FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2309, 1257 aa 1>>>pF1KE2309 1257 - 1257 aa - 1257 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 12.4802+/-0.000446; mu= -9.4624+/- 0.028 mean_var=482.8480+/-97.846, 0's: 0 Z-trim(123.1): 164 B-trim: 0 in 0/59 Lambda= 0.058367 statistics sampled from 42133 (42326) to 42133 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.496), width: 16 Scan time: 14.730 The best scores are: opt bits E(85289) NP_003595 (OMIM: 300904) insulin receptor substrat (1257) 8609 740.7 1.5e-212 XP_006724776 (OMIM: 300904) PREDICTED: insulin rec (1256) 8602 740.1 2.2e-212 XP_005262277 (OMIM: 300904) PREDICTED: insulin rec (1256) 8594 739.4 3.5e-212 XP_011529363 (OMIM: 300904) PREDICTED: insulin rec (1300) 8594 739.4 3.6e-212 NP_005535 (OMIM: 125853,147545) insulin receptor s (1242) 758 79.6 1.5e-13 NP_003740 (OMIM: 125853,600797) insulin receptor s (1338) 716 76.0 1.8e-12 NP_000217 (OMIM: 144200,607606) keratin, type I cy ( 623) 360 45.8 0.0011 >>NP_003595 (OMIM: 300904) insulin receptor substrate 4 (1257 aa) initn: 8609 init1: 8609 opt: 8609 Z-score: 3937.1 bits: 740.7 E(85289): 1.5e-212 Smith-Waterman score: 8609; 100.0% identity (100.0% similar) in 1257 aa overlap (1-1257:1-1257) 10 20 30 40 50 60 pF1KE2 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KE2 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR 1210 1220 1230 1240 1250 >>XP_006724776 (OMIM: 300904) PREDICTED: insulin recepto (1256 aa) initn: 8602 init1: 8602 opt: 8602 Z-score: 3933.9 bits: 740.1 E(85289): 2.2e-212 Smith-Waterman score: 8602; 100.0% identity (100.0% similar) in 1256 aa overlap (1-1256:1-1256) 10 20 30 40 50 60 pF1KE2 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KE2 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRG 1210 1220 1230 1240 1250 >>XP_005262277 (OMIM: 300904) PREDICTED: insulin recepto (1256 aa) initn: 8594 init1: 8594 opt: 8594 Z-score: 3930.3 bits: 739.4 E(85289): 3.5e-212 Smith-Waterman score: 8594; 100.0% identity (100.0% similar) in 1255 aa overlap (1-1255:1-1255) 10 20 30 40 50 60 pF1KE2 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KE2 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRE 1210 1220 1230 1240 1250 >>XP_011529363 (OMIM: 300904) PREDICTED: insulin recepto (1300 aa) initn: 8594 init1: 8594 opt: 8594 Z-score: 3930.1 bits: 739.4 E(85289): 3.6e-212 Smith-Waterman score: 8594; 100.0% identity (100.0% similar) in 1255 aa overlap (1-1255:1-1255) 10 20 30 40 50 60 pF1KE2 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLETADAPARLEYYENARKFRH 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLIALFTQDEYFAMV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAAAEPPFYKDVWQVIVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGAHLLTLLSARRH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LGLVPLEPGGWLRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSRRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE2 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGS 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE2 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGS 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE2 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCVD 610 620 630 640 650 660 670 680 690 700 710 720 pF1KE2 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVSSSDYMPM 670 680 690 700 710 720 730 740 750 760 770 780 pF1KE2 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 APQNVSASKKRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSESDYM 730 740 750 760 770 780 790 800 810 820 830 840 pF1KE2 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG 790 800 810 820 830 840 850 860 870 880 890 900 pF1KE2 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LDKEVSYNWDPKDAASKPSGEGSFSKPGDGGSPSKPSDHEPPKNKAKRPNRLSFITKGYK 850 860 870 880 890 900 910 920 930 940 950 960 pF1KE2 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IKPKPQKPTHEQREADSSSDYVNMDFTKRESNTPAPSTQGLPDSWGIIAEPRQSAFSNYV 910 920 930 940 950 960 970 980 990 1000 1010 1020 pF1KE2 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NVEFGVPFPNPANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVI 970 980 990 1000 1010 1020 1030 1040 1050 1060 1070 1080 pF1KE2 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FNSAMTPAMALADSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQ 1030 1040 1050 1060 1070 1080 1090 1100 1110 1120 1130 1140 pF1KE2 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ERRRPQSRSQSFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASAL 1090 1100 1110 1120 1130 1140 1150 1160 1170 1180 1190 1200 pF1KE2 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSANLARGD 1150 1160 1170 1180 1190 1200 1210 1220 1230 1240 1250 pF1KE2 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NQAGGAAAAAAAPEPPPRSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRDGNFK 1210 1220 1230 1240 1250 1260 XP_011 SPLQSDYIATKTHFRRKVMLMEFYLRLLQICLKERKLRGF 1270 1280 1290 1300 >>NP_005535 (OMIM: 125853,147545) insulin receptor subst (1242 aa) initn: 911 init1: 510 opt: 758 Z-score: 364.3 bits: 79.6 E(85289): 1.5e-13 Smith-Waterman score: 1196; 29.3% identity (53.3% similar) in 1231 aa overlap (78-1218:12-1140) 50 60 70 80 90 100 pF1KE2 SSCPGAMWLSTATGSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLET-ADAP .: : ::::: : :.:.:::. . : .: NP_005 MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGP 10 20 30 40 110 120 130 140 150 160 pF1KE2 ARLEYYENARKFRHSVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRH :::::::: .:.::. : :.: : : .::....:::.. .: NP_005 ARLEYYENEKKWRHKSSA-------------------PKRSIPLESCFNINKRADSKNKH 50 60 70 80 170 180 190 200 210 220 pF1KE2 LIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGT--LGAQPDGEPAALAAA- :.::.:.::.::..:..:.::.::: : .: ..: .. :. ::: : . ... NP_005 LVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSGL 90 100 110 120 130 140 230 240 250 260 270 pF1KE2 -AAAE-------PP--FYKDVWQVIVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVA :.: :: .:.:::::.::.:::. :.: :..:::::.. . ::.::.:.: NP_005 GEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLIGIYRLCLTSKTISFVKLNSEAA 150 160 170 180 190 200 280 290 300 310 320 330 pF1KE2 SVVVQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDCVVAQNMHELFLEKMRALCA .::.::..::::::::..::.:::::.: ::::.:::::: :::::::: .:: :::. . NP_005 AVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSVVAQNMHETILEAMRAM-S 210 220 230 240 250 260 340 350 360 370 380 pF1KE2 DEYRARCRSYSISIGAHLLTLLSARRHLGLVPLEPGGWLRRSRFEQFC------------ ::.: : .: : : .. ... :.::. : : :::: :.. NP_005 DEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSRTESITATSPASMVGGKP 270 280 290 300 310 320 390 400 410 420 430 pF1KE2 ---HLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGRRSRRAVSVPASFFRRLAP ..:: .::: : .: . . ::. : .: : : : : : . : . : . : NP_005 GSFRVRASSDGEGTM--SRPASVDGSPVSPST-NRTHAHRHRGSAR-LHPPLNHSRSI-P 330 340 350 360 370 440 450 460 470 480 490 pF1KE2 SPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGNPQGKEDQEGSGGDYM-PMNNWGSGN :: :. .: :: :.:.. :. :: .: . : . .: . NP_005 MPASRCSPSA--------TSPVSLSSSSTSGH-----------GSTSDCLFPRRSSASVS 380 390 400 410 500 510 520 530 540 550 pF1KE2 GRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGSGGNQCSRDGQGTAGGHG : : :: :. . .:: . .. . : : . . : .. : . ::.: NP_005 GSPSDGGFISSDEYGSSPCDFRSSFRSVTPDS---LGHTPPARGEEELS--NYICMGGKG 420 430 440 450 460 470 560 570 580 590 600 610 pF1KE2 SGGGQRPGGGHG-SGGGQGPGDGHGSGGGKNSGGGKGSGSGKGSDGDGERGKSLKKRSYF . :.: . : ::.: :.: : .: . :. .....: :.. ..::.. NP_005 PSTLTAPNGHYILSRGGNGHRCTPGTGLG-TSPALAGDEAASAADLDNR----FRKRTHS 480 490 500 510 520 620 630 640 650 660 pF1KE2 GKLTQSKQQQMPPPPPPP----------PPPPPAGGTGGKGKSGGRFRLYFCVDRGATKE . . . .: : : ::.::.:: . :. . : :. .: NP_005 AGTSPTITHQKTPSQSSVASIEEYTEMMPAYPPGGGSGG--RLPGHRHSAFVPTRSYPEE 530 540 550 560 570 580 670 680 690 700 710 720 pF1KE2 CKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMRPGVATPLVS----SSDYMPMAP : . : : :: . :: :.:: :::: :. : :.:::::.: NP_005 GLEMH-------PLERRGGHHRPDSSTLHTDDGYMPMSPGVA-PVPSGRKGSGDYMPMSP 590 600 610 620 630 730 740 750 760 770 pF1KE2 QNVSASK------KRHSRSPFEDSRGYMMMFPRVSPPPAPSPPKAPDTNKEDDSKDNDSE ..::: . .:: . : ::::: : : .:. .:.... ... .. NP_005 KSVSAPQQIINPIRRHPQR--VDPNGYMMMSP--SGGCSPDIGGGPSSSSSSSNAVPSGT 640 650 660 670 680 690 780 790 800 810 820 pF1KE2 SDYMFMAPGAGAI-------PKNPRNPQGGSSSKSWSSYFSL-P--NPFRSSP----LGQ : . . :.:. :: : . .::. ..:... : . ::: : NP_005 SYGKLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGP 700 710 720 730 740 750 830 840 850 860 870 pF1KE2 NDNSEYVPMLPGKFLGRGLDKEVSYNWDPKDAA-------SKPSGEGSFSKPGDGGSPSK .: .. :.: : :.. :... .:...: : ::. .. .: .: : NP_005 ED-PQHKPVLSYYSLPRSF-KHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSST 760 770 780 790 800 810 880 890 900 910 920 pF1KE2 PSDHEPPKNKAKRPNRLSFITKGYKIKPKPQKPTHE------QREADSSSDYVNMDFTKR :: :. : ...:. .: :. :..:.... . NP_005 SSDS------------LGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTAAQTNSRLARPT 820 830 840 850 930 940 950 960 970 980 pF1KE2 ESNTPAPSTQGLP-------DSWGIIAEPRQSAFSNYVNVEFGVPFPNPANDLSDLLRAI . . :... :: .. .. :. .. ..:::.::: .: : : NP_005 RLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIEFG-------SDQSGYL--- 860 870 880 890 900 990 1000 1010 1020 1030 1040 pF1KE2 PRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVIFNSAMTPAMALADSAIRYDAET ..:... :. : . . . : .:: : .. . :. : . .: NP_005 --SGPVAFHSS----PSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQE-STGVEM 910 920 930 940 950 960 1050 1060 1070 1080 1090 1100 pF1KE2 GRIYVVDPFSEC-CMDISLSPSRCSEPPPVARLLQEEEQERRRPQSRSQSFFAAARAAVS ::. . : . : :: :. .. .. .: . . .: :.... NP_005 GRLGPAPPGAASICRPTRAVPS--SRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIA 970 980 990 1000 1010 1020 1110 1120 1130 1140 1150 pF1KE2 AFPTDSLERDLSPSSAPAVASAAEPTLALSQV-VAAASALAAAP-GIGAAAAAAGFDSAS : . :: : ... . :..: :: . . .:: :.: ..: : :. .: . . . NP_005 AEEV-SLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSP 1030 1040 1050 1060 1070 1160 1170 1180 1190 1200 1210 pF1KE2 ARWFQPVANAADAEAVRGAQDVAG-GSNPGAHNPSANLARGDNQA-GGAAAAAAAPEPPP : . . :: .. : .. .:.:.: . .. : . : ::....... : NP_005 NRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAVGGGGGSSSSSEDVK 1080 1090 1100 1110 1120 1130 1220 1230 1240 1250 pF1KE2 RSRRVPRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR : NP_005 RHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDLVKDFKQCPQECTPEP 1140 1150 1160 1170 1180 1190 >>NP_003740 (OMIM: 125853,600797) insulin receptor subst (1338 aa) initn: 1124 init1: 469 opt: 716 Z-score: 344.7 bits: 76.0 E(85289): 1.8e-12 Smith-Waterman score: 1136; 29.9% identity (52.1% similar) in 1308 aa overlap (79-1226:31-1212) 50 60 70 80 90 100 pF1KE2 SCPGAMWLSTATGSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLKLE------- : : ::::::::::.:.:::. NP_003 MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA 10 20 30 40 50 60 110 120 130 140 150 pF1KE2 -----TADAPARLEYYENARKFRHSVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSV .: : ::::::. .:.: . .:: :.:::.: :... NP_003 TAGGGSAPQPPRLEYYESEKKWR------------SKAGA-------PKRVIALDCCLNI 70 80 90 100 160 170 180 190 200 210 pF1KE2 SQRADARYRHLIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGAQPDGE ..::::....::::.:.:::::..::::.:::.:: :. :. :. : .. : : . NP_003 NKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEG---RAAAGDAPPAAA 110 120 130 140 150 220 230 240 250 pF1KE2 PAAL------------AAAAAAEPPF---------YKDVWQVIVKPRGLGHRKELSGVFR ::: :.::.:: . :..:::: .::.:::. :.:.::.: NP_003 PAASCSASLPGALGGSAGAAGAEDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYR 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE2 LCLTDEEVVFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDCV :::. . . ::.:: : ::..::..:::::::...::.:::::.: ::::::::.:: : NP_003 LCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSV 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE2 VAQNMHELFLEKMRALCAD-EYRARCRSYSISIGA-HLLTLLSARRHLGLVPLEPG--GW ::::.:: .:: :.:: :.: : .: : . .: : ... .:::: :: : :. : NP_003 VAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGL 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE2 LRRSRFEQFCHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGRRSRRAVSVPAS .:::: ... .:: :.:. :.. . :... :. NP_003 VRRSRTDSLA------------------ATP--PAAKCSSCRVRTASEGDGGAAAGAAAA 340 350 360 370 440 450 460 470 480 pF1KE2 FFR--RLAPSPARPRHPAEAPNNGARLSSEVSGSGSGNFGEEGN--PQGKEDQEGSGGDY : .: :: : :..:: : .:: : :. : . : : :. : . NP_003 GARPVSVAGSPLSP-GPVRAP---LSRSHTLSG-GCGGRGSKVALLPAGGALQH-SRSMS 380 390 400 410 420 430 490 500 510 520 530 pF1KE2 MPM-NNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQ------CSGEGQ-GSRGGQGSNGQG ::. .. .... :: ......:.:: : . : :: : :. ...:. NP_003 MPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQRPSSGSASASGSP 440 450 460 470 480 490 540 550 560 570 580 pF1KE2 SGGNQCSRDGQGTAGG-------HGSGG----GQRPGGGHGSGGGQGPGDGHGSGGGKNS : . : : :.. : : :. .. : . :.:::. : . .. NP_003 SDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGGEFYGYMTMDRPLSHC 500 510 520 530 540 550 590 600 610 620 630 640 pF1KE2 GGGKGSGSGKGSDGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGK : . :: ... : .:: :.::.: . : ..:. .: : . .: NP_003 GRSYRRVSGDAAQ-DLDRG--LRKRTY-SLTTPARQRPVPQPSSASLDEYTLMRATFSG- 560 570 580 590 600 650 660 670 680 690 700 pF1KE2 SGGRFRLYFCVDRGATKECKEAKEVKDAEIPEGAAR---GPHRARAFDEDEDDPYVPMRP :.:: .: . :. . .: :: . : ::. . . :: :.:: : NP_003 SAGR----LCPSCPAS-----SPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTP 610 620 630 640 650 710 720 730 740 750 pF1KE2 GVA-----TPLVSSSDYMPMAPQNVSASKKRHSRSPFEDSRGYMMMFPRVSPP-PAPSP- :.: . :.:::::.: .::: :. .: . . . : ..: :::. NP_003 GAALAGSGSGSCRSDDYMPMSPASVSAPKQ--ILQP-RAAAAAAAAVPSAGPAGPAPTSA 660 670 680 690 700 710 760 770 780 pF1KE2 -----P------KA--PDTNKEDDS-------------KDNDSE----SDYMFMAPGAGA : :: : .. .:: . :.. .::. ..:. .. NP_003 AGRTFPASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAV 720 730 740 750 760 770 790 800 810 820 830 840 pF1KE2 IPKNPRN------PQGGSSSKSWSS--YFSLPNPFRSSPLGQNDNSEYVPMLPGKFLGRG .: . :: .. . : ::: ... .:...:: : .. .:: NP_003 TTGTPPDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLM--SSPVGRI 780 790 800 810 820 830 850 860 870 880 890 pF1KE2 LDKEV---SYNWDPKDAASKPSGEGSFSKPGDG-GSPSKPSDHEPP-----KNKAKRPNR :..: . . :..::: : : . : :: .:: .: ...: ::.: NP_003 LEEERLEPQATPGPSQAASA-FGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTR 840 850 860 870 880 890 900 910 920 930 pF1KE2 LSFITKGYKIKPKPQKPT-HEQR---EADSSSDYVNMDFTKRES--NTPAP-------ST ::. .: :. :. :: : : ..:.:.:: . . . ::: :. NP_003 LSL--EGL-----PSLPSMHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASS 900 910 920 930 940 940 950 960 970 pF1KE2 QGL-----PDSW------GIIAEPRQ-SAFSNYVNVEF--------GVPFPNPANDLSDL ..: : : : .. :: : .:.:.:..: :.: .:...:. : NP_003 SSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGL 950 960 970 980 990 1000 980 990 1000 1010 1020 1030 pF1KE2 LRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEE------GDYIEVIFNSAMTPAMALA : :.:. : :::: : ::. :.... :. .. ::.. :.. NP_003 LS--PEAS-----SPYPPLPPRP-SASPSSSLQPPPPPPAPGELYRLPPASAVATAQG-P 1010 1020 1030 1040 1050 1040 1050 1060 1070 1080 1090 pF1KE2 DSAIRYDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQERRRPQSRSQSF .: ...:: ..: . .. .: : :.: .:. NP_003 GAASSLSSDTGDN---GDYTEMAFGVAATP-----PQPIA--------APPKPE------ 1060 1070 1080 1090 1100 1110 1120 1130 1140 1150 pF1KE2 FAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAASALAAAPGIGAAAAA :::.: ::....: : .:..: : :: : :: . NP_003 --AARVAS---PTSGVKR----LSLMEQVSGVEAFLQASQ--------PPDPHRGAKVIR 1100 1110 1120 1130 1160 1170 1180 1190 1200 1210 pF1KE2 AGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGAHNPSA--NLARGDNQAGGAAAAA : : ..: . . ... .: .. . . :: :: .. :.. .. ::.... NP_003 A--DPQGGRRRHSSETFSSTTTVTPVSP-SFAHNPKRHNSASVENVSLRKSSEGGVGVGP 1140 1150 1160 1170 1180 1190 1220 1230 1240 1250 pF1KE2 AAPEPPPRSRRV--PRPPEREDSDNDDDTHVRMDFARRDNQFDSPKRGR .. . :: : : : :: NP_003 GGGDEPPTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYI 1200 1210 1220 1230 1240 1250 >>NP_000217 (OMIM: 144200,607606) keratin, type I cytosk (623 aa) initn: 1534 init1: 309 opt: 360 Z-score: 187.1 bits: 45.8 E(85289): 0.0011 Smith-Waterman score: 372; 44.3% identity (66.5% similar) in 158 aa overlap (453-607:460-601) 430 440 450 460 470 pF1KE2 RRAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGS---GNFGEEGNPQGKED :.. . : ::.:. :. : :. :. . NP_000 IECQNQEYSLLLSIKMRLEKEIETYHNLLEGGQEDFESSGAGKIGLGGRGGSGGSYGRGS 430 440 450 460 470 480 480 490 500 510 520 530 pF1KE2 QEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQG . ::::.: :.:.: : :::.:: : ::.. .:: :: : :: :: :. : NP_000 RGGSGGSYG-----GGGSGGGYGGGSGSRG-GSGGSYGGG---SGSGGGSGGGYGG---G 490 500 510 520 530 540 550 560 570 580 590 pF1KE2 SGGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKG :::.. . :..:::..:.: ::: :::::.: : : :::. .:::..:.::: : NP_000 SGGGHSG----GSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSGFG 540 550 560 570 580 590 600 610 620 630 640 650 pF1KE2 SDGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTGGKGKSGGRFRLYFCV ... : : NP_000 GESGGSYGGGEEASGSGGGYGGGSGKSSHS 600 610 620 1257 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 17:45:56 2016 done: Mon Nov 7 17:45:58 2016 Total Scan time: 14.730 Total Display time: 0.360 Function used was FASTA [36.3.4 Apr, 2011]