FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9548, 398 aa 1>>>pF1KE9548 398 - 398 aa - 398 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8267+/-0.000426; mu= 19.6477+/- 0.027 mean_var=104.9699+/-26.153, 0's: 0 Z-trim(111.2): 745 B-trim: 974 in 1/50 Lambda= 0.125182 statistics sampled from 18898 (19751) to 18898 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.585), E-opt: 0.2 (0.232), width: 16 Scan time: 7.830 The best scores are: opt bits E(85289) NP_001048 (OMIM: 162321) substance-K receptor [Hom ( 398) 2679 495.3 1.1e-139 NP_001050 (OMIM: 162332,614840) neuromedin-K recep ( 465) 1330 251.7 2.6e-66 NP_001049 (OMIM: 162323) substance-P receptor isof ( 407) 1304 247.0 6.3e-65 NP_056542 (OMIM: 162323) substance-P receptor isof ( 311) 1192 226.6 6.5e-59 NP_057624 (OMIM: 605569) probable G-protein couple ( 423) 581 116.4 1.3e-25 NP_000901 (OMIM: 162642) neuropeptide Y receptor t ( 381) 508 103.2 1.1e-21 XP_005263090 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 508 103.2 1.1e-21 XP_005263091 (OMIM: 162642) PREDICTED: neuropeptid ( 381) 508 103.2 1.1e-21 NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 503 102.2 2.1e-21 NP_000900 (OMIM: 162641) neuropeptide Y receptor t ( 384) 489 99.7 1.2e-20 XP_011530312 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 489 99.7 1.2e-20 XP_005263088 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 489 99.7 1.2e-20 NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 467 95.7 1.9e-19 XP_011527461 (OMIM: 244200,607123) PREDICTED: prok ( 348) 460 94.4 4.4e-19 NP_658986 (OMIM: 244200,607123) prokineticin recep ( 384) 460 94.5 4.6e-19 XP_016883135 (OMIM: 244200,607123) PREDICTED: prok ( 384) 460 94.5 4.6e-19 NP_620414 (OMIM: 607122) prokineticin receptor 1 [ ( 393) 460 94.5 4.7e-19 XP_011528651 (OMIM: 182453) PREDICTED: somatostati ( 418) 447 92.2 2.5e-18 NP_001042 (OMIM: 182453) somatostatin receptor typ ( 418) 447 92.2 2.5e-18 XP_016884413 (OMIM: 182453) PREDICTED: somatostati ( 418) 447 92.2 2.5e-18 XP_005261778 (OMIM: 182453) PREDICTED: somatostati ( 418) 447 92.2 2.5e-18 NP_001265616 (OMIM: 182453) somatostatin receptor ( 418) 447 92.2 2.5e-18 XP_016884412 (OMIM: 182453) PREDICTED: somatostati ( 418) 447 92.2 2.5e-18 XP_006724374 (OMIM: 182453) PREDICTED: somatostati ( 418) 447 92.2 2.5e-18 NP_002502 (OMIM: 162341) neuromedin-B receptor iso ( 390) 445 91.8 3.1e-18 NP_940799 (OMIM: 601898) growth hormone secretagog ( 366) 438 90.5 7.1e-18 NP_001718 (OMIM: 300107) bombesin receptor subtype ( 399) 433 89.7 1.4e-17 NP_001138754 (OMIM: 600018) mu-type opioid recepto ( 406) 432 89.5 1.6e-17 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 429 88.9 2.2e-17 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 429 88.9 2.2e-17 NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 429 88.9 2.3e-17 XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 429 89.0 2.4e-17 XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 429 89.0 2.4e-17 XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 429 89.0 2.4e-17 XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 429 89.0 2.4e-17 XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 429 89.0 2.4e-17 NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 426 88.4 3.3e-17 NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 426 88.4 3.4e-17 NP_003605 (OMIM: 603692) galanin receptor type 3 [ ( 368) 423 87.8 4.6e-17 NP_000905 (OMIM: 600018) mu-type opioid receptor i ( 400) 423 87.8 4.9e-17 NP_001272453 (OMIM: 600018) mu-type opioid recepto ( 493) 423 88.0 5.5e-17 NP_001138751 (OMIM: 600018) mu-type opioid recepto ( 493) 423 88.0 5.5e-17 NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 421 87.4 5.8e-17 NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 420 87.3 7e-17 NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 420 87.3 7e-17 NP_001138755 (OMIM: 600018) mu-type opioid recepto ( 397) 420 87.3 7.1e-17 NP_001138756 (OMIM: 600018) mu-type opioid recepto ( 403) 420 87.3 7.1e-17 NP_001272452 (OMIM: 600018) mu-type opioid recepto ( 414) 420 87.3 7.3e-17 NP_001008503 (OMIM: 600018) mu-type opioid recepto ( 418) 420 87.3 7.3e-17 NP_001138758 (OMIM: 600018) mu-type opioid recepto ( 420) 420 87.3 7.3e-17 >>NP_001048 (OMIM: 162321) substance-K receptor [Homo sa (398 aa) initn: 2679 init1: 2679 opt: 2679 Z-score: 2628.8 bits: 495.3 E(85289): 1.1e-139 Smith-Waterman score: 2679; 99.5% identity (99.5% similar) in 398 aa overlap (1-398:1-398) 10 20 30 40 50 60 pF1KE9 MGTCDIVTEANISSGPESNTTGTTAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA :::::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: NP_001 MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 HLQAKKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST :::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA 310 320 330 340 350 360 370 380 390 pF1KE9 GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI :::::::::::::::::::::::::::::::::::::: NP_001 GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI 370 380 390 >>NP_001050 (OMIM: 162332,614840) neuromedin-K receptor (465 aa) initn: 1307 init1: 728 opt: 1330 Z-score: 1311.4 bits: 251.7 E(85289): 2.6e-66 Smith-Waterman score: 1330; 53.4% identity (75.6% similar) in 373 aa overlap (14-380:68-435) 10 20 30 40 pF1KE9 MGTCDIVTEANISSGPESNTTGTTAFSMPSWQLALWATAYLAL : : .: :. : .:::..:::. :: .. NP_001 ETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTN--QFVQPSWRIALWSLAYGVV 40 50 60 70 80 90 50 60 70 80 90 100 pF1KE9 VLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGR : ::: :: :::::::::.:::::::::.::::..: :::::. ::.:: :. :::: NP_001 VAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGA 100 110 120 130 140 150 110 120 130 140 150 160 pF1KE9 AFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALA .: :::.:::::.:.:::::::::.::::::. :..::::: .:: ::..::..:. :: NP_001 NYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLA 160 170 180 190 200 210 170 180 190 200 210 220 pF1KE9 SPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLT :::.:: . . : : : : ::: : : . ::..:: :.: .:: .: ..:...:.: NP_001 FPQCLYSKTKVMPGRTLCFVQWPE--GPKQHFTYHIIVIILVYCFPLLIMGITYTIVGIT 220 230 240 250 260 270 230 240 250 260 270 280 pF1KE9 LWRRAVPGHQAHGANLRHLQAKKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHK :: .:: . ..:.::.: :: :..::.::::::::::.:::: .. ... : NP_001 LWGGEIPGDTCDKYH-EQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWK 280 290 300 310 320 330 290 300 310 320 330 340 pF1KE9 FIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTS .::::::: :::::::::::::::::::.:::.::. ::: ::.. .. :.::: : NP_001 YIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRF 340 350 360 370 380 390 350 360 370 380 390 pF1KE9 LSTR------VNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVE .: :.: .. ..: .:. .... . . :.: : NP_001 HPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSS 400 410 420 430 440 450 pF1KE9 I NP_001 FISSPYTSVDEYS 460 >>NP_001049 (OMIM: 162323) substance-P receptor isoform (407 aa) initn: 1296 init1: 840 opt: 1304 Z-score: 1286.7 bits: 247.0 E(85289): 6.3e-65 Smith-Waterman score: 1304; 50.9% identity (77.9% similar) in 371 aa overlap (9-379:8-372) 10 20 30 40 50 60 pF1KE9 MGTCDIVTEANISSGPESNTTGTTAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA ....: . .::. . : .:.::..:::.:: ..:...:.::..:.::::: NP_001 MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILA 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS :.:::::::::.::::.:. :::::.. ::.:: :: ::.: .: :.:.:::.:.:.: NP_001 HKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFAS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK ::::::.: ::::::.::.:::::: .::.:: ::..:: :: :: .:::. . . NP_001 IYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR :.. ::: . .::. : .::::::: :. ::.:.:.::: .:: .. . . NP_001 CMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYH-E 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE9 HLQAKKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST ...::.: :: :..:: ::::::::.:..:.: .. :.: .:::::::::..::::::: NP_001 QVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSST 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE9 MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA ::::::::::: ::: ::. ::::::... . ::. : :.:. . .... NP_001 MYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRL---- 300 310 320 330 340 350 370 380 390 pF1KE9 GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI .:. : ..... .:.:: NP_001 -ETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS 360 370 380 390 400 >>NP_056542 (OMIM: 162323) substance-P receptor isoform (311 aa) initn: 1186 init1: 840 opt: 1192 Z-score: 1178.6 bits: 226.6 E(85289): 6.5e-59 Smith-Waterman score: 1192; 55.4% identity (81.0% similar) in 305 aa overlap (9-313:8-311) 10 20 30 40 50 60 pF1KE9 MGTCDIVTEANISSGPESNTTGTTAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA ....: . .::. . : .:.::..:::.:: ..:...:.::..:.::::: NP_056 MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILA 10 20 30 40 50 70 80 90 100 110 120 pF1KE9 HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS :.:::::::::.::::.:. :::::.. ::.:: :: ::.: .: :.:.:::.:.:.: NP_056 HKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFAS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE9 IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK ::::::.: ::::::.::.:::::: .::.:: ::..:: :: :: .:::. . . NP_056 IYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVV 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE9 CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR :.. ::: . .::. : .::::::: :. ::.:.:.::: .:: .. . . NP_056 CMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYH-E 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE9 HLQAKKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST ...::.: :: :..:: ::::::::.:..:.: .. :.: .:::::::::..::::::: NP_056 QVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSST 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE9 MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA ::::::::::: : NP_056 MYNPIIYCCLNDR 300 310 >>NP_057624 (OMIM: 605569) probable G-protein coupled re (423 aa) initn: 370 init1: 370 opt: 581 Z-score: 580.8 bits: 116.4 E(85289): 1.3e-25 Smith-Waterman score: 581; 31.3% identity (61.2% similar) in 345 aa overlap (34-372:72-410) 10 20 30 40 50 60 pF1KE9 CDIVTEANISSGPESNTTGTTAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRR :: .:: ... .. ::..: .:. ..: NP_057 FSWNNYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFIIVFSLFGNVLVCHVIFKNQR 50 60 70 80 90 100 70 80 90 100 110 120 pF1KE9 MRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYS :...:. ::::::.::. .. .:. :..: .. : ::...:. . . .. :: . NP_057 MHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWIFGKGMCHVSRFAQYCSLHVSALT 110 120 130 140 150 160 130 140 150 160 170 pF1KE9 MTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQ--C---FYSTVTMDQGA .::::.::...:.::..::.: . :: :: .: .. :. : : . : NP_057 LTAIAVDRHQVIMHPLKPRISITKGVIYIAVIWTMATFFSLPHAICQKLFTFKYSEDIVR 170 180 190 200 210 220 180 190 200 210 220 230 pF1KE9 TKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGAN . :. .:: . : :... :.:.::: .. :::. .. :: . : . NP_057 SLCLPDFPEPADLFWKYL-DLATFILLYILPLLIISVAYARVAKKLWLCNMIGDVTTEQY 230 240 250 260 270 280 240 250 260 270 280 290 pF1KE9 LRHLQAKKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMS . . ::: .: ..:::. ::.::.: . : .: : . . . .:.:. :.::: NP_057 FALRRKKKKTIKMLMLVVVLFALCWFPLNCYVLLLSSK----VIRTNNALYFAFHWFAMS 290 300 310 320 330 300 310 320 330 340 350 pF1KE9 STMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLF :: :::.::: ::. :: .. . : .::. .:. :. . .. . . NP_057 STCYNPFIYCWLNENFRIELKALLSMCQRPPKPQEDR-PPSPVPSFRVAWTEKNDGQRAP 340 350 360 370 380 390 360 370 380 390 pF1KE9 MAGDTAP-SEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI .:.. : :. ::. NP_057 LANNLLPTSQLQSGKTDLSSVEPIVTMS 400 410 420 >>NP_000901 (OMIM: 162642) neuropeptide Y receptor type (381 aa) initn: 518 init1: 272 opt: 508 Z-score: 510.1 bits: 103.2 E(85289): 1.1e-21 Smith-Waterman score: 508; 30.9% identity (61.9% similar) in 291 aa overlap (39-324:56-342) 10 20 30 40 50 60 pF1KE9 EANISSGPESNTTGTTAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVT :: ...:..: ::..:: ... . ::::: NP_000 TTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVT 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE9 NYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIA :.::.:::.::: . .. :...:. . : .: ..:.. :. :: ..:.:: NP_000 NFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIA 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE9 ADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCF---YSTVTM--DQGATKCVV ::. ::. .. ..: . .:. : .. :::: . :: . . : . :. NP_000 LDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTE 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE9 AWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQ :: . . .: : . ..: :::... .:. : : .. :: .:: .. : NP_000 KWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPG----AANDHYHQ 210 220 230 240 250 260 250 260 270 280 290 300 pF1KE9 AKKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYN ..: .: .: ::..::. ::: : . . ... .. : . .. .. .:: ::. : NP_000 RRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFAN 270 280 290 300 310 320 310 320 330 340 350 360 pF1KE9 PIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDT :..: .: .:..: :::: NP_000 PLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV 330 340 350 360 370 380 >>XP_005263090 (OMIM: 162642) PREDICTED: neuropeptide Y (381 aa) initn: 518 init1: 272 opt: 508 Z-score: 510.1 bits: 103.2 E(85289): 1.1e-21 Smith-Waterman score: 508; 30.9% identity (61.9% similar) in 291 aa overlap (39-324:56-342) 10 20 30 40 50 60 pF1KE9 EANISSGPESNTTGTTAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVT :: ...:..: ::..:: ... . ::::: XP_005 TTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVT 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE9 NYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIA :.::.:::.::: . .. :...:. . : .: ..:.. :. :: ..:.:: XP_005 NFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIA 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE9 ADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCF---YSTVTM--DQGATKCVV ::. ::. .. ..: . .:. : .. :::: . :: . . : . :. XP_005 LDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTE 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE9 AWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQ :: . . .: : . ..: :::... .:. : : .. :: .:: .. : XP_005 KWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPG----AANDHYHQ 210 220 230 240 250 260 250 260 270 280 290 300 pF1KE9 AKKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYN ..: .: .: ::..::. ::: : . . ... .. : . .. .. .:: ::. : XP_005 RRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFAN 270 280 290 300 310 320 310 320 330 340 350 360 pF1KE9 PIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDT :..: .: .:..: :::: XP_005 PLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV 330 340 350 360 370 380 >>XP_005263091 (OMIM: 162642) PREDICTED: neuropeptide Y (381 aa) initn: 518 init1: 272 opt: 508 Z-score: 510.1 bits: 103.2 E(85289): 1.1e-21 Smith-Waterman score: 508; 30.9% identity (61.9% similar) in 291 aa overlap (39-324:56-342) 10 20 30 40 50 60 pF1KE9 EANISSGPESNTTGTTAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVT :: ...:..: ::..:: ... . ::::: XP_005 TTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVT 30 40 50 60 70 80 70 80 90 100 110 120 pF1KE9 NYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIA :.::.:::.::: . .. :...:. . : .: ..:.. :. :: ..:.:: XP_005 NFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIA 90 100 110 120 130 140 130 140 150 160 170 180 pF1KE9 ADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCF---YSTVTM--DQGATKCVV ::. ::. .. ..: . .:. : .. :::: . :: . . : . :. XP_005 LDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTE 150 160 170 180 190 200 190 200 210 220 230 240 pF1KE9 AWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQ :: . . .: : . ..: :::... .:. : : .. :: .:: .. : XP_005 KWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPG----AANDHYHQ 210 220 230 240 250 260 250 260 270 280 290 300 pF1KE9 AKKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYN ..: .: .: ::..::. ::: : . . ... .. : . .. .. .:: ::. : XP_005 RRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFAN 270 280 290 300 310 320 310 320 330 340 350 360 pF1KE9 PIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDT :..: .: .:..: :::: XP_005 PLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV 330 340 350 360 370 380 >>NP_004239 (OMIM: 600895) prolactin-releasing peptide r (370 aa) initn: 492 init1: 357 opt: 503 Z-score: 505.3 bits: 102.2 E(85289): 2.1e-21 Smith-Waterman score: 503; 30.0% identity (64.4% similar) in 323 aa overlap (9-319:31-347) 10 20 30 pF1KE9 MGTCDIVTEANISSGPESNTTGTTAFSMPSWQLA---- ::. ..: ... . .. . : ::. NP_004 MASSTTRGPRVSDLFSGLPPAVTTPANQSAEASAGNGSVAGADAPAVTPFQSLQLVHQLK 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE9 -LWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVY : . : ..:.:...:: ... .: ::...:::..: ::::.:. : . . ....: NP_004 GLIVLLYSVVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNLALSDVLMCTACVPLTLAY 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE9 ASH-NIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVI : . : :: ..:.. .. ....::....:.::.:::...:::.. :.: . .. NP_004 AFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRYVVLVHPLRRRISLRLSAYAV 130 140 150 160 170 180 160 170 180 190 200 210 pF1KE9 AGIWLVALALASPQCFYST-VTMDQGATK-CVVAWPEDSGGKTLLLYHLVVIALIYFLPL .:: .. .:: : .. : . .. : : . . : . :.... :.::: NP_004 LAIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQERQRQLYAWGLLLVT--YLLPL 190 200 210 220 230 220 230 240 250 260 pF1KE9 AVMFVAYSVIGLTLWRRAVPGHQAHG-ANLRHLQAKKKFVKTMVLVVLTFAICWLPYHLY :....: ... : :.::: ... :. . . .. : .:.::..::.:::: :.. NP_004 LVILLSYVRVSVKLRNRVVPGCVTQSQADWDRARRRRTFC-LLVVVVVVFAVCWLPLHVF 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE9 FILGSFQE---DIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCP .: ... : : ..: : ::::::. :::.:: :. :: .: NP_004 NLLRDLDPHAIDPYAFGLVQ---LLCHWLAMSSACYNPFIYAWLHDSFREELRKLLVAWP 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE9 WVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGY NP_004 RKIAPHGQNMTVSVVI 360 370 >>NP_000900 (OMIM: 162641) neuropeptide Y receptor type (384 aa) initn: 457 init1: 282 opt: 489 Z-score: 491.5 bits: 99.7 E(85289): 1.2e-20 Smith-Waterman score: 503; 30.5% identity (60.1% similar) in 341 aa overlap (28-355:35-366) 10 20 30 40 50 pF1KE9 MGTCDIVTEANISSGPESNTTGTTAFSMPSWQLALWATAYLALVLVAVTGNAIVIWI .: .. : :: :.....:.:: .: : NP_000 LFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIII 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE9 ILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAM :: ...::.::: .::::...:: .: . :.:::. . : ::.:.: .. . ... NP_000 ILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE9 FVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYST------ :::.:.. ::..:.. :..: : . . . :: ::..:.: . : .:.. NP_000 TVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPF 130 140 150 160 170 180 180 190 200 210 220 pF1KE9 --VTMDQGATK--CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRR ::.: : : .: :: : : ....: :: :: .:. : : . : :: NP_000 QNVTLDAYKDKYVCFDQFPSDSHR---LSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 AVPGHQAHGANLRHLQAKKKFVKTMVL-VVLTFAICWLPYHLYFILGSFQEDIY--CHKF . . . : ..:. .. :.: .:..::.:::: .. . .....: :.. NP_000 NNMMDKMRDNKYRSSETKR--INIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHN 250 260 270 280 290 290 300 310 320 330 340 pF1KE9 IQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSL . ..: :: :: :::.: ::. :. ... : : . . ..: : ... NP_000 L--LFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRS--RDDDYETIAMSTM 300 310 320 330 340 350 350 360 370 380 390 pF1KE9 STRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI : :.. :. NP_000 HTDVSKTSLKQASPVAFKKINNNDDNEKI 360 370 380 398 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 15:26:19 2016 done: Sun Nov 6 15:26:20 2016 Total Scan time: 7.830 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]