 aa overlap (4-326:26-340) 10 20 30 pF1KE9 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSP :.:. : : :: : .. . :::: . NP_001 MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPG-RNASQNGTLSEGQ---- 10 20 30 40 50 40 50 60 70 80 90 pF1KE9 GTYERLALLLGSIGLLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFT :. .... . . :.:. .: .:. . .. ...: :.. ..:....: :. ...: : NP_001 GSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELL-MLSVPFL 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE9 FVSCLRNGWVWDTVGCVWDGFSGSLFGIVSIATLTVLAYERYIRVVH----ARVINFSWA .: : : . .. : .. ..:: ::::. .::. ::: :: . : NP_001 VTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVA 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE9 WRAITYIWLYSLAWAGAPLLGWNRYILDVHG-LGCTVDWKSKDAND--SSFVLFLFLGCL . .:. :: :.. ..: . : ..:.. . :. .:::. :: . NP_001 KVVNLGVWVLSLLVI-LPIVVFSRTAANSDGTVACNM-LMPEPAQRWLVGFVLYTFLMGF 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE9 VVPLGVIAHCYGHILYSIRMLRCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPY ..:.:.: :: :. ..::. : . . :.:.. : ......:..::::. NP_001 LLPVGAICLCYVLIIAKMRMVALKAGWQQRK-----RSERKITLMVMMVVMVFVICWMPF 240 250 260 270 280 280 290 300 310 320 330 pF1KE9 IVICFLVVNGHGHLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRC :. .:: .. :.: .: ... .:. ::..: :. .:.::. ..::: NP_001 YVV--QLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDN 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE9 QRPAKDLPAAGSEMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNG NP_001 AAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL 350 360 370 380 390 402 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 12:38:09 2016 done: Sun Nov 6 12:38:10 2016 Total Scan time: 8.400 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]