Result of FASTA (omim) for
pFN21AE1627
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1627, 142 aa
1>>>pF1KE1627 142 - 142 aa - 142 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9796+/-0.000351; mu= 12.7403+/- 0.022
mean_var=61.4578+/-12.167, 0's: 0 Z-trim(114.0): 25 B-trim: 0 in 0/54
Lambda= 0.163601
statistics sampled from 23558 (23577) to 23558 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.679), E-opt: 0.2 (0.276), width: 16
Scan time: 4.830
The best scores are: opt bits E(85289)
NP_001891 (OMIM: 123858) cystatin-D precursor [Hom ( 142) 947 231.7 3.1e-61
NP_001313 (OMIM: 123856) cystatin-SA precursor [Ho ( 141) 566 141.7 3.7e-34
NP_001890 (OMIM: 123857) cystatin-S precursor [Hom ( 141) 556 139.4 1.9e-33
NP_001889 (OMIM: 123855) cystatin-SN precursor [Ho ( 141) 540 135.6 2.6e-32
NP_000090 (OMIM: 105150,604312,611953) cystatin-C ( 146) 499 125.9 2.2e-29
NP_001275543 (OMIM: 105150,604312,611953) cystatin ( 146) 499 125.9 2.2e-29
NP_001314 (OMIM: 601891) cystatin-M precursor [Hom ( 149) 216 59.2 2.8e-09
NP_001268659 (OMIM: 608683) cystatin-8 precursor [ ( 142) 209 57.5 8.5e-09
NP_005483 (OMIM: 608683) cystatin-8 precursor [Hom ( 142) 209 57.5 8.5e-09
NP_003641 (OMIM: 603253) cystatin-F precursor [Hom ( 145) 205 56.5 1.7e-08
NP_570612 (OMIM: 609731) cystatin-11 isoform 1 pre ( 138) 204 56.3 1.9e-08
NP_542177 (OMIM: 616536) cystatin-9-like precursor ( 147) 181 50.9 8.6e-07
NP_001008693 (OMIM: 616543) cystatin-9 precursor [ ( 159) 127 38.2 0.0063
>>NP_001891 (OMIM: 123858) cystatin-D precursor [Homo sa (142 aa)
initn: 947 init1: 947 opt: 947 Z-score: 1220.3 bits: 231.7 E(85289): 3.1e-61
Smith-Waterman score: 947; 99.3% identity (99.3% similar) in 142 aa overlap (1-142:1-142)
10 20 30 40 50 60
pF1KE1 MMWPMHTPLLLLTALMVAVAGSASAQSRTLAGGIHATDLNDKSVQRALDFAISEYNKVIN
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
NP_001 MMWPMHTPLLLLTALMVAVAGSASAQSRTLAGGIHATDLNDKSVQCALDFAISEYNKVIN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 KDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKEEEFCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKEEEFCS
70 80 90 100 110 120
130 140
pF1KE1 FQINEVPWEDKISILNYKCRKV
::::::::::::::::::::::
NP_001 FQINEVPWEDKISILNYKCRKV
130 140
>>NP_001313 (OMIM: 123856) cystatin-SA precursor [Homo s (141 aa)
initn: 563 init1: 381 opt: 566 Z-score: 734.3 bits: 141.7 E(85289): 3.7e-34
Smith-Waterman score: 566; 56.7% identity (83.7% similar) in 141 aa overlap (1-141:1-140)
10 20 30 40 50 60
pF1KE1 MMWPMHTPLLLLTALMVAVAGSASAQSRTLAGGIHATDLNDKSVQRALDFAISEYNKVIN
: ::. : ::::.. ::.: : . ..: . :::. .::::. ::::: :.::::::. .
NP_001 MAWPLCTLLLLLATQAVALAWSPQEEDRIIEGGIYDADLNDERVQRALHFVISEYNKA-T
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 KDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKEEEFCS
.:::: : :.:. : .::::::::.:... ::: :::::::::.: :..::.:.....::
NP_001 EDEYYRRLLRVLRAREQIVGGVNYFFDIEVGRTICTKSQPNLDTCAFHEQPELQKKQLCS
60 70 80 90 100 110
130 140
pF1KE1 FQINEVPWEDKISILNYKCRKV
::: ::::::..:..: .:..
NP_001 FQIYEVPWEDRMSLVNSRCQEA
120 130 140
>>NP_001890 (OMIM: 123857) cystatin-S precursor [Homo sa (141 aa)
initn: 624 init1: 385 opt: 556 Z-score: 721.6 bits: 139.4 E(85289): 1.9e-33
Smith-Waterman score: 556; 56.0% identity (83.7% similar) in 141 aa overlap (1-141:1-140)
10 20 30 40 50 60
pF1KE1 MMWPMHTPLLLLTALMVAVAGSASAQSRTLAGGIHATDLNDKSVQRALDFAISEYNKVIN
: :. : :::...: :.:.:.. ..: . :::. .::::. ::::: ::::::::. .
NP_001 MARPLCTLLLLMATLAGALASSSKEENRIIPGGIYDADLNDEWVQRALHFAISEYNKA-T
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 KDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKEEEFCS
.:::: :::::. : .: :::::.:.:. ::: :::::::::.: :..::.:.....::
NP_001 EDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCS
60 70 80 90 100 110
130 140
pF1KE1 FQINEVPWEDKISILNYKCRKV
:.: ::::::..:..: .:..
NP_001 FEIYEVPWEDRMSLVNSRCQEA
120 130 140
>>NP_001889 (OMIM: 123855) cystatin-SN precursor [Homo s (141 aa)
initn: 557 init1: 373 opt: 540 Z-score: 701.2 bits: 135.6 E(85289): 2.6e-32
Smith-Waterman score: 540; 56.0% identity (82.3% similar) in 141 aa overlap (1-141:1-140)
10 20 30 40 50 60
pF1KE1 MMWPMHTPLLLLTALMVAVAGSASAQSRTLAGGIHATDLNDKSVQRALDFAISEYNKVIN
: . : ::::..: ::.: : . ..: . :::. .::::. ::::: ::::::::. .
NP_001 MAQYLSTLLLLLATLAVALAWSPKEEDRIIPGGIYNADLNDEWVQRALHFAISEYNKA-T
10 20 30 40 50
70 80 90 100 110 120
pF1KE1 KDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKEEEFCS
::.:: :::.:. : :: ::::::.:.:. ::: :::::::::.: :..::.:.....::
NP_001 KDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPELQKKQLCS
60 70 80 90 100 110
130 140
pF1KE1 FQINEVPWEDKISILNYKCRKV
:.: :::::.. :... .:..
NP_001 FEIYEVPWENRRSLVKSRCQES
120 130 140
>>NP_000090 (OMIM: 105150,604312,611953) cystatin-C prec (146 aa)
initn: 493 init1: 334 opt: 499 Z-score: 648.6 bits: 125.9 E(85289): 2.2e-29
Smith-Waterman score: 499; 51.7% identity (79.3% similar) in 145 aa overlap (1-140:1-144)
10 20 30 40 50
pF1KE1 MMWPMHTPLLLLTALMVAVA-----GSASAQSRTLAGGIHATDLNDKSVQRALDFAISEY
: :...:::::. : ::.: ::. .. :.:: .......:.::::::..::
NP_000 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 NKVINKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKE
::. : : :.:: :::. : .:::.::::...:..:::::::.:::::::::.:::.::.
NP_000 NKASN-DMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKR
70 80 90 100 110
120 130 140
pF1KE1 EEFCSFQINEVPWEDKISILNYKCRKV
. :::::: :::. ... . :.
NP_000 KAFCSFQIYAVPWQGTMTLSKSTCQDA
120 130 140
>>NP_001275543 (OMIM: 105150,604312,611953) cystatin-C p (146 aa)
initn: 493 init1: 334 opt: 499 Z-score: 648.6 bits: 125.9 E(85289): 2.2e-29
Smith-Waterman score: 499; 51.7% identity (79.3% similar) in 145 aa overlap (1-140:1-144)
10 20 30 40 50
pF1KE1 MMWPMHTPLLLLTALMVAVA-----GSASAQSRTLAGGIHATDLNDKSVQRALDFAISEY
: :...:::::. : ::.: ::. .. :.:: .......:.::::::..::
NP_001 MAGPLRAPLLLLAILAVALAVSPAAGSSPGKPPRLVGGPMDASVEEEGVRRALDFAVGEY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 NKVINKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKE
::. : : :.:: :::. : .:::.::::...:..:::::::.:::::::::.:::.::.
NP_001 NKASN-DMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKR
70 80 90 100 110
120 130 140
pF1KE1 EEFCSFQINEVPWEDKISILNYKCRKV
. :::::: :::. ... . :.
NP_001 KAFCSFQIYAVPWQGTMTLSKSTCQDA
120 130 140
>>NP_001314 (OMIM: 601891) cystatin-M precursor [Homo sa (149 aa)
initn: 87 init1: 53 opt: 216 Z-score: 287.5 bits: 59.2 E(85289): 2.8e-09
Smith-Waterman score: 216; 26.8% identity (64.8% similar) in 142 aa overlap (4-139:7-146)
10 20 30 40 50
pF1KE1 MMWPMHTPLLLLTALMVAVAGSASAQSRT-LAGGIHATDLNDKSVQRALDFAISEYN
:. : :.. ..:. .: :. . ..: .. . .: .::.: . :.. ::
NP_001 MARSNLPLALGLALVAFCLLALPRDARARPQERMVGELRDLSPDDPQVQKAAQAAVASYN
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 KVINKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQP-----NLDNCPFNDQP
:. :: : ... : .:.:.:..:......: : : :.. .: .::.
NP_001 MGSNSI-YYFRDTHIIKAQSQLVAGIKYFLTMEMGSTDCRKTRVTGDHVDLTTCPLAAGA
70 80 90 100 110
120 130 140
pF1KE1 KLKEEEFCSFQINEVPWEDKISILNYKCRKV
. .:. :.:.. :::... ..:...:
NP_001 Q-QEKLRCDFEVLVVPWQNSSQLLKHNCVQM
120 130 140
>>NP_001268659 (OMIM: 608683) cystatin-8 precursor [Homo (142 aa)
initn: 146 init1: 104 opt: 209 Z-score: 278.9 bits: 57.5 E(85289): 8.5e-09
Smith-Waterman score: 209; 26.5% identity (68.2% similar) in 132 aa overlap (9-139:9-139)
10 20 30 40 50
pF1KE1 MMWPMHTPLLLLTALMVAVAGSASAQSRT-LAGGIHATDLNDKSVQRALDFAISEYNKVI
:.::: .. :: . ...: . .. .. .. .:.. : ::..::::
NP_001 MPRCRWLSLILLTIPLALVARKDPKKNETGVLRKLKPVNASNANVKQCLWFAMQEYNKE-
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 NKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKEEEFC
..:.: .... : :... ..: ..:...:. : : . . : .... :::.. :
NP_001 SEDKYVFLVVKTLQAQLQVTNLLEYLIDVEIARSDCRKPLSTNEICAIQENSKLKRKLSC
60 70 80 90 100 110
120 130 140
pF1KE1 SFQINEVPWEDKISILNYKCRKV
:: .. .::. ...... ::
NP_001 SFLVGALPWNGEFTVMEKKCEDA
120 130 140
>>NP_005483 (OMIM: 608683) cystatin-8 precursor [Homo sa (142 aa)
initn: 146 init1: 104 opt: 209 Z-score: 278.9 bits: 57.5 E(85289): 8.5e-09
Smith-Waterman score: 209; 26.5% identity (68.2% similar) in 132 aa overlap (9-139:9-139)
10 20 30 40 50
pF1KE1 MMWPMHTPLLLLTALMVAVAGSASAQSRT-LAGGIHATDLNDKSVQRALDFAISEYNKVI
:.::: .. :: . ...: . .. .. .. .:.. : ::..::::
NP_005 MPRCRWLSLILLTIPLALVARKDPKKNETGVLRKLKPVNASNANVKQCLWFAMQEYNKE-
10 20 30 40 50
60 70 80 90 100 110
pF1KE1 NKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQPNLDNCPFNDQPKLKEEEFC
..:.: .... : :... ..: ..:...:. : : . . : .... :::.. :
NP_005 SEDKYVFLVVKTLQAQLQVTNLLEYLIDVEIARSDCRKPLSTNEICAIQENSKLKRKLSC
60 70 80 90 100 110
120 130 140
pF1KE1 SFQINEVPWEDKISILNYKCRKV
:: .. .::. ...... ::
NP_005 SFLVGALPWNGEFTVMEKKCEDA
120 130 140
>>NP_003641 (OMIM: 603253) cystatin-F precursor [Homo sa (145 aa)
initn: 186 init1: 90 opt: 205 Z-score: 273.7 bits: 56.5 E(85289): 1.7e-08
Smith-Waterman score: 205; 30.3% identity (60.5% similar) in 119 aa overlap (22-139:27-144)
10 20 30 40 50
pF1KE1 MMWPMHTPLLLLTALMVAVAGSASAQSRTLAGGIHATDLNDKSVQRALDFAISEY
: . .::. : .. :: .: .: ... ..
NP_003 MRAAGTLLAFCCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE1 NKVINKDEYYSRPLQVMAAYQQIVGGVNYYFNVKFGRTTCTKSQP-NLDNCPFNDQPKLK
:. : : . . .. : ::: :..:...:..::::: :.: ::.: :. . ::
NP_003 NNCTN-DMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTLK
70 80 90 100 110
120 130 140
pF1KE1 EEEFCSFQINEVPWEDKISILNYKCRKV
. : .. ::: ... . .:
NP_003 QTLSCYSEVWVVPWLQHFEVPVLRCH
120 130 140
142 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 13:06:53 2016 done: Sun Nov 6 13:06:53 2016
Total Scan time: 4.830 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]