FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4025, 232 aa 1>>>pF1KE4025 232 - 232 aa - 232 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8086+/-0.00045; mu= 8.4622+/- 0.028 mean_var=200.8165+/-43.804, 0's: 0 Z-trim(117.1): 166 B-trim: 1258 in 1/49 Lambda= 0.090505 statistics sampled from 28492 (28736) to 28492 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.705), E-opt: 0.2 (0.337), width: 16 Scan time: 5.750 The best scores are: opt bits E(85289) NP_060301 (OMIM: 610432,616260) E3 ubiquitin-prote ( 232) 1618 223.4 2.5e-58 XP_011524347 (OMIM: 610432,616260) PREDICTED: E3 u ( 227) 1457 202.4 5.3e-52 XP_011524349 (OMIM: 610432,616260) PREDICTED: E3 u ( 191) 1189 167.3 1.6e-41 XP_011524348 (OMIM: 610432,616260) PREDICTED: E3 u ( 196) 1189 167.3 1.7e-41 NP_061153 (OMIM: 612451) E3 ubiquitin-protein liga ( 228) 233 42.6 0.00068 >>NP_060301 (OMIM: 610432,616260) E3 ubiquitin-protein l (232 aa) initn: 1618 init1: 1618 opt: 1618 Z-score: 1168.1 bits: 223.4 E(85289): 2.5e-58 Smith-Waterman score: 1618; 100.0% identity (100.0% similar) in 232 aa overlap (1-232:1-232) 10 20 30 40 50 60 pF1KE4 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 KYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDEN 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 PSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRVLDRSLLEYVNHSNTT :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRVLDRSLLEYVNHSNTT 190 200 210 220 230 >>XP_011524347 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (227 aa) initn: 1529 init1: 1457 opt: 1457 Z-score: 1054.6 bits: 202.4 E(85289): 5.3e-52 Smith-Waterman score: 1457; 99.5% identity (99.5% similar) in 207 aa overlap (1-207:1-207) 10 20 30 40 50 60 pF1KE4 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDEN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDEN 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 PSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRVLDRSLLEYVNHSNTT ::::::::::::::::::::::::: : XP_011 PSSFSGSLIRHLQVSHTLFYDDFIDNNTKIHLSCCCPRPHFHPQVPQ 190 200 210 220 >>XP_011524349 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (191 aa) initn: 1189 init1: 1189 opt: 1189 Z-score: 866.3 bits: 167.3 E(85289): 1.6e-41 Smith-Waterman score: 1189; 100.0% identity (100.0% similar) in 168 aa overlap (1-168:1-168) 10 20 30 40 50 60 pF1KE4 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDEN :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVDNNTKIHLSCCC 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 PSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRVLDRSLLEYVNHSNTT XP_011 PRPHFHPQVPQ 190 >>XP_011524348 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (196 aa) initn: 1189 init1: 1189 opt: 1189 Z-score: 866.2 bits: 167.3 E(85289): 1.7e-41 Smith-Waterman score: 1279; 84.5% identity (84.5% similar) in 232 aa overlap (1-232:1-196) 10 20 30 40 50 60 pF1KE4 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 KYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPVFCPLCRLIPDEN :::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KYIDKYGPLQELEETAARCVCPFCQRELYEDSLLDHCITHHRSERRPV------------ 130 140 150 160 190 200 210 220 230 pF1KE4 PSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRVLDRSLLEYVNHSNTT :::::::::::::::::::::::::::: XP_011 ------------------------DFNIIEEALIRRVLDRSLLEYVNHSNTT 170 180 190 >>NP_061153 (OMIM: 612451) E3 ubiquitin-protein ligase R (228 aa) initn: 494 init1: 190 opt: 233 Z-score: 190.8 bits: 42.6 E(85289): 0.00068 Smith-Waterman score: 471; 33.0% identity (64.1% similar) in 206 aa overlap (31-224:23-227) 10 20 30 40 50 60 pF1KE4 MGSVLSTDSGKSAPASATARALERRRDPELPVTSFDCAVCLEVLHQPVRTRCGHVFCRSC :. : : ::::: ..::.. :::::: .: NP_061 MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSAC 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 IATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSEMRAHIRTCQ . :: .: .: ::. : . :: :... ....: .: : ::..:.:. ::. NP_061 LQECLKPKKPVCGVCRSAL-APGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCS 60 70 80 90 100 110 130 140 150 160 pF1KE4 KYIDKY--GPLQELEETA--ARCV-------CPFC-QRELYEDSLLDHCITHHRSERRPV :: . : ..... : : ::.: .... ...:..:: : .. . : NP_061 KYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSV 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 FCPLCRLIPDENPSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRVLDRSLLEYVNH ::.: .: .:. :... .:.: : . :: :.:... :: .. .::.::... NP_061 VCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ 180 190 200 210 220 230 pF1KE4 SNTT 232 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:20:09 2016 done: Sun Nov 6 04:20:09 2016 Total Scan time: 5.750 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]