FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5652, 505 aa 1>>>pF1KE5652 505 - 505 aa - 505 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6557+/-0.000442; mu= 16.2299+/- 0.027 mean_var=72.0308+/-14.192, 0's: 0 Z-trim(110.9): 169 B-trim: 436 in 1/53 Lambda= 0.151118 statistics sampled from 19135 (19308) to 19135 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.587), E-opt: 0.2 (0.226), width: 16 Scan time: 5.600 The best scores are: opt bits E(85289) NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 3375 745.5 8.1e-215 NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 3091 683.6 3.4e-196 XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 2949 652.6 6.5e-187 NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 1864 416.1 1.2e-115 XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1841 411.1 4e-114 NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 1841 411.1 4e-114 XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 1841 411.1 4e-114 NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 1702 380.8 5.2e-105 NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 1620 363.0 1.5e-99 NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 1595 357.4 5.2e-98 XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 1428 321.1 5.3e-87 XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370) 1410 317.1 5.7e-86 XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370) 1410 317.1 5.7e-86 XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 1392 313.2 9.8e-85 XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 1392 313.2 9.8e-85 NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 1345 302.9 1.3e-81 XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 1327 299.0 1.9e-80 NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 1300 293.1 1.2e-78 XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449) 1292 291.4 3.7e-78 XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462) 1292 291.4 3.8e-78 XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463) 1292 291.4 3.8e-78 NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 1292 291.4 4.1e-78 NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 1291 291.2 4.4e-78 NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 1285 289.9 1.2e-77 XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 1279 288.6 2.9e-77 XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 1279 288.6 2.9e-77 XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 1261 284.6 4.2e-76 XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 1261 284.6 4.2e-76 NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 1220 275.7 2.2e-73 XP_011542691 (OMIM: 118502,610353) PREDICTED: neur ( 331) 1215 274.5 3.3e-73 XP_016868493 (OMIM: 118502,610353) PREDICTED: neur ( 331) 1215 274.5 3.3e-73 NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 1204 272.2 2.6e-72 XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556) 1198 270.9 6.6e-72 NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 1164 263.5 1e-69 XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 1164 263.5 1e-69 XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486) 1079 245.0 3.8e-64 NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 1020 232.1 2.8e-60 NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 1014 230.8 6.6e-60 NP_001243502 (OMIM: 118504,188890,600513) neuronal ( 451) 978 222.9 1.5e-57 XP_016883114 (OMIM: 118504,188890,600513) PREDICTE ( 451) 978 222.9 1.5e-57 XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 960 219.0 2e-56 XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329) 915 209.1 1.6e-53 XP_011519494 (OMIM: 118509) PREDICTED: neuronal ac ( 316) 900 205.8 1.5e-52 XP_011520455 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 412) 870 199.4 1.7e-50 NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412) 870 199.4 1.7e-50 XP_011519479 (OMIM: 118511,612001) PREDICTED: neur ( 401) 863 197.8 4.9e-50 XP_016877372 (OMIM: 118511,612001) PREDICTED: neur ( 440) 862 197.6 6.1e-50 XP_016877371 (OMIM: 118511,612001) PREDICTED: neur ( 441) 862 197.6 6.1e-50 XP_016855669 (OMIM: 118507,605375) PREDICTED: neur ( 332) 761 175.5 2e-43 XP_016877370 (OMIM: 118505,612052) PREDICTED: neur ( 245) 753 173.7 5.3e-43 >>NP_000734 (OMIM: 118503,612052) neuronal acetylcholine (505 aa) initn: 3375 init1: 3375 opt: 3375 Z-score: 3977.6 bits: 745.5 E(85289): 8.1e-215 Smith-Waterman score: 3375; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505) 10 20 30 40 50 60 pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL 430 440 450 460 470 480 490 500 pF1KE5 WVFTLVCILGTAGLFLQPLMAREDA ::::::::::::::::::::::::: NP_000 WVFTLVCILGTAGLFLQPLMAREDA 490 500 >>NP_001160166 (OMIM: 118503,612052) neuronal acetylchol (489 aa) initn: 3091 init1: 3091 opt: 3091 Z-score: 3643.2 bits: 683.6 E(85289): 3.4e-196 Smith-Waterman score: 3091; 99.8% identity (99.8% similar) in 465 aa overlap (1-465:1-465) 10 20 30 40 50 60 pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGSGPLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPT 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFL ::::::::::::::::::::::::::::::::::::::::::: : NP_001 RSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEEQKAQEIQQLKRKEKST 430 440 450 460 470 480 490 500 pF1KE5 WVFTLVCILGTAGLFLQPLMAREDA NP_001 ETSDQEPGL >>XP_006720445 (OMIM: 118503,612052) PREDICTED: neuronal (438 aa) initn: 2949 init1: 2949 opt: 2949 Z-score: 3476.6 bits: 652.6 E(85289): 6.5e-187 Smith-Waterman score: 2949; 100.0% identity (100.0% similar) in 438 aa overlap (68-505:1-438) 40 50 60 70 80 90 pF1KE5 LFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLK :::::::::::::::::::::::::::::: XP_006 MSQLVKVDEVNQIMETNLWLKQIWNDYKLK 10 20 30 100 110 120 130 140 150 pF1KE5 WNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 WNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKS 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE5 SCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKH 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE5 DIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE5 SVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHT 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE5 MPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MPSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPC 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE5 QDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKA 340 350 360 370 380 390 460 470 480 490 500 pF1KE5 QNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA :::::::::::::::::::::::::::::::::::::::::::::::: XP_006 QNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA 400 410 420 430 >>NP_004189 (OMIM: 606888) neuronal acetylcholine recept (494 aa) initn: 2175 init1: 1832 opt: 1864 Z-score: 2197.4 bits: 416.1 E(85289): 1.2e-115 Smith-Waterman score: 2191; 67.9% identity (85.4% similar) in 471 aa overlap (35-500:34-488) 10 20 30 40 50 60 pF1KE5 PLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHF :.:::..:: ::..:::: :::::: .:: NP_004 SKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 EVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLY ::...::..::::::::::::::..:::::::.:.: .: : : .::::.:::::::::: NP_004 EVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 NNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDK :::::::::. ::::::::.: .:: ::::::::: .:.:.::::.:::..:::::.::: NP_004 NNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 AKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFY :.:::..:::.....:.::..:: :: : ::::::::::::::: :::::.::::::.:: NP_004 AEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 TINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLI :::::::::.::::::::::::::::::::::::::::::::::::::::::::::.::. NP_004 TINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 GEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRP---TS ::::::::::::::::.::::::.::::::::::: :::::::.:::.:..: : : NP_004 GEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTR 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 NEGNAQKPRPLYGAELSNLNCFSRAESKG--CKEGYPCQDGMCGYCHHRRIKISNFSANL . :. :: : .: .:: ..: : . : .::. :: :. NP_004 GTGSDAVPRGL-----------ARRPAKGKLASHGEPRHLKECFHCHK-----SNELATS 370 380 390 400 420 430 440 450 460 470 pF1KE5 TRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIF : : . .. :. : :::....:.::..::::::..::.::..:::::::::.::.: NP_004 KRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVF 410 420 430 440 450 460 480 490 500 pF1KE5 LWVFTLVCILGTAGLFLQPLMAREDA :::: .::..::::::::::. NP_004 LWVFIIVCVFGTAGLFLQPLLGNTGKS 470 480 490 >>XP_011542690 (OMIM: 118502,610353) PREDICTED: neuronal (529 aa) initn: 1864 init1: 1602 opt: 1841 Z-score: 2169.8 bits: 411.1 E(85289): 4e-114 Smith-Waterman score: 1842; 56.7% identity (76.1% similar) in 506 aa overlap (14-501:33-526) 10 20 30 pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVA-----RASEAEHRL ::: : : :.: .:.: :: XP_011 PSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW :..::. ::. ::: :.:: ::..: .:..::. ::: ::.: ::.:::: :.::::.: XP_011 FKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRW 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 NPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSS ::.:.:. .:::.. :: ::::::::: :.: : ::: : :: : :.::::.::: XP_011 NPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE5 CKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHD :.::::.:::: ::: ::::::.:::::::: . ....::::::::::::..: : .. XP_011 CSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 IKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCIS ::.:: :::::.::.. :::::::::::::::::::: :::::::::::::::.::::: XP_011 KKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCIS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 VLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTM ::::::::::.::: ::::::::::::::::::::::::::::::::::::.:.:.:::: XP_011 VLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTM 310 320 330 340 350 360 340 350 360 370 380 pF1KE5 PSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR----PLYGAELSNLNCFSRA-----ESK : ::. ..:. .:: ..:.:: . : : : ::.. : :.. XP_011 PHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDR 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE5 GCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSAL--SPEIKEAI :. : .:.. : : ..:. ...:.:. . : ::....:. XP_011 WACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLSPHMQKAL 430 440 450 460 470 450 460 470 480 490 500 pF1KE5 QSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA ..:.:::....... . ...:::::::::::::::.: .::.::: :::: :..: XP_011 EGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 480 490 500 510 520 >>NP_000733 (OMIM: 118502,610353) neuronal acetylcholine (529 aa) initn: 1864 init1: 1602 opt: 1841 Z-score: 2169.8 bits: 411.1 E(85289): 4e-114 Smith-Waterman score: 1842; 56.7% identity (76.1% similar) in 506 aa overlap (14-501:33-526) 10 20 30 pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVA-----RASEAEHRL ::: : : :.: .:.: :: NP_000 PSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW :..::. ::. ::: :.:: ::..: .:..::. ::: ::.: ::.:::: :.::::.: NP_000 FKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRW 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 NPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSS ::.:.:. .:::.. :: ::::::::: :.: : ::: : :: : :.::::.::: NP_000 NPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE5 CKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHD :.::::.:::: ::: ::::::.:::::::: . ....::::::::::::..: : .. NP_000 CSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 IKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCIS ::.:: :::::.::.. :::::::::::::::::::: :::::::::::::::.::::: NP_000 KKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCIS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 VLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTM ::::::::::.::: ::::::::::::::::::::::::::::::::::::.:.:.:::: NP_000 VLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTM 310 320 330 340 350 360 340 350 360 370 380 pF1KE5 PSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR----PLYGAELSNLNCFSRA-----ESK : ::. ..:. .:: ..:.:: . : : : ::.. : :.. NP_000 PHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDR 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE5 GCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSAL--SPEIKEAI :. : .:.. : : ..:. ...:.:. . : ::....:. NP_000 WACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLSPHMQKAL 430 440 450 460 470 450 460 470 480 490 500 pF1KE5 QSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA ..:.:::....... . ...:::::::::::::::.: .::.::: :::: :..: NP_000 EGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 480 490 500 510 520 >>XP_006716345 (OMIM: 118502,610353) PREDICTED: neuronal (529 aa) initn: 1864 init1: 1602 opt: 1841 Z-score: 2169.8 bits: 411.1 E(85289): 4e-114 Smith-Waterman score: 1842; 56.7% identity (76.1% similar) in 506 aa overlap (14-501:33-526) 10 20 30 pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVA-----RASEAEHRL ::: : : :.: .:.: :: XP_006 PSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW :..::. ::. ::: :.:: ::..: .:..::. ::: ::.: ::.:::: :.::::.: XP_006 FKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRW 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 NPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSS ::.:.:. .:::.. :: ::::::::: :.: : ::: : :: : :.::::.::: XP_006 NPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSS 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE5 CKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHD :.::::.:::: ::: ::::::.:::::::: . ....::::::::::::..: : .. XP_006 CSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNS 190 200 210 220 230 240 220 230 240 250 260 270 pF1KE5 IKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCIS ::.:: :::::.::.. :::::::::::::::::::: :::::::::::::::.::::: XP_006 KKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCIS 250 260 270 280 290 300 280 290 300 310 320 330 pF1KE5 VLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTM ::::::::::.::: ::::::::::::::::::::::::::::::::::::.:.:.:::: XP_006 VLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTM 310 320 330 340 350 360 340 350 360 370 380 pF1KE5 PSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR----PLYGAELSNLNCFSRA-----ESK : ::. ..:. .:: ..:.:: . : : : ::.. : :.. XP_006 PHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDR 370 380 390 400 410 420 390 400 410 420 430 440 pF1KE5 GCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSAL--SPEIKEAI :. : .:.. : : ..:. ...:.:. . : ::....:. XP_006 WACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLSPHMQKAL 430 440 450 460 470 450 460 470 480 490 500 pF1KE5 QSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA ..:.:::....... . ...:::::::::::::::.: .::.::: :::: :..: XP_006 EGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 480 490 500 510 520 >>NP_001269384 (OMIM: 118502,610353) neuronal acetylchol (514 aa) initn: 1810 init1: 1464 opt: 1702 Z-score: 2006.3 bits: 380.8 E(85289): 5.2e-105 Smith-Waterman score: 1762; 55.5% identity (73.7% similar) in 506 aa overlap (14-501:33-511) 10 20 30 pF1KE5 MGSGPLSLPLALSPPRLLLLLLLSLLPVA-----RASEAEHRL ::: : : :.: .:.: :: NP_001 PSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE5 FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW :..::. ::. ::: :.:: ::: ::.: ::.:::: :.::::.: NP_001 FKHLFRGYNRWARPVPNTSD---------------VDEKNQMMTTNVWLKQEWSDYKLRW 70 80 90 100 100 110 120 130 140 150 pF1KE5 NPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSS ::.:.:. .:::.. :: ::::::::: :.: : ::: : :: : :.::::.::: NP_001 NPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSS 110 120 130 140 150 160 160 170 180 190 200 210 pF1KE5 CKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHD :.::::.:::: ::: ::::::.:::::::: . ....::::::::::::..: : .. NP_001 CSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNS 170 180 190 200 210 220 220 230 240 250 260 270 pF1KE5 IKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCIS ::.:: :::::.::.. :::::::::::::::::::: :::::::::::::::.::::: NP_001 KKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCIS 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE5 VLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTM ::::::::::.::: ::::::::::::::::::::::::::::::::::::.:.:.:::: NP_001 VLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTM 290 300 310 320 330 340 340 350 360 370 380 pF1KE5 PSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR----PLYGAELSNLNCFSRA-----ESK : ::. ..:. .:: ..:.:: . : : : ::.. : :.. NP_001 PHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDR 350 360 370 380 390 400 390 400 410 420 430 440 pF1KE5 GCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSAL--SPEIKEAI :. : .:.. : : ..:. ...:.:. . : ::....:. NP_001 WACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLSPHMQKAL 410 420 430 440 450 450 460 470 480 490 500 pF1KE5 QSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA ..:.:::....... . ...:::::::::::::::.: .::.::: :::: :..: NP_001 EGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 460 470 480 490 500 510 >>NP_000735 (OMIM: 118504,188890,600513) neuronal acetyl (627 aa) initn: 1909 init1: 1592 opt: 1620 Z-score: 1908.3 bits: 363.0 E(85289): 1.5e-99 Smith-Waterman score: 1620; 66.1% identity (83.6% similar) in 360 aa overlap (12-368:11-370) 10 20 30 40 50 pF1KE5 MGSGPLSLPLALSPPRLLLL---LLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVS : :: :::: :: . : ..::.::...:: ::. :::::.: NP_000 MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANIS 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 DPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIW : :...: .:..::. ::: ::.: ::.:.:: :.::::.:.:.:: .. .:.:.. :: NP_000 DVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIW 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 KPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKF .::::::::: ::: : ::: : . :.: : ::::.::::.::::.:::: ::::::: NP_000 RPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 GSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYI :::.::::::::: . : .. :.::::::.:. : : . ::.:: ::::::::.. : NP_000 GSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 RRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPST ::::::::::::::::::: ::::::::::.::::.:::::::::::::::.::: :::: NP_000 RRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPST 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE5 SLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMT ::::::::::::::::::::::::::::::::.:.: :::::.::. :::...::...: NP_000 SLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMK 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 RPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSA ::. . : .. NP_000 RPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPG 360 370 380 390 400 410 >-- initn: 324 init1: 278 opt: 284 Z-score: 334.2 bits: 71.7 E(85289): 7.1e-12 Smith-Waterman score: 284; 40.6% identity (66.4% similar) in 128 aa overlap (374-501:508-624) 350 360 370 380 390 400 pF1KE5 TVFLNLLPRVMFMTRPTSNEGNAQKPRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCG :: :.. : : :: . ::. : NP_000 VEGGVRCRSRSIQYCVPRDDAAPEADGQAAGA-LASRNTHS-AELPPPDQPSPCK---CT 480 490 500 510 520 530 410 420 430 440 450 460 pF1KE5 YCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKE :... ..: .. :::... ::: . .:...:.:::...::.. NP_000 -CKKEPSSVSPSATVKTRSTKAPPPHL-----PLSPALTRAVEGVQYIADHLKAEDTDFS 540 550 560 570 580 470 480 490 500 pF1KE5 IQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA ...:::::::::::::::.: .::.:::.:::: : .: NP_000 VKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI 590 600 610 620 >>NP_001186208 (OMIM: 606888) neuronal acetylcholine rec (479 aa) initn: 2069 init1: 1563 opt: 1595 Z-score: 1880.7 bits: 357.4 E(85289): 5.2e-98 Smith-Waterman score: 2059; 65.2% identity (82.2% similar) in 471 aa overlap (35-500:34-473) 10 20 30 40 50 60 pF1KE5 PLSLPLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHF :.:::..:: ::..:::: :::::: .:: NP_001 SKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 EVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLY ::...::..: :::::::.:.: .: : : .::::.:::::::::: NP_001 EVAITQLANV---------------IWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLY 70 80 90 100 130 140 150 160 170 180 pF1KE5 NNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDK :::::::::. ::::::::.: .:: ::::::::: .:.:.::::.:::..:::::.::: NP_001 NNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDK 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE5 AKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFY :.:::..:::.....:.::..:: :: : ::::::::::::::: :::::.::::::.:: NP_001 AEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFY 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE5 TINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLI :::::::::.::::::::::::::::::::::::::::::::::::::::::::::.::. NP_001 TINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLV 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE5 GEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRP---TS ::::::::::::::::.::::::.::::::::::: :::::::.:::.:..: : : NP_001 GEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTR 290 300 310 320 330 340 370 380 390 400 410 pF1KE5 NEGNAQKPRPLYGAELSNLNCFSRAESKG--CKEGYPCQDGMCGYCHHRRIKISNFSANL . :. :: : .: .:: ..: : . : .::. :: :. NP_001 GTGSDAVPRGL-----------ARRPAKGKLASHGEPRHLKECFHCHK-----SNELATS 350 360 370 380 390 420 430 440 450 460 470 pF1KE5 TRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIF : : . .. :. : :::....:.::..::::::..::.::..:::::::::.::.: NP_001 KRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVF 400 410 420 430 440 450 480 490 500 pF1KE5 LWVFTLVCILGTAGLFLQPLMAREDA :::: .::..::::::::::. NP_001 LWVFIIVCVFGTAGLFLQPLLGNTGKS 460 470 505 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 10:37:58 2016 done: Tue Nov 8 10:37:59 2016 Total Scan time: 5.600 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]