FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1751, 254 aa 1>>>pF1KE1751 254 - 254 aa - 254 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9688+/-0.000271; mu= 17.9017+/- 0.017 mean_var=74.4412+/-14.787, 0's: 0 Z-trim(120.9): 5 B-trim: 0 in 0/55 Lambda= 0.148651 statistics sampled from 36855 (36860) to 36855 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.765), E-opt: 0.2 (0.432), width: 16 Scan time: 8.190 The best scores are: opt bits E(85289) NP_003802 (OMIM: 606182) tumor necrosis factor lig ( 254) 1681 368.8 5.3e-102 NP_003798 (OMIM: 604520) tumor necrosis factor lig ( 240) 162 43.0 0.00059 XP_016882906 (OMIM: 604520) PREDICTED: tumor necro ( 240) 162 43.0 0.00059 NP_742011 (OMIM: 604520) tumor necrosis factor lig ( 204) 151 40.6 0.0027 >>NP_003802 (OMIM: 606182) tumor necrosis factor ligand (254 aa) initn: 1681 init1: 1681 opt: 1681 Z-score: 1952.2 bits: 368.8 E(85289): 5.3e-102 Smith-Waterman score: 1681; 100.0% identity (100.0% similar) in 254 aa overlap (1-254:1-254) 10 20 30 40 50 60 pF1KE1 MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MEYASDASLDPEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLACPWAVSGARA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 SPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 SPGSAASPRLREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 TGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 LTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRV 190 200 210 220 230 240 250 pF1KE1 TPEIPAGLPSPRSE :::::::::::::: NP_003 TPEIPAGLPSPRSE 250 >>NP_003798 (OMIM: 604520) tumor necrosis factor ligand (240 aa) initn: 190 init1: 64 opt: 162 Z-score: 192.0 bits: 43.0 E(85289): 0.00059 Smith-Waterman score: 169; 29.5% identity (52.6% similar) in 251 aa overlap (3-240:11-240) 10 20 30 40 50 pF1KE1 MEYASDASLD-PEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLAC .. :.. : : . . : ..: : : :. :::::..:. :: NP_003 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSV---ARVGLGLLLLLMGAGLAV---Q 10 20 30 40 50 60 70 80 90 100 pF1KE1 PWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMF----AQLVAQNVLLID--G : . . : .. :: .:: : .. :.. :.. :.:.. : : : NP_003 GWFLLQLHWRLGEMVT-RLPDGPAGSWEQ---LIQERRSHEVNPAAHLTGANSSLTGSGG 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 PLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLAL :: : .. ::: . ::::.. . :::.::: ::.. ...: : : : .: NP_003 PLLWETQLGLA---FLRGLSYHDGA--LVVTKAGYYYIYSKVQLGGV--GCPLGLASTIT 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 HLQPLRSAAGAAALALTVDLPPASSEARNSAF-----GFQGRLLHLSAGQRLGVHLHTEA : :. : : :. ..: .:. .: : ..:: ::... :.. : NP_003 HGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDER 170 180 190 200 210 220 230 240 250 pF1KE1 RARHAWQLTQGA-TVLGLFRVTPEIPAGLPSPRSE .: : .:. . .: : : NP_003 LVR----LRDGTRSYFGAFMV 230 240 >>XP_016882906 (OMIM: 604520) PREDICTED: tumor necrosis (240 aa) initn: 190 init1: 64 opt: 162 Z-score: 192.0 bits: 43.0 E(85289): 0.00059 Smith-Waterman score: 169; 29.5% identity (52.6% similar) in 251 aa overlap (3-240:11-240) 10 20 30 40 50 pF1KE1 MEYASDASLD-PEAPWPPAPRARACRVLPWALVAGLLLLLLLAAACAVFLAC .. :.. : : . . : ..: : : :. :::::..:. :: XP_016 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSV---ARVGLGLLLLLMGAGLAV---Q 10 20 30 40 50 60 70 80 90 100 pF1KE1 PWAVSGARASPGSAASPRLREGPELSPDDPAGLLDLRQGMF----AQLVAQNVLLID--G : . . : .. :: .:: : .. :.. :.. :.:.. : : : XP_016 GWFLLQLHWRLGEMVT-RLPDGPAGSWEQ---LIQERRSHEVNPAAHLTGANSSLTGSGG 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 PLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLAL :: : .. ::: . ::::.. . :::.::: ::.. ...: : : : .: XP_016 PLLWETQLGLA---FLRGLSYHDGA--LVVTKAGYYYIYSKVQLGGV--GCPLGLASTIT 120 130 140 150 160 170 180 190 200 210 220 pF1KE1 HLQPLRSAAGAAALALTVDLPPASSEARNSAF-----GFQGRLLHLSAGQRLGVHLHTEA : :. : : :. ..: .:. .: : ..:: ::... :.. : XP_016 HGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEKVVVRVLDER 170 180 190 200 210 220 230 240 250 pF1KE1 RARHAWQLTQGA-TVLGLFRVTPEIPAGLPSPRSE .: : .:. . .: : : XP_016 LVR----LRDGTRSYFGAFMV 230 240 >>NP_742011 (OMIM: 604520) tumor necrosis factor ligand (204 aa) initn: 135 init1: 64 opt: 151 Z-score: 180.2 bits: 40.6 E(85289): 0.0027 Smith-Waterman score: 151; 30.1% identity (53.2% similar) in 186 aa overlap (71-240:30-204) 50 60 70 80 90 pF1KE1 LAAACAVFLACPWAVSGARASPGSAASPRLREGPELSPDDPAG----LLDLRQGMF---- :.. .. : ::: :.. :.. NP_742 MEESVVRPSVFVVDGQTDIPFTRLGRSHRRQSCSVARDGPAGSWEQLIQERRSHEVNPA 10 20 30 40 50 100 110 120 130 140 150 pF1KE1 AQLVAQNVLLID--GPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELR :.:.. : : ::: : .. ::: . ::::.. . :::.::: ::.. ...: NP_742 AHLTGANSSLTGSGGPLLWETQLGLA---FLRGLSYHDGA--LVVTKAGYYYIYSKVQLG 60 70 80 90 100 110 160 170 180 190 200 pF1KE1 RVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAF-----GFQGRLLH : : : .: : :. : : :. ..: .:. .: : ..: NP_742 GV--GCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGGVVH 120 130 140 150 160 170 210 220 230 240 250 pF1KE1 LSAGQRLGVHLHTEARARHAWQLTQGA-TVLGLFRVTPEIPAGLPSPRSE : ::... :.. : .: : .:. . .: : : NP_742 LEAGEKVVVRVLDERLVR----LRDGTRSYFGAFMV 180 190 200 254 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 13:30:17 2016 done: Sun Nov 6 13:30:18 2016 Total Scan time: 8.190 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]