FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6149, 596 aa 1>>>pF1KB6149 596 - 596 aa - 596 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.2538+/-0.000552; mu= -0.1687+/- 0.033 mean_var=414.2426+/-103.038, 0's: 0 Z-trim(115.2): 250 B-trim: 1205 in 1/52 Lambda= 0.063015 statistics sampled from 25160 (25442) to 25160 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.653), E-opt: 0.2 (0.298), width: 16 Scan time: 11.110 The best scores are: opt bits E(85289) NP_009130 (OMIM: 604459,611064) interleukin-1 rece ( 596) 4055 384.3 6.2e-106 NP_001135995 (OMIM: 604459,611064) interleukin-1 r ( 535) 3335 318.8 3e-86 NP_001020413 (OMIM: 300283) interleukin-1 receptor ( 682) 586 69.0 5.8e-11 XP_005274725 (OMIM: 300283) PREDICTED: interleukin ( 708) 586 69.0 6e-11 NP_001560 (OMIM: 300283) interleukin-1 receptor-as ( 712) 586 69.0 6e-11 NP_001020414 (OMIM: 300283) interleukin-1 receptor ( 633) 574 67.9 1.2e-10 XP_011529460 (OMIM: 300283) PREDICTED: interleukin ( 603) 567 67.2 1.8e-10 NP_001561 (OMIM: 603304) interleukin-1 receptor-as ( 625) 451 56.7 2.7e-07 XP_006719502 (OMIM: 606883,607676,610799) PREDICTE ( 336) 435 54.9 5.2e-07 NP_001138729 (OMIM: 606883,607676,610799) interleu ( 336) 435 54.9 5.2e-07 XP_016874880 (OMIM: 606883,607676,610799) PREDICTE ( 336) 435 54.9 5.2e-07 XP_005269005 (OMIM: 606883,607676,610799) PREDICTE ( 336) 435 54.9 5.2e-07 NP_001138728 (OMIM: 606883,607676,610799) interleu ( 336) 435 54.9 5.2e-07 XP_005269006 (OMIM: 606883,607676,610799) PREDICTE ( 336) 435 54.9 5.2e-07 NP_001138730 (OMIM: 606883,607676,610799) interleu ( 336) 435 54.9 5.2e-07 XP_005269004 (OMIM: 606883,607676,610799) PREDICTE ( 336) 435 54.9 5.2e-07 NP_001107654 (OMIM: 606883,607676,610799) interleu ( 460) 435 55.0 6.3e-07 XP_011536733 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07 NP_057207 (OMIM: 606883,607676,610799) interleukin ( 460) 435 55.0 6.3e-07 XP_006719501 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07 XP_005269002 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07 XP_005269001 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07 XP_005269000 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07 XP_011536735 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07 XP_016874879 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07 XP_011536734 (OMIM: 606883,607676,610799) PREDICTE ( 460) 435 55.0 6.3e-07 XP_006719505 (OMIM: 606883,607676,610799) PREDICTE ( 257) 390 50.6 7.6e-06 XP_006719503 (OMIM: 606883,607676,610799) PREDICTE ( 257) 390 50.6 7.6e-06 XP_006719506 (OMIM: 606883,607676,610799) PREDICTE ( 257) 390 50.6 7.6e-06 XP_006719504 (OMIM: 606883,607676,610799) PREDICTE ( 257) 390 50.6 7.6e-06 >>NP_009130 (OMIM: 604459,611064) interleukin-1 receptor (596 aa) initn: 4055 init1: 4055 opt: 4055 Z-score: 2022.8 bits: 384.3 E(85289): 6.2e-106 Smith-Waterman score: 4055; 99.8% identity (100.0% similar) in 596 aa overlap (1-596:1-596) 10 20 30 40 50 60 pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 YVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 FPNILFKETANVTVDNVLIPEHNEKGVLLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: NP_009 FPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE 490 500 510 520 530 540 550 560 570 580 590 pF1KB6 ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_009 ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE 550 560 570 580 590 >>NP_001135995 (OMIM: 604459,611064) interleukin-1 recep (535 aa) initn: 3335 init1: 3335 opt: 3335 Z-score: 1669.5 bits: 318.8 E(85289): 3e-86 Smith-Waterman score: 3514; 89.6% identity (89.8% similar) in 596 aa overlap (1-596:1-535) 10 20 30 40 50 60 pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK :::::::::::::::::::::::::::::::::::::::::::: NP_001 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGL---------------- 10 20 30 40 70 80 90 100 110 120 pF1KB6 YVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGG ::::::::::::::: NP_001 ---------------------------------------------GAVLSPSEKSYQEGG 50 130 140 150 160 170 180 pF1KB6 FPNILFKETANVTVDNVLIPEHNEKGVLLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY ::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::: NP_001 FPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVY 60 70 80 90 100 110 190 200 210 220 230 240 pF1KB6 RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLI 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB6 YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANIL 180 190 200 210 220 230 310 320 330 340 350 360 pF1KB6 LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSF 240 250 260 270 280 290 370 380 390 400 410 420 pF1KB6 GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFC 300 310 320 330 340 350 430 440 450 460 470 480 pF1KB6 LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVE 360 370 380 390 400 410 490 500 510 520 530 540 pF1KB6 DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCE 420 430 440 450 460 470 550 560 570 580 590 pF1KB6 ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE 480 490 500 510 520 530 >>NP_001020413 (OMIM: 300283) interleukin-1 receptor-ass (682 aa) initn: 646 init1: 321 opt: 586 Z-score: 317.8 bits: 69.0 E(85289): 5.8e-11 Smith-Waterman score: 668; 28.8% identity (53.8% similar) in 626 aa overlap (16-549:18-632) 10 20 30 40 50 pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHI .:...:: .. .. :.:. . : : .: . . ..: NP_001 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLC 10 20 30 40 50 60 70 80 90 100 pF1KB6 EKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNY------------- :. .:. : .:: : ..: ..::...: .. :: .:: . NP_001 ER---SGQR-TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTA 60 70 80 90 100 110 110 120 130 140 pF1KB6 ---GAVLSPSE-------------KSYQEGGFPNILFK---ETANVTVDNVLIPEHN--- ... .:.: ... .::. . : . : : : NP_001 PRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPA 120 130 140 150 160 170 150 160 170 180 pF1KB6 --------EKGV-LLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLT :..: ::... : .: .::.:: ... :::: . :::. ..: . NP_001 PSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTV 180 190 200 210 220 230 190 200 210 220 230 240 pF1KB6 YAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGT :::: .:.. .. . ::.:.: : :.::::...:.: ... .::.: .. ::. NP_001 YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGS 240 250 260 270 280 290 250 260 270 280 290 300 pF1KB6 LFDRLQCVGDTAP-LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQP : :::.: .. : : : :. ::.: ..::..::. .: :.: :.:.:.:.:::... : NP_001 LEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTP 300 310 320 330 340 350 310 320 330 340 350 360 pF1KB6 KLTDFAMAHFRSHL---EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVI :: ::..:.: :: . :.. : :.:::::. :.:.. ::..:::.:. NP_001 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV 360 370 380 390 400 410 370 380 390 400 pF1KB6 MEVLTGCRVVLDDPKHIQ-LRDLLRELMEKRG--LDSCLS-------------------- .:.:.: :.: . . :.::..: :. : : : : NP_001 LETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIY 420 430 440 450 460 470 410 420 430 440 450 pF1KB6 --FLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTS :: . ::: ... : :: : ::: :: : . :. :. . . . : NP_001 KKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQE-NSYVSSTGRAHSGAAPWQP 480 490 500 510 520 530 460 470 480 490 500 pF1KB6 LKSFRCPSPLFLENV---PSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFE-------- : . : :.. :. :::.::: : . .:: ..: . :.. NP_001 LAAPSGASAQAAEQLQRGPNQPVESDES----LGGLSAALRSWHLTPSCPLDPAPLREAG 540 550 560 570 580 510 520 530 540 550 560 pF1KB6 CSQSEVM-FLSLDKKPESKRNE-EACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSE : :... : . : :. . :. . ::. : :. :. NP_001 CPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDG 590 600 610 620 630 640 570 580 590 pF1KB6 APGHSCRSRPVESSCSSKFSWDEYEQYKKE NP_001 ALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS 650 660 670 680 >>XP_005274725 (OMIM: 300283) PREDICTED: interleukin-1 r (708 aa) initn: 646 init1: 321 opt: 586 Z-score: 317.6 bits: 69.0 E(85289): 6e-11 Smith-Waterman score: 641; 33.2% identity (58.1% similar) in 434 aa overlap (158-549:231-658) 130 140 150 160 170 180 pF1KB6 ETANVTVDNVLIPEHNEKGVLLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQNL : .::.:: ... :::: . :::. ..: XP_005 APSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT 210 220 230 240 250 260 190 200 210 220 230 240 pF1KB6 TYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNG .:::: .:.. .. . ::.:.: : :.::::...:.: ... .::.: .. :: XP_005 VYAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNG 270 280 290 300 310 320 250 260 270 280 290 300 pF1KB6 TLFDRLQCVGDTAP-LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQ .: :::.: .. : : : :. ::.: ..::..::. .: :.: :.:.:.:.:::... XP_005 SLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLT 330 340 350 360 370 310 320 330 340 350 360 pF1KB6 PKLTDFAMAHFRSHL---EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIV ::: ::..:.: :: . :.. : :.:::::. :.:.. ::..:::.: XP_005 PKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVV 380 390 400 410 420 430 370 380 390 400 pF1KB6 IMEVLTGCRVVLDDPKHIQ-LRDLLRELMEKRG--LDSCLS------------------- ..:.:.: :.: . . :.::..: :. : : : : XP_005 VLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQI 440 450 460 470 480 490 410 420 430 440 450 pF1KB6 ---FLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPT :: . ::: ... : :: : ::: :: : . :. :. . . . : XP_005 YKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQE-NSYVSSTGRAHSGAAPWQ 500 510 520 530 540 550 460 470 480 490 500 pF1KB6 SLKSFRCPSPLFLENV---PSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFE------- : . : :.. :. :::.::: : . .:: ..: . :.. XP_005 PLAAPSGASAQAAEQLQRGPNQPVESDES----LGGLSAALRSWHLTPSCPLDPAPLREA 560 570 580 590 600 610 510 520 530 540 550 560 pF1KB6 -CSQSEVM-FLSLDKKPESKRNE-EACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSS : :... : . : :. . :. . ::. : :. :. XP_005 GCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKLALYED 620 630 640 650 660 670 570 580 590 pF1KB6 EAPGHSCRSRPVESSCSSKFSWDEYEQYKKE XP_005 GALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS 680 690 700 >>NP_001560 (OMIM: 300283) interleukin-1 receptor-associ (712 aa) initn: 669 init1: 321 opt: 586 Z-score: 317.6 bits: 69.0 E(85289): 6e-11 Smith-Waterman score: 673; 28.2% identity (54.1% similar) in 614 aa overlap (16-546:18-622) 10 20 30 40 50 pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHI .:...:: .. .. :.:. . : : .: . . ..: NP_001 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLC 10 20 30 40 50 60 70 80 90 100 pF1KB6 EKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNY------------- :. .:. : .:: : ..: ..::...: .. :: .:: . NP_001 ER---SGQR-TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTA 60 70 80 90 100 110 110 120 130 140 pF1KB6 ---GAVLSPSE-------------KSYQEGGFPNILFK---ETANVTVDNVLIPEHN--- ... .:.: ... .::. . : . : : : NP_001 PRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPA 120 130 140 150 160 170 150 160 170 180 pF1KB6 --------EKGV-LLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLT :..: ::... : .: .::.:: ... :::: . :::. ..: . NP_001 PSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTV 180 190 200 210 220 230 190 200 210 220 230 240 pF1KB6 YAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGT :::: .:.. .. . ::.:.: : :.::::...:.: ... .::.: .. ::. NP_001 YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGS 240 250 260 270 280 290 250 260 270 280 290 300 pF1KB6 LFDRLQCVGDTAP-LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQP : :::.: .. : : : :. ::.: ..::..::. .: :.: :.:.:.:.:::... : NP_001 LEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTP 300 310 320 330 340 350 310 320 330 340 350 360 pF1KB6 KLTDFAMAHFRSHL---EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVI :: ::..:.: :: . :.. : :.:::::. :.:.. ::..:::.:. NP_001 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV 360 370 380 390 400 410 370 380 390 400 pF1KB6 MEVLTGCRVVLDDPKHIQ-LRDLLRELMEKRGL-----DSCLS----------------- .:.:.: :.: . . :.::..: :. :. .: :. NP_001 LETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIY 420 430 440 450 460 470 410 420 430 440 450 pF1KB6 --FLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTS :: . ::: ... : :: : ::: :: : .: . ::. :: . : NP_001 KKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVV---AGVPGH 480 490 500 510 520 530 460 470 480 490 500 510 pF1KB6 LKSFRC--PSPLFLENVPSIPVEDDESQNNNLL--PSDEGLRIDRMTQKTPFECSQSEVM .. : ::: : : . . . : :: . . .. :. : . .:. NP_001 SEAASCIPPSPQENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDES 540 550 560 570 580 590 520 530 540 550 560 570 pF1KB6 FLSLDKKPESKRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSR . .:. .: . .: . . .:. :. NP_001 LGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSA 600 610 620 630 640 650 580 590 pF1KB6 PVESSCSSKFSWDEYEQYKKE NP_001 SSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQ 660 670 680 690 700 710 >>NP_001020414 (OMIM: 300283) interleukin-1 receptor-ass (633 aa) initn: 573 init1: 321 opt: 574 Z-score: 312.2 bits: 67.9 E(85289): 1.2e-10 Smith-Waterman score: 602; 28.0% identity (53.7% similar) in 603 aa overlap (16-549:18-583) 10 20 30 40 50 pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHI .:...:: .. .. :.:. . : : .: . . ..: NP_001 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLC 10 20 30 40 50 60 70 80 90 100 pF1KB6 EKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNY------------- :. .:. : .:: : ..: ..::...: .. :: .:: . NP_001 ER---SGQR-TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTA 60 70 80 90 100 110 110 120 130 140 pF1KB6 ---GAVLSPSE-------------KSYQEGGFPNILFK---ETANVTVDNVLIPEHN--- ... .:.: ... .::. . : . : : : NP_001 PRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPA 120 130 140 150 160 170 150 160 170 180 pF1KB6 --------EKGV-LLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLT :..: ::... : .: .::.:: ... :::: . :::. ..: . NP_001 PSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTV 180 190 200 210 220 230 190 200 210 220 230 240 pF1KB6 YAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGT :::: .:.. .. . ::.:.: : :.::::...:.: ... .::.: .. ::. NP_001 YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGS 240 250 260 270 280 290 250 260 270 280 290 300 pF1KB6 LFDRLQCVGDTAP-LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQP : :::.: .. : : : :. ::.: ..::..::. .: :.: :.:.:.:.:::... : NP_001 LEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTP 300 310 320 330 340 350 310 320 330 340 350 360 pF1KB6 KLTDFAMAHFRSHL---EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVI :: ::..:.: :: . :.. : :.:::::. :.:.. ::..:::.:. NP_001 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV 360 370 380 390 400 410 370 380 390 400 410 pF1KB6 MEVLTGCRVVLDDPKHIQLRDLLRELMEK-----RGLDSCLSFLDKKVPPCPRNFSAKLF .:.:.: :.: . . . :. : .:: :. . : . .:: :.. : NP_001 LETLAGQRAV--KTHGARTKYLVYERLEKLQAVVAGVPGH-SEAASCIPPSPQENS--YV 420 430 440 450 460 420 430 440 450 460 470 pF1KB6 CLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPV .:: . : .: . :: ::. :. :. :: NP_001 SSTGRAHSGAAPWQP-------LAAPSGASAQAAEQ---------------LQRGPNQPV 470 480 490 500 480 490 500 510 520 pF1KB6 EDDESQNNNLLPSDEGLRIDRMTQKTPFE--------CSQSEVM-FLSLDKKPESKRNE- :.::: : . .:: ..: . :.. : :... : . : :. . NP_001 ESDES----LGGLSAALRSWHLTPSCPLDPAPLREAGCPQGDTAGESSWGSGPGSRPTAV 510 520 530 540 550 560 530 540 550 560 570 580 pF1KB6 EACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDE :. . ::. : :. :. NP_001 EGLALGSSASSSSEPPQIIINPARQKMVQKLALYEDGALDSLQLLSSSSLPGLGLEQDRQ 570 580 590 600 610 620 >>XP_011529460 (OMIM: 300283) PREDICTED: interleukin-1 r (603 aa) initn: 573 init1: 321 opt: 567 Z-score: 309.0 bits: 67.2 E(85289): 1.8e-10 Smith-Waterman score: 594; 30.8% identity (59.3% similar) in 413 aa overlap (16-374:18-424) 10 20 30 40 50 pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHI .:...:: .. .. :.:. . : : .: . . ..: XP_011 MAGGPGPGEPAAPGAQHFLYEVPPWVMCRFYKVMDALEPA-DWCQFAALIVRDQTELRLC 10 20 30 40 50 60 70 80 90 100 pF1KB6 EKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNY------------- :. .:. : .:: : ..: ..::...: .. :: .:: . XP_011 ER---SGQR-TASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPLPSPGTTA 60 70 80 90 100 110 110 120 130 140 pF1KB6 ---GAVLSPSE-------------KSYQEGGFPNILFK---ETANVTVDNVLIPEHN--- ... .:.: ... .::. . : . : : : XP_011 PRPSSIPAPAEAEAWSPRKLPSSASTFLSPAFPGSQTHSGPELGLVPSPASLWPPPPSPA 120 130 140 150 160 170 150 160 170 180 pF1KB6 --------EKGV-LLKSSISFQ------NIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLT :..: ::... : .: .::.:: ... :::: . :::. ..: . XP_011 PSSTKPGPESSVSLLQGARPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTV 180 190 200 210 220 230 190 200 210 220 230 240 pF1KB6 YAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGT :::: .:.. .. . ::.:.: : :.::::...:.: ... .::.: .. ::. XP_011 YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGS 240 250 260 270 280 290 250 260 270 280 290 300 pF1KB6 LFDRLQCVGDTAP-LPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQP : :::.: .. : : : :. ::.: ..::..::. .: :.: :.:.:.:.:::... : XP_011 LEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSP-SLIHGDIKSSNVLLDERLTP 300 310 320 330 340 350 310 320 330 340 350 360 pF1KB6 KLTDFAMAHFRSHL---EHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVI :: ::..:.: :: . :.. : :.:::::. :.:.. ::..:::.:. XP_011 KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVV 360 370 380 390 400 410 370 380 390 400 410 420 pF1KB6 MEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGR .:.:.: :.: XP_011 LETLAGQRAVKTHGARTKYLENSYVSSTGRAHSGAAPWQPLAAPSGASAQAAEQLQRGPN 420 430 440 450 460 470 >>NP_001561 (OMIM: 603304) interleukin-1 receptor-associ (625 aa) initn: 511 init1: 231 opt: 451 Z-score: 251.8 bits: 56.7 E(85289): 2.7e-07 Smith-Waterman score: 492; 25.6% identity (52.3% similar) in 606 aa overlap (27-543:15-594) 10 20 30 40 50 60 pF1KB6 MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEK .:: .:. . : .: . .. ..:.:.. NP_001 MACYIYQLPSWVLDDLCRNMDALS-EWDWMEFASYVITDLTQLRKIKS 10 20 30 40 70 80 90 100 pF1KB6 YVD-QGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNY-------------- . :: : :::::: :.... :. .:...: .. :: ..: :. NP_001 MERVQGVSITRELLWWWGMRQATVQQLVDLLCRLELYRAAQIILNWKPAPEIRCPIPAFP 50 60 70 80 90 100 110 120 pF1KB6 ---------GAVLSPSEKSYQEG---------------------GF--------PNILFK .: . .: .:: .: :. : . NP_001 DSVKPEKPLAASVRKAEDEQEEGQPVRMATFPGPGSSPARAHQPAFLQPPEEDAPHSLRS 110 120 130 140 150 160 130 140 150 160 170 180 pF1KB6 E--TANVTVD-NVLIPEHNEKGVLLKSSI--SFQNIIEGTRNFHKDFLIGEGEIFEVYRV . :.. . : .. ::.... : .:. : .....: .:... :..: . .::: NP_001 DLPTSSDSKDFSTSIPKQEKLLSLAGDSLFWSEADVVQATDDFNQNRKISQGTFADVYRG 170 180 190 200 210 220 190 200 210 220 230 pF1KB6 EIQNLTYAVKLFKQEKKMQCKK--HWKRFL-SELEVLLLFHHPNILELAAYFTETEKFCL . .. . .::. .. :.. .::. .::.. : :::.: . .. . . . NP_001 HRHGKPF---VFKKLRETACSSPGSIERFFQAELQICLRCCHPNVLPVLGFCAARQFHSF 230 240 250 260 270 280 240 250 260 270 280 290 pF1KB6 IYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANI ::::: ::.: :::: : . :::: :..: :. :..:::... .: ....:.:. NP_001 IYPYMANGSLQDRLQGQGGSDPLPWPQRVSICSGLLCAVEYLHGLE---IIHSNVKSSNV 290 300 310 320 330 340 300 310 320 330 340 350 pF1KB6 LLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSS---KHLW-----YMPEEYIRQGKL :::... ::: :: .:: : .: :. . :: :.::..:: :.: NP_001 LLDQNLTPKL-----AHPMAHL----CPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQL 350 360 370 380 390 360 370 380 390 pF1KB6 SIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELM---------EKRGLDS---- . ..:..: :::. ::::: .. .. . . :.::: . .: :... NP_001 TKRVDIFSCGIVLAEVLTGIPAMDNNRSPVYLKDLLLSDIPSSTASLCSRKTGVENVMAK 400 410 420 430 440 450 400 410 420 430 440 450 pF1KB6 --CLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAED- : ..:.: . :.. . : : : : :..:: ... ... : : NP_001 EICQKYLEKGAGRLPEDCAEALATAACLCLRRRN---TSLQEVCGSVAAVEERLRGRETL 460 470 480 490 500 460 470 480 490 500 510 pF1KB6 -PPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEV : ..:. : . : : :. .:..: :. ::. ... NP_001 LPWSGLSEGTGSSS-------NTPEETDDVDNSSLDASSSMSVAPWAGAATPLLPTENGE 510 520 530 540 550 560 520 530 540 550 560 570 pF1KB6 MFLSLDKKPESKRNEEAC---NMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHS : . :. . ::: . :.. : :: NP_001 GRLRVIVGREADSSSEACVGLEPPQDVTETSWQIEINEAKRKLMENILLYKEEKVDSIEL 570 580 590 600 610 620 580 590 pF1KB6 CRSRPVESSCSSKFSWDEYEQYKKE NP_001 FGP >>XP_006719502 (OMIM: 606883,607676,610799) PREDICTED: i (336 aa) initn: 473 init1: 266 opt: 435 Z-score: 246.8 bits: 54.9 E(85289): 5.2e-07 Smith-Waterman score: 491; 32.2% identity (62.2% similar) in 304 aa overlap (152-449:43-336) 130 140 150 160 170 pF1KB6 PNILFKETANVTVDNVLIPEHNEKGVLLKSSISFQNIIEGTRNFHKDFL------IGEGE :.:: .. . : :: . . .::: XP_006 PVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGG 20 30 40 50 60 70 180 190 200 210 220 230 pF1KB6 IFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETE . ::. ..: : ::: . . .. ..: .:..:. .: :..:: .. .. . XP_006 FGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGD 80 90 100 110 120 130 240 250 260 270 280 290 pF1KB6 KFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSIS .::.: :: ::.:.:::.:. : :: ::.: : : ...:..::. . : .:. XP_006 DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---IHRDIK 140 150 160 170 180 300 310 320 330 340 350 pF1KB6 SANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKT :::::::. : :..::..: :. :. . :. ::: :: : .: :... :. XP_006 SANILLDEAFTAKISDFGLA--RAS-EKFAQTV-MTSRIVGTTAYMAPEALR-GEITPKS 190 200 210 220 230 240 360 370 380 390 400 410 pF1KB6 DVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFS :.::::.:..:..:: .: :. .. :: ..: .: . . ...:::. . XP_006 DIYSFGVVLLEIITGLPAV-DEHREPQLLLDIKEEIEDEE-KTIEDYIDKKMNDADSTSV 250 260 270 280 290 300 420 430 440 450 460 470 pF1KB6 AKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVP .. .:..: . . ::.. .: . :. :: XP_006 EAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 310 320 330 480 490 500 510 520 530 pF1KB6 SIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMP >>NP_001138729 (OMIM: 606883,607676,610799) interleukin- (336 aa) initn: 473 init1: 266 opt: 435 Z-score: 246.8 bits: 54.9 E(85289): 5.2e-07 Smith-Waterman score: 491; 32.2% identity (62.2% similar) in 304 aa overlap (152-449:43-336) 130 140 150 160 170 pF1KB6 PNILFKETANVTVDNVLIPEHNEKGVLLKSSISFQNIIEGTRNFHKDFL------IGEGE :.:: .. . : :: . . .::: NP_001 PVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGG 20 30 40 50 60 70 180 190 200 210 220 230 pF1KB6 IFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETE . ::. ..: : ::: . . .. ..: .:..:. .: :..:: .. .. . NP_001 FGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGD 80 90 100 110 120 130 240 250 260 270 280 290 pF1KB6 KFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSIS .::.: :: ::.:.:::.:. : :: ::.: : : ...:..::. . : .:. NP_001 DLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH---IHRDIK 140 150 160 170 180 300 310 320 330 340 350 pF1KB6 SANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKT :::::::. : :..::..: :. :. . :. ::: :: : .: :... :. NP_001 SANILLDEAFTAKISDFGLA--RAS-EKFAQTV-MTSRIVGTTAYMAPEALR-GEITPKS 190 200 210 220 230 240 360 370 380 390 400 410 pF1KB6 DVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFS :.::::.:..:..:: .: :. .. :: ..: .: . . ...:::. . NP_001 DIYSFGVVLLEIITGLPAV-DEHREPQLLLDIKEEIEDEE-KTIEDYIDKKMNDADSTSV 250 260 270 280 290 300 420 430 440 450 460 470 pF1KB6 AKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVP .. .:..: . . ::.. .: . :. :: NP_001 EAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 310 320 330 480 490 500 510 520 530 pF1KB6 SIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMP 596 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 14:47:38 2016 done: Sun Nov 6 14:47:40 2016 Total Scan time: 11.110 Total Display time: 0.100 Function used was FASTA [36.3.4 Apr, 2011]