FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9563, 479 aa 1>>>pF1KE9563 479 - 479 aa - 479 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8550+/-0.000385; mu= 21.0971+/- 0.024 mean_var=94.2634+/-21.711, 0's: 0 Z-trim(114.1): 650 B-trim: 2204 in 2/49 Lambda= 0.132100 statistics sampled from 22932 (23704) to 22932 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.278), width: 16 Scan time: 6.720 The best scores are: opt bits E(85289) NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 3247 629.6 5.9e-180 NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 2918 566.8 4.2e-161 NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 2916 566.4 5.4e-161 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 797 162.7 2.3e-39 NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 782 159.7 1.4e-38 XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 782 159.7 1.4e-38 NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 782 159.8 1.5e-38 NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 782 159.8 1.5e-38 NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 782 159.8 1.5e-38 XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 782 159.8 1.5e-38 XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 782 159.8 1.5e-38 XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 782 159.8 1.5e-38 NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 753 154.4 8e-37 NP_076917 (OMIM: 601305) 5-hydroxytryptamine recep ( 357) 709 145.7 2e-34 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 695 143.0 1.2e-33 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 695 143.0 1.2e-33 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 695 143.1 1.3e-33 XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 695 143.1 1.3e-33 XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 695 143.1 1.4e-33 XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 695 143.3 1.7e-33 XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 686 141.3 3.9e-33 XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 685 141.1 4.3e-33 XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 685 141.1 4.4e-33 NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 685 141.1 4.6e-33 NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 685 141.2 4.8e-33 NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 685 141.2 4.8e-33 NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 626 130.1 1.4e-29 NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 608 126.6 1.4e-28 NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 597 124.5 6.1e-28 NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 541 113.8 9.6e-25 XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 535 112.6 1.9e-24 NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 535 112.6 1.9e-24 NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 523 110.3 9.6e-24 NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 523 110.3 9.8e-24 XP_011531966 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 517 109.1 2.1e-23 NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 517 109.1 2.1e-23 XP_005264808 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 517 109.1 2.1e-23 NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 517 109.1 2.1e-23 NP_000857 (OMIM: 182134) 5-hydroxytryptamine recep ( 366) 517 109.1 2.1e-23 NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 517 109.1 2.1e-23 NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 506 107.1 9.6e-23 NP_000786 (OMIM: 126450,159900) D(2) dopamine rece ( 443) 506 107.1 1e-22 XP_016872785 (OMIM: 126450,159900) PREDICTED: D(2) ( 443) 506 107.1 1e-22 NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 476 101.5 5.5e-21 NP_001159419 (OMIM: 103780,164230,181500,182135,60 ( 387) 475 101.2 5.5e-21 NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 469 100.0 1.2e-20 NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 469 100.0 1.2e-20 NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 469 100.0 1.2e-20 NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 469 100.0 1.2e-20 NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 469 100.1 1.3e-20 >>NP_062873 (OMIM: 182137) 5-hydroxytryptamine receptor (479 aa) initn: 3247 init1: 3247 opt: 3247 Z-score: 3351.7 bits: 629.6 E(85289): 5.9e-180 Smith-Waterman score: 3247; 100.0% identity (100.0% similar) in 479 aa overlap (1-479:1-479) 10 20 30 40 50 60 pF1KE9 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 370 380 390 400 410 420 430 440 450 460 470 pF1KE9 LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD 430 440 450 460 470 >>NP_000863 (OMIM: 182137) 5-hydroxytryptamine receptor (445 aa) initn: 2940 init1: 2917 opt: 2918 Z-score: 3013.2 bits: 566.8 E(85289): 4.2e-161 Smith-Waterman score: 2918; 98.2% identity (98.9% similar) in 441 aa overlap (1-438:1-441) 10 20 30 40 50 60 pF1KE9 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 370 380 390 400 410 420 430 440 450 460 470 pF1KE9 LAERPERPEFVLRA---CTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMI ::::::::::::. : .. NP_000 LAERPERPEFVLQNADYCRKKGHDS 430 440 >>NP_062874 (OMIM: 182137) 5-hydroxytryptamine receptor (432 aa) initn: 2916 init1: 2916 opt: 2916 Z-score: 3011.3 bits: 566.4 E(85289): 5.4e-161 Smith-Waterman score: 2916; 100.0% identity (100.0% similar) in 432 aa overlap (1-432:1-432) 10 20 30 40 50 60 pF1KE9 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 DAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 VSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 YLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 IYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 ECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 IPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALK 370 380 390 400 410 420 430 440 450 460 470 pF1KE9 LAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD :::::::::::: NP_062 LAERPERPEFVL 430 >>NP_000670 (OMIM: 104220) alpha-1B adrenergic receptor (520 aa) initn: 626 init1: 268 opt: 797 Z-score: 827.9 bits: 162.7 E(85289): 2.3e-39 Smith-Waterman score: 797; 36.4% identity (69.3% similar) in 352 aa overlap (64-409:28-373) 40 50 60 70 80 90 pF1KE9 DGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITL :...:. . . .. . .: .: . : NP_000 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFIL 10 20 30 40 50 100 110 120 130 140 150 pF1KE9 LTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHF ..:.:: ::..:: ..:: :.::.::.::.::: .. .:.:: .. ...: :..:.. NP_000 FAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLG-YWVLGRI 60 70 80 90 100 110 160 170 180 190 200 210 pF1KE9 FCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASI ::... :.::.::::::..::.::::::.:. : ::. . . .::::.::. : NP_000 FCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVI 120 130 140 150 160 170 220 230 240 250 260 270 pF1KE9 TLPPLFGWAQNV-NDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAK .. ::.:: . . :::: : .... :...:. .::::..:.: :: ..: .:.... : NP_000 SIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTT-K 180 190 200 210 220 230 280 290 300 310 320 pF1KE9 HKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHE-RKNISI----FKREQKAAT . : . : .. :. .. .. :. . .. :. :..:.. :.::.::: NP_000 NLEAGVMK-EMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAK 240 250 260 270 280 290 330 340 350 360 370 380 pF1KE9 TLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFF ::::.:: : .::::::. : :. : : : .. .:::: :: .::.:: NP_000 TLGIVVGMFILCWLPFFI---ALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCS 300 310 320 330 340 350 390 400 410 420 430 440 pF1KE9 NRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRP ..... .. .: :: :. .:. NP_000 SKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSG 360 370 380 390 400 410 >>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor (429 aa) initn: 644 init1: 324 opt: 782 Z-score: 813.4 bits: 159.7 E(85289): 1.4e-38 Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397) 40 50 60 70 80 90 pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL ..:.: . . : ...: :: . :. NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF 10 20 30 100 110 120 130 140 150 pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF . :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. : NP_150 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS ::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: :: NP_150 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA :.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. . NP_150 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG : :. . :: . : . . . . : : : . :.::.::: ::: NP_150 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD :.:: :..:::::::. :. . : : . .:::: :: :::.:: ... NP_150 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE 280 290 300 310 320 330 400 410 420 430 440 pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR .. .....: :: :. . : : : .: . .: .. . . .:... : : NP_150 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT 340 350 360 370 380 390 450 460 470 pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD : : NP_150 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARGHTPMT 400 410 420 >>XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A adrene (429 aa) initn: 644 init1: 324 opt: 782 Z-score: 813.4 bits: 159.7 E(85289): 1.4e-38 Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397) 40 50 60 70 80 90 pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL ..:.: . . : ...: :: . :. XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF 10 20 30 100 110 120 130 140 150 pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF . :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. : XP_006 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS ::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: :: XP_006 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA :.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. . XP_006 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG : :. . :: . : . . . . : : : . :.::.::: ::: XP_006 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD :.:: :..:::::::. :. . : : . .:::: :: :::.:: ... XP_006 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE 280 290 300 310 320 330 400 410 420 430 440 pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR .. .....: :: :. . : : : .: . .: .. . . .:... : : XP_006 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT 340 350 360 370 380 390 450 460 470 pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD : : XP_006 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARGHTPMT 400 410 420 >>NP_150647 (OMIM: 104221) alpha-1A adrenergic receptor (455 aa) initn: 644 init1: 324 opt: 782 Z-score: 813.1 bits: 159.8 E(85289): 1.5e-38 Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397) 40 50 60 70 80 90 pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL ..:.: . . : ...: :: . :. NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF 10 20 30 100 110 120 130 140 150 pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF . :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. : NP_150 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS ::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: :: NP_150 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA :.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. . NP_150 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG : :. . :: . : . . . . : : : . :.::.::: ::: NP_150 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD :.:: :..:::::::. :. . : : . .:::: :: :::.:: ... NP_150 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE 280 290 300 310 320 330 400 410 420 430 440 pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR .. .....: :: :. . : : : .: . .: .. . . .:... : : NP_150 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT 340 350 360 370 380 390 450 460 470 pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD : : NP_150 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARRGMDCRYFTKNCREHIKHVNFMMPPWRK 400 410 420 430 440 450 >>NP_000671 (OMIM: 104221) alpha-1A adrenergic receptor (466 aa) initn: 644 init1: 324 opt: 782 Z-score: 813.0 bits: 159.8 E(85289): 1.5e-38 Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397) 40 50 60 70 80 90 pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL ..:.: . . : ...: :: . :. NP_000 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF 10 20 30 100 110 120 130 140 150 pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF . :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. : NP_000 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS ::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: :: NP_000 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA :.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. . NP_000 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG : :. . :: . : . . . . : : : . :.::.::: ::: NP_000 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD :.:: :..:::::::. :. . : : . .:::: :: :::.:: ... NP_000 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE 280 290 300 310 320 330 400 410 420 430 440 pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR .. .....: :: :. . : : : .: . .: .. . . .:... : : NP_000 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT 340 350 360 370 380 390 450 460 470 pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD : : NP_000 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPT 400 410 420 430 440 450 >>NP_150646 (OMIM: 104221) alpha-1A adrenergic receptor (475 aa) initn: 644 init1: 324 opt: 782 Z-score: 812.9 bits: 159.8 E(85289): 1.5e-38 Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397) 40 50 60 70 80 90 pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL ..:.: . . : ...: :: . :. NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF 10 20 30 100 110 120 130 140 150 pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF . :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. : NP_150 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS ::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: :: NP_150 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA :.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. . NP_150 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG : :. . :: . : . . . . : : : . :.::.::: ::: NP_150 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD :.:: :..:::::::. :. . : : . .:::: :: :::.:: ... NP_150 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE 280 290 300 310 320 330 400 410 420 430 440 pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR .. .....: :: :. . : : : .: . .: .. . . .:... : : NP_150 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT 340 350 360 370 380 390 450 460 470 pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD : : NP_150 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARTKSRSVTRLECSGMILAHCNLRLPGSRD 400 410 420 430 440 450 >>XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A adrene (475 aa) initn: 644 init1: 324 opt: 782 Z-score: 812.9 bits: 159.8 E(85289): 1.5e-38 Smith-Waterman score: 782; 35.6% identity (62.6% similar) in 396 aa overlap (66-452:10-397) 40 50 60 70 80 90 pF1KE9 GADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEK-VVIGSILTLITLL ..:.: . . : ...: :: . :. XP_016 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF 10 20 30 100 110 120 130 140 150 pF1KE9 TIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFF . :: ::..:: ..:.. ..: ::.::.::: .. .:.:: .. ...: : ::. : XP_016 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLG-YWAFGRVF 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE9 CNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYP--VRQNGKCMAKMILSVWLLSAS ::.. :.::.::::::: ::.::::::.:.. :: :: : : :: .: :: :: XP_016 CNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMA--LLCVWALSLV 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE9 ITLPPLFGWAQNVNDDK-VCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAA :.. ::::: : . .:. .: :... ::...:. .::.:....: :: ..: .:.. . XP_016 ISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESR 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE9 KHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLK-HERKNISIFKREQKAATTLG : :. . :: . : . . . . : : : . :.::.::: ::: XP_016 GLK-SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLG 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE9 IIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRD :.:: :..:::::::. :. . : : . .:::: :: :::.:: ... XP_016 IVVGCFVLCWLPFFLVMPIGSFFPDFKPSET---VFKIVFWLGYLNSCINPIIYPCSSQE 280 290 300 310 320 330 400 410 420 430 440 pF1KE9 LRTTYRSLL--QCQYRNINRKLSAAG--MHEALKLAERPERPEFVLRACTRRVLLRPEKR .. .....: :: :. . : : : .: . .: .. . . .:... : : XP_016 FKKAFQNVLRIQCLCRKQSSK-HALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKT 340 350 360 370 380 390 450 460 470 pF1KE9 PPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD : : XP_016 DGVCEWKFFSSMPRGSARITVSKDQSSCTTARTKSRSVTRLECSGMILAHCNLRLPGSRD 400 410 420 430 440 450 479 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 15:23:58 2016 done: Sun Nov 6 15:23:59 2016 Total Scan time: 6.720 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]