FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9564, 402 aa 1>>>pF1KE9564 402 - 402 aa - 402 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9465+/-0.000274; mu= 21.2616+/- 0.017 mean_var=97.7387+/-20.917, 0's: 0 Z-trim(120.7): 80 B-trim: 1946 in 1/54 Lambda= 0.129730 statistics sampled from 36243 (36383) to 36243 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.751), E-opt: 0.2 (0.427), width: 16 Scan time: 10.750 The best scores are: opt bits E(85289) NP_000946 (OMIM: 176802) prostaglandin E2 receptor ( 402) 2678 511.1 2e-144 XP_016857362 (OMIM: 600563) PREDICTED: prostagland ( 291) 528 108.5 2.2e-23 NP_001034674 (OMIM: 600563) prostaglandin F2-alpha ( 297) 528 108.5 2.2e-23 NP_000950 (OMIM: 600563) prostaglandin F2-alpha re ( 359) 528 108.6 2.5e-23 NP_000949 (OMIM: 601586) prostaglandin E2 receptor ( 488) 456 95.3 3.5e-19 NP_001051 (OMIM: 188070,614009) thromboxane A2 rec ( 343) 428 89.9 1e-17 XP_011526516 (OMIM: 188070,614009) PREDICTED: thro ( 343) 428 89.9 1e-17 NP_963998 (OMIM: 188070,614009) thromboxane A2 rec ( 407) 428 89.9 1.2e-17 NP_942010 (OMIM: 176806) prostaglandin E2 receptor ( 365) 406 85.8 1.9e-16 NP_942009 (OMIM: 176806) prostaglandin E2 receptor ( 374) 406 85.8 1.9e-16 NP_942008 (OMIM: 176806) prostaglandin E2 receptor ( 388) 406 85.8 2e-16 NP_942007 (OMIM: 176806) prostaglandin E2 receptor ( 390) 406 85.8 2e-16 NP_942012 (OMIM: 176806) prostaglandin E2 receptor ( 390) 406 85.8 2e-16 NP_001119516 (OMIM: 176806) prostaglandin E2 recep ( 390) 406 85.8 2e-16 XP_011540112 (OMIM: 176806) PREDICTED: prostagland ( 410) 406 85.8 2e-16 NP_942011 (OMIM: 176806) prostaglandin E2 receptor ( 418) 406 85.8 2.1e-16 XP_016865148 (OMIM: 601586) PREDICTED: prostagland ( 313) 354 76.0 1.5e-13 XP_016865147 (OMIM: 601586) PREDICTED: prostagland ( 325) 351 75.4 2.2e-13 XP_016865146 (OMIM: 601586) PREDICTED: prostagland ( 326) 351 75.4 2.2e-13 XP_016865145 (OMIM: 601586) PREDICTED: prostagland ( 350) 351 75.5 2.3e-13 XP_005259152 (OMIM: 600022) PREDICTED: prostacycli ( 257) 331 71.6 2.5e-12 XP_005259150 (OMIM: 600022) PREDICTED: prostacycli ( 342) 331 71.7 3.1e-12 NP_000951 (OMIM: 600022) prostacyclin receptor [Ho ( 386) 331 71.8 3.3e-12 NP_000947 (OMIM: 176804,208550) prostaglandin E2 r ( 358) 329 71.3 4.1e-12 NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 256 57.8 5.8e-08 NP_001268398 (OMIM: 604687,607277) prostaglandin D ( 296) 250 56.5 1e-07 XP_005267948 (OMIM: 604687,607277) PREDICTED: pros ( 359) 250 56.6 1.2e-07 NP_000944 (OMIM: 604687,607277) prostaglandin D2 r ( 359) 250 56.6 1.2e-07 >>NP_000946 (OMIM: 176802) prostaglandin E2 receptor EP1 (402 aa) initn: 2678 init1: 2678 opt: 2678 Z-score: 2713.9 bits: 511.1 E(85289): 2e-144 Smith-Waterman score: 2678; 100.0% identity (100.0% similar) in 402 aa overlap (1-402:1-402) 10 20 30 40 50 60 pF1KE9 MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 AGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 GLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 LQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 PPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 GIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLR 310 320 330 340 350 360 370 380 390 400 pF1KE9 QLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF :::::::::::::::::::::::::::::::::::::::::: NP_000 QLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF 370 380 390 400 >>XP_016857362 (OMIM: 600563) PREDICTED: prostaglandin F (291 aa) initn: 624 init1: 369 opt: 528 Z-score: 540.8 bits: 108.5 E(85289): 2.2e-23 Smith-Waterman score: 560; 32.9% identity (61.0% similar) in 313 aa overlap (7-314:1-266) 10 20 30 40 50 60 pF1KE9 MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQA .... . . .. :: . ::. . : . .. ::.: .:: ::.:.: .: XP_016 MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKA 10 20 30 40 50 70 80 90 100 110 pF1KE9 AGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRA-----PAGGACHFLGG :.:.. : :.:::....:. ::. ::.: ::... .:.. . .. : ..: XP_016 YQRFRQK-SKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 CMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLAR :::: :::::::: ::.:::.:::.:..:..... .... :..: :. .::::. XP_016 CMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 VGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWR :..: :::: . :.. . ::. :::.:: ..:.::...:..:::.... XP_016 HRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 RRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEM : . :..:.: .:: XP_016 ----------------------------------------------SQQHRQGRSHHLEM 240 300 310 320 330 340 350 pF1KE9 VGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLR : ::..:: ::::::::.: XP_016 VIQLLAIMCVSCICWSPFLGYRIILNGKEKYKVYEEQSDFLHRK 250 260 270 280 290 >>NP_001034674 (OMIM: 600563) prostaglandin F2-alpha rec (297 aa) initn: 524 init1: 369 opt: 528 Z-score: 540.7 bits: 108.5 E(85289): 2.2e-23 Smith-Waterman score: 560; 32.9% identity (61.0% similar) in 313 aa overlap (7-314:1-266) 10 20 30 40 50 60 pF1KE9 MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQA .... . . .. :: . ::. . : . .. ::.: .:: ::.:.: .: NP_001 MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKA 10 20 30 40 50 70 80 90 100 110 pF1KE9 AGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRA-----PAGGACHFLGG :.:.. : :.:::....:. ::. ::.: ::... .:.. . .. : ..: NP_001 YQRFRQK-SKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 CMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLAR :::: :::::::: ::.:::.:::.:..:..... .... :..: :. .::::. NP_001 CMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 VGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWR :..: :::: . :.. . ::. :::.:: ..:.::...:..:::.... NP_001 HRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 RRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEM : . :..:.: .:: NP_001 ----------------------------------------------SQQHRQGRSHHLEM 240 300 310 320 330 340 350 pF1KE9 VGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLR : ::..:: ::::::::.: NP_001 VIQLLAIMCVSCICWSPFLGYRIILNGKEKYKVYEEQSDFLHRLQWPTLE 250 260 270 280 290 >>NP_000950 (OMIM: 600563) prostaglandin F2-alpha recept (359 aa) initn: 785 init1: 369 opt: 528 Z-score: 539.8 bits: 108.6 E(85289): 2.5e-23 Smith-Waterman score: 739; 34.3% identity (62.2% similar) in 394 aa overlap (7-394:1-341) 10 20 30 40 50 60 pF1KE9 MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQA .... . . .. :: . ::. . : . .. ::.: .:: ::.:.: .: NP_000 MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKA 10 20 30 40 50 70 80 90 100 110 pF1KE9 AGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRA-----PAGGACHFLGG :.:.. : :.:::....:. ::. ::.: ::... .:.. . .. : ..: NP_000 YQRFRQK-SKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 CMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLAR :::: :::::::: ::.:::.:::.:..:..... .... :..: :. .::::. NP_000 CMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 VGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWR :..: :::: . :.. . ::. :::.:: ..:.::...:..:::.... NP_000 HRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFK 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 RRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEM : . :..:.: .:: NP_000 ----------------------------------------------SQQHRQGRSHHLEM 240 300 310 320 330 340 350 pF1KE9 VGQLVGIMVVSCICWSPMLVLVA-LAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILL : ::..:: ::::::::.:: .: ....: : . ..:.:.:.::::::::::::: NP_000 VIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILL 250 260 270 280 290 300 360 370 380 390 400 pF1KE9 RQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF :.:::..: .: :.. .. :: ::...: NP_000 RKAVLKNLYKLASQCCGVHV------ISLHIWELSSIKNSLKVAAISESPVAEKSAST 310 320 330 340 350 >>NP_000949 (OMIM: 601586) prostaglandin E2 receptor EP4 (488 aa) initn: 343 init1: 161 opt: 456 Z-score: 465.4 bits: 95.3 E(85289): 3.5e-19 Smith-Waterman score: 467; 30.9% identity (60.9% similar) in 353 aa overlap (19-361:2-339) 10 20 30 40 50 pF1KE9 MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSG-ASPA-LPIFSMTLGAVSNLLALALLA ..: : ..... :. ::. .: . .:.:.::.:...: NP_000 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLC 10 20 30 40 60 70 80 90 100 110 pF1KE9 QAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGA-CHFLGGCM .. :.... .:: .: .: .::: : .. . ... : :. :.: :.. . NP_000 KS----RKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFIL 50 60 70 80 90 120 130 140 150 160 170 pF1KE9 VFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVG .::.: : . :.:.::: ..... ... :. : :.: :: : . :: .: NP_000 LFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLG 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE9 RYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRR .:::: ::::: . .: . ..:... .::...::.: :::: . :. NP_000 SSRLQYPDTWCFIDW-TTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMH-RQF 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE9 SRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTF--FGGSRSSGSARRARAHDVEM :: . : ... :. .::..: . :.. .. .. : : :: . ...: NP_000 MRR--TSLGTEQH-----HAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQM 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE9 VGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQR-----PLFLAVRLASWNQILDPWV : :.. .: :: :..: : :. . ::.: : . :.:.:: : :::::. NP_000 VILLIATSLVVLICSIPLVVRVF--VNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWI 280 290 300 310 320 360 370 380 390 400 pF1KE9 YILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF :::::..:: . NP_000 YILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEI 330 340 350 360 370 380 >>NP_001051 (OMIM: 188070,614009) thromboxane A2 recepto (343 aa) initn: 571 init1: 292 opt: 428 Z-score: 438.9 bits: 89.9 E(85289): 1e-17 Smith-Waterman score: 640; 34.9% identity (58.0% similar) in 407 aa overlap (1-392:8-343) 10 20 30 40 50 pF1KE9 MSPC-GPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLL ..:: : :..: : :.:: . : .: .:::: NP_001 MWPNGSSLGPCFRPTNITLE-ERRLIASPWFAASFCV---------------VGLASNLL 10 20 30 40 60 70 80 90 100 pF1KE9 ALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTA-----GRAPAG ::..:: : . :: .:: :. .:. ::. : .. :..:. ..: . :. NP_001 ALSVLAGARQGGSHTRS--SFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGC 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE9 GACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALA :.:.: :.:::: ::::: .:: :: .:.:::. . : .: :: ... : :.::: NP_001 RLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALA 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE9 VALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGL ..:::: :::: .::::.:::. :: .: .. .. ::. :: ... ... ::.: NP_001 LGLLPLLGVGRYTVQYPGSWCFLTLGAESG--DVAFGLLFSMLGGLSVGLSFLLNTVSVA 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE9 ALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARR .: .. :: ..:. .: NP_001 TLCHVY----------------------HGQEAAQ-----------------------QR 230 290 300 310 320 330 pF1KE9 ARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAV---------GGWSSTSLQRPLFLAVR : .:::..::.:::::. .:: :.::..: .: .: : . .. :.. .: NP_001 PRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLR 240 250 260 270 280 290 340 350 360 370 380 390 pF1KE9 LASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSG .:.::::::::::::.:.::::.: :: ... : .:.: :. . :.:. NP_001 VATWNQILDPWVYILFRRAVLRRL----QPRLSTR--PRSLSLQPQLTQRSGLQ 300 310 320 330 340 400 pF1KE9 LSHF >>XP_011526516 (OMIM: 188070,614009) PREDICTED: thrombox (343 aa) initn: 571 init1: 292 opt: 428 Z-score: 438.9 bits: 89.9 E(85289): 1e-17 Smith-Waterman score: 640; 34.9% identity (58.0% similar) in 407 aa overlap (1-392:8-343) 10 20 30 40 50 pF1KE9 MSPC-GPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLL ..:: : :..: : :.:: . : .: .:::: XP_011 MWPNGSSLGPCFRPTNITLE-ERRLIASPWFAASFCV---------------VGLASNLL 10 20 30 40 60 70 80 90 100 pF1KE9 ALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTA-----GRAPAG ::..:: : . :: .:: :. .:. ::. : .. :..:. ..: . :. XP_011 ALSVLAGARQGGSHTRS--SFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGC 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE9 GACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALA :.:.: :.:::: ::::: .:: :: .:.:::. . : .: :: ... : :.::: XP_011 RLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALA 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE9 VALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGL ..:::: :::: .::::.:::. :: .: .. .. ::. :: ... ... ::.: XP_011 LGLLPLLGVGRYTVQYPGSWCFLTLGAESG--DVAFGLLFSMLGGLSVGLSFLLNTVSVA 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE9 ALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARR .: .. :: ..:. .: XP_011 TLCHVY----------------------HGQEAAQ-----------------------QR 230 290 300 310 320 330 pF1KE9 ARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAV---------GGWSSTSLQRPLFLAVR : .:::..::.:::::. .:: :.::..: .: .: : . .. :.. .: XP_011 PRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLR 240 250 260 270 280 290 340 350 360 370 380 390 pF1KE9 LASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSG .:.::::::::::::.:.::::.: :: ... : .:.: :. . :.:. XP_011 VATWNQILDPWVYILFRRAVLRRL----QPRLSTR--PRSLSLQPQLTQRSGLQ 300 310 320 330 340 400 pF1KE9 LSHF >>NP_963998 (OMIM: 188070,614009) thromboxane A2 recepto (407 aa) initn: 571 init1: 292 opt: 428 Z-score: 438.0 bits: 89.9 E(85289): 1.2e-17 Smith-Waterman score: 624; 35.4% identity (57.6% similar) in 384 aa overlap (1-369:8-326) 10 20 30 40 50 pF1KE9 MSPC-GPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLL ..:: : :..: : :.:: . : .: .:::: NP_963 MWPNGSSLGPCFRPTNITLE-ERRLIASPWFAASFCV---------------VGLASNLL 10 20 30 40 60 70 80 90 100 pF1KE9 ALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTA-----GRAPAG ::..:: : . :: .:: :. .:. ::. : .. :..:. ..: . :. NP_963 ALSVLAGARQGGSHTRS--SFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGC 50 60 70 80 90 100 110 120 130 140 150 160 pF1KE9 GACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALA :.:.: :.:::: ::::: .:: :: .:.:::. . : .: :: ... : :.::: NP_963 RLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALA 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE9 VALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGL ..:::: :::: .::::.:::. :: .: .. .. ::. :: ... ... ::.: NP_963 LGLLPLLGVGRYTVQYPGSWCFLTLGAESG--DVAFGLLFSMLGGLSVGLSFLLNTVSVA 170 180 190 200 210 220 230 240 250 260 270 280 pF1KE9 ALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARR .: .. :: ..:. .: NP_963 TLCHVY----------------------HGQEAAQ-----------------------QR 230 290 300 310 320 330 pF1KE9 ARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAV---------GGWSSTSLQRPLFLAVR : .:::..::.:::::. .:: :.::..: .: .: : . .. :.. .: NP_963 PRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLR 240 250 260 270 280 290 340 350 360 370 380 390 pF1KE9 LASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSG .:.::::::::::::.:.::::.: : : NP_963 VATWNQILDPWVYILFRRAVLRRLQPRLSTRPRRSLTLWPSLEYSGTISAHCNLRLPGSS 300 310 320 330 340 350 400 pF1KE9 LSHF NP_963 DSRASASRAAGITGVSHCARPCMLFDPEFDLLAGVQLLPFEPPTGKALSRKD 360 370 380 390 400 >>NP_942010 (OMIM: 176806) prostaglandin E2 receptor EP3 (365 aa) initn: 527 init1: 216 opt: 406 Z-score: 416.3 bits: 85.8 E(85289): 1.9e-16 Smith-Waterman score: 543; 33.6% identity (55.8% similar) in 387 aa overlap (4-362:14-357) 10 20 30 40 pF1KE9 MSPCGPLNLSLAGE-ATTCAAPWVPNTSAVPPSG-----ASPALPIFSMT : :: : .: : .: : . : :: .: :.:: . NP_942 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 LGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRA : :.: ::. ::.. . : :. . .::: .. : :::.:... .:. .: . . NP_942 TGFVGNALAM-LLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQR 70 80 90 100 110 110 120 130 140 150 pF1KE9 -----PAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALA :.: : :.: :. ::: :... .::::: ... : .:..... .: .: NP_942 WEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE9 AVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGG-------WRQALLAGLFASLGL .: ..:: ::::. ::.: .:.:::::::. : :. : . ..:. :: ::: NP_942 GVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGL 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE9 VALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASA .:: ... :: :: ..: :: :.. .: .:: .. ..: NP_942 LALTVTFSCN----LATIKALV---SRCRAKATASQSSAQWG-------RITTETAI--- 240 250 260 270 280 280 290 300 310 320 pF1KE9 STFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSS------ ::.::: : .::::.:... . . .: NP_942 -------------------------QLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKT 290 300 310 330 340 350 360 370 380 pF1KE9 -TSLQRP--LFL-AVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLT : :. .:: :::::: :::::::::.:::. .::.. NP_942 HTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQEEFWGN 320 330 340 350 360 390 400 pF1KE9 PSAWEASSLRSSRHSGLSHF >>NP_942009 (OMIM: 176806) prostaglandin E2 receptor EP3 (374 aa) initn: 529 init1: 216 opt: 406 Z-score: 416.2 bits: 85.8 E(85289): 1.9e-16 Smith-Waterman score: 545; 33.2% identity (56.3% similar) in 391 aa overlap (4-365:14-360) 10 20 30 40 pF1KE9 MSPCGPLNLSLAGE-ATTCAAPWVPNTSAVPPSG-----ASPALPIFSMT : :: : .: : .: : . : :: .: :.:: . NP_942 MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 LGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRA : :.: ::. ::.. . : :. . .::: .. : :::.:... .:. .: . . NP_942 TGFVGNALAM-LLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQR 70 80 90 100 110 110 120 130 140 150 pF1KE9 -----PAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALA :.: : :.: :. ::: :... .::::: ... : .:..... .: .: NP_942 WEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLL 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE9 AVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGG-------WRQALLAGLFASLGL .: ..:: ::::. ::.: .:.:::::::. : :. : . ..:. :: ::: NP_942 GVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGL 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE9 VALLAALVCNTLSGLALLRARWRR-RSRRPPPASGPDSRRRWGAHGPRSASASSASSIAS .:: ... :: :: ..: : :.. :.. .: .:: .. ..: NP_942 LALTVTFSCN----LATIKALVSRCRAK----ATASQSSAQWG-------RITTETAI-- 240 250 260 270 280 280 290 300 310 320 pF1KE9 ASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSS----- ::.::: : .::::.:... . . .: NP_942 --------------------------QLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCK 290 300 310 330 340 350 360 370 380 pF1KE9 --TSLQRP--LFL-AVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGL : :. .:: :::::: :::::::::.:::. .::.. .. NP_942 THTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQMRKRRLREQEEFWGN 320 330 340 350 360 370 390 400 pF1KE9 TPSAWEASSLRSSRHSGLSHF 402 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 13:25:39 2016 done: Sun Nov 6 13:25:41 2016 Total Scan time: 10.750 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]