FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5364, 299 aa 1>>>pF1KE5364 299 - 299 aa - 299 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1681+/-0.00033; mu= 16.8434+/- 0.021 mean_var=71.4870+/-14.596, 0's: 0 Z-trim(115.8): 12 B-trim: 0 in 0/53 Lambda= 0.151691 statistics sampled from 26446 (26456) to 26446 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.675), E-opt: 0.2 (0.31), width: 16 Scan time: 4.870 The best scores are: opt bits E(85289) NP_076979 (OMIM: 611235) trimeric intracellular ca ( 299) 2042 455.7 5e-128 NP_060582 (OMIM: 611236,615066) trimeric intracell ( 291) 836 191.8 1.4e-48 XP_005252134 (OMIM: 611236,615066) PREDICTED: trim ( 220) 791 181.8 1e-45 XP_005252133 (OMIM: 611236,615066) PREDICTED: trim ( 225) 791 181.9 1e-45 XP_011517131 (OMIM: 611236,615066) PREDICTED: trim ( 215) 662 153.6 3.1e-37 XP_011517133 (OMIM: 611236,615066) PREDICTED: trim ( 215) 662 153.6 3.1e-37 XP_005252132 (OMIM: 611236,615066) PREDICTED: trim ( 237) 655 152.1 9.8e-37 XP_011517135 (OMIM: 611236,615066) PREDICTED: trim ( 175) 430 102.8 5.2e-22 XP_011517134 (OMIM: 611236,615066) PREDICTED: trim ( 200) 312 77.0 3.4e-14 >>NP_076979 (OMIM: 611235) trimeric intracellular cation (299 aa) initn: 2042 init1: 2042 opt: 2042 Z-score: 2419.5 bits: 455.7 E(85289): 5e-128 Smith-Waterman score: 2042; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299) 10 20 30 40 50 60 pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 EGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_076 EGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD 250 260 270 280 290 >>NP_060582 (OMIM: 611236,615066) trimeric intracellular (291 aa) initn: 829 init1: 829 opt: 836 Z-score: 993.3 bits: 191.8 E(85289): 1.4e-48 Smith-Waterman score: 836; 41.5% identity (76.2% similar) in 294 aa overlap (11-299:7-291) 10 20 30 40 50 60 pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML ::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. ::: NP_060 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA ::::. ::. :::.:: . ...:...:::::..::. :::: :: . .:::.:. . NP_060 HCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI ::::.:. ::. :. ::. .:..::.:::: ::..:.: ....:::.:..: :::: .: NP_060 MKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITNFERLVKGDWKPEGDEW 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL :.::.:.:..: :...::.:.:. : .:: .:.:..:.:.:. :. . .:.. . : . NP_060 LKMSYPAKVTLLGSVIFTFQHTQHLAISKHNLMFLYTIFIVATKITMMTTQTSTMTFAPF 180 190 200 210 220 230 250 260 270 280 290 pF1KE5 EGYICPVLFG-----SACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKA : . .::: :.: .. ... : :.: ... .: . :.. .::.. NP_060 EDTLSWMLFGWQQPFSSC----EKKSEAKSPSNGV-----GSLASKPVDVASDNVKKKHT 240 250 260 270 280 pF1KE5 KKAD :: . NP_060 KKNE 290 >>XP_005252134 (OMIM: 611236,615066) PREDICTED: trimeric (220 aa) initn: 791 init1: 791 opt: 791 Z-score: 941.8 bits: 181.8 E(85289): 1e-45 Smith-Waterman score: 791; 49.1% identity (84.1% similar) in 214 aa overlap (11-224:7-220) 10 20 30 40 50 60 pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML ::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. ::: XP_005 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA ::::. ::. :::.:: . ...:...:::::..::. :::: :: . .:::.:. . XP_005 HCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI ::::.:. ::. :. ::. .:..::.:::: ::..:.: ....:::.:..: :::: .: XP_005 MKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITNFERLVKGDWKPEGDEW 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL :.::.:.:..: :...::.:.:. : .:: .:.:..:.:.:. : XP_005 LKMSYPAKVTLLGSVIFTFQHTQHLAISKHNLMFLYTIFIVATK 180 190 200 210 220 250 260 270 280 290 pF1KE5 EGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD >>XP_005252133 (OMIM: 611236,615066) PREDICTED: trimeric (225 aa) initn: 791 init1: 791 opt: 791 Z-score: 941.6 bits: 181.9 E(85289): 1e-45 Smith-Waterman score: 791; 49.1% identity (84.1% similar) in 214 aa overlap (11-224:7-220) 10 20 30 40 50 60 pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML ::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. ::: XP_005 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA ::::. ::. :::.:: . ...:...:::::..::. :::: :: . .:::.:. . XP_005 HCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI ::::.:. ::. :. ::. .:..::.:::: ::..:.: ....:::.:..: :::: .: XP_005 MKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITNFERLVKGDWKPEGDEW 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL :.::.:.:..: :...::.:.:. : .:: .:.:..:.:.:. : XP_005 LKMSYPAKVTLLGSVIFTFQHTQHLAISKHNLMFLYTIFIVATKSLNWR 180 190 200 210 220 250 260 270 280 290 pF1KE5 EGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD >>XP_011517131 (OMIM: 611236,615066) PREDICTED: trimeric (215 aa) initn: 662 init1: 662 opt: 662 Z-score: 789.3 bits: 153.6 E(85289): 3.1e-37 Smith-Waterman score: 662; 50.3% identity (83.4% similar) in 175 aa overlap (11-185:7-181) 10 20 30 40 50 60 pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML ::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. ::: XP_011 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA ::::. ::. :::.:: . ...:...:::::..::. :::: :: . .:::.:. . XP_011 HCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI ::::.:. ::. :. ::. .:..::.:::: ::..:.: ....:::.:..: :::: .: XP_011 MKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITNFERLVKGDWKPEGDEW 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL :.::. XP_011 LKMSYFRVHVQNVQPCQGNPAGVSYLHIPAHPASGNIKA 180 190 200 210 >>XP_011517133 (OMIM: 611236,615066) PREDICTED: trimeric (215 aa) initn: 662 init1: 662 opt: 662 Z-score: 789.3 bits: 153.6 E(85289): 3.1e-37 Smith-Waterman score: 662; 50.3% identity (83.4% similar) in 175 aa overlap (11-185:7-181) 10 20 30 40 50 60 pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML ::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. ::: XP_011 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA ::::. ::. :::.:: . ...:...:::::..::. :::: :: . .:::.:. . XP_011 HCFGGGILSCLLLAEPPLKFLANHTNILLASSIWYITFFCPHDLVSQGYSYLPVQLLASG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI ::::.:. ::. :. ::. .:..::.:::: ::..:.: ....:::.:..: :::: .: XP_011 MKEVTRTWKIVGGVTHANSYYKNGWIVMIAIGWARGAGGTIITNFERLVKGDWKPEGDEW 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE5 LHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDAL :.::. XP_011 LKMSYFRVHVQNVQPCQGNPAGVSYLHIPAHPASGNIKA 180 190 200 210 >>XP_005252132 (OMIM: 611236,615066) PREDICTED: trimeric (237 aa) initn: 648 init1: 648 opt: 655 Z-score: 780.5 bits: 152.1 E(85289): 9.8e-37 Smith-Waterman score: 655; 40.2% identity (74.4% similar) in 246 aa overlap (59-299:1-237) 30 40 50 60 70 80 pF1KE5 YFIVSILYLKYEPGAVELSRRHPIASWLCAMLHCFGSYILADLLLGEPLIDYFSNNSSIL ::::::. ::. :::.:: . ...:...:: XP_005 MLHCFGGGILSCLLLAEPPLKFLANHTNIL 10 20 30 90 100 110 120 130 140 pF1KE5 LASAVWYLIFFCPLDLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFVM :::..::. :::: :: . .:::.:. .::::.:. ::. :. ::. .:..::.:: XP_005 LASSIWYITFFCPHDLVSQGYSYLPVQLLASGMKEVTRTWKIVGGVTHANSYYKNGWIVM 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE5 IATGWVKGSGVALMSNFEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVS :: ::..:.: ....:::.:..: :::: .: :.::.:.:..: :...::.:.:. : .: XP_005 IAIGWARGAGGTIITNFERLVKGDWKPEGDEWLKMSYPAKVTLLGSVIFTFQHTQHLAIS 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE5 KASLIFIFTLFMVSCKVFLTATHSHSSPFDALEGYICPVLFG-----SACGGDHHHDNHG : .:.:..:.:.:. :. . .:.. . : .: . .::: :.: .. ... XP_005 KHNLMFLYTIFIVATKITMMTTQTSTMTFAPFEDTLSWMLFGWQQPFSSC----EKKSEA 160 170 180 190 200 270 280 290 pF1KE5 GSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD : :.: ... .: . :.. .::..:: . XP_005 KSPSNGV-----GSLASKPVDVASDNVKKKHTKKNE 210 220 230 >>XP_011517135 (OMIM: 611236,615066) PREDICTED: trimeric (175 aa) initn: 423 init1: 423 opt: 430 Z-score: 516.2 bits: 102.8 E(85289): 5.2e-22 Smith-Waterman score: 430; 37.0% identity (72.8% similar) in 184 aa overlap (121-299:1-175) 100 110 120 130 140 150 pF1KE5 SAVWYLIFFCPLDLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFVMIA ::::.:. ::. :. ::. .:..::.:::: XP_011 MKEVTRTWKIVGGVTHANSYYKNGWIVMIA 10 20 30 160 170 180 190 200 210 pF1KE5 TGWVKGSGVALMSNFEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKA ::..:.: ....:::.:..: :::: .: :.::.:.:..: :...::.:.:. : .:: XP_011 IGWARGAGGTIITNFERLVKGDWKPEGDEWLKMSYPAKVTLLGSVIFTFQHTQHLAISKH 40 50 60 70 80 90 220 230 240 250 260 pF1KE5 SLIFIFTLFMVSCKVFLTATHSHSSPFDALEGYICPVLFG-----SACGGDHHHDNHGGS .:.:..:.:.:. :. . .:.. . : .: . .::: :.: .. ... : XP_011 NLMFLYTIFIVATKITMMTTQTSTMTFAPFEDTLSWMLFGWQQPFSSC----EKKSEAKS 100 110 120 130 140 270 280 290 pF1KE5 HSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD :.: ... .: . :.. .::..:: . XP_011 PSNGV-----GSLASKPVDVASDNVKKKHTKKNE 150 160 170 >>XP_011517134 (OMIM: 611236,615066) PREDICTED: trimeric (200 aa) initn: 328 init1: 311 opt: 312 Z-score: 375.8 bits: 77.0 E(85289): 3.4e-14 Smith-Waterman score: 312; 48.4% identity (81.3% similar) in 91 aa overlap (11-101:7-91) 10 20 30 40 50 60 pF1KE5 MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAML ::::.:::. .:: ::.....::.. .: .:::. :. ..::.::. ::: XP_011 MDSPWDELALAFSRTSMFPFFDIAHYLVSVMAVKRQPGAAALAWKNPISSWFTAML 10 20 30 40 50 70 80 90 100 110 120 pF1KE5 HCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVA ::::. ::. :::.:: . ...:...:::::.. :: XP_011 HCFGGGILSCLLLAEPPLKFLANHTNILLASSI------CPAKVTLLGSVIFTFQHTQHL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE5 MKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEI XP_011 AISKHNLMFLYTIFIVATKITMMTTQTSTMTFAPFEDTLSWMLFGWQQPFSSCEKKSEAK 120 130 140 150 160 170 >-- initn: 168 init1: 157 opt: 164 Z-score: 200.8 bits: 44.6 E(85289): 0.00019 Smith-Waterman score: 164; 27.4% identity (65.0% similar) in 117 aa overlap (188-299:93-200) 160 170 180 190 200 210 pF1KE5 GVALMSNFEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFT :..: :...::.:.:. : .:: .:.:..: XP_011 ILSCLLLAEPPLKFLANHTNILLASSICPAKVTLLGSVIFTFQHTQHLAISKHNLMFLYT 70 80 90 100 110 120 220 230 240 250 260 270 pF1KE5 LFMVSCKVFLTATHSHSSPFDALEGYICPVLFG-----SACGGDHHHDNHGGSHSGGGPG .:.:. :. . .:.. . : .: . .::: :.: ... . .. :.. : XP_011 IFIVATKITMMTTQTSTMTFAPFEDTLSWMLFGWQQPFSSC--EKKSEAKSPSNGVG--- 130 140 150 160 170 280 290 pF1KE5 AQHSAMPAKSKEELSEGSRKKKAKKAD .. .: . :.. .::..:: . XP_011 ----SLASKPVDVASDNVKKKHTKKNE 180 190 200 299 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 00:08:37 2016 done: Tue Nov 8 00:08:38 2016 Total Scan time: 4.870 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]