Result of FASTA (omim) for
pFN21AE9547
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9547, 553 aa
1>>>pF1KE9547 553 - 553 aa - 553 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1499+/-0.000375; mu= 19.7757+/- 0.023
mean_var=72.8252+/-14.637, 0's: 0 Z-trim(113.8): 239 B-trim: 339 in 1/50
Lambda= 0.150291
statistics sampled from 23022 (23270) to 23022 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.632), E-opt: 0.2 (0.273), width: 16
Scan time: 9.240
The best scores are: opt bits E(85289)
NP_004237 (OMIM: 603659) glucagon-like peptide 2 r ( 553) 3802 834.0 0
XP_016880828 (OMIM: 603659) PREDICTED: glucagon-li ( 559) 3780 829.2 0
XP_011522379 (OMIM: 603659) PREDICTED: glucagon-li ( 578) 2879 633.8 4.3e-181
XP_016880830 (OMIM: 603659) PREDICTED: glucagon-li ( 448) 2588 570.7 3.5e-162
XP_005256918 (OMIM: 603659) PREDICTED: glucagon-li ( 400) 2582 569.3 7.8e-162
XP_016880829 (OMIM: 603659) PREDICTED: glucagon-li ( 483) 2582 569.4 9e-162
NP_002053 (OMIM: 138032) glucagon-like peptide 1 r ( 463) 1281 287.3 7.2e-77
XP_016866239 (OMIM: 138032) PREDICTED: glucagon-li ( 468) 1281 287.3 7.3e-77
XP_016879935 (OMIM: 125853,138033) PREDICTED: gluc ( 475) 1237 277.8 5.5e-74
NP_000151 (OMIM: 125853,138033) glucagon receptor ( 477) 1231 276.5 1.4e-73
XP_006722340 (OMIM: 125853,138033) PREDICTED: gluc ( 477) 1231 276.5 1.4e-73
XP_011521841 (OMIM: 125853,138033) PREDICTED: gluc ( 444) 1035 233.9 8e-61
XP_016879936 (OMIM: 125853,138033) PREDICTED: gluc ( 355) 993 224.8 3.7e-58
NP_000155 (OMIM: 137241) gastric inhibitory polype ( 466) 985 223.1 1.5e-57
NP_001295347 (OMIM: 137241) gastric inhibitory pol ( 430) 978 221.6 4.1e-57
NP_001295188 (OMIM: 601970) vasoactive intestinal ( 422) 772 176.9 1.1e-43
NP_003373 (OMIM: 601970) vasoactive intestinal pol ( 438) 769 176.3 1.8e-43
XP_005249618 (OMIM: 601970) PREDICTED: vasoactive ( 463) 769 176.3 1.9e-43
XP_011509923 (OMIM: 182098) PREDICTED: secretin re ( 445) 748 171.7 4.3e-42
XP_011514852 (OMIM: 601970) PREDICTED: vasoactive ( 439) 747 171.5 5e-42
XP_016866240 (OMIM: 138032) PREDICTED: glucagon-li ( 287) 743 170.5 6.5e-42
XP_006716171 (OMIM: 601970) PREDICTED: vasoactive ( 392) 744 170.8 7.1e-42
XP_006716170 (OMIM: 601970) PREDICTED: vasoactive ( 455) 744 170.8 8e-42
XP_016860159 (OMIM: 182098) PREDICTED: secretin re ( 435) 736 169.1 2.6e-41
XP_016868069 (OMIM: 601970) PREDICTED: vasoactive ( 300) 719 165.3 2.5e-40
XP_016860161 (OMIM: 182098) PREDICTED: secretin re ( 377) 695 160.2 1.1e-38
XP_011525018 (OMIM: 137241) PREDICTED: gastric inh ( 291) 663 153.1 1.1e-36
NP_002971 (OMIM: 182098) secretin receptor precurs ( 440) 660 152.6 2.4e-36
XP_005263787 (OMIM: 182098) PREDICTED: secretin re ( 262) 636 147.2 5.8e-35
XP_005265496 (OMIM: 192321) PREDICTED: vasoactive ( 410) 634 147.0 1.1e-34
XP_005265495 (OMIM: 192321) PREDICTED: vasoactive ( 416) 634 147.0 1.1e-34
NP_001238811 (OMIM: 192321) vasoactive intestinal ( 416) 634 147.0 1.1e-34
XP_011532381 (OMIM: 192321) PREDICTED: vasoactive ( 416) 634 147.0 1.1e-34
NP_001238814 (OMIM: 192321) vasoactive intestinal ( 430) 634 147.0 1.2e-34
NP_004615 (OMIM: 192321) vasoactive intestinal pol ( 457) 634 147.0 1.2e-34
NP_001238813 (OMIM: 192321) vasoactive intestinal ( 409) 632 146.5 1.5e-34
XP_005265494 (OMIM: 192321) PREDICTED: vasoactive ( 456) 632 146.6 1.6e-34
XP_011525011 (OMIM: 137241) PREDICTED: gastric inh ( 508) 628 145.7 3.2e-34
XP_011525012 (OMIM: 137241) PREDICTED: gastric inh ( 508) 628 145.7 3.2e-34
NP_001109 (OMIM: 102981) pituitary adenylate cycla ( 468) 626 145.3 4.1e-34
XP_016860160 (OMIM: 182098) PREDICTED: secretin re ( 409) 621 144.1 7.9e-34
XP_011525013 (OMIM: 137241) PREDICTED: gastric inh ( 472) 621 144.2 8.8e-34
XP_016860162 (OMIM: 182098) PREDICTED: secretin re ( 267) 616 142.9 1.2e-33
XP_005249675 (OMIM: 102981) PREDICTED: pituitary a ( 411) 590 137.4 8.3e-32
NP_001186566 (OMIM: 102981) pituitary adenylate cy ( 447) 590 137.4 8.9e-32
NP_001158209 (OMIM: 114131,166710) calcitonin rece ( 508) 590 137.5 9.8e-32
NP_001291451 (OMIM: 601970) vasoactive intestinal ( 358) 568 132.6 2e-30
XP_011525016 (OMIM: 137241) PREDICTED: gastric inh ( 369) 565 132.0 3.3e-30
XP_011525017 (OMIM: 137241) PREDICTED: gastric inh ( 369) 565 132.0 3.3e-30
XP_005265401 (OMIM: 125350,156400,168468,215045,60 ( 562) 559 130.8 1.1e-29
>>NP_004237 (OMIM: 603659) glucagon-like peptide 2 recep (553 aa)
initn: 3802 init1: 3802 opt: 3802 Z-score: 4454.1 bits: 834.0 E(85289): 0
Smith-Waterman score: 3802; 99.8% identity (100.0% similar) in 553 aa overlap (1-553:1-553)
10 20 30 40 50 60
pF1KE9 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 YLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 MYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 KRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 PRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 ILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 ILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 QLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKNFRFLGKCPKK
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
NP_004 QLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE9 LSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTM
490 500 510 520 530 540
550
pF1KE9 ANTMEEILEESEI
:::::::::::::
NP_004 ANTMEEILEESEI
550
>>XP_016880828 (OMIM: 603659) PREDICTED: glucagon-like p (559 aa)
initn: 2877 init1: 2877 opt: 3780 Z-score: 4428.2 bits: 829.2 E(85289): 0
Smith-Waterman score: 3780; 98.7% identity (98.9% similar) in 559 aa overlap (1-553:1-559)
10 20 30 40 50 60
pF1KE9 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS
70 80 90 100 110 120
130 140 150 160 170
pF1KE9 YLPWWSEE------SSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYAL
:::::::: ::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YLPWWSEELCLLSESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYAL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE9 LSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVV
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE9 FYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE9 PERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVN
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE9 FFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAK
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE9 LIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKNFRFL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_016 LIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFL
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE9 GKCPKKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKCPKKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECS
490 500 510 520 530 540
540 550
pF1KE9 EGDVTMANTMEEILEESEI
:::::::::::::::::::
XP_016 EGDVTMANTMEEILEESEI
550
>>XP_011522379 (OMIM: 603659) PREDICTED: glucagon-like p (578 aa)
initn: 2879 init1: 2879 opt: 2879 Z-score: 3372.2 bits: 633.8 E(85289): 4.3e-181
Smith-Waterman score: 3742; 95.5% identity (95.7% similar) in 578 aa overlap (1-553:1-578)
10 20 30 40 50 60
pF1KE9 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS
70 80 90 100 110 120
130 140 150
pF1KE9 YLPWWSE-------------------------ESSGRAYRHCLAQGTWQTIENATDIWQD
::::::: ::::::::::::::::::::::::::::
XP_011 YLPWWSEDHQQIQGQLKLFSGKISGYKLQAKQESSGRAYRHCLAQGTWQTIENATDIWQD
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE9 DSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHM
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE9 NLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANY
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE9 LWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNG
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE9 NKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLG
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE9 VHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFL
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE9 LARHSGCRACVLGKNFRFLGKCPKKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGA
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_011 LARHSGCRACVLGKDFRFLGKCPKKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGA
490 500 510 520 530 540
520 530 540 550
pF1KE9 QPQQDHARWPRGSSLSECSEGDVTMANTMEEILEESEI
::::::::::::::::::::::::::::::::::::::
XP_011 QPQQDHARWPRGSSLSECSEGDVTMANTMEEILEESEI
550 560 570
>>XP_016880830 (OMIM: 603659) PREDICTED: glucagon-like p (448 aa)
initn: 2584 init1: 2584 opt: 2588 Z-score: 3032.8 bits: 570.7 E(85289): 3.5e-162
Smith-Waterman score: 2806; 80.8% identity (81.0% similar) in 553 aa overlap (1-553:1-448)
10 20 30 40 50 60
pF1KE9 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 IKQVTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVPCPS
::::
XP_016 IKQV--------------------------------------------------------
130 140 150 160 170 180
pF1KE9 YLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQL
:::::::::::
XP_016 -------------------------------------------------DRYALLSTLQL
70
190 200 210 220 230 240
pF1KE9 MYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYS
80 90 100 110 120 130
250 260 270 280 290 300
pF1KE9 KRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLW
140 150 160 170 180 190
310 320 330 340 350 360
pF1KE9 PRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLK
200 210 220 230 240 250
370 380 390 400 410 420
pF1KE9 ILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFI
260 270 280 290 300 310
430 440 450 460 470 480
pF1KE9 QLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKNFRFLGKCPKK
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
XP_016 QLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKK
320 330 340 350 360 370
490 500 510 520 530 540
pF1KE9 LSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTM
380 390 400 410 420 430
550
pF1KE9 ANTMEEILEESEI
:::::::::::::
XP_016 ANTMEEILEESEI
440
>>XP_005256918 (OMIM: 603659) PREDICTED: glucagon-like p (400 aa)
initn: 2582 init1: 2582 opt: 2582 Z-score: 3026.4 bits: 569.3 E(85289): 7.8e-162
Smith-Waterman score: 2582; 99.7% identity (100.0% similar) in 385 aa overlap (169-553:16-400)
140 150 160 170 180 190
pF1KE9 AQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALT
::::::::::::::::::::::::::::::
XP_005 MSLYPALHTYLGGVKVDRYALLSTLQLMYTVGYSFSLISLFLALT
10 20 30 40
200 210 220 230 240 250
pF1KE9 LLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMST
50 60 70 80 90 100
260 270 280 290 300 310
pF1KE9 SCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPW
110 120 130 140 150 160
320 330 340 350 360 370
pF1KE9 GFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRD
170 180 190 200 210 220
380 390 400 410 420 430
pF1KE9 YKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGF
230 240 250 260 270 280
440 450 460 470 480 490
pF1KE9 ANGEVKAELRKYWVRFLLARHSGCRACVLGKNFRFLGKCPKKLSEGDGAEKLRKLQPSLN
:::::::::::::::::::::::::::::::.::::::::::::::::::::::::::::
XP_005 ANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKLSEGDGAEKLRKLQPSLN
290 300 310 320 330 340
500 510 520 530 540 550
pF1KE9 SGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMANTMEEILEESEI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMANTMEEILEESEI
350 360 370 380 390 400
>>XP_016880829 (OMIM: 603659) PREDICTED: glucagon-like p (483 aa)
initn: 3012 init1: 2582 opt: 2582 Z-score: 3025.3 bits: 569.4 E(85289): 9e-162
Smith-Waterman score: 2881; 82.0% identity (84.2% similar) in 556 aa overlap (1-553:1-483)
10 20 30 40 50 60
pF1KE9 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKLGSSRAGPGRGSAGLLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVS
10 20 30 40 50 60
70 80 90 100 110
pF1KE9 IKQ---VTGSLLEETTRKWAQYKQACLRDLLKEPSGIFCNGTFDQYVCWPHSSPGNVSVP
::: ::: :. ..:. .: ...
XP_016 IKQAYFVTGHLI-----------STCVGLILLLEMSLY----------------------
70 80
120 130 140 150 160 170
pF1KE9 CPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLST
:. : :. .:::::::::
XP_016 -PAL--------------HTYLGGV-------------------------KVDRYALLST
90 100
180 190 200 210 220 230
pF1KE9 LQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYN
110 120 130 140 150 160
240 250 260 270 280 290
pF1KE9 SYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYSKRPDNENGWMSYLSEMSTSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPER
170 180 190 200 210 220
300 310 320 330 340 350
pF1KE9 RLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFI
230 240 250 260 270 280
360 370 380 390 400 410
pF1KE9 FLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIR
290 300 310 320 330 340
420 430 440 450 460 470
pF1KE9 LFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKNFRFLGKC
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
XP_016 LFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKC
350 360 370 380 390 400
480 490 500 510 520 530
pF1KE9 PKKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PKKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGD
410 420 430 440 450 460
540 550
pF1KE9 VTMANTMEEILEESEI
::::::::::::::::
XP_016 VTMANTMEEILEESEI
470 480
>>NP_002053 (OMIM: 138032) glucagon-like peptide 1 recep (463 aa)
initn: 1224 init1: 993 opt: 1281 Z-score: 1501.0 bits: 287.3 E(85289): 7.2e-77
Smith-Waterman score: 1287; 45.0% identity (72.6% similar) in 453 aa overlap (47-487:4-449)
20 30 40 50 60 70
pF1KE9 LLPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIKQV----TGSL--LE
::: :.:.:: . .. :. :
NP_002 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLW
10 20 30
80 90 100 110 120
pF1KE9 ETTRKWAQYKQACLRDLLKEP---SGIFCNGTFDQYVCWPHSSPGN-VSVPCPSYLPWWS
::..:: .:.. : :.: ..: . .::: :::.:.::: . ::. :.: :: :::: :
NP_002 ETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWAS
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE9 EESSGRAYRHCLAQGTWQTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGY
.:..:: : :.: : .:.. :.: ::: :.. ... . :: : ..:::::
NP_002 SVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLL-FLYIIYTVGY
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE9 SFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNE
..:. .: .: ..:: .:.:::::::::.:::::::::.:.:..::... :: . .
NP_002 ALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQ-Q
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE9 NGWMSYLSEM-STSCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLL
. : . :: . : ::: : .:..: :.::: ::::::.::.::: .:: :. .. :.
NP_002 HQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVS
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE9 LGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLL
.::. :.:::::::... :. :::: :.: . : ::: :... . :::.::.... ..
NP_002 IGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIV
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE9 ISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLS
.:::::. :: : : :::::::.::::::.::..:.:. :....: ..:.:: .:...
NP_002 VSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFT
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE9 SFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKNFRFLGKCP-KKLSEG
::.:..::. : :.:.::. :.:: : :. : . : .... : ::: ..:: :
NP_002 SFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQR----DSSMKPL-KCPTSSLSSG
400 410 420 430 440
490 500 510 520 530 540
pF1KE9 DGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMANTM
:
NP_002 ATAGSSMYTATCQASCS
450 460
>>XP_016866239 (OMIM: 138032) PREDICTED: glucagon-like p (468 aa)
initn: 1224 init1: 993 opt: 1281 Z-score: 1500.9 bits: 287.3 E(85289): 7.3e-77
Smith-Waterman score: 1281; 46.1% identity (74.1% similar) in 425 aa overlap (69-487:37-454)
40 50 60 70 80 90
pF1KE9 FHRKCSLWAPGRPFLTLVLLVSIKQVTGSLLEETTRKWAQYKQACLRDLLKEP---SGIF
: ::..:: .:.. : :.: ..: . .:
XP_016 SVLGGEGAGEGLAEPTGLPYMPSPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLF
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE9 CNGTFDQYVCWPHSSPGN-VSVPCPSYLPWWSEESSGRAYRHCLAQGTWQTIENATDIWQ
:: :::.:.::: . ::. :.: :: :::: : .:..:: : :.: : .:.. :.
XP_016 CNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWR
70 80 90 100 110 120
160 170 180 190 200 210
pF1KE9 DDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISLFLALTLLLFLRKLHCTRNYIH
: ::: :.. ... . :: : ..:::::..:. .: .: ..:: .:.:::::::::
XP_016 DLSECEESKRGERSSPEEQLL-FLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH
130 140 150 160 170 180
220 230 240 250 260 270
pF1KE9 MNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEM-STSCRSVQVLLHYFVGA
.:::::::::.:.:..::... :: . .. : . :: . : ::: : .:..: :.:
XP_016 LNLFASFILRALSVFIKDAALKWMYSTAAQ-QHQWDGLLSYQDSLSCRLVFLLMQYCVAA
190 200 210 220 230 240
280 290 300 310 320 330
pF1KE9 NYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFARAHLENTGCWTT
:: ::::::.::.::: .:: :. .. :. .::. :.:::::::... :. ::::
XP_016 NYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTR
250 260 270 280 290 300
340 350 360 370 380 390
pF1KE9 NGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQMCFRDYKYRLAKSTLVLIPL
:.: . : ::: :... . :::.::.... ...:::::. :: : : :::::::.::::
XP_016 NSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPL
310 320 330 340 350 360
400 410 420 430 440 450
pF1KE9 LGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFLVALQYGFANGEVKAELRKYWVR
::.::..:.:. :....: ..:.:: .:...::.:..::. : :.:.::. :.:: : :
XP_016 LGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWER
370 380 390 400 410 420
460 470 480 490 500 510
pF1KE9 FLLARHSGCRACVLGKNFRFLGKCP-KKLSEGDGAEKLRKLQPSLNSGRLLHLAMRGLGE
. : . : .... : ::: ..:: : :
XP_016 WRLEHLHIQR----DSSMKPL-KCPTSSLSSGATAGSSMYTATCQASCS
430 440 450 460
520 530 540 550
pF1KE9 LGAQPQQDHARWPRGSSLSECSEGDVTMANTMEEILEESEI
>>XP_016879935 (OMIM: 125853,138033) PREDICTED: glucagon (475 aa)
initn: 1188 init1: 756 opt: 1237 Z-score: 1449.3 bits: 277.8 E(85289): 5.5e-74
Smith-Waterman score: 1237; 44.4% identity (74.3% similar) in 417 aa overlap (48-458:6-420)
20 30 40 50 60 70
pF1KE9 LPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIKQVTGSLLEETTRKWA
: ::.: :.::.. . ...... .::
XP_016 MPPCQPQRPLLLLLLLLACQVPSAQVMDFLFEKWK
10 20 30
80 90 100 110 120 130
pF1KE9 QYKQACLRDL--LKEPSGIFCNGTFDQYVCWPHSSPGNVS--VPCPSYLPWWSEESSGRA
: . : ..: : :. . :: :::.: ::: ..:.:.. . :: :::: . . .
XP_016 LYGDQCHHNLSLLPPPTELVCNRTFDKYSCWP-DTPANTTANISCPWYLPWHHKVQHRFV
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE9 YRHCLAQGTWQTIENATDIWQDDSECS-ENHSFKQNVDRYALLSTLQLMYTVGYSFSLIS
...: .: : . :.: :.:. ... .. . . . :..:.:::::::.:: .
XP_016 FKRCGPDGQWVRGPRGQP-WRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGA
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE9 LFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSY
:.:::..: : ::::::: :: ::::::.:.. .::: : .. . ::.. .. . ..
XP_016 LLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTW
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE9 LSEMSTS-CRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFP
::. ... :: . :...: . ::: ::::::::::.:: ..:::: .. :: .::. :
XP_016 LSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAP
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE9 VLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKA
.::::::. .. .::. :::.: : .:::.: :..: . .:::::..:..::..::.:
XP_016 MLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRA
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE9 HQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHGFL
.:: :::.:::::::.:::::::::..:.:.::....: . .::..: ::::.:.:
XP_016 RQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLL
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE9 VALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKNFRFLGKCPKKLSEGDGAEKLR
::. : : : ::..:::. : :. :..
XP_016 VAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGG
400 410 420 430 440 450
>>NP_000151 (OMIM: 125853,138033) glucagon receptor prec (477 aa)
initn: 1126 init1: 756 opt: 1231 Z-score: 1442.2 bits: 276.5 E(85289): 1.4e-73
Smith-Waterman score: 1231; 44.6% identity (74.5% similar) in 419 aa overlap (48-458:6-422)
20 30 40 50 60 70
pF1KE9 LPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIK-QV-TGSLLEETTRK
: ::.: :.::.. . :: ...... .:
NP_000 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEK
10 20 30
80 90 100 110 120 130
pF1KE9 WAQYKQACLRDL--LKEPSGIFCNGTFDQYVCWPHSSPGNVS--VPCPSYLPWWSEESSG
: : . : ..: : :. . :: :::.: ::: ..:.:.. . :: :::: . .
NP_000 WKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWP-DTPANTTANISCPWYLPWHHKVQHR
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE9 RAYRHCLAQGTWQTIENATDIWQDDSECS-ENHSFKQNVDRYALLSTLQLMYTVGYSFSL
....: .: : . :.: :.:. ... .. . . . :..:.:::::::.::
NP_000 FVFKRCGPDGQWVRGPRGQP-WRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSL
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE9 ISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWM
.:.:::..: : ::::::: :: ::::::.:.. .::: : .. . ::.. .. .
NP_000 GALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVS
160 170 180 190 200 210
260 270 280 290 300
pF1KE9 SYLSEMSTS-CRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWA
..::. ... :: . :...: . ::: ::::::::::.:: ..:::: .. :: .::.
NP_000 TWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE9 FPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKL
:.::::::. .. .::. :::.: : .:::.: :..: . .:::::..:..::..::
NP_000 APMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKL
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE9 KAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSFHG
.:.:: :::.:::::::.:::::::::..:.:.::....: . .::..: ::::.:
NP_000 RARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQG
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE9 FLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKNFRFLGKCPKKLSEGDGAEK
.:::. : : : ::..:::. : :. :..
NP_000 LLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRG
400 410 420 430 440 450
553 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 13:55:17 2016 done: Sun Nov 6 13:55:18 2016
Total Scan time: 9.240 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]