FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB9099, 222 aa 1>>>pF1KB9099 222 - 222 aa - 222 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.5578+/-0.000381; mu= 18.1679+/- 0.023 mean_var=64.7872+/-13.093, 0's: 0 Z-trim(112.2): 38 B-trim: 0 in 0/50 Lambda= 0.159342 statistics sampled from 21057 (21081) to 21057 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.613), E-opt: 0.2 (0.247), width: 16 Scan time: 6.050 The best scores are: opt bits E(85289) NP_000718 (OMIM: 114209) voltage-dependent calcium ( 222) 1518 357.6 9.7e-99 NP_665813 (OMIM: 606898) voltage-dependent calcium ( 260) 559 137.2 2.5e-32 XP_006723379 (OMIM: 606898) PREDICTED: voltage-dep ( 189) 414 103.7 2.2e-22 NP_665814 (OMIM: 606898) voltage-dependent calcium ( 214) 302 78.0 1.3e-14 NP_114103 (OMIM: 606898) voltage-dependent calcium ( 189) 204 55.4 7.4e-08 XP_016882582 (OMIM: 606899) PREDICTED: voltage-dep ( 275) 158 45.0 0.00015 NP_114102 (OMIM: 606899) voltage-dependent calcium ( 275) 158 45.0 0.00015 NP_085915 (OMIM: 154045,615277) lens fiber membran ( 215) 144 41.7 0.0011 NP_006069 (OMIM: 602911,614256) voltage-dependent ( 323) 138 40.5 0.004 >>NP_000718 (OMIM: 114209) voltage-dependent calcium cha (222 aa) initn: 1518 init1: 1518 opt: 1518 Z-score: 1893.7 bits: 357.6 E(85289): 9.7e-99 Smith-Waterman score: 1518; 100.0% identity (100.0% similar) in 222 aa overlap (1-222:1-222) 10 20 30 40 50 60 pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPHMEHHNTTCEAAHFGLWRICTKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPHMEHHNTTCEAAHFGLWRICTKR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB9 IPMDDSKTCGPITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IPMDDSKTCGPITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIIL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB9 GSLCVLLSLGKKRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMIDSEDTVWIEYYYSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GSLCVLLSLGKKRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMIDSEDTVWIEYYYSW 130 140 150 160 170 180 190 200 210 220 pF1KB9 SFACACAAFILLFLGGLALLLFSLPRMPRNPWESCMDAEPEH :::::::::::::::::::::::::::::::::::::::::: NP_000 SFACACAAFILLFLGGLALLLFSLPRMPRNPWESCMDAEPEH 190 200 210 220 >>NP_665813 (OMIM: 606898) voltage-dependent calcium cha (260 aa) initn: 584 init1: 328 opt: 559 Z-score: 701.3 bits: 137.2 E(85289): 2.5e-32 Smith-Waterman score: 559; 39.7% identity (72.1% similar) in 219 aa overlap (8-215:38-252) 10 20 30 pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSP ::...:. .: .::. .: :. :. :. NP_665 LQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNT 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB9 HMEHHNTTCEAAHFGLWRICTKR-----IPMDDSKTCGPITLPGEKNCSYFRHFNPGESS . . ...:::::.:::. :::: .:.: :::: :::: ::.::. :. ::.. NP_665 YKANGSAVCEAAHLGLWKACTKRLWQADVPVD-RDTCGPAELPGEANCTYFKFFTTGENA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB9 EIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPASMFYAFAGLCIL .::. ::.:: ...::.::...:. . :: ::... :.: ..::: ... ....:: .: NP_665 RIFQRTTKKEVNLAAAVIAVLGLAVMALGCLCIIMVLSKGAEFLLRVGAVCFGLSGLLLL 130 140 150 160 170 180 160 170 180 190 200 pF1KB9 VSVEVMRQSVKRMI-----DSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRM ::.::.:.::. .. . . . : ::::..:. .: ..:.::. .::..:: NP_665 VSLEVFRHSVRALLQRVSPEPPPAPRLTYEYSWSLGCGVGAGLILLLGAGCFLLLTLPSW 190 200 210 220 230 240 210 220 pF1KB9 PRNPWES-CMDAEPEH : : : : NP_665 P---WGSLCPKRGHRAT 250 260 >>XP_006723379 (OMIM: 606898) PREDICTED: voltage-depende (189 aa) initn: 425 init1: 264 opt: 414 Z-score: 523.0 bits: 103.7 E(85289): 2.2e-22 Smith-Waterman score: 414; 39.2% identity (75.2% similar) in 153 aa overlap (8-155:38-189) 10 20 30 pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSP ::...:. .: .::. .: :. :. :. XP_006 LQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNT 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB9 HMEHHNTTCEAAHFGLWRICTKR-----IPMDDSKTCGPITLPGEKNCSYFRHFNPGESS . . ...:::::.:::. :::: .:.: . :::: :::: ::.::. :. ::.. XP_006 YKANGSAVCEAAHLGLWKACTKRLWQADVPVDRD-TCGPAELPGEANCTYFKFFTTGENA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB9 EIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPASMFYAFAGLCIL .::. ::.:: ...::.::...:. . :: ::... :.: ..::: ... ..... .: XP_006 RIFQRTTKKEVNLAAAVIAVLGLAVMALGCLCIIMVLSKGAEFLLRVGAVCFGLSASQML 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB9 VSVEVMRQSVKRMIDSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRMPRNPW .. XP_006 PAI >>NP_665814 (OMIM: 606898) voltage-dependent calcium cha (214 aa) initn: 467 init1: 161 opt: 302 Z-score: 383.1 bits: 78.0 E(85289): 1.3e-14 Smith-Waterman score: 348; 32.9% identity (55.3% similar) in 219 aa overlap (8-215:38-206) 10 20 30 pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSP ::...:. .: .::. .: :. :. :. NP_665 LQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNT 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB9 HMEHHNTTCEAAHFGLWRICTKR-----IPMDDSKTCGPITLPGEKNCSYFRHFNPGESS . . ...:::::.:::. :::: .:.: :::: :::: ::.::. :. ::.. NP_665 YKANGSAVCEAAHLGLWKACTKRLWQADVPVD-RDTCGPAELPGEANCTYFKFFTTGENA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB9 EIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPASMFYAFAGLCIL .::. ::.: :: .: NP_665 RIFQRTTKK----------------------------------------------GLLLL 130 140 160 170 180 190 200 pF1KB9 VSVEVMRQSVKRMI-----DSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRM ::.::.:.::. .. . . . : ::::..:. .: ..:.::. .::..:: NP_665 VSLEVFRHSVRALLQRVSPEPPPAPRLTYEYSWSLGCGVGAGLILLLGAGCFLLLTLPSW 150 160 170 180 190 200 210 220 pF1KB9 PRNPWES-CMDAEPEH : : : : NP_665 P---WGSLCPKRGHRAT 210 >>NP_114103 (OMIM: 606898) voltage-dependent calcium cha (189 aa) initn: 322 init1: 162 opt: 204 Z-score: 262.1 bits: 55.4 E(85289): 7.4e-08 Smith-Waterman score: 204; 41.9% identity (68.9% similar) in 74 aa overlap (8-76:38-110) 10 20 30 pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSP ::...:. .: .::. .: :. :. :. NP_114 LQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTEFWVELNT 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB9 HMEHHNTTCEAAHFGLWRICTKR-----IPMDDSKTCGPITLPGEKNCSYFRHFNPGESS . . ...:::::.:::. :::: .:.: :::: ::: NP_114 YKANGSAVCEAAHLGLWKACTKRLWQADVPVD-RDTCGPAELPGGLLLLVSLEVFRHSVR 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB9 EIFEFTTQKEYSISAAAIAIFSLGFIILGSLCVLLSLGKKRDYLLRPASMFYAFAGLCIL NP_114 ALLQRVSPEPPPAPRLTYEYSWSLGCGVGAGLILLLGAGCFLLLTLPSWPWGSLCPKRGH 130 140 150 160 170 180 >>XP_016882582 (OMIM: 606899) PREDICTED: voltage-depende (275 aa) initn: 114 init1: 52 opt: 158 Z-score: 202.8 bits: 45.0 E(85289): 0.00015 Smith-Waterman score: 158; 25.6% identity (55.8% similar) in 199 aa overlap (19-203:20-201) 10 20 30 40 50 pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPH-MEHHNTTCE---AAHFGLWR :..:. :: ::.: . . .: : : : : :::: XP_016 MSHCSSRALTLLSSVFGACGLLLVGIAVSTDYWLYMEEGTVLPQNQTTEVKMALHAGLWR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 ICTKRIPMDDSKTCGPITLPG-EKN-CSYFRHFNPGESSEIFEFTTQKEYSI-SAAAIAI .: . : ::. : ..: : . . : : . .. .:. . . XP_016 VCF---------------FAGREKGRCVASEYFLEPEINLVTENTENILKTVRTATPFPM 70 80 90 100 120 130 140 150 160 pF1KB9 FSLGFIILGSLCVLLSLGK---KRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMI--- :: :... .. :. ..:. .: : ...:. ..:: ..:.. .. .:.. . XP_016 VSL-FLVFTAF-VISNIGHIRPQRTILAFVSGIFFILSGLSLVVGLVLYISSINDEVMNR 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 DSEDTVWIEYYYSWSFACACAAFILLFLGG-LALLLFSLPRMPRNPWESCMDAEPEH : . ...: :.:::: : ..:.: .: ... ::. XP_016 PSSSEQYFHYRYGWSFAFAASSFLLKEGAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSD 170 180 190 200 210 220 XP_016 CSDYSGQFLQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHISTSPC 230 240 250 260 270 >>NP_114102 (OMIM: 606899) voltage-dependent calcium cha (275 aa) initn: 114 init1: 52 opt: 158 Z-score: 202.8 bits: 45.0 E(85289): 0.00015 Smith-Waterman score: 158; 25.6% identity (55.8% similar) in 199 aa overlap (19-203:20-201) 10 20 30 40 50 pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPH-MEHHNTTCE---AAHFGLWR :..:. :: ::.: . . .: : : : : :::: NP_114 MSHCSSRALTLLSSVFGACGLLLVGIAVSTDYWLYMEEGTVLPQNQTTEVKMALHAGLWR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB9 ICTKRIPMDDSKTCGPITLPG-EKN-CSYFRHFNPGESSEIFEFTTQKEYSI-SAAAIAI .: . : ::. : ..: : . . : : . .. .:. . . NP_114 VCF---------------FAGREKGRCVASEYFLEPEINLVTENTENILKTVRTATPFPM 70 80 90 100 120 130 140 150 160 pF1KB9 FSLGFIILGSLCVLLSLGK---KRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMI--- :: :... .. :. ..:. .: : ...:. ..:: ..:.. .. .:.. . NP_114 VSL-FLVFTAF-VISNIGHIRPQRTILAFVSGIFFILSGLSLVVGLVLYISSINDEVMNR 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 DSEDTVWIEYYYSWSFACACAAFILLFLGG-LALLLFSLPRMPRNPWESCMDAEPEH : . ...: :.:::: : ..:.: .: ... ::. NP_114 PSSSEQYFHYRYGWSFAFAASSFLLKEGAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSD 170 180 190 200 210 220 NP_114 CSDYSGQFLQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHISTSPC 230 240 250 260 270 >>NP_085915 (OMIM: 154045,615277) lens fiber membrane in (215 aa) initn: 169 init1: 82 opt: 144 Z-score: 186.8 bits: 41.7 E(85289): 0.0011 Smith-Waterman score: 144; 23.0% identity (51.5% similar) in 200 aa overlap (13-197:9-197) 10 20 30 40 50 pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHWAVLSPHMEHHNTTCEAAHFGLWRIC--T ::: .: .: ..:..:::: .. . :: :::: : . NP_085 MYSFMGGGLFCAWVGTILLVVAMATDHWM-------QYRLSGSFAHQGLWRYCLGN 10 20 30 40 60 70 80 90 100 110 pF1KB9 KRIPMDDSKTCGPITLPGEK-NCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGF : . :: : ::. . : :. .. :: . .. : . .: NP_085 KCYLQTDSIGEPPGQGPGRAWGKSRADLGAQGHLYSRWRTLRLKEGKGATQAYWNATRAF 50 60 70 80 90 100 120 130 140 150 160 pF1KB9 IILGSLCVL-------LSLGKKRDY--LLRPAS---MFYAFAGLCILVSVEVMRQSVKRM .::..::.. ...... . . :: : ::.. . : ..... .. . . NP_085 MILSALCAISGIIMGIMAFAHQPTFSRISRPFSAGIMFFS-STLFVVLALAIYTGVTVSF 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 IDSEDTVWIEYYYSWSFACACAAFILLFLGGLALLLFSLPRMPRNPWESCMDAEPEH . . : .:::. . .: .. :..:. NP_085 LGRRFGDW---RFSWSYILGWVAVLMTFFAGIFYMCAYRVHECRRLSTPR 170 180 190 200 210 >>NP_006069 (OMIM: 602911,614256) voltage-dependent calc (323 aa) initn: 152 init1: 58 opt: 138 Z-score: 177.1 bits: 40.5 E(85289): 0.004 Smith-Waterman score: 167; 26.4% identity (53.8% similar) in 212 aa overlap (5-202:9-201) 10 20 30 40 pF1KB9 MSQTKMLKVRVTLFCILAGIVLAMTAVVTDHW----AVLSPHMEHHNTTCEA---- .:: . : : :.. : :: ::.: .: . . .: : . NP_006 MGLFDRGVQMLLTTVGAF---AAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEV 10 20 30 40 50 50 60 70 80 90 100 pF1KB9 -AHFGLWRICTKRIPMDDSKTCGPITLPGEKNCSYFRHFNPGESSEIFEFTTQKEY--SI .: :::: : : .. : :. . :: : ... .: : . . .. NP_006 MTHSGLWRTC-----------CLEGNFKGL--CKQIDHF-PEDAD--YEADTAEYFLRAV 60 70 80 90 100 110 120 130 140 150 160 pF1KB9 SAAAI-AIFSLGFIILGSLCVLLS-LGKKRDYLLRPASMFYAFAGLCILVSVEVMRQSVK :..: :.:. ....:.::. : . : : .. :..:.. ::: .... :. .. NP_006 RASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANA 110 120 130 140 150 160 170 180 190 200 210 220 pF1KB9 RMIDSEDTVWIEYYYSWSFACACAAFILL-FLGGLALLLFSLPRMPRNPWESCMDAEPEH .. :. : :.::: . .::. ..: ::. .: NP_006 GDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQAS 170 180 190 200 210 220 NP_006 AITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAA 230 240 250 260 270 280 222 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 19:20:14 2016 done: Sat Nov 5 19:20:15 2016 Total Scan time: 6.050 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]