FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2244, 252 aa 1>>>pF1KE2244 252 - 252 aa - 252 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4661+/-0.000777; mu= 13.7806+/- 0.047 mean_var=64.1715+/-12.660, 0's: 0 Z-trim(108.1): 36 B-trim: 44 in 1/50 Lambda= 0.160104 statistics sampled from 9935 (9971) to 9935 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.306), width: 16 Scan time: 2.310 The best scores are: opt bits E(32554) CCDS9500.1 FGF14 gene_id:2259|Hs108|chr13 ( 252) 1718 405.2 2.2e-113 CCDS9501.1 FGF14 gene_id:2259|Hs108|chr13 ( 247) 1225 291.3 4.2e-79 CCDS3301.1 FGF12 gene_id:2257|Hs108|chr3 ( 243) 938 225.0 3.7e-59 CCDS46983.1 FGF12 gene_id:2257|Hs108|chr3 ( 181) 933 223.8 6.4e-59 CCDS55511.1 FGF13 gene_id:2258|Hs108|chrX ( 226) 931 223.4 1.1e-58 CCDS55513.1 FGF13 gene_id:2258|Hs108|chrX ( 255) 931 223.4 1.2e-58 CCDS14665.1 FGF13 gene_id:2258|Hs108|chrX ( 245) 919 220.6 7.9e-58 CCDS14664.1 FGF13 gene_id:2258|Hs108|chrX ( 192) 910 218.5 2.7e-57 CCDS55512.1 FGF13 gene_id:2258|Hs108|chrX ( 199) 908 218.0 3.8e-57 CCDS11105.1 FGF11 gene_id:2256|Hs108|chr17 ( 225) 780 188.5 3.4e-48 CCDS9298.1 FGF9 gene_id:2254|Hs108|chr13 ( 208) 419 105.1 4e-23 CCDS5998.1 FGF20 gene_id:26281|Hs108|chr8 ( 211) 413 103.7 1.1e-22 CCDS75996.1 FGF16 gene_id:8823|Hs108|chrX ( 207) 401 100.9 7.1e-22 CCDS34021.1 FGF5 gene_id:2250|Hs108|chr4 ( 268) 337 86.2 2.5e-17 CCDS10131.1 FGF7 gene_id:2252|Hs108|chr15 ( 194) 312 80.3 1e-15 CCDS8194.1 FGF4 gene_id:2249|Hs108|chr11 ( 206) 303 78.3 4.6e-15 CCDS12037.1 FGF22 gene_id:27006|Hs108|chr19 ( 170) 294 76.2 1.6e-14 CCDS3950.1 FGF10 gene_id:2255|Hs108|chr5 ( 208) 287 74.6 6e-14 CCDS4275.1 FGF1 gene_id:2246|Hs108|chr5 ( 155) 280 72.9 1.4e-13 CCDS8527.1 FGF6 gene_id:2251|Hs108|chr12 ( 208) 281 73.2 1.6e-13 CCDS8195.1 FGF3 gene_id:2248|Hs108|chr11 ( 239) 248 65.6 3.5e-11 CCDS34059.1 FGF2 gene_id:2247|Hs108|chr4 ( 288) 243 64.5 9.2e-11 >>CCDS9500.1 FGF14 gene_id:2259|Hs108|chr13 (252 aa) initn: 1718 init1: 1718 opt: 1718 Z-score: 2148.9 bits: 405.2 E(32554): 2.2e-113 Smith-Waterman score: 1718; 100.0% identity (100.0% similar) in 252 aa overlap (1-252:1-252) 10 20 30 40 50 60 pF1KE2 MVKPVPLFRRTDFKLLLCNHKDLFFLRVSKLLDCFSPKSMWFLWNIFSKGTHMLQCLCGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS95 MVKPVPLFRRTDFKLLLCNHKDLFFLRVSKLLDCFSPKSMWFLWNIFSKGTHMLQCLCGK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 SLKKNKNPTDPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS95 SLKKNKNPTDPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 IQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS95 IQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 NKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS95 NKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIM 190 200 210 220 230 240 250 pF1KE2 NGGKPVNKSKTT :::::::::::: CCDS95 NGGKPVNKSKTT 250 >>CCDS9501.1 FGF14 gene_id:2259|Hs108|chr13 (247 aa) initn: 1223 init1: 1223 opt: 1225 Z-score: 1533.6 bits: 291.3 E(32554): 4.2e-79 Smith-Waterman score: 1225; 96.9% identity (97.4% similar) in 192 aa overlap (62-252:56-247) 40 50 60 70 80 90 pF1KE2 LDCFSPKSMWFLWNIFSKGTHMLQCLCGKSLKKNK-NPTDPQLKGIVTRLYCRQGYYLQM ::: . ::::::::::::::::::::: CCDS95 ASRRRSSPSKNRGLCNGNLVDIFSKVRIFGLKKRRLRRQDPQLKGIVTRLYCRQGYYLQM 30 40 50 60 70 80 100 110 120 130 140 150 pF1KE2 HPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS95 HPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKF 90 100 110 120 130 140 160 170 180 190 200 210 pF1KE2 KESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS95 KESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAM 150 160 170 180 190 200 220 230 240 250 pF1KE2 YREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT :::::::::::::::::::::::::::::::::::::::::: CCDS95 YREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT 210 220 230 240 >>CCDS3301.1 FGF12 gene_id:2257|Hs108|chr3 (243 aa) initn: 924 init1: 886 opt: 938 Z-score: 1175.5 bits: 225.0 E(32554): 3.7e-59 Smith-Waterman score: 938; 71.4% identity (88.3% similar) in 196 aa overlap (57-251:54-243) 30 40 50 60 70 80 pF1KE2 RVSKLLDCFSPKSMWFLWNIFSKGTHMLQCLC-GKSLKKNKNPTDPQLKGIVTRLYCRQG .: :.. . : .::::::::::. .:: CCDS33 VSASKRRSSPSKDGRSLCERHVLGVFSKVRFCSGRKRPVRRRP-EPQLKGIVTRLFSQQG 30 40 50 60 70 80 90 100 110 120 130 140 pF1KE2 YYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFT :.:::::::..:::::.... :::::::::::::::::::..::.::::::::: :..:: CCDS33 YFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFT 90 100 110 120 130 140 150 160 170 180 190 200 pF1KE2 PECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKP ::::::::::::::::::: :::::::::::::::::::: :::::::::::..::.::: CCDS33 PECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKP 150 160 170 180 190 200 210 220 230 240 250 pF1KE2 LEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT .:: ::::::::..:: : : :...:.. ::::: ::...: CCDS33 IEVCMYREPSLHEIGE---KQG--RSRKSSGTPTMNGGKVVNQDST 210 220 230 240 >>CCDS46983.1 FGF12 gene_id:2257|Hs108|chr3 (181 aa) initn: 924 init1: 886 opt: 933 Z-score: 1171.2 bits: 223.8 E(32554): 6.4e-59 Smith-Waterman score: 933; 75.3% identity (91.2% similar) in 182 aa overlap (70-251:5-181) 40 50 60 70 80 90 pF1KE2 MWFLWNIFSKGTHMLQCLCGKSLKKNKNPTDPQLKGIVTRLYCRQGYYLQMHPDGALDGT .::::::::::. .:::.:::::::..::: CCDS46 MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGT 10 20 30 100 110 120 130 140 150 pF1KE2 KDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYY ::.... :::::::::::::::::::..::.::::::::: :..:::::::::::::::: CCDS46 KDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYY 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE2 VIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDV ::::: :::::::::::::::::::: :::::::::::..::.:::.:: ::::::::.. CCDS46 VIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEI 100 110 120 130 140 150 220 230 240 250 pF1KE2 GETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT :: : : :...:.. ::::: ::...: CCDS46 GE---KQGR--SRKSSGTPTMNGGKVVNQDST 160 170 180 >>CCDS55511.1 FGF13 gene_id:2258|Hs108|chrX (226 aa) initn: 938 init1: 902 opt: 931 Z-score: 1167.2 bits: 223.4 E(32554): 1.1e-58 Smith-Waterman score: 931; 66.3% identity (86.5% similar) in 208 aa overlap (47-252:19-226) 20 30 40 50 60 70 pF1KE2 LCNHKDLFFLRVSKLLDCFSPKSMWFLWNIFSKGTHMLQCLCGKSL--KKNKNPTDPQLK : : . : :.. :.: .: .:::: CCDS55 MLRQDSIQSAELKKKESPFRAKCHEIFCCPLKQVHHKENTEPEEPQLK 10 20 30 40 80 90 100 110 120 130 pF1KE2 GIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNG ::::.:: ::::.::.. ::..:::::.... ::::::::::::::::::.: ::.:::. CCDS55 GIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNS 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE2 EGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKK ::::: :::::::::::::::::::: ::::.::::.:::.:.:::::::. ::::.::: CCDS55 EGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKK 110 120 130 140 150 160 200 210 220 230 240 250 pF1KE2 TKPAAHFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT .:::::::::::.::::.::::::. : . . ::.:: :.:...:::: ......: CCDS55 NKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 170 180 190 200 210 220 >>CCDS55513.1 FGF13 gene_id:2258|Hs108|chrX (255 aa) initn: 938 init1: 902 opt: 931 Z-score: 1166.4 bits: 223.4 E(32554): 1.2e-58 Smith-Waterman score: 931; 66.3% identity (86.5% similar) in 208 aa overlap (47-252:48-255) 20 30 40 50 60 70 pF1KE2 LCNHKDLFFLRVSKLLDCFSPKSMWFLWNIFSKGTHMLQCLCGKSL--KKNKNPTDPQLK : : . : :.. :.: .: .:::: CCDS55 LDDAPPGTQEYIMLRQDSIQSAELKKKESPFRAKCHEIFCCPLKQVHHKENTEPEEPQLK 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE2 GIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNG ::::.:: ::::.::.. ::..:::::.... ::::::::::::::::::.: ::.:::. CCDS55 GIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNS 80 90 100 110 120 130 140 150 160 170 180 190 pF1KE2 EGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKK ::::: :::::::::::::::::::: ::::.::::.:::.:.:::::::. ::::.::: CCDS55 EGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKK 140 150 160 170 180 190 200 210 220 230 240 250 pF1KE2 TKPAAHFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT .:::::::::::.::::.::::::. : . . ::.:: :.:...:::: ......: CCDS55 NKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 200 210 220 230 240 250 >>CCDS14665.1 FGF13 gene_id:2258|Hs108|chrX (245 aa) initn: 921 init1: 902 opt: 919 Z-score: 1151.7 bits: 220.6 E(32554): 7.9e-58 Smith-Waterman score: 919; 65.9% identity (87.0% similar) in 208 aa overlap (45-252:44-245) 20 30 40 50 60 70 pF1KE2 LLLCNHKDLFFLRVSKLLDCFSPKSMWFLWNIFSKGTHMLQCLCGKSLKKNKNPTDPQLK :.::. : :.. .. . : .:::: CCDS14 RQAREREKSNACKCVSSPSKGKTSCDKNKLNVFSRVK-----LFGSKKRRRRRP-EPQLK 20 30 40 50 60 80 90 100 110 120 130 pF1KE2 GIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNG ::::.:: ::::.::.. ::..:::::.... ::::::::::::::::::.: ::.:::. CCDS14 GIVTKLYSRQGYHLQLQADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNS 70 80 90 100 110 120 140 150 160 170 180 190 pF1KE2 EGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKK ::::: :::::::::::::::::::: ::::.::::.:::.:.:::::::. ::::.::: CCDS14 EGYLYTSELFTPECKFKESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKK 130 140 150 160 170 180 200 210 220 230 240 250 pF1KE2 TKPAAHFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT .:::::::::::.::::.::::::. : . . ::.:: :.:...:::: ......: CCDS14 NKPAAHFLPKPLKVAMYKEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 190 200 210 220 230 240 >>CCDS14664.1 FGF13 gene_id:2258|Hs108|chrX (192 aa) initn: 938 init1: 902 opt: 910 Z-score: 1142.1 bits: 218.5 E(32554): 2.7e-57 Smith-Waterman score: 910; 70.6% identity (91.4% similar) in 187 aa overlap (66-252:6-192) 40 50 60 70 80 90 pF1KE2 SPKSMWFLWNIFSKGTHMLQCLCGKSLKKNKNPTDPQLKGIVTRLYCRQGYYLQMHPDGA :. ..::::::::.:: ::::.::.. ::. CCDS14 MALLRKSYSEPQLKGIVTKLYSRQGYHLQLQADGT 10 20 30 100 110 120 130 140 150 pF1KE2 LDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVF .:::::.... ::::::::::::::::::.: ::.:::.::::: ::::::::::::::: CCDS14 IDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFKESVF 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE2 ENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREPS ::::: ::::.::::.:::.:.:::::::. ::::.:::.:::::::::::.::::.::: CCDS14 ENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMYKEPS 100 110 120 130 140 150 220 230 240 250 pF1KE2 LHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT :::. : . . ::.:: :.:...:::: ......: CCDS14 LHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 160 170 180 190 >>CCDS55512.1 FGF13 gene_id:2258|Hs108|chrX (199 aa) initn: 938 init1: 902 opt: 908 Z-score: 1139.4 bits: 218.0 E(32554): 3.8e-57 Smith-Waterman score: 908; 69.6% identity (91.1% similar) in 191 aa overlap (63-252:9-199) 40 50 60 70 80 90 pF1KE2 DCFSPKSMWFLWNIFSKGTHMLQCLCGKSLKKNKNPT-DPQLKGIVTRLYCRQGYYLQMH :..:. . .::::::::.:: ::::.::.. CCDS55 MSGKVTKPKEEKDASKEPQLKGIVTKLYSRQGYHLQLQ 10 20 30 100 110 120 130 140 150 pF1KE2 PDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFK ::..:::::.... ::::::::::::::::::.: ::.:::.::::: ::::::::::: CCDS55 ADGTIDGTKDEDSTYTLFNLIPVGLRVVAIQGVQTKLYLAMNSEGYLYTSELFTPECKFK 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE2 ESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMY ::::::::: ::::.::::.:::.:.:::::::. ::::.:::.:::::::::::.:::: CCDS55 ESVFENYYVTYSSMIYRQQQSGRGWYLGLNKEGEIMKGNHVKKNKPAAHFLPKPLKVAMY 100 110 120 130 140 150 220 230 240 250 pF1KE2 REPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT .::::::. : . . ::.:: :.:...:::: ......: CCDS55 KEPSLHDLTEFSRSGSGTPTKSRSVSGVLNGGKSMSHNEST 160 170 180 190 >>CCDS11105.1 FGF11 gene_id:2256|Hs108|chr17 (225 aa) initn: 771 init1: 771 opt: 780 Z-score: 978.8 bits: 188.5 E(32554): 3.4e-48 Smith-Waterman score: 780; 65.7% identity (85.7% similar) in 175 aa overlap (57-230:52-225) 30 40 50 60 70 80 pF1KE2 RVSKLLDCFSPKSMWFLWNIFSKGTHMLQCLCG-KSLKKNKNPTDPQLKGIVTRLYCRQG ::: . . ...: .::::::::.:.:::: CCDS11 RPVSAQRRVCPRGTKSLCQKQLLILLSKVRLCGGRPARPDRGP-EPQLKGIVTKLFCRQG 30 40 50 60 70 80 90 100 110 120 130 140 pF1KE2 YYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFT .::: .:::...:: .:... : :::::::::::.::..: : :.:::.:: :: : :: CCDS11 FYLQANPDGSIQGTPEDTSSFTHFNLIPVGLRVVTIQSAKLGHYMAMNAEGLLYSSPHFT 90 100 110 120 130 140 150 160 170 180 190 200 pF1KE2 PECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKP ::.::: :::::::.:.: ::::..:::::.:::.::::.:::::::::: ::::::: CCDS11 AECRFKECVFENYYVLYASALYRQRRSGRAWYLGLDKEGQVMKGNRVKKTKAAAHFLPKL 150 160 170 180 190 200 210 220 230 240 250 pF1KE2 LEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT ::::::.:::::.: :. :. .: CCDS11 LEVAMYQEPSLHSVPEASPSSPPAP 210 220 252 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:32:50 2016 done: Sun Nov 6 14:32:51 2016 Total Scan time: 2.310 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]