Result of FASTA (omim) for
pFN21AE1680
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE1680, 194 aa
1>>>pF1KE1680 194 - 194 aa - 194 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7851+/-0.000385; mu= 15.7372+/- 0.024
mean_var=52.2061+/-10.489, 0's: 0 Z-trim(110.6): 83 B-trim: 0 in 0/51
Lambda= 0.177506
statistics sampled from 18917 (19000) to 18917 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.594), E-opt: 0.2 (0.223), width: 16
Scan time: 5.270
The best scores are: opt bits E(85289)
NP_002000 (OMIM: 148180) fibroblast growth factor ( 194) 1325 347.0 1.1e-95
NP_004456 (OMIM: 149730,180920,602115) fibroblast ( 208) 599 161.1 1.1e-39
XP_005248321 (OMIM: 149730,180920,602115) PREDICTE ( 208) 599 161.1 1.1e-39
NP_065688 (OMIM: 605831) fibroblast growth factor ( 170) 457 124.7 8e-29
NP_002001 (OMIM: 600921,612961) fibroblast growth ( 208) 383 105.8 4.8e-23
NP_003859 (OMIM: 300827,309630) fibroblast growth ( 207) 380 105.0 8.2e-23
NP_062825 (OMIM: 605558,615721) fibroblast growth ( 211) 377 104.3 1.4e-22
NP_004455 (OMIM: 165190,190330) fibroblast growth ( 268) 322 90.2 3e-18
NP_004106 (OMIM: 601515,609307) fibroblast growth ( 247) 314 88.2 1.2e-17
NP_001308873 (OMIM: 601515,609307) fibroblast grow ( 184) 312 87.6 1.3e-17
NP_001308861 (OMIM: 601515,609307) fibroblast grow ( 184) 312 87.6 1.3e-17
NP_001308865 (OMIM: 601515,609307) fibroblast grow ( 184) 312 87.6 1.3e-17
NP_001308870 (OMIM: 601515,609307) fibroblast grow ( 185) 312 87.6 1.3e-17
NP_001308862 (OMIM: 601515,609307) fibroblast grow ( 187) 312 87.6 1.3e-17
NP_001308867 (OMIM: 601515,609307) fibroblast grow ( 187) 312 87.6 1.3e-17
NP_001308869 (OMIM: 601515,609307) fibroblast grow ( 187) 312 87.6 1.3e-17
NP_001308876 (OMIM: 601515,609307) fibroblast grow ( 200) 312 87.6 1.4e-17
NP_001308877 (OMIM: 601515,609307) fibroblast grow ( 213) 312 87.6 1.5e-17
NP_001308874 (OMIM: 601515,609307) fibroblast grow ( 213) 312 87.6 1.5e-17
NP_787125 (OMIM: 601515,609307) fibroblast growth ( 252) 312 87.7 1.7e-17
NP_004105 (OMIM: 300070) fibroblast growth factor ( 245) 308 86.6 3.4e-17
NP_378668 (OMIM: 300070) fibroblast growth factor ( 192) 305 85.8 4.7e-17
NP_066360 (OMIM: 601513,617166) fibroblast growth ( 243) 306 86.1 4.8e-17
NP_001132970 (OMIM: 300070) fibroblast growth fact ( 199) 305 85.8 4.8e-17
NP_004103 (OMIM: 601514) fibroblast growth factor ( 225) 305 85.9 5.3e-17
NP_001132973 (OMIM: 300070) fibroblast growth fact ( 226) 305 85.9 5.4e-17
NP_001132974 (OMIM: 300070) fibroblast growth fact ( 226) 305 85.9 5.4e-17
NP_001132972 (OMIM: 300070) fibroblast growth fact ( 255) 305 85.9 5.9e-17
XP_005262456 (OMIM: 300070) PREDICTED: fibroblast ( 255) 305 85.9 5.9e-17
XP_005247284 (OMIM: 601513,617166) PREDICTED: fibr ( 207) 301 84.8 1e-16
XP_006713601 (OMIM: 601513,617166) PREDICTED: fibr ( 178) 298 84.0 1.5e-16
NP_004104 (OMIM: 601513,617166) fibroblast growth ( 181) 298 84.0 1.5e-16
XP_011533298 (OMIM: 600921,612961) PREDICTED: fibr ( 158) 297 83.7 1.6e-16
NP_066276 (OMIM: 134921) fibroblast growth factor ( 208) 293 82.8 4.2e-16
NP_001290389 (OMIM: 601514) fibroblast growth fact ( 166) 291 82.2 4.9e-16
NP_001998 (OMIM: 164980) fibroblast growth factor ( 206) 286 81.0 1.4e-15
NP_005238 (OMIM: 164950,610706) fibroblast growth ( 239) 282 80.0 3.3e-15
NP_000791 (OMIM: 131220) fibroblast growth factor ( 155) 275 78.1 8e-15
NP_001138407 (OMIM: 131220) fibroblast growth fact ( 155) 275 78.1 8e-15
NP_001244137 (OMIM: 131220) fibroblast growth fact ( 155) 275 78.1 8e-15
NP_001244139 (OMIM: 131220) fibroblast growth fact ( 155) 275 78.1 8e-15
NP_001244138 (OMIM: 131220) fibroblast growth fact ( 155) 275 78.1 8e-15
NP_001138364 (OMIM: 131220) fibroblast growth fact ( 155) 275 78.1 8e-15
NP_001244134 (OMIM: 131220) fibroblast growth fact ( 155) 275 78.1 8e-15
NP_001138406 (OMIM: 131220) fibroblast growth fact ( 155) 275 78.1 8e-15
NP_001244136 (OMIM: 131220) fibroblast growth fact ( 155) 275 78.1 8e-15
XP_016861368 (OMIM: 601513,617166) PREDICTED: fibr ( 157) 267 76.0 3.3e-14
NP_001997 (OMIM: 134920) fibroblast growth factor ( 288) 267 76.2 5.6e-14
NP_001244140 (OMIM: 131220) fibroblast growth fact ( 154) 264 75.3 5.6e-14
XP_005268447 (OMIM: 131220) PREDICTED: fibroblast ( 154) 264 75.3 5.6e-14
>>NP_002000 (OMIM: 148180) fibroblast growth factor 7 pr (194 aa)
initn: 1325 init1: 1325 opt: 1325 Z-score: 1838.9 bits: 347.0 E(85289): 1.1e-95
Smith-Waterman score: 1325; 100.0% identity (100.0% similar) in 194 aa overlap (1-194:1-194)
10 20 30 40 50 60
pF1KE1 MHKWILTWILPTLLYRSCFHIICLVGTISLACNDMTPEQMATNVNCSSPERHTRSYDYME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MHKWILTWILPTLLYRSCFHIICLVGTISLACNDMTPEQMATNVNCSSPERHTRSYDYME
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE1 GGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE1 MNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVALNQKGIPVRGKKTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVALNQKGIPVRGKKTK
130 140 150 160 170 180
190
pF1KE1 KEQKTAHFLPMAIT
::::::::::::::
NP_002 KEQKTAHFLPMAIT
190
>>NP_004456 (OMIM: 149730,180920,602115) fibroblast grow (208 aa)
initn: 692 init1: 523 opt: 599 Z-score: 833.6 bits: 161.1 E(85289): 1.1e-39
Smith-Waterman score: 609; 47.3% identity (75.4% similar) in 207 aa overlap (1-193:1-206)
10 20 30 40
pF1KE1 MHKWILTW---ILPTL--LYRSCFHIICLVGTISLACN----DM-TPEQM-ATNVNCSSP
: ::::: .: : :: .. ::... ..:. :: .:: ... . :::
NP_004 MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 E---RHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVG
::.:::....: :.: :.:: :...:.:.: :::.::.. . :.:.:: .: .:
NP_004 SSAGRHVRSYNHLQG-DVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIG
70 80 90 100 110
110 120 130 140 150 160
pF1KE1 IVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVA
.::.:...:..::::::.::::..:: :.::..:: : :: :::::: .: ::: .:.::
NP_004 VVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVA
120 130 140 150 160 170
170 180 190
pF1KE1 LNQKGIPVRGKKTKKEQKTAHFLPMAIT
:: :: : ::.::.... .::::::..
NP_004 LNGKGAPRRGQKTRRKNTSAHFLPMVVHS
180 190 200
>>XP_005248321 (OMIM: 149730,180920,602115) PREDICTED: f (208 aa)
initn: 692 init1: 523 opt: 599 Z-score: 833.6 bits: 161.1 E(85289): 1.1e-39
Smith-Waterman score: 609; 47.3% identity (75.4% similar) in 207 aa overlap (1-193:1-206)
10 20 30 40
pF1KE1 MHKWILTW---ILPTL--LYRSCFHIICLVGTISLACN----DM-TPEQM-ATNVNCSSP
: ::::: .: : :: .. ::... ..:. :: .:: ... . :::
XP_005 MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE1 E---RHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVG
::.:::....: :.: :.:: :...:.:.: :::.::.. . :.:.:: .: .:
XP_005 SSAGRHVRSYNHLQG-DVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIG
70 80 90 100 110
110 120 130 140 150 160
pF1KE1 IVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVA
.::.:...:..::::::.::::..:: :.::..:: : :: :::::: .: ::: .:.::
XP_005 VVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVA
120 130 140 150 160 170
170 180 190
pF1KE1 LNQKGIPVRGKKTKKEQKTAHFLPMAIT
:: :: : ::.::.... .::::::..
XP_005 LNGKGAPRRGQKTRRKNTSAHFLPMVVHS
180 190 200
>>NP_065688 (OMIM: 605831) fibroblast growth factor 22 i (170 aa)
initn: 463 init1: 432 opt: 457 Z-score: 638.4 bits: 124.7 E(85289): 8e-29
Smith-Waterman score: 457; 46.3% identity (75.5% similar) in 147 aa overlap (48-194:25-170)
20 30 40 50 60 70
pF1KE1 CFHIICLVGTISLACNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYL
: : ::: ..:: :.: :::: :...:
NP_065 MRRRLWLGLAWLLLARAPDAAGTPSASRGPRSYPHLEG-DVRWRRLFSSTHFFL
10 20 30 40 50
80 90 100 110 120 130
pF1KE1 RIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDC
:.: :.:.::. ... .:.:::.: ::.:.::.: : ::.:::..:.::... . ::
NP_065 RVDPGGRVQGTRWRHGQDSILEIRSVHVGVVVIKAVSSGFYVAMNRRGRLYGSRLYTVDC
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE1 NFKELILENHYNTYASAKWTHNGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT
:.: : :: .::::: .: . : ::.::...: : : .:.. . .:::::. ..
NP_065 RFRERIEENGHNTYASQRWRRRGQPMFLALDRRGGPRPGGRTRRYHLSAHFLPVLVS
120 130 140 150 160 170
>>NP_002001 (OMIM: 600921,612961) fibroblast growth fact (208 aa)
initn: 345 init1: 253 opt: 383 Z-score: 534.7 bits: 105.8 E(85289): 4.8e-23
Smith-Waterman score: 383; 41.0% identity (78.4% similar) in 139 aa overlap (57-193:55-192)
30 40 50 60 70 80
pF1KE1 TISLACNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVK
:...: .: :.:.::: ..:.: : ..
NP_002 LPVDSPVLLSDHLGQSEAGGLPRGPAVTDLDHLKGI-LRRRQLYCRTGFHLEIFPNGTIQ
30 40 50 60 70 80
90 100 110 120 130 140
pF1KE1 GTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILEN
::.. .. ..:.:. ..:::.:.:.::.: .::.::..:.::.... ...: :.: . ::
NP_002 GTRKDHSRFGILEFISIAVGLVSIRGVDSGLYLGMNEKGELYGSEKLTQECVFREQFEEN
90 100 110 120 130 140
150 160 170 180 190
pF1KE1 HYNTYASAKWTH--NGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT
::::.: . : .: ...::::. : : .: .::..:: .:::: .
NP_002 WYNTYSSNLYKHVDTGRRYYVALNKDGTPREGTRTKRHQKFTHFLPRPVDPDKVPELYKD
150 160 170 180 190 200
NP_002 ILSQS
>>NP_003859 (OMIM: 300827,309630) fibroblast growth fact (207 aa)
initn: 381 init1: 260 opt: 380 Z-score: 530.5 bits: 105.0 E(85289): 8.2e-23
Smith-Waterman score: 380; 43.3% identity (79.1% similar) in 134 aa overlap (62-193:58-191)
40 50 60 70 80 90
pF1KE1 CNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEM
: .: :.:.::: ..:.: : :.::..
NP_003 ADSPGFLNERLGQIEGKLQRGSPTDFAHLKGILRRRQLYCRTGFHLEIFPNGTVHGTRHD
30 40 50 60 70 80
100 110 120 130 140 150
pF1KE1 KNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTY
.. ..:.:. ..:::...:.::.: .::.::..:.::..:. ...: :.: . :: ::::
NP_003 HSRFGILEFISLAVGLISIRGVDSGLYLGMNERGELYGSKKLTRECVFREQFEENWYNTY
90 100 110 120 130 140
160 170 180 190
pF1KE1 ASAKWTHNGGE--MFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT
::. . :. .: ..::::. : : .: .::..:: .:::: .
NP_003 ASTLYKHSDSERQYYVALNKDGSPREGYRTKRHQKFTHFLPRPVDPSKLPSMSRDLFHYR
150 160 170 180 190 200
>>NP_062825 (OMIM: 605558,615721) fibroblast growth fact (211 aa)
initn: 345 init1: 250 opt: 377 Z-score: 526.3 bits: 104.3 E(85289): 1.4e-22
Smith-Waterman score: 377; 43.3% identity (76.9% similar) in 134 aa overlap (62-193:62-195)
40 50 60 70 80 90
pF1KE1 CNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEM
: .: :.:.::: ..:.: :.:.::..
NP_062 ERPPLLGERRSAAERSARGGPGAAQLAHLHGILRRRQLYCRTGFHLQILPDGSVQGTRQD
40 50 60 70 80 90
100 110 120 130 140 150
pF1KE1 KNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTY
.. ..:.:. .::::.:.:.::.: .::.:: .:.::.... . .: :.: . :: ::::
NP_062 HSLFGILEFISVAVGLVSIRGVDSGLYLGMNDKGELYGSEKLTSECIFREQFEENWYNTY
100 110 120 130 140 150
160 170 180 190
pF1KE1 ASAKWTHN--GGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT
.: . :. : ..:::::. : : : ..:..:: .:::: .
NP_062 SSNIYKHGDTGRRYFVALNKDGTPRDGARSKRHQKFTHFLPRPVDPERVPELYKDLLMYT
160 170 180 190 200 210
>>NP_004455 (OMIM: 165190,190330) fibroblast growth fact (268 aa)
initn: 275 init1: 203 opt: 322 Z-score: 448.6 bits: 90.2 E(85289): 3e-18
Smith-Waterman score: 322; 41.5% identity (72.5% similar) in 142 aa overlap (55-190:78-217)
30 40 50 60 70 80
pF1KE1 VGTISLACNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQ--WYLRIDKR
:... .: :. :.::. ..:.:
NP_004 QSSSSAMSSSSASSSPAASLGSQGSGLEQSSFQWSPSGR-RTGSLYCRVGIGFHLQIYPD
50 60 70 80 90 100
90 100 110 120 130 140
pF1KE1 GKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKEL
:::.:..: : ...:: .:. :::.:.:: :. .:::.:.:::.:. . ..::.:.:
NP_004 GKVNGSHEA-NMLSVLEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRER
110 120 130 140 150 160
150 160 170 180 190
pF1KE1 ILENHYNTYASA--KWTHNGGEMFVALNQKGIPVRG--KKTKKEQKTAHFLPMAIT
. :: ::::::: . ..: : .::::..: :: ..: .. ..::::
NP_004 FQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQP
170 180 190 200 210 220
NP_004 ELSFTVTVPEKKKPPSPIKPKIPLSAPRKNTNSVKYRLKFRFG
230 240 250 260
>>NP_004106 (OMIM: 601515,609307) fibroblast growth fact (247 aa)
initn: 339 init1: 225 opt: 314 Z-score: 438.0 bits: 88.2 E(85289): 1.2e-17
Smith-Waterman score: 314; 35.7% identity (69.2% similar) in 143 aa overlap (50-190:58-198)
20 30 40 50 60 70
pF1KE1 HIICLVGTISLACNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRI
.:. : : . : : ::.:: .::..
NP_004 RRRSSPSKNRGLCNGNLVDIFSKVRIFGLKKRRLRRQDPQLKGI--VTRLYCRQGYYLQM
30 40 50 60 70 80
80 90 100 110 120 130
pF1KE1 DKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNF
: . ::.. ..: ..... :.. .:::.::.. .:.::: :: :: .. . .:.:
NP_004 HPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKF
90 100 110 120 130 140
140 150 160 170 180 190
pF1KE1 KELILENHYNTYASA--KWTHNGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT
:: ..::.: :.: . ..: :..::..: ..:...:: . .:::::
NP_004 KESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAM
150 160 170 180 190 200
NP_004 YREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT
210 220 230 240
>>NP_001308873 (OMIM: 601515,609307) fibroblast growth f (184 aa)
initn: 339 init1: 225 opt: 312 Z-score: 437.2 bits: 87.6 E(85289): 1.3e-17
Smith-Waterman score: 312; 37.0% identity (72.4% similar) in 127 aa overlap (66-190:9-135)
40 50 60 70 80 90
pF1KE1 TPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNY
: ::.:: .::.. : . ::.. ..:
NP_001 MHPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNS
10 20 30
100 110 120 130 140 150
pF1KE1 NIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASA-
..... :.. .:::.::.. .:.::: :: :: .. . .:.::: ..::.: :.:
NP_001 TLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYYVIYSSML
40 50 60 70 80 90
160 170 180 190
pF1KE1 -KWTHNGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT
. ..: :..::..: ..:...:: . .:::::
NP_001 YRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDVGETVPKP
100 110 120 130 140 150
NP_001 GVTPSKSTSASAIMNGGKPVNKSKTT
160 170 180
194 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 14:13:52 2016 done: Sun Nov 6 14:13:53 2016
Total Scan time: 5.270 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]