FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9525, 364 aa 1>>>pF1KE9525 364 - 364 aa - 364 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.0264+/-0.000398; mu= 24.3970+/- 0.025 mean_var=106.9403+/-28.569, 0's: 0 Z-trim(112.3): 515 B-trim: 2194 in 2/50 Lambda= 0.124023 statistics sampled from 20507 (21242) to 20507 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.249), width: 16 Scan time: 6.830 The best scores are: opt bits E(85289) NP_064445 (OMIM: 300822,303700,303900) long-wave-s ( 364) 2482 455.3 9.6e-128 NP_000504 (OMIM: 300821,303700,303800) medium-wave ( 364) 2419 444.1 2.4e-124 NP_001699 (OMIM: 190900,613522) short-wave-sensiti ( 348) 1027 195.0 2.2e-49 NP_000530 (OMIM: 136880,180380,610445,613731) rhod ( 348) 990 188.3 2.2e-47 NP_055137 (OMIM: 606695) opsin-3 [Homo sapiens] ( 402) 527 105.6 2e-22 NP_006574 (OMIM: 605224) visual pigment-like recep ( 337) 500 100.6 5.3e-21 NP_859528 (OMIM: 609042) opsin-5 [Homo sapiens] ( 354) 436 89.2 1.5e-17 XP_016865905 (OMIM: 609042) PREDICTED: opsin-5 iso ( 408) 436 89.3 1.6e-17 XP_016865900 (OMIM: 609042) PREDICTED: opsin-5 iso ( 298) 405 83.6 6.5e-16 NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 371 77.8 5.6e-14 XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 371 77.9 5.8e-14 XP_016872446 (OMIM: 606665) PREDICTED: melanopsin ( 405) 354 74.7 4.2e-13 NP_001025186 (OMIM: 606665) melanopsin isoform 2 [ ( 489) 354 74.8 4.6e-13 XP_016872444 (OMIM: 606665) PREDICTED: melanopsin ( 539) 354 74.9 4.9e-13 NP_005949 (OMIM: 600665) melatonin receptor type 1 ( 350) 345 72.9 1.2e-12 NP_001048 (OMIM: 162321) substance-K receptor [Hom ( 398) 339 72.0 2.7e-12 NP_001050 (OMIM: 162332,614840) neuromedin-K recep ( 465) 331 70.6 7.8e-12 NP_004215 (OMIM: 300207) melatonin-related recepto ( 617) 325 69.8 1.9e-11 NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 323 69.1 1.9e-11 NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 323 69.1 2e-11 NP_001049 (OMIM: 162323) substance-P receptor isof ( 407) 319 68.4 3.2e-11 XP_016865902 (OMIM: 609042) PREDICTED: opsin-5 iso ( 285) 317 67.8 3.5e-11 XP_016865901 (OMIM: 609042) PREDICTED: opsin-5 iso ( 285) 317 67.8 3.5e-11 NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 316 67.8 4.6e-11 NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 316 67.8 4.6e-11 NP_001138755 (OMIM: 600018) mu-type opioid recepto ( 397) 316 67.8 4.7e-11 NP_000905 (OMIM: 600018) mu-type opioid receptor i ( 400) 316 67.8 4.7e-11 NP_001138756 (OMIM: 600018) mu-type opioid recepto ( 403) 316 67.9 4.7e-11 NP_001138754 (OMIM: 600018) mu-type opioid recepto ( 406) 316 67.9 4.7e-11 NP_001272452 (OMIM: 600018) mu-type opioid recepto ( 414) 316 67.9 4.8e-11 NP_001008503 (OMIM: 600018) mu-type opioid recepto ( 418) 316 67.9 4.8e-11 NP_001138758 (OMIM: 600018) mu-type opioid recepto ( 420) 316 67.9 4.8e-11 NP_001008505 (OMIM: 600018) mu-type opioid recepto ( 446) 316 67.9 4.9e-11 NP_001138751 (OMIM: 600018) mu-type opioid recepto ( 493) 316 68.0 5.2e-11 NP_001272453 (OMIM: 600018) mu-type opioid recepto ( 493) 316 68.0 5.2e-11 NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 313 67.2 6.5e-11 NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 313 67.2 6.5e-11 NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 309 66.5 1.1e-10 XP_011541141 (OMIM: 125853,600804) PREDICTED: mela ( 362) 308 66.3 1.2e-10 NP_005950 (OMIM: 125853,600804) melatonin receptor ( 362) 308 66.3 1.2e-10 NP_000902 (OMIM: 165195) delta-type opioid recepto ( 372) 307 66.2 1.4e-10 NP_056542 (OMIM: 162323) substance-P receptor isof ( 311) 305 65.7 1.6e-10 NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 300 64.9 3.2e-10 XP_016874309 (OMIM: 602351) PREDICTED: chemokine-l ( 371) 298 64.6 4.2e-10 NP_004063 (OMIM: 602351) chemokine-like receptor 1 ( 371) 298 64.6 4.2e-10 NP_001135815 (OMIM: 602351) chemokine-like recepto ( 373) 298 64.6 4.2e-10 NP_001135817 (OMIM: 602351) chemokine-like recepto ( 373) 298 64.6 4.2e-10 NP_001135816 (OMIM: 602351) chemokine-like recepto ( 373) 298 64.6 4.2e-10 NP_115940 (OMIM: 176400,604161,614837) kiSS-1 rece ( 398) 298 64.6 4.3e-10 XP_016865898 (OMIM: 609042) PREDICTED: opsin-5 iso ( 303) 296 64.1 4.9e-10 >>NP_064445 (OMIM: 300822,303700,303900) long-wave-sensi (364 aa) initn: 2482 init1: 2482 opt: 2482 Z-score: 2414.4 bits: 455.3 E(85289): 9.6e-128 Smith-Waterman score: 2482; 99.5% identity (100.0% similar) in 364 aa overlap (1-364:1-364) 10 20 30 40 50 60 pF1KE9 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 IFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 IFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIAFSWIWS ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::. NP_064 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 AVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 AVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 QVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 QVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 PLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_064 PLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSS 310 320 330 340 350 360 pF1KE9 VSPA :::: NP_064 VSPA >>NP_000504 (OMIM: 300821,303700,303800) medium-wave-sen (364 aa) initn: 2419 init1: 2419 opt: 2419 Z-score: 2353.5 bits: 444.1 E(85289): 2.4e-124 Smith-Waterman score: 2419; 95.9% identity (98.6% similar) in 364 aa overlap (1-364:1-364) 10 20 30 40 50 60 pF1KE9 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 IFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFV :::: :::::::::::::::::::::::::::::::::::::::::::::.:::: :::: NP_000 IFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIAFSWIWS ::::::::::::::::::::::::::::::::.::::::::::::::::::::::::::. NP_000 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 AVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYL ::::::::::::::::::::::::::::::::::::::::::::::::: ::.::.:::: NP_000 AVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 QVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFH :::::::::::::::::::::::::::::::::..:.: :::::.:::::::::::: :: NP_000 QVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFH 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 PLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSS ::::::::.::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSS 310 320 330 340 350 360 pF1KE9 VSPA :::: NP_000 VSPA >>NP_001699 (OMIM: 190900,613522) short-wave-sensitive o (348 aa) initn: 1047 init1: 957 opt: 1027 Z-score: 1007.6 bits: 195.0 E(85289): 2.2e-49 Smith-Waterman score: 1027; 43.2% identity (75.7% similar) in 345 aa overlap (23-363:5-347) 10 20 30 40 50 60 pF1KE9 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM .. .. . : .:. ::..::.::::: :...: ...: NP_001 MRKMSEEEFYLFKNISSV-GPWDGPQYHIAPVWAFYLQAAFM 10 20 30 40 70 80 90 100 110 120 pF1KE9 IFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFV : . :..::.::...::::.:::.::::.. . . ... .: . .:::: NP_001 GTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFV 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE9 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIAFSWIWS .:. .:.:::. .. :.. ::::....::..:.:::::: ::..: :.. . .: . NP_001 FGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIG 110 120 130 140 150 160 190 200 210 220 230 pF1KE9 AVWTAPPIFGWSRYWPHGLKTSCGPDVFS-GSSYPGVQSYMIVLMVTCCIIPLAIIMLCY . ::.:::::. :.::. ::::: .. :..: . .:: :.. : :.::..: . : NP_001 IGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRS-ESYTWFLFIFCFIVPLSLICFSY 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 LQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAF :. :..::: ::.:: .:::::.::.::::::. ..:::. ::. :: . . : .... NP_001 TQLLRALKAVAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 HPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLF-GKKVDDGSELSSASKTEVSSV ....:..:.::: ::::.:: :::.::. ::... :: . : :. :..:::::.: NP_001 DLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTV 290 300 310 320 330 340 360 pF1KE9 SS--VSPA :: :.: NP_001 SSTQVGPN >>NP_000530 (OMIM: 136880,180380,610445,613731) rhodopsi (348 aa) initn: 965 init1: 965 opt: 990 Z-score: 971.8 bits: 188.3 E(85289): 2.2e-47 Smith-Waterman score: 990; 43.2% identity (74.5% similar) in 345 aa overlap (21-359:2-346) 10 20 30 40 50 pF1KE9 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNST---RGPFEGPNYHIAPRWVYHLTS ..:.. : ::.: :.::: :.:..: : . . . NP_000 MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLA 10 20 30 40 60 70 80 90 100 110 pF1KE9 VWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSG ..:..... . : :.: .:.. :::: :::.::.::::::: .. . : .. ... : NP_000 AYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHG 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE9 YFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIAFSW :::.: : :::. ..: : .::::.... ::..:::::..: :: . ::.:.::.: NP_000 YFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTW 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE9 IWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIML . . . .:::. ::::: :.::. ::: : .. . . .:..: ..:. ::. ::.. NP_000 VMALACAAPPLAGWSRYIPEGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFF 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 CYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGY :: :. .... .: ::.:: .::::::::::::..:..:. .:: ::. : . .. : NP_000 CYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGS 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 AFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLF--GKK-VDDGSELSSASKTE : :.. ..::.:::::.:::::::..::.:::::.: . ::. . : ...:::: NP_000 NFGPIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTE 290 300 310 320 330 340 360 pF1KE9 VSSVSSVSPA .:.:. NP_000 TSQVAPA >>NP_055137 (OMIM: 606695) opsin-3 [Homo sapiens] (402 aa) initn: 541 init1: 233 opt: 527 Z-score: 523.5 bits: 105.6 E(85289): 2e-22 Smith-Waterman score: 527; 31.8% identity (64.0% similar) in 311 aa overlap (38-337:23-324) 10 20 30 40 50 60 pF1KE9 QRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRW---VYHLTSVWMIFVV :: . . :: . .:. .. . . NP_055 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIG 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 TASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFVLGHP .: .: :::. .::..:: : . .:::....:: .... :...:. . . .: NP_055 LLGVGNNLLVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFVSCLRNGWVWDTV 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 MCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIAFSWIWSAVWT :: .:.. :: ::... .:.....::.. : . . :. : .:.. :..: .:. NP_055 GCVWDGFSGSLFGIVSIATLTVLAYERYIRVVHAR-VINFS--WAWRAITYIWLYSLAWA 120 130 140 150 160 190 200 210 220 230 240 pF1KE9 APPIFGWSRYW--PHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQV . :..::.:: ::: .: : : .. .:... :.. : ..::..: :: .. NP_055 GAPLLGWNRYILDVHGL--GCTVDWKSKDAND--SSFVLFLFLGCLVVPLGVIAHCYGHI 170 180 190 200 210 220 250 260 270 280 290 pF1KE9 WLAIRAVAKQQKESESTQ-----KAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANP-G .:: . . .. .. : : ::....: .:::.. ::: :: . :: ..: : NP_055 LYSIRML-RCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPY-IVICFLVVNGHG 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE9 YAFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVS . : .. . :::: :.::::::::: :.:: .:::. NP_055 HLVTPTISIVSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGS 290 300 310 320 330 340 360 pF1KE9 SVSSVSPA NP_055 EMQIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL 350 360 370 380 390 400 >>NP_006574 (OMIM: 605224) visual pigment-like receptor (337 aa) initn: 349 init1: 242 opt: 500 Z-score: 498.1 bits: 100.6 E(85289): 5.3e-21 Smith-Waterman score: 500; 28.7% identity (64.5% similar) in 307 aa overlap (53-356:25-328) 30 40 50 60 70 80 pF1KE9 TQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVTASVFTNGLVLAATMKFK ........:.. :...: .::. .:.: NP_006 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMAGMISIISNIIVLGIFIKYK 10 20 30 40 50 90 100 110 120 130 140 pF1KE9 KLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFVLGHPMC-VLEGYTVSLCGITGL .:: : : :..::::.:.. . :. .: .... : . .:. : : : .. . :.... NP_006 ELRTPTNAIIINLAVTDIGVSSIGYPMSAASDLYGSWKFGYAGCQVYAGLNI-FFGMASI 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE9 WSLAIISWERWLVVCKPFGNVRFDAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPHGLKT :.... .:.:..: : . :. .. : : .:: . :. ::.::. : : . NP_006 GLLTVVAVDRYLTICLPDVGRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGA 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE9 SCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRA-VAKQQKESESTQ .: . ... . :: ..... :.::.... :: .: :.:. .... :: . . NP_006 TCTINWRKNDR--SFVSYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRD 180 190 200 210 220 230 270 280 290 300 310 pF1KE9 KAEK-EVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFHPLMAALPAYFAKSATIYNP ... .::.: :.:: . : :.::.. .:. . . : :: . ::::.:.::: NP_006 WSDQIDVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNP 240 250 260 270 280 290 320 330 340 350 360 pF1KE9 VIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA ::: :..:: .: .: .. . ..: .:: NP_006 CIYVVANKKFRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI 300 310 320 330 >>NP_859528 (OMIM: 609042) opsin-5 [Homo sapiens] (354 aa) initn: 340 init1: 234 opt: 436 Z-score: 436.0 bits: 89.2 E(85289): 1.5e-17 Smith-Waterman score: 436; 24.8% identity (61.0% similar) in 315 aa overlap (51-357:30-344) 30 40 50 60 70 pF1KE9 DSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVTA-SVFTNGLVLAATM : :.. ... .. :.: :: :: . NP_859 MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSS 10 20 30 40 50 80 90 100 110 120 130 pF1KE9 KFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFVLGHPMCVLEGYTVSLCGIT . :: .: . . .:::: ::. .:... ..:.. .:.: : :.. . : NP_859 RRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCG 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE9 GLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPHGL .: ... .: .:.: .: .: . : : . .: : ... ::. :. : . : :. . NP_859 SLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPF 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE9 KTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQ----QKE ::: : . ... : : ... .. : ..: :.:.. :... ... .:. ... NP_859 GTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE9 SESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFHPLMAALPAYFAKSAT .:.. : ..:...... .. . : ::. . ..: . .. ....:. .::::. NP_859 IHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAA 240 250 260 270 280 290 320 330 340 350 360 pF1KE9 IYNPVIYVFMNRQFRNCI---LQLFGKKVDDGSELSSASKTEVSSVSSVSPA .:::.:: .. .: : :. :: .: .: ... .. :: NP_859 MYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFRLHTVTTVRKSSAVLEIHEEWE 300 310 320 330 340 350 >>XP_016865905 (OMIM: 609042) PREDICTED: opsin-5 isoform (408 aa) initn: 340 init1: 234 opt: 436 Z-score: 435.5 bits: 89.3 E(85289): 1.6e-17 Smith-Waterman score: 436; 24.8% identity (61.0% similar) in 315 aa overlap (51-357:30-344) 30 40 50 60 70 pF1KE9 DSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVTA-SVFTNGLVLAATM : :.. ... .. :.: :: :: . XP_016 MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMSS 10 20 30 40 50 80 90 100 110 120 130 pF1KE9 KFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFVLGHPMCVLEGYTVSLCGIT . :: .: . . .:::: ::. .:... ..:.. .:.: : :.. . : XP_016 RRKKKLRPAEIMTINLAVCDLGISVVGKPFTIISCFCHRWVFGWIGCRWYGWAGFFFGCG 60 70 80 90 100 110 140 150 160 170 180 190 pF1KE9 GLWSLAIISWERWLVVCKPFGNVRFDAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPHGL .: ... .: .:.: .: .: . : : . .: : ... ::. :. : . : :. . XP_016 SLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPEPF 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE9 KTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAIRAVAKQ----QKE ::: : . ... : : ... .. : ..: :.:.. :... ... .:. ... XP_016 GTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFDSR 180 190 200 210 220 230 260 270 280 290 300 310 pF1KE9 SESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFHPLMAALPAYFAKSAT .:.. : ..:...... .. . : ::. . ..: . .. ....:. .::::. XP_016 IHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKSAA 240 250 260 270 280 290 320 330 340 350 360 pF1KE9 IYNPVIYVFMNRQFRNCI---LQLFGKKVDDGSELSSASKTEVSSVSSVSPA .:::.:: .. .: : :. :: .: .: ... .. :: XP_016 MYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFRLHTVTTVRKSSAVLEIHEEDKGRLWH 300 310 320 330 340 350 XP_016 QLSCGENSEMTASSETLGTKAHSPLQETREGENEAVGGNNKCSGCEECI 360 370 380 390 400 >>XP_016865900 (OMIM: 609042) PREDICTED: opsin-5 isoform (298 aa) initn: 308 init1: 202 opt: 405 Z-score: 406.7 bits: 83.6 E(85289): 6.5e-16 Smith-Waterman score: 405; 25.4% identity (61.8% similar) in 283 aa overlap (82-357:7-288) 60 70 80 90 100 110 pF1KE9 VYHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISI :::: : . . .:::: ::. .:... ..: XP_016 MSSRRKKKLR-PAEIMTINLAVCDLGISVVGKPFTI 10 20 30 120 130 140 150 160 170 pF1KE9 VNQVSGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLAIV .. .:.: : :.. . : .: ... .: .:.: .: .: . : : . XP_016 ISCFCHRWVFGWIGCRWYGWAGFFFGCGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYI 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE9 GIAFSWIWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCIIP .: : ... ::. :. : . : :. . ::: : . ... : : ... .. : ..: XP_016 CLAAIWAYASFWTTMPLVGLGDYVPEPFGTSCTLDWWLAQASVGGQVFILNILFFCLLLP 100 110 120 130 140 150 240 250 260 270 280 pF1KE9 LAIIMLCYLQVWLAIRAVAKQ----QKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFF :.:.. :... ... .:. ... .:.. : ..:...... .. . : ::. XP_016 TAVIVFSYVKIIAKVKSSSKEVAHFDSRIHSSHVLEMKLTKVAMLICAGFLIAWIPYAVV 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE9 ACFAAANPGYAFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCI---LQLFGKKVDDG . ..: . .. ....:. .::::..:::.:: .. .: : :. :: .: XP_016 SVWSAFGRPDSIPIQLSVVPTLLAKSAAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEG 220 230 240 250 260 270 350 360 pF1KE9 SELSSASKTEVSSVSSVSPA .: ... .. :: XP_016 FRLHTVTTVRKSSAVLEIHEEWE 280 290 >>NP_150598 (OMIM: 606665) melanopsin isoform 1 [Homo sa (478 aa) initn: 445 init1: 137 opt: 371 Z-score: 372.0 bits: 77.8 E(85289): 5.6e-14 Smith-Waterman score: 500; 28.0% identity (63.9% similar) in 346 aa overlap (18-335:27-363) 10 20 30 40 pF1KE9 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTY----TNSNSTRGPFEG----- :. ::.:::: . . : .. : . . NP_150 MNPPSGPRVPPSPTQEPSCMATPAPPSWWDSSQSSISSLGRLPSISPTAPGTWAAAWVPL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 PNYHIAPRWVYHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAE :. . . : : .: ...: .... : :. . . ..:: : : ...::::.:. NP_150 PTVDVPDHAHYTLGTV-ILLVGLTGMLGNLTVIYTFCRSRSLRTPANMFIINLAVSDFLM 70 80 90 100 110 110 120 130 140 150 pF1KE9 TVIASTISIVNQVSGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKP---F . . . ..... ...:. : . .. .: ::... .:. :. .:.::. .: : NP_150 SFTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFGISSMITLTAIALDRYLVITRPLATF 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE9 GNV-RFDAKLAIVGIAFSWIWSAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQS : . . : ....:. :... .:. ::.:::: : :.:: :::. : .: . :.:.. NP_150 GVASKRRAAFVLLGV---WLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMSFT--PAVRA 180 190 200 210 220 230 220 230 240 250 260 pF1KE9 YMIVLMVTCCII---PLAIIMLCYLQVWLAIRAVAKQQK-------ESEST---QKAEKE : ..: ::.. :: ::. ::. .. ::: ... . ..:: :. ..: NP_150 YTMLL---CCFVFFLPLLIIIYCYIFIFRAIRETGRALQTFGACKGNGESLWQRQRLQSE 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE9 --VTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAFHPLMAALPAYFAKSATIYNPVIYV ........:. . . :.::. : : :. .... : :...:: .::...:.::.::. NP_150 CKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMSSVPAVIAKASAIHNPIIYA 300 310 320 330 340 350 330 340 350 360 pF1KE9 FMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA . . ..: : : NP_150 ITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRSTLTSHTSNLSWISIRRRQES 360 370 380 390 400 410 364 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 12:42:59 2016 done: Sun Nov 6 12:43:00 2016 Total Scan time: 6.830 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]